cloud-sailing:

Santiago, Chile by So Cal Metro on Flickr.

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COVID-19 has killed at least 19,000 New Yorkers and dealt a body blow with lasting consequences to the city. Two paths lie ahead. If pandemics become common, then not only New York City but all of America’s service-based economy faces a bleak future. If this terrible plague is a unique event, then things will eventually get almost back to normal. To save both the nation’s biggest and most productive metropolis and tens of millions of service jobs across the county, we must invest enormously to prevent future pandemics.

At first, it was hard to hear what Turk Wendell was saying from atop his tractor.

At first, it was hard to hear what Turk Wendell was saying from atop his tractor.

At first, it was hard to hear what Turk Wendell was saying from atop his tractor.

Edwin Cabrera, a father of two, was unlocking his e-bike after dropping off a pizza on Fort George Hill near Fairview Ave. on May 3 when two suspects jumped out of the shadows and attacked him around 9 p.m.

Unilever is recalling Wall’s Mini Calippo (Orange and Lemon-Lime) multi-packs because they may contain small pieces of metal. The presence of metal makes this product unsafe to eat.

Filed under: Food and Drink, North America, United States

Traveling "home" this holiday season? Don't fall into your old routine. Your high school hangout may be an easy go-to, but if you don't live there anymore there's a good chance you're missing out on some great new local spots. (Plus, be honest: you already know what all your classmates are up to from Facebook.)

We turned to local writers to help you rediscover your hometown over Thanksgiving and the winter holidays. Each city guide features a great new restaurant to try while you're in town, a cool neighborhood that wasn't on the radar last year or a store where you can pick up a keepsake to bring your old home back to your new home. We'll also catch you up to speed on the hot topics of conversation in each city, so you'll come back savvy enough to join the local sports banter or eat your holiday weight in Cronuts.

Click your city below to learn what's new since the last time you went home:

Continue reading Discover Something New at Home this Holiday Season

Discover Something New at Home this Holiday Season originally appeared on Gadling on Mon, 25 Nov 2013 12:15:00 EST. Please see our terms for use of feeds.

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Filed under: Food and Drink, North America, United States

Traveling "home" this holiday season? Don't fall into your old routine. Your high school hangout may be an easy go-to, but if you don't live there anymore there's a good chance you're missing out on some great new local spots. (Plus, be honest: you already know what all your classmates are up to from Facebook.)

AOL Travel turned to local writers to help you rediscover your hometown over the winter holidays. Each city guide features a great new restaurant to try while you're in town, a cool neighborhood that wasn't on the radar last year or a store where you can pick up a keepsake to bring your old home back to your new home. AOL Travel also will catch you up to speed on the hot topics of conversation in each city, so you'll come back savvy enough to join the local sports banter or eat your holiday weight in Cronuts.

Click your city below to learn what's new since the last time you went home:

Continue reading Discover Something New at Home this Holiday Season

Discover Something New at Home this Holiday Season originally appeared on Gadling on Wed, 18 Dec 2013 11:04:00 EST. Please see our terms for use of feeds.

Permalink | Email this | Comments

β-1,3-d-Glucan is a ubiquitous glucose polymer produced by plants, bacteria, and most fungi. It has been used as a diagnostic tool in patients with invasive mycoses via a highly-sensitive reagent consisting of the blood coagulation system of horseshoe crab. However, no method is currently available for measuring β-1,6-glucan, another primary β-glucan structure of fungal polysaccharides. Herein, we describe the development of an economical and highly-sensitive and specific assay for β-1,6-glucan using a modified recombinant endo-β-1,6-glucanase having diminished glucan hydrolase activity. The purified β-1,6-glucanase derivative bound to the β-1,6-glucan pustulan with a KD of 16.4 nm. We validated the specificity of this β-1,6-glucan probe by demonstrating its ability to detect cell wall β-1,6-glucan from both yeast and hyphal forms of the opportunistic fungal pathogen Candida albicans, without any detectable binding to glucan lacking the long β-1,6-glucan branch. We developed a sandwich ELISA-like assay with a low limit of quantification for pustulan (1.5 pg/ml), and we successfully employed this assay in the quantification of extracellular β-1,6-glucan released by >250 patient-derived strains of different Candida species (including Candida auris) in culture supernatant in vitro. We also used this assay to measure β-1,6-glucan in vivo in the serum and in several organs in a mouse model of systemic candidiasis. Our work describes a reliable method for β-1,6-glucan detection, which may prove useful for the diagnosis of invasive fungal infections.

