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Drug Shows Some Benefit for Kids With Autism

Title: Drug Shows Some Benefit for Kids With Autism
Category: Health News
Created: 5/1/2013 12:36:00 PM
Last Editorial Review: 5/2/2013 12:00:00 AM




ben

Longer Wait for Mammogram After Benign Breast Biopsy May Be Warranted

Title: Longer Wait for Mammogram After Benign Breast Biopsy May Be Warranted
Category: Health News
Created: 5/2/2013 12:35:00 PM
Last Editorial Review: 5/3/2013 12:00:00 AM




ben

HPV Vaccine Produces Early Benefits for Teen Girls: Study

Title: HPV Vaccine Produces Early Benefits for Teen Girls: Study
Category: Health News
Created: 4/27/2015 12:00:00 AM
Last Editorial Review: 4/27/2015 12:00:00 AM




ben

Few Sickle Cell Patients Receiving Beneficial Drug, Study Finds

Title: Few Sickle Cell Patients Receiving Beneficial Drug, Study Finds
Category: Health News
Created: 4/28/2015 12:00:00 AM
Last Editorial Review: 4/29/2015 12:00:00 AM




ben

The Family That Eats Together, Benefits

Title: The Family That Eats Together, Benefits
Category: Health News
Created: 5/3/2017 12:00:00 AM
Last Editorial Review: 5/3/2017 12:00:00 AM




ben

Home Gym: The Benefits of a Cross-Country Ski Machine

Title: Home Gym: The Benefits of a Cross-Country Ski Machine
Category: Health News
Created: 5/3/2018 12:00:00 AM
Last Editorial Review: 5/3/2018 12:00:00 AM




ben

Breast Milk Has Biggest Benefit for Preemies' Brains: Study

Title: Breast Milk Has Biggest Benefit for Preemies' Brains: Study
Category: Health News
Created: 4/27/2019 12:00:00 AM
Last Editorial Review: 4/29/2019 12:00:00 AM




ben

Benlysta Approved for Children With Lupus

Title: Benlysta Approved for Children With Lupus
Category: Health News
Created: 4/29/2019 12:00:00 AM
Last Editorial Review: 4/30/2019 12:00:00 AM




ben

The Surprising Benefits of Weekend Workouts

Title: The Surprising Benefits of Weekend Workouts
Category: Health News
Created: 5/3/2019 12:00:00 AM
Last Editorial Review: 5/3/2019 12:00:00 AM




ben

Eating Fish in Moderation During Pregnancy Benefits Fetus: Study

Title: Eating Fish in Moderation During Pregnancy Benefits Fetus: Study
Category: Health News
Created: 3/20/2020 12:00:00 AM
Last Editorial Review: 3/23/2020 12:00:00 AM




ben

Seniors, Getting Off the Sofa Brings Big Health Benefits

Title: Seniors, Getting Off the Sofa Brings Big Health Benefits
Category: Health News
Created: 3/5/2020 12:00:00 AM
Last Editorial Review: 3/6/2020 12:00:00 AM




ben

Austedo (deutetrabenazine)

Title: Austedo (deutetrabenazine)
Category: Medications
Created: 4/17/2020 12:00:00 AM
Last Editorial Review: 4/17/2020 12:00:00 AM




ben

Ingrezza (valbenazine)

Title: Ingrezza (valbenazine)
Category: Medications
Created: 4/21/2020 12:00:00 AM
Last Editorial Review: 4/21/2020 12:00:00 AM




ben

To bend with ease, take care of your knees

At some point during your life, it’s likely you’ll experience problems with your knees. Knees play an important role in helping us walk and bend, which means that they’re frequently in use. And like all parts of our bodies, sometimes they can wear out or be injured.




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SCFTIR1/AFB Auxin Signaling for Bending Termination during Shoot Gravitropism




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Loss of nucleus accumbens low-frequency fluctuations is a signature of chronic pain [Neuroscience]

Chronic pain is a highly prevalent disease with poorly understood pathophysiology. In particular, the brain mechanisms mediating the transition from acute to chronic pain remain largely unknown. Here, we identify a subcortical signature of back pain. Specifically, subacute back pain patients who are at risk for developing chronic pain exhibit...




ben

Will the Addition of Oscillations in Mechanical Insufflation-Exsufflation Ever Be Beneficial?




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Survival benefit of lung transplantation compared with medical management and pulmonary rehabilitation for patients with end-stage COPD

Background

COPD patients account for a large proportion of lung transplants; lung transplantation survival benefit for COPD patients is not well established.

Methods

We identified 4521 COPD patients in the United Network for Organ Sharing (UNOS) dataset transplanted from May 2005 to August 2016, and 604 patients assigned to receive pulmonary rehabilitation and medical management in the National Emphysema Treatment Trial (NETT). After trimming the populations for NETT eligibility criteria and data completeness, 1337 UNOS and 596 NETT patients remained. Kaplan–Meier estimates of transplant-free survival from transplantation for UNOS, and NETT randomisation, were compared between propensity score-matched UNOS (n=401) and NETT (n=262) patients.

Results

In propensity-matched analyses, transplanted patients had better survival compared to medically managed patients in NETT (p=0.003). Stratifying on 6 min walk distance (6 MWD) and FEV1, UNOS patients with 6 MWD <1000 ft (~300 m) or FEV1 <20% of predicted had better survival than NETT counterparts (median survival 5.0 years UNOS versus 3.4 years NETT; log-rank p<0.0001), while UNOS patients with 6 MWD ≥1000 ft (~300 m) and FEV1 ≥20% had similar survival to NETT counterparts (median survival, 5.4 years UNOS versus 4.9 years NETT; log-rank p=0.73), interaction p=0.01.

Conclusions

Overall survival is better for matched lung transplant patients compared with medical management alone. Patients who derive maximum benefit are those with 6 MWD <1000 ft (~300 m) or FEV1 <20% of predicted, compared with pulmonary rehabilitation and medical management.




ben

Tarburina zagrosiana n. gen., n. sp., a new larger benthic porcelaneous foraminifer from the late Maastrichtian of Iran

A new larger benthic porcelaneous foraminifer of soritid affinity is described as Tarburina zagrosiana n. gen., n. sp. from the late Maastrichtian of the Tarbur Formation, Zagros