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Homeland Security issues alert on cybercriminals increasingly exploiting COVID-19 pandemic

The U.S. Department of Homeland Security issued an alert April 8 warning that cybercriminals are increasingly exploiting the COVID-19 pandemic to target individuals, small and medium businesses and large organizations.




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State oil ADNOC sells 35 percent in refining to Eni, OMV

ADNOC sold a 20 percent state in its refinery operations to Italy's Eni and 15 percent to OMV, from Austria in one of the biggest refinery transactions ever.




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Measles vaccinations in U.S. children fall up to 60 percent since pandemic, CDC says

Pediatric vaccination against measles has declined by as much as 60 percent nationally since the start of the COVID-19 outbreak, according to new data released Friday by the Centers for Disease Control and Prevention.




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Effects of Low-Energy Diet or Exercise on Cardiovascular Function in Working-Age Adults With Type 2 Diabetes: A Prospective, Randomized, Open-Label, Blinded End Point Trial

OBJECTIVE

To confirm the presence of subclinical cardiovascular dysfunction in working-age adults with type 2 diabetes (T2D) and determine whether this is improved by a low-energy meal replacement diet (MRP) or exercise training.

RESEARCH DESIGN AND METHODS

This article reports on a prospective, randomized, open-label, blinded end point trial with nested case-control study. Asymptomatic younger adults with T2D were randomized 1:1:1 to a 12-week intervention of 1) routine care, 2) supervised aerobic exercise training, or 3) a low-energy (~810 kcal/day) MRP. Participants underwent echocardiography, cardiopulmonary exercise testing, and cardiac magnetic resonance (CMR) at baseline and 12 weeks. The primary outcome was change in left ventricular (LV) peak early diastolic strain rate (PEDSR) as measured by CMR. Healthy volunteers were enrolled for baseline case-control comparison.

RESULTS

Eighty-seven participants with T2D (age 51 ± 7 years, HbA1c 7.3 ± 1.1%) and 36 matched control participants were included. At baseline, those with T2D had evidence of diastolic dysfunction (PEDSR 1.01 ± 0.19 vs. 1.10 ± 0.16 s–1, P = 0.02) compared with control participants. Seventy-six participants with T2D completed the trial (30 routine care, 22 exercise, and 24 MRP). The MRP arm lost 13 kg in weight and had improved blood pressure, glycemia, LV mass/volume, and aortic stiffness. The exercise arm had negligible weight loss but increased exercise capacity. PEDSR increased in the exercise arm versus routine care (β = 0.132, P = 0.002) but did not improve with the MRP (β = 0.016, P = 0.731).

CONCLUSIONS

In asymptomatic working-age adults with T2D, exercise training improved diastolic function. Despite beneficial effects of weight loss on glycemic control, concentric LV remodeling, and aortic stiffness, a low-energy MRP did not improve diastolic function.




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Commercially Available Insulin Products Demonstrate Stability Throughout the Cold Supply Chain Across the U.S.

OBJECTIVE

A recent publication questioned the integrity of insulin purchased from U.S. retail pharmacies. We sought to independently validate the method used, isotope dilution solid-phase extraction (SPE) liquid chromatography mass spectrometry (LC-MS), and expand analysis to two U.S. Pharmacopeia (USP) methods (high-performance LC with ultraviolet detection and LC-MS).

RESEARCH DESIGN AND METHODS

Each method was used to evaluate nine insulin formulations, purchased at four pharmacies, within five geographic locations in the U.S.

RESULTS

All human and analog insulins measured by the USP methods (n = 174) contained the expected quantity of active insulin (100 ± 5 units/mL). When using isotope dilution SPE-LC-MS, units-per-milliliter values were well below product labeling due to unequal recovery of the internal standard compared with target insulin.

CONCLUSIONS

Insulin purchased from U.S. pharmacies is consistent with product labeling.





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Can High-Intensity Exercise Improve Your Memory?

Exercise like walking, swimming, and even dancing have been shown to be good for your memory, but the optimal intensity of that exercise has been unclear... until now

-- Read more on ScientificAmerican.com




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Association of BMI, Fitness, and Mortality in Patients With Diabetes: Evaluating the Obesity Paradox in the Henry Ford Exercise Testing Project (FIT Project) Cohort

OBJECTIVE

To determine the effect of fitness on the association between BMI and mortality among patients with diabetes.

