BACKGROUND AND PURPOSE:

Prediction of aneurysm instability is crucial to guide treatment decisions and to select appropriate patients with unruptured intracranial aneurysms (IAs) for preventive treatment. High-resolution 4D MR flow imaging and 3D quantification of aneurysm morphology could offer insights and new imaging markers for aneurysm instability. In this cross-sectional study, we aim to identify 4D MR flow imaging markers for aneurysm instability by relating hemodynamics in the aneurysm sac to 3D morphologic proxy parameters for aneurysm instability.

SUMMARY:

Vascular inflammation is widely recognized as an important factor in the atherosclerotic process, particularly in terms of plaque development and progression. Conventional tests, such as measuring circulating inflammatory biomarkers, lack the precision to identify specific areas of vascular inflammation. In this context, noninvasive imaging modalities can detect perivascular fat changes, serving as a marker of vascular inflammation. This review aims to provide a comprehensive overview of the key concepts related to perivascular carotid fat and its pathophysiology. Additionally, we examine the existing literature on the association of pericarotid fat with features of plaque vulnerability and cerebrovascular events. Finally, we scrutinize the advantages and limitations of the noninvasive assessment of pericarotid fat.

Metastatic porocarcinomas (PCs) are vanishingly rare, highly aggressive skin adnexal tumors with mortality rates exceeding 70%. Their rarity has precluded the understanding of their disease pathogenesis, let alone the conduct of clinical trials to evaluate treatment strategies. There are no effective agents for unresectable PCs. Here, we successfully demonstrate how functional precision medicine was implemented in the clinic for a metastatic PC with no known systemic treatment options. Comprehensive genomic profiling of the tumor specimen did not yield any actionable genomic aberrations. However, ex vivo drug testing predicted pazopanib efficacy, and indeed, administration of pazopanib elicited remarkable clinicoradiological response. Pazopanib and its class of drugs should be evaluated for efficacy in other cases of PC, and the rationale for efficacy should be determined when PC tumor models become available. A functional precision medicine approach could be useful to derive effective treatment options for rare cancers.

α-Synuclein (AS) is a small presynaptic protein that is genetically, biochemically, and neuropathologically linked to Parkinson's disease (PD) and related synucleinopathies. We present here a review of the topic of this relationship, focusing on more recent knowledge. In particular, we review the genetic evidence linking AS to familial and sporadic PD, including a number of recently identified point mutations in the SNCA gene. We briefly go over the relevant neuropathological findings, stressing the evidence indicating a correlation between aberrant AS deposition and nervous system dysfunction. We analyze the structural characteristics of the protein, in relation to both its physiologic and pathological conformations, with particular emphasis on posttranslational modifications, aggregation properties, and secreted forms. We review the interrelationship of AS with various cellular compartments and functions, with particular focus on the synapse and protein degradation systems. We finally go over the recent exciting data indicating that AS can provide the basis for novel robust biomarkers in the field of synucleinopathies, while at the same time results from the first clinical trials specifically targeting AS are being reported.

This week we discuss the bacon that broke Anna's back, Kelley shows us the power of the nip-nado, Pascal meets the Bok Choys, Josh is sponsored by revengecrabs.com, and Robert speedruns the produce department.

The post RPG Cast – Episode 567: “Supermarket Cloth Map” appeared first on RPGamer.

Today in "person you already like says something you already agree with, but it’s still good to hear them say it" news, Arkane founder and im-simmy RPG studio WolfEye head Raphael Colantonio has spoken on Microsoft’s decision to shutter Prey (2017) studio Arkane Austin - alongside a handful of others - back in May.

Colantonio, who founded Arkane in 1999 and departed in 2017 to form Weird West studio WolfEye, recently chatted to Jeremy Peel for PC Gamer about Arkane’s closure, saying:

I think if you look a little bit, it's obvious that Arkane Austin was a very special group of people that have made some cool things and that could pull it off again. I think it was a decision that just came down to, 'We need to cut something.' Was it to please the investors, the stock market? They're playing a different game.