β-Glucocerebrosidase (GBA) hydrolyzes glucosylceramide (GlcCer) to generate ceramide. Previously, we demonstrated that lysosomal GBA1 and nonlysosomal GBA2 possess not only GlcCer hydrolase activity, but also transglucosylation activity to transfer the glucose residue from GlcCer to cholesterol to form β-cholesterylglucoside (β-GlcChol) in vitro. β-GlcChol is a member of sterylglycosides present in diverse species. How GBA1 and GBA2 mediate β-GlcChol metabolism in the brain is unknown. Here, we purified and characterized sterylglycosides from rodent and fish brains. Although glucose is thought to be the sole carbohydrate component of sterylglycosides in vertebrates, structural analysis of rat brain sterylglycosides revealed the presence of galactosylated cholesterol (β-GalChol), in addition to β-GlcChol. Analyses of brain tissues from GBA2-deficient mice and GBA1- and/or GBA2-deficient Japanese rice fish (Oryzias latipes) revealed that GBA1 and GBA2 are responsible for β-GlcChol degradation and formation, respectively, and that both GBA1 and GBA2 are responsible for β-GalChol formation. Liquid chromatography–tandem MS revealed that β-GlcChol and β-GalChol are present throughout development from embryo to adult in the mouse brain. We found that β-GalChol expression depends on galactosylceramide (GalCer), and developmental onset of β-GalChol biosynthesis appeared to be during myelination. We also found that β-GlcChol and β-GalChol are secreted from neurons and glial cells in association with exosomes. In vitro enzyme assays confirmed that GBA1 and GBA2 have transgalactosylation activity to transfer the galactose residue from GalCer to cholesterol to form β-GalChol. This is the first report of the existence of β-GalChol in vertebrates and how β-GlcChol and β-GalChol are formed in the brain.

The enactment of President Clinton’s Limited English Proficiency (LEP) Executive Order, issued in 2000, triggered a proliferation of efforts to provide services to individuals who cannot speak, understand, read, or write English fluently. With increased service provision, state and local government agencies have expressed a strong and growing interest in assuring the quality and cost-effectiveness of language access services. This paper attempts to catalog and describe some of those tools and practices.

Researchers at MIT have developed a new method of electrically stimulating deep brain tissues without opening the skull

Since 1997, more than 100,000 Parkinson’s Disease patients have been treated with deep brain stimulation (DBS), a surgical technique that involves the implantation of ultra-thin wire electrodes. The implanted device, sometimes referred to as a ‘brain pacemaker’, delivers electrical pulses to a structure called the subthalamic nucleus, located near the centre of the brain, and effectively alleviates many of the physical symptoms of the disease, such as tremor, muscle rigidity, and slowed movements.

DBS is generally safe but, like any surgical procedure, comes with some risks. First and foremost, it is highly invasive, requiring small holes to be drilled in the patient’s skull, through which the electrodes are inserted. Potential complications of this include infection, stroke, and bleeding on the brain. The electrodes, which are implanted for long periods of time, sometimes move out of place; they can also cause swelling at the implantation site; and the wire connecting them to the battery, typically placed under the skin of the chest, can erode, all of which require additional surgical procedures.

Related: Blowing up the brain to reveal its finer details

Related: Traces of memory in a dish | Mo Costandi

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I have an online gf it seems kind of serious but we've never really made attempts on meeting but i slept with someone irl,is that cheating? Should I tell her?

Testimony of MPI President Demetrios G. Papademetriou before the House Judiciary’s Subcommittee on Immigration, Citizenship, Refugees, Border Security, and International Law.

The singer-composer, who has collaborated with quite a few international names in music, has his plans firmly in place.

Typically, at least two discarded babies are found in the Mamelodi City Dump every week. AIDS Hope seeks to eliminate this horrible reality.

Seven thousand were reported homeless after fire destroyed homes in Lorega cemetery, Cebu City, on 18 March. OM helps provide basic relief.

Jemina (Finland) joined the Transform team in Athens. Changes in travel plans meant she used the metro system—between stations with very special names.

A MDT trainee puts what she has learned into practice as she teaches German to an Egyptian immigrant in Switzerland.

Logos Hope crew member Tom Critchley spent three months in Finland. He shares about contemporary Christian music in Finland, focusing on the metal band Terapia.

A married Maryland couple in their 80s were the victims in a shooting at a veterans cemetery in Delaware

Royal Enfield Meteor 350 Fireball is expected to come with multiple optional accessories. Very recently, images that appear to be the screenshots of the official configurator have leaked on the web revealing some juicy details.

Now we've got Indian helmet brands launching new products with one of the latest one being Mavox. We had to try out an IS:4151 standard helmet, so folks at Mavox sent us an FX22.D2P full-face helmet.

The Food Corporation of India (FCI) has been able to buy half of its wheat procurement target of 40.7 million tonne by Wednesday despite a delayed start this year as Punjab has exceeded expectation by purchasing nearly 75% of its target in only 22 days.

The Covid-19 pandemic is expected to exert downward pressure on the credit quality of sugar mills by eroding operating profitability and shoring up debt in fiscal 2021.

While DronaMaps is helping map Covid-19 patients in Haryana and other states, Blinkin has provided remote tech support for installing air ventilation systems in two Wuhan hospitals

Work on the Pune Metro comprising two lines of 32 km started in December 2016 and was to end in 2022. Commissioning of work on 10 km of Line 1 and Line 2 was to be done in the first half of 2020.

The bank has witnessed asset quality weakening further in December quarter with the gross non-performing assets (NPA) as of December 2018 increasing to Rs 4,056 crore (8.49%) compared to Rs 2, 663 crore (5.95%).

Gaming has been serious business for some time, but Fortnite’s experiment shows the success of metaverse.

Whitepaper that discusses types of computer worms and how metamorphic worms differ from the rest.

The United States is experiencing a significant shift in its energy landscape. Last year, utility-scale wind and solar power combined for 47 percent of new generation capacity in the U.S. Based on this expansion, 11 states now generate more than 10 percent of their electricity from solar, wind, and geothermal power, with three of these states — Iowa, South Dakota, and Kansas — exceeding 20 percent. In 2014, California became the first state in the nation to garner 5 percent of its electricity from utility-scale solar. When including hydropower, four states —Idaho, Washington, Oregon, and South Dakota — now exceed 70 percent renewables generation.

To help ensure the safety of fish passing through the new turbines at 912-MW Priest Rapids, Public Utility District No. 2 of Grant County is employing the BioPA method to analyze the biological performance of proposed designs - and to choose an improved one for this facility.

Durban - After 19 hours of being beaten and forced at gunpoint to extort money from family and friends a Bellair man is lucky to be alive and counts Durban’s metro police officers as his heroes. Sibusiso Dlamini, 36, was alone at his girlfriend’s residence when there was a knock on the door at 3am last Tuesday. “I heard my name called and I went to check who it was. That was when four men armed with guns, wearing masks, abducted me.” Dlamini was taken to a river that remains unknown to him, where he begged for his life. “They kept telling me different stories that my landlord, friends and work...

The FCA has issued its long awaited consultation on extension of the Senior Managers and Certification Regime (also known as “Accountability II”). Consultation Paper (CP17/25), which sets out the “what” and the “why&rdq...

After 19 hours of being beaten and forced at gunpoint to extort money from family and friends a Bellair man is lucky to be alive.

With the new advances, fertility doctors will be able to hand-select the healthiest and quality sperm for artificial insemination, in effect increasing a woman's chance of becoming pregnant.

Washington: Orders for vaccines against diseases such as measles have declined since a national emergency was declared in the United States because of the coronavirus pandemic, the US Centers for Disease Control and Prevention said Friday.The number of vaccine doses ordered around the country has...

The skywatching event lasts about a week, with the best views arriving before dawn on Tuesday.

How cool is that?

Being a tour manager means being a logistics coordinator, accountant, event planner, human resources professional, crisis manager, and counselor. Everything that goes on during the tour - or leading up to it - runs through them. Really, it's one of the most important yet least-discussed jobs in the music business. That’s why Mike wrote a feature article for the March/April 2020 issue of Canadian Musician trying to make sense of tour managers’ responsibilities and share a few of their stories.

One of those interesting and fun conversations for the magazine was with Erika Duffee, the go-to tour manager for Canadian pop-rock star Scott Helman and arena-filling Italian pianist Ludovico Einaudi, among others, which we share on today’s episode. You'll hear about the many facets of this odd role along with some great stories from the road and other insights.

http://canadianmusician.com

This episode is sponsored by Bandzoogle. Try it free for 30 days and use the promo code “CMPOD” to get 15% off your first year of any subscription. https://bandzoogle.com/?pc=cmpod

Every year for the past 20, Rosa Maria Fuenzalida has visited her mother's grave on Mother's Day without fail in the central Chilean city of Curico.

Adam Silver reportedly said the league does not have to make a decision on playing or cancelling the 2019-20 season this month and can wait until sometime in June.

While meteorites are very rare, they are out there, and it's not impossible that you could find a piece of space rock if you know what you're looking for.