RESEARCH DESIGN AND METHODS

We identified 8,528 patients with diabetes (self-report, medication use, or electronic medical record diagnosis) from the Henry Ford Exercise Testing Project (FIT Project). Patients with a BMI <18.5 kg/m2 or cancer were excluded. Fitness was measured as the METs achieved during a physician-referred treadmill stress test and categorized as low (<6), moderate (6–9.9), or high (≥10). Adjusted hazard ratios for mortality were calculated using standard BMI (kilograms per meter squared) cutoffs of normal (18.5–24.9), overweight (25–29.9), and obese (≥30). Adjusted splines centered at 22.5 kg/m2 were used to examine BMI as a continuous variable.

RESULTS

Patients had a mean age of 58 ± 11 years (49% women) with 1,319 deaths over a mean follow-up of 10.0 ± 4.1 years. Overall, obese patients had a 30% lower mortality hazard (P < 0.001) compared with normal-weight patients. In adjusted spline modeling, higher BMI as a continuous variable was predominantly associated with a lower mortality risk in the lowest fitness group and among patients with moderate fitness and BMI ≥30 kg/m2. Compared with the lowest fitness group, patients with higher fitness had an ~50% (6–9.9 METs) and 70% (≥10 METs) lower mortality hazard regardless of BMI (P < 0.001).

CONCLUSIONS

Among patients with diabetes, the obesity paradox was less pronounced for patients with the highest fitness level, and these patients also had the lowest risk of mortality.




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Can a Company be pro-regulation and pro-commerce? Gregg Renfrew from Beautycounter thinks so

It’s the middle of an election year and, according to the Pew Research Center, the country hasn’t been this polarized since the Civil War. In such a climate, it would seem to be an oxymoron for a company to push for both financial growth and tighter regulations. Gregg Renfrew, CEO & Founder of Beautycounter, wouldn’t […]




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Amylin Replacement With Pramlintide in Type 1 and Type 2 Diabetes: A Physiological Approach to Overcome Barriers With Insulin Therapy

John B. Buse
Jul 1, 2002; 20:
Feature Articles






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Despite Fierce Teacher Opposition, West Virginia House Votes to Allow Charter Schools

The West Virginia House of Delegates passed its version of a sweeping education omnibus bill, which would allow the state's first charter schools.




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How Schools Will Overcome the 'Coronavirus Slide:' Ideas From 5 Superintendents

With many school buildings closed for the rest of the academic year—and more to follow—district leaders turn their attention to making up for what may be deep learning losses.




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How Schools Will Overcome the 'Coronavirus Slide:' Ideas From 5 Superintendents

With many school buildings closed for the rest of the academic year—and more to follow—district leaders turn their attention to making up for what may be deep learning losses.




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How Schools Will Overcome the 'Coronavirus Slide:' Ideas From 5 Superintendents

With many school buildings closed for the rest of the academic year—and more to follow—district leaders turn their attention to making up for what may be deep learning losses.




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How Schools Will Overcome the 'Coronavirus Slide:' Ideas From 5 Superintendents

With many school buildings closed for the rest of the academic year—and more to follow—district leaders turn their attention to making up for what may be deep learning losses.




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Tax implications for commercial lawyers / presented by Judy Choate, KPMG.




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Alternative Dispute Resolution (Family and Commercial).




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Australian Commercial Law Conference : ethics in commercial practice : dealing with conflicts / paper presented by John Goldberg, Cowell Clarke.




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Ethics in Commercial Practice - Dealing With conflicts - Slides - John Goldberg.




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Commercial and Estate Litigation Conflicts and other Ethical Duties - Dr Rachael Gray - SLIDES.




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From trash to treasure : a true story of the amazing unconditional love and mercy of God / Lee Habbershaw.

From Trash to Treasure is an intensely honest account of a life powerfully redeemed and is a demonstration of the goodness of God. Lee Habbershaw's journey to recovery from sexual abuse moved me to tears - sometimes in compassion, but often in joy. The book is rich with the landmark of life events and Biblical truths which, layer by layer, led Lee into the powerful teaching and counselling ministry she operates in today. This book could change your life (page 7)




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Des maladies de l'encéphale et de la moelle épinière / par Jean Abercrombie, ouvrage traduit de l'anglais et augmenté de notes très nombreuses, par A.N. Gendrin.

A Paris : Germer-Bailliere ; A Londres : J.-B. Bailliere, 1835.




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Des méningites suppurées non tuberculeuses / par Albert Vaudremer.

Dijon : Darantiere, 1893.




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Des moyens simples a employer pour guerir et eviter la tuberculose / par Jeanne Leclerc.

Paris : Société d’éditions scientifiques, 1896.




