Omadacycline is an aminomethylcycline antibiotic with in vitro activity against pathogens causing community-acquired bacterial pneumonia (CABP). This study investigated the activity of omadacycline against Legionella pneumophila strains isolated between 1995 and 2014 from nosocomial or community-acquired respiratory infections. Omadacycline exhibited extracellular activity similar to comparator antibiotics; intracellular penetrance was found by day 3 of omadacycline exposure. These results support the utility of omadacycline as an effective antibiotic for the treatment of CABP caused by L. pneumophila.

Nine hundred Haemophilus influenzae clinical isolates from 83 U.S. and European medical centers were tested for susceptibility by reference broth microdilution methods against ceftolozane-tazobactam and comparators. Results were stratified by β-lactamase production and infection type. Overall, ceftolozane-tazobactam MIC_50/90 values were 0.12/0.25 mg/liter, and 99.0% of isolates were inhibited at the susceptible breakpoint of ≤0.5 mg/liter; the highest MIC value was only 2 mg/liter. Our results support using ceftolozane-tazobactam to treat H. influenzae infections.

We report the diagnostic challenges and the clinical course of a patient with an extraordinary presentation of B-lymphoblastic leukemia (B-ALL) with eosinophilia. We identified a novel ZBTB20-JAK2 gene fusion as a chimeric RNA transcript using the Archer platform. This gene fusion from the same patient was recently identified by Peterson et al. (2019) at the genomic level using a different sequencing technology platform. The configuration of this gene fusion predicts the production of a kinase-activating JAK2 fusion protein, which would normally lead to a diagnosis of Philadelphia chromosome–like B-ALL (Ph-like B-ALL). However, the unusual presentation of eosinophilia led us to demonstrate the presence of this gene fusion in nonlymphoid hematopoietic cells by fluorescence in situ hybridization (FISH) studies with morphologic correlation. Therefore, we believe this disease, in fact, represents blast crisis arising from an underlying myeloid neoplasm with JAK2 rearrangements. This case illustrates the difficulty in differentiating Ph-like B-ALL and myeloid/lymphoid neoplasm with eosinophilia and gene rearrangements (MLN-EGR) in blast crisis. As currently defined, the diagnosis of MLN-EGR relies on the hematologic presentations and the identification of marker gene fusions (including PCM1-JAK2, ETV6-JAK2, and BCR-JAK2). However, these same gene fusions, when limited to B-lymphoblasts, also define Ph-like B-ALL. Yet, our case does not conform to either condition. Therefore, the assessment for lineage restriction of gene rearrangements to reflect the pathophysiologic difference between B-ALL and MLN-EGR in blast crisis is likely a more robust diagnostic approach and allows the inclusion of MLN-EGR with novel gene fusions.

Background:

Percent density (PD) is a strong risk factor for breast cancer that is potentially modifiable by lifestyle factors. PD is a composite of the dense (DA) and nondense (NDA) areas of a mammogram, representing predominantly fibroglandular or fatty tissues, respectively. Alcohol and tobacco use have been associated with increased breast cancer risk. However, their effects on mammographic density (MD) phenotypes are poorly understood.

Mammographic breast density is a strong risk factor for breast cancer. We comprehensively investigated the associations of body mass index (BMI) change from ages 10, 18, and 30 to age at mammogram with mammographic breast density in postmenopausal women. We used multivariable linear regression models, adjusted for confounders, to investigate the associations of BMI change with volumetric percent density, dense volume, and nondense volume, assessed using Volpara in 367 women. At the time of mammogram, the mean age was 57.9 years. Compared with women who had a BMI gain of 0.1–5 kg/m² from age 10, women who had a BMI gain of 5.1–10 kg/m² had a 24.4% decrease [95% confidence interval (CI), 6.0%–39.2%] in volumetric percent density; women who had a BMI gain of 10.1–15 kg/m² had a 46.1% decrease (95% CI, 33.0%–56.7%) in volumetric percent density; and women who had a BMI gain of >15 kg/m² had a 56.5% decrease (95% CI, 46.0%–65.0%) in volumetric percent density. Similar, but slightly attenuated associations were observed for BMI gain from ages 18 and 30 to age at mammogram and volumetric percent density. BMI gain over the life course was positively associated with nondense volume, but not dense volume. We observed strong associations between BMI change over the life course and mammographic breast density. The inverse associations between early-life adiposity change and volumetric percent density suggest that childhood adiposity may confer long-term protection against postmenopausal breast cancer via its effect of mammographic breast density.

Nắm rõ và tuân theo những nguyên tắc thiết kế nội thất dưới đây sẽ giúp bạn tránh được những sai lầm không đáng có trong quá trình lập kế hoạch và triển khai dự án thiết kế nội thất.

