Holding this year’s presidency of the Group of 20 (G20) large industrial and emerging economies is allowing Brazil to push forward the dream of creating a global biofuels market without the current trade barriers. Brazil is trying, at least since the beginning of this century, to free up global trade in ethanol, but so far […]

Meghan Markle ready to make peace with Kate Middleton, Queen Camilla Meghan Markle has reportedly made a big decision about the years-long royal feud.According to Closer magazine, the Duchess of Sussex may take advantage of Christmas to send a message of "peace and harmony" to Kate Middleton...

Overcoming poor market depth and liquidity is crucial for Asia's capital markets to grow and remain attractive to investors. A coordinated approach addressing regulatory frameworks, market infrastructure, and risk management is essential for building resilient, diverse, and efficient markets.

Asia and the Pacific is central to global climate change efforts, but robust capital markets are needed to mobilize private climate finance. Sustainable finance frameworks, transition finance, and carbon markets can build deeper markets that empower climate action.

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This paper explores how oil price windfalls impact labor market regulation across 83 countries from 1970 to 2014.

This edition of the ASEAN+3 Bond Market Guide series focuses on updates in the Republic of Korea’s (ROK) market since the publication of the previous guide for the ROK in 2018.

Tracking data from a pregnant porbeagle shark near Bermuda suggest it was eaten by a great white shark – a kind of predation that has never been seen before

Breaching is a common behaviour in a wide range of sharks and rays, and it is thought to have functions related to courtship, birthing and hygiene

Fishers in Albania caught a blue shark with an 18-centimetre fragment of swordfish bill embedded in its skull, in the first known case of a shark surviving such an injury

Experiments show that illuminating the underside of a decoy seal reduces attacks by great white sharks, revealing a possible strategy to protect surfers and swimmers

A better understanding of what happens to our bodies when we get fitter can unlock ways to speed up the journey – and it might be simpler than you think

Could the universe's missing matter be hiding in a "dark" extra dimension? We now have simple ways to test this outlandish idea - and the existence of extra dimensions more generally

Cosmological puzzles are tempting astronomers to rethink our simple picture of the universe – and ask whether dark matter is even stranger than we thought

Commercially available quantum technology could let stock traders coordinate decisions to buy or sell nearly instantaneously using a technique called “quantum telepathy”

The hunt for particles of dark matter has been stymied once again, with physicists placing constraints on this mysterious substance that are 5 times tighter than the previous best

Could the universe's missing matter be hiding in a "dark" extra dimension? We now have simple ways to test this outlandish idea - and the existence of extra dimensions more generally

Geologists hoping to declare a new epoch dominated by humanity’s influence on Earth have chosen Crawford Lake in Canada as the location where the start of the Anthropocene is defined

Lake Maracaibo in Venezuela, the largest lake in South America, has been captured in detail by the European Space Agency's Copernicus Sentinel-2 mission

When most people are asked to name a river, they often reach for the Amazon or Nile, but these aren’t the only remarkable rivers out there. Here are 10 more from around the world – and solar system

Lightning strikes during volcanic eruptions could have provided nitrogen in a form that was needed by early life forms

Global warming means many of the world’s ancient rivers of ice will be gone within decades, threatening ecosystems that rely on their meltwater, a looming crisis that photographer Edward Burtynsky highlights in his work

These stunning photographs are all shortlisted for the Sony World Photography Awards 2024

Climate change is making extreme cold upwellings more common in certain regions of the world, and these events can be catastrophic for animals such as bull sharks

The networks of fibre optic cables that criss-cross the planet could be used to better understand what’s happening inside it

Long feted by fossil hunters and geologists, if UNESCO recognises the extraordinary rock formation at Madygen in Kyrgyzstan, it will soon be a player on the world stage

Pascal Maitre's photos from the Democratic Republic of Congo detail the problems arising as demand for cobalt grows

Experiments show that illuminating the underside of a decoy seal reduces attacks by great white sharks, revealing a possible strategy to protect surfers and swimmers

In the foundations of a Maya temple, researchers found the charred bones of royal individuals – possibly evidence of a fiery ritual to mark the end of one dynasty and the beginning of another

An analysis of 20,000 metal objects from Bronze Age Europe suggests human economic behaviour may not have changed much over the past 3500 years