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Inflexion Games are closing their UK office, laying off staff and restructuring their main Canadian studio after failing to find commercial success with their Victorian fantasy survival game Nightingale. Reportedly, at least 22 people have been let go.

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I have zero archaeology experience or knowledge, but I bet archaeologists really love their jobs (for the most part). They get to analyse and discover cool artefacts and educate us on the histories of forgotten civilisations. That's dreamy stuff, that is. But I do wonder what it's like for archaeologists to discover and study something they shouldn't have; something with a disturbing secret - a curse, maybe. Bite-sized horror game The Children Of Clay explores this idea and I'd like more of it, please.

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I've spent quite a lot of today trying to figure out why, exactly, some of the monsters in the Monster Hunter Wilds beta looked like bundles of copulating pyramids slathered in crocodile gravy. Nic clued me in on this reddit thread earlier, which cites unnamed Chinese players who've allegedly data-mined the beta's monster models, and learned that they are extremely large, encompassing hundreds of thousands of polygons.

If every monster in Monster Hunter Wilds were that fancy all of the time, your computer would become a volcano. As such, the game resorts to loading-on-demand systems to ensure that you only see those gorgeous details when the monsters are close by and, as the case may be, angrily sitting on you. When they're further afield, the flourishes fall away to free up memory and processing power. The popular Redditor explanation for the presence of monsters that look like Henry Moore sculpture is basically that the LOD systems are being forgetful, and neglecting to load the additional polygons at proximity.

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We’re still a week away from Blizzard’s Warcraft 30th Anniversary Direct next Wednesday the 13th of November, but art from an apparent remaster of 1995 real time strategy game Warcraft II: Tides Of Darkness has leaked online, via Xibbly user Stiven. It’s a thin one, as far as leaks go, but does show what looks to be cover, logo art, and a Battle.net icon. Thanks for the spot, Percy Coswald Gamer.

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We'll have a review of Planet Coaster 2 soon, but I keep making Brendy do other tasks so he's not had enough time yet to ride the rails. That means it falls to me to at least let you know that Frontier's theme park builder is out now.

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There must be hundreds of typewriters in the hall, their collective clacks a tidal wave of soulless automation, rising up to greet agent Kiran Estevez as she enters, pistol and flashlight in hands. Exploring rooms to the side, Alan Wake 2: The Lake House’s star finds whiteboards and documents revealing the typewriter’s purpose: to mimic Wake’s writing. Pages are graded along criteria such as ‘style’, ‘tone’, and ‘content’, then “fed into the algorithm” as references until “near-identical stories” to Wake’s can be produced.

“If Jules could simply cut the painter open and pull the painting out of him, he would,” reads one of the real Alan’s typewritten pages. That’s Jules Marmont, the obsessive head of the titular FBC centre. The Marmonts - Jules and his wife Diana - are running experiments to forcibly and synthetically create works of art, aiming to mimic creative passion convincingly enough for the paranatural entity inside Cauldron Lake to respond, as it has in the past.

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October marked the "biggest" sales month for supermarkets in the UK so far despite food price hikes.

Astronomers have been spotting strange banana-shaped galaxies and the evidence seems to indicate that filaments of dark matter make them take this shape

The books, TV, games and more that New Scientist staff have enjoyed this week

Brown dwarfs could be hiding dark matter inside their cores – if they are, there would be signs that could help us track it down

A faint glow from all of the galaxies that have ever existed fills the cosmos, and NASA's New Horizons spacecraft has made the best measurement ever of just how faint it is

The long-standing mystery of how supermassive black holes grew so huge so quickly could be solved by decaying dark matter

A powerful new AI called o1 is the most dangerous that OpenAI has ever released, the firm claims – but who are these warnings for, asks Chris Stokel-Walker

Two large grizzly bears followed 13 hikers down a trail in Banff National Park for 20 minutes — with one even making a few quick runs at the group.

People keep predicting that each wave of new technology will mean humans can put their feet up. It hasn't happened yet. Some economists and anthropologists who study the subject say even with the arrival of artificial intelligence, humans will remain integral to making the world go round.