Infographic dưới đây giới thiệu một số nguyên tắc cơ bản trong thiết kế nhà bếp hiện đại, góp phần mang tới sự tiện nghi và cảm giác thoải mái cho người nội trợ.

Hào hứng khi mua nhà lần đầu tiên nhưng vì thiếu kinh nghiệm, chủ quan nên nhiều người đã mắc phải sai lầm đáng tiếc. Để việc mua nhà không gây hối tiếc trong tương lai, hãy đảm bảo bạn không mắc phải 9 sai lầm dưới đây:

Giao dịch bất động sản là quá trình phức tạp, trải qua nhiều công đoạn. Nếu nhà đầu tư không cẩn trọng, rất có thể bị mất sạch vốn do vướng phải những giao dịch bất chính, chụp giật.

Khi mua bán bất động sản, khách hàng cần yêu cầu bên bán cung cấp đầy đủ các giấy tờ để chứng minh pháp lý của bất động sản giao dịch. Các giấy tờ đó là gì? Các bước thực hiện giao dịch ra sao?... sẽ được Batdongsan.com.vn trả lời cụ thể qua infographic dưới đây:

Căn hộ chung cư là loại hình nhà ở nằm trong một dự án gồm nhiều căn hộ, quá trình mua bán, chất lượng bàn giao và việc hoàn thiện đều được thực hiện theo hợp đồng ký với chủ đầu tư. Để giúp người mua chung cư lần đầu không bỡ ngỡ, Batdongsan.com.vn tổng hợp những thông tin chính mà người mua cần tìm hiểu trước khi thực hiện giao dịch như sau:

Không phải ai cũng có đủ điều kiện để mua một ngôi nhà mới nên nhiều người chọn mua nhà cũ để tiết kiệm chi phí. Nếu chưa có kinh nghiệm chọn mua nhà cũ, bạn hãy xem 6 lưu ý dưới đây để chọn được ngôi nhà ưng ý:

Tự làm vườn không chỉ tiết kiệm túi tiền mà còn góp phần bảo vệ hành tinh xanh. Hãy thử tái chế những món đồ bỏ đi ở quanh nhà và tạo nên một khu vườn nhỏ gọn, phong cách, phù hợp với mọi không gian.

Theo nhận định của các chuyên gia, những đợt phát hành trái phiếu ồ ạt của các doanh nghiệp bất động sản tiềm ẩn nhiều rủi ro và là dấu hiệu của việc khát vốn.

Theo Bộ Tài chính, chính sách thắt chặt tín dụng với ngành bất động sản đã khiến các doanh nghiệp trong ngành này phải huy động vốn với mức lãi suất cao.

Ngân hàng Nhà nước đưa ra loạt yêu cầu đối với các ngân hàng trong việc đầu tư vào trái phiếu doanh nghiệp để cơ cấu nợ hay vào công ty bất động sản...

Các NHTM thắt chặt hơn trong việc kiểm soát đầu tư trái phiếu doanh nghiệp bất động sản, không mua trái phiếu để cơ cấu lại vốn và đảm bảo đúng quy định về các giới hạn, tỷ lệ đảm bảo an toàn.

Thị trường trái phiếu doanh nghiệp sôi động với sức nóng tăng lên từ cả phía cung và phía cầu. Nhà đầu tư trong nước mua tới 22.664 tỷ đồng (61,5%) trái phiếu doanh nghiệp BĐS.

Hầu hết chuyên gia khẳng định trái phiếu doanh nghiệp không dành cho nhà đầu tư cá nhân, thậm chí với ngân hàng, quỹ đầu tư “cuộc chơi” này cũng tồn tại nhiều rủi ro.

Trong năm 2020, lượng phát hành trái phiếu doanh nghiệp bất động sản được dự báo sẽ bùng nổ với mức tăng lên đến 80-90%.

Trái phiếu doanh nghiệp mang lại nhiều lợi ích trong việc giải quyết sự phụ thuộc nguồn vốn ngân hàng cho các doanh nghiệp BĐS. Tuy nhiên thị trường này chưa thật đảm bảo tính minh bạch, chưa có đầy đủ cơ chế kiểm soát hiệu quả việc phát hành và giao dịch trái phiếu doanh nghiệp riêng lẻ.

Hiệp hội Bất động sản TP.HCM (HoREA) vừa đưa ra kiến nghị liên quan đến nghị định 163/2018/NĐ-CP quy định về phát hành trái phiếu doanh nghiệp.

Để tạo thêm kênh huy động vốn cho bất động sản thay nguồn tín dụng ngân hàng, Hiệp hội Bất động sản TP.HCM (HoREA) đề nghị không siết trái phiếu doanh nghiệp bất động sản.

The Law on Housing of Vietnam allows foreigners to purchase Vietnam property but with strict conditions and procedures as listed in the following infographic.