Title: Parkinson's: Treatment for Symptoms
Category: Health News
Created: 8/31/2006 12:00:00 AM
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Title: Brain 'Pacemaker' Treats Parkinson's
Category: Health News
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Title: Does Hope Have a Dark Side?
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Title: Sleep Boosts Memory for Parkinson's Patients, Study Suggests
Category: Health News
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Title: Discovery May Improve Diagnosis of Alzheimer's, Parkinson's
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Title: Spinal Fluid Test May Aid Early Detection of Parkinson's Disease
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Title: Deep Brain Stimulation Safe for Older Parkinson's Patients: Study
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Title: Arkansas Law Restricting Abortion Pills Remains on Hold
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Category: Health News
Created: 8/28/2019 12:00:00 AM
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Title: U.S. Opioid Deaths Take a Small Dip, as Fentanyl Leaves Deadly Mark
Category: Health News
Created: 8/29/2019 12:00:00 AM
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Title: Is It Parkinson's? These 10 Signs Could Tell
Category: Health News
Created: 8/19/2022 12:00:00 AM
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COPD and asthma are two of the most common chronic lung diseases, affecting over 545 million people globally and 34 million in the United States. Annual health care costs related to chronic lung disease are estimated at €380 billion in the European Union, and $24–$50 billion in the United States averaging to $4,000 in out-of-pocket costs per person in the U.S. A full-text literature search was conducted for English publications between January 1, 2005–March 18, 2024. It returned over 5,000 publications that were further narrowed using key search words, resulting in 172 peer-reviewed articles. Using their experience and subject expertise, the authors further narrowed the peer-reviewed articles to 55 that were in their opinion relevant. Also, 38 recently published industry reports and news articles specific to downstream effects of inhaler market changes and the future impact were included. The literature suggests that individuals with chronic lung disease face increased challenges with access to inhaled medication due to rising medication costs, discontinuation of branded medications, introduction of generic medications not covered by insurance, exclusionary preferred drug list tactics that force health care providers into non-medical switching of medication or devices, and ongoing medication shortages. Providers experience ongoing hurdles in prescribing appropriate inhaled medications for individuals with chronic lung disease, including increased time and costs spent on administrative tasks due to inhaler denials, a loss of patient trust, and limits on their ability to prescribe appropriate inhaled medication for individuals with chronic lung disease.

Organic anion transporting polypeptide (OATP) 1B1 and OATP1B3 are important hepatic transporters. We previously identified OATP1B3 being critically implicated in the disposition of abiraterone. We aimed to further investigate the effects of abiraterone on the activities of OATP1B1 and OATP1B3 utilizing a validated endogenous biomarker coproporphyrin I (CP-I). We used OATP1B-transfected cells to characterize the inhibitory potential of abiraterone against OATP1B-mediated uptake of CP-I. Inhibition constant (K_i) was incorporated into our physiologically based pharmacokinetic (PBPK) modeling to simulate the systemic exposures of CP-I among cancer populations receiving either our model-informed 500 mg or clinically approved 1000 mg abiraterone acetate (AA) dosage. Simulated data were compared with clinical CP-I concentrations determined among our nine metastatic prostate cancer patients receiving 500 mg AA treatment. Abiraterone inhibited OATP1B3-mediated, but not OATP1B1-mediated, uptake of CP-I in vitro, with an estimated K_i of 3.93 μM. Baseline CP-I concentrations were simulated to be 0.81 ± 0.26 ng/ml and determined to be 0.72 ± 0.16 ng/ml among metastatic prostate cancer patients, both of which were higher than those observed for healthy subjects. PBPK simulations revealed an absence of OATP1B3-mediated interaction between abiraterone and CP-I. Our clinical observations confirmed that CP-I concentrations remained comparable to baseline levels up to 12 weeks post 500 mg AA treatment. Using CP-I as an endogenous biomarker, we identified the inhibition of abiraterone on OATP1B3 but not OATP1B1 in vitro, which was predicted and observed to be clinically insignificant. We concluded that the interaction risk between AA and substrates of OATP1Bs is low.

BACKGROUND AND PURPOSE:

Hemangioblastoma is a rare vascular tumor that occurs within the central nervous system in children. Differentiating hemangioblastoma from other posterior fossa tumors can be challenging on imaging, and preoperative diagnosis can change the neurosurgical approach. We hypothesize that a "lightbulb sign" on the arterial spin-labeling (ASL) sequence (diffuse homogeneous intense hyperperfusion within the solid component of the tumor) will provide additional imaging finding to differentiate hemangioblastoma from other posterior fossa tumors.