A pediatrician, author and co-inventor of a low-cost COVID-19 vaccine warns that the anti-vaccine movement has morphed into a political force that threatens the world's gains against deadly childhood infections like measles.

A new Government Accountability Office report says that the Justice Department kept FBI employees in the dark for seven years after Congress updated whistleblower protections for bureau personnel in 2016.

Liverpool already have one song synonymous with the club but they did attempt to officially do likewise with another. The Reds tried to trademark 'Allez Allez Allez'..

Apple Music gives a whole new meaning to the phrase the hits just keep on coming.  It’s not the opposing candidates, it’s public AI systems that are spreading election disinformation, and LockBit, the cybercriminal gang may be back from the dead and saying so long to the ChatGPT plugins, which went from innovation to legacy […]

A bold new study in Physical Review suggests that a wobble detected in Mars' orbit could be the result of dark matter made up of primordial black holes.

After years trapped in licensing hell, the classic action-RPG is back. But does it still hold up in the days of Dark Souls?

Genetic testing on samples collected during the earliest days of the covid-19 outbreak suggests it is likely that the virus spread from animals to humans at the Huanan seafood market

A better understanding of what happens to our bodies when we get fitter can unlock ways to speed up the journey – and it might be simpler than you think

People report greater life satisfaction six months after starting Parkrun events, which could partly be due to the supportive environment

Australians have been urged to look before they cook and read the safety advice on food labels. The Food Safety Information Council (FSIC) issued the call ahead of Australian Food Safety week from Nov. 9 to 16. Lydia Buchtmann, FSIC CEO, said the charity’s research shows that only 3 in... Continue Reading

Listings outpace demand in Toronto and Vancouver

Dallas Mavericks minority owner Mark Cuban returned to the Bluesky social media platform with a post after weeks of contentious X posts.

Jessica Simpson sparked rumors this week with a cryptic post about making new music and having put up with "everything I did not deserve."

House Republicans are once again at odds with one another after conservatives threatened to protest Speaker Johnson's bid to lead the conference again.

Why are there so many VPNs for Apple TV? Oh, right—geofencing.

Researchers show the average surface temperature on our planet has shifted between 51.8 to 96.8 degrees Fahrenheit

With no conclusive laboratory results, researchers are turning to other methods to find the elusive substance

Sharks less likely to interact as LED lights get brighter

FrontierMath's difficult questions remain unpublished so that AI companies can't train against it.

Caitlin Clark took more than her fair share of verbal abuse during the WNBA season. Now, even though the season has long since passed, she's still taking abuse.

The post Knicks Legend Throws Shade at Caitlin Clark During Live Broadcast appeared first on Breitbart.

A Kenora, Ont., resident says she wants to see more resources for people who encounter sick or injured animals after seeing a deer in her yard with a tomato cage stuck on its head. Here's how the community has responded to the incident, and what we know about the deer's status.

1. Church of England head Justin Welby who married Prince Harry and Meghan Markle resigns over pedophile scandal  Hindustan Times
2. Archbishop of Canterbury, Trump critic Justin Welby resigns. What is the sex abuse scandal?  The Times of India
3. Video | UK Church Abuse Scandal: Head Of Church Of England Steps Down  NDTV
4. ‘Church in crisis’: what the papers say about the archbishop of Canterbury’s resignation  The Guardian
5. World News Today Live Updates on November 13, 2024 : Archbishop of Canterbury Justin Welby resigns amid sexual abuse case—Who is he? What's the scandal? All you need to know  Mint

1. Jharkhand election 2024 live: Over 13% voter turnout in 43 seats till 9am  Hindustan Times
2. Jharkhand Election 2024 Live Updates: Former CM, BJP candidate Champai Soren casts vote  The Times of India
3. Vote to protect rights, strengthen Constitution: Rahul to Jharkhand voters  The Hindu
4. Jharkhand elections phase 1: NDA vs INDIA bloc face-off with crucial tribal votes in play  India Today
5. Think of forming inclusive government not one that divides: Kharge to voters  Deccan Herald

Directors Raj & DK bring texture and technique to this Indian spin-off of ‘Citadel’, with uneven results