Generative visuals and eerie sound design based on height maps of glaciers, canyons and estuaries. London-based motion graphic designer Sophie Marschner transforms real-world data into a delicate digital topography in Monolith. By using the height maps of various large-scale landmarks, including glaciers, canyons and estuaries, Marschner maps the outside world into a more intimate, digital […]

The post Sophie Marschner turns real-world data into a digital topography in Monolith appeared first on FACT Magazine.

Today, Anna and Chris get counseled. Phil gets jealous of someone’s fishing skills. Cassandra gets every support conversation. And you, dear listener, get a podcast!

Everyone lets Manny know he needs a 3DS. Phil breaks his 3DS. Anna Marie leaves the show half way through to go play her 3DS....

Tara Reade has claimed in a new interview that Joe Biden used graphic language to proposition her for sex when he allegedly assaulted her in 1993.

Nation replaces Brazil for first time in annual list of murders compiled by Global Witness

The Philippines has replaced Brazil as the most murderous country in the world for people defending their land and environment, according to research that puts a spotlight on the administration of President Rodrigo Duterte.

More than three defenders were killed across the world every week in 2018, according to the annual toll by the independent watchdog Global Witness, highlighting the continued dangers facing those who stand up to miners, loggers, farmers, poachers and other extractive industries.

Philippine legislators pushed on Wednesday to get the country's biggest broadcaster back on air, amid widespread shock and dismay over an order by the industry regulator for the station to cease operations after its 25-year licence expired.

Read our live updates on coronavirus HERE Cornavirus: The symptoms

Read our live coronavirus updates HERE

The Duke of Edinburgh's tribute about the 'vital and urgent work being done by so many' is his first major statement since his retirement in 2017

Former Home Office Permanent Secretary Sir Philip Rutnam has formally begun legal action against Home Secretary Priti Patel, claiming "constructive dismissal".

A dolphin named Honey has died while living alone in a tank at an abandoned Japanese aquarium, according to advocacy organisation Dolphin Project.

The wife of former Premier League footballer Kevin Phillips has been released without charge after being arrested on suspicion of attempted murder following a stabbing.

Nicola Sturgeon has extended the coronavirus lockdown in Scotland by three weeks, insisting that any easing of restrictions could be "very risky".

The far-sighted internationally renowned theatre personality, Phillip Zarrilli, passed away on April 28, after a fourteen-year battle with cancer that

Professional poker player Phil Galfond overcame a €900,000 deficit in a 25,000-hand head-to-head challenge against a pot-limit Omaha regular known as "VeniVidi1993" online.

The new Labour Leader has promoted the prominent backbencher Jess Phillips to his top team.

Legal action has been formally launched against Priti Patel following allegations of bullying from a top civil servant.

But in one sign of a turning tide in Number 10, the UK Government is reportedly considering a proposal to allow Brits to meet up with small "bubbles" of up to 10 of their closest family or friends.

Avery died in 2013 of complications following heart surgery

'We worked very hard to make it feel like it was a real, accurate and truthful representation of sex amongst young people today,' said the actor

TV presenter, wife Stephanie and their daughters played a game of Murder Mystery

• Head coach died ‘peacefully at home’ say Dolphins
• Shula recorded only two losing seasons in long career in Miami

Don Shula, the head coach with the most wins in NFL history, has died at the age of 90.

Shula is most famous for leading the 1972 Miami Dolphins to the only undefeated NFL season in history. The team said in a statement on Monday that Shula had “died peacefully” at home.

Related: Favre says Packers 'burned a bridge' with Aaron Rodgers in NFL draft

The Greatest.

Thank you for everything, Coach Shula. pic.twitter.com/7eXY4ZOKn6

As authors from Chaucer to Hollinghurst have shown, sex reveals our emotions, instincts and morals. The question is not why write about sex, claims author Garth Greenwell, it’s why write about anything else?

There is a widely held belief, among English-language writers, that sex is impossible to write about well – or at least much harder to write about well than anything else. I once heard a wonderful writer, addressing students at the Iowa Writers’ Workshop, say that her ideal of a sex scene would be the sentence: “They sat down on the sofa …” followed by white space. This is a prejudice I can’t understand. One of the glories of being a writer in English is that two of our earliest geniuses, Chaucer and Shakespeare, wrote of the sexual body so exuberantly, claiming it for literature and bringing its vocabulary – including all those wonderful four-letter words – into the texture of our literary language. This is a gift not all languages have received; a translator once complained to me that in her language there was only the diction of the doctor’s office or of pornography, neither of which felt native to poetry.

More than this, surely it is absurd to claim that a central activity of human life, a territory of feeling and drama, is off-limits to art. Sex is a uniquely useful tool for a writer, a powerful means not just of revealing character or exploring relationships, but of asking the largest questions about human beings.