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Des reflexes tendineux / par Constant Petitclerc.

Paris : A. Delahaye et E. Lecrosnier, 1880.




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Diagnostica dei batteri delle acque con una guida alle ricerche batteriologiche e microscopiche / del Alessandro Lustig.

Torino : Rosenberg & Sellier, 1890.




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Die acute Pneumonie, und ihre sichere Heilung mit Quecksilberchlorür ohne Blutentziehung / eine Monographie von Max Wittich.

Erlangen : F. Enke, 1850.




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Die Behandlung der Tuberculosen Wirbelentzundung nebst Pathologischen Erfahrungen auf Grund von 700 Fallen / von Julius Dollinger.

Stuttgart : Enke, 1896.




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Die Blasenbandwürmer und ihre Entwicklung : zugleich ein Beitrag zur Kentniss der Cysticercusleber / von Rud Leuckart.

Giessen : J. Ricker, 1856.




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Die Krankheiten des Zwerchfells des Menschen / von Carl Wilhelm Mehliss.

Eisleben : G. Reichardt, 1845.




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Die Tuberculose / mit Beitr. von Max Scheimpflug et al.

Wien : Braumuller, 1898.




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Die Zählung der Blutkörperchen und deren Bedeutung für Diagnose und Therapie / von Emil Reinert.

Leipzig : F.C.W. Vogel, 1891.




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Dirty dustbins and sloppy streets : a practical treatise on the scavenging and cleansing of cities and towns / by H. Percy Boulnois.

[London] : E. & F.N. Spon, 1881.




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Discourse on the enlarged and pendulous abdomen : showing it to be a visceral affection, attended with important consequences in the human economy : with cursory observations on diet, exercise, and the general management of health : for the use of the dys

London : Longman, Brown, Green, and Longmans, 1842.




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Du développement du foetus chez les femmes a bassin vicié : recherches cliniques au point de vue de l’accouchement prématuré artificiel / par Felice la Torre.

Paris : O. Doin, 1887.




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Du diabète phosphatique : recherches sur l'élimination des phosphates par les urines, conditions physiologiques modifiant l'élimination des phosphates, influence du régime alimentaire, variations pathologiques / par L.-J. Teiss

Paris : J.-B. Baillière, 1877.




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Du mercure : action physiologique et thérapeutique / par H. Hallopeau.

Paris : J.-B. Baillière, 1878.




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Du molluscum : recherches critiques sur les formes, la nature et le traitement des affections cutanées de ce nom, suivies de la description détaillée d'une nouvelle variété / par Maximilien Maurice Jacobovics.

Londres : Paris, 1840.




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Du palper abdominal appliqué à la recherche du volume du foetus par rapport aux dimensions du bassin (palper mensurateur) / par Albert Le Cudennec.

Paris : G. Steinheil, 1891.




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Du procédé opératoire a suivre dans l'exploration des organes par la percussion médiate : et collection de mémoires sur la physiologie, la pathologie et le diagnostic / par P.A. Piorry.

Paris ; Londres : Baillière ... : Legoubey, libraire ... ; J.B. Baillière ..., 1831.




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The early stages of tuberculosis / by G.A. Gibson.

Edinburgh : Oliver and Boyd, 1884.




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Edinburgh merchants and merchandise in old times.

London : W. and R. Chambers, 1859.




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Éléments d'analyse chimique médicale, appliquée aux recherches cliniques / par le Dr Sonnié-Moret.

Paris : Société d’éditions scientifiques, 1896.




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Ernestus Godofredus Baldinger ... disputationem inauguralem ... Ioan. Conr. Stockar à Neuforn ... de usu cantharidum interno ... habendam annunciat. Praemittitur: historia mercurii et mercurialium medica, et nunc quidem eius pars III.

Goettingae : Litteris Ioann. Christ. Dieterich, Acad. Typogr, [1781]




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Essai clinique et expérimental sur la fièvre des tuberculeux (toxicité des crachats, toxicité des urines) / par Le Docteur Edouard Chretien.

Paris : Steinheil, 1896.




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Essai de pneumatologie médicale : recherches physiologiques, cliniques et thérapeutiques sur les gaz / par J.-N. Demarquay.

Londres : Paris, 1866.




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Our word of the week is Wercan

Each week, the Indigenous Services Branch of the State Library of NSW will be posting an Indigenous ‘word of the wee




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Despite Fierce Teacher Opposition, West Virginia House Votes to Allow Charter Schools

The West Virginia House of Delegates passed its version of a sweeping education omnibus bill, which would allow the state's first charter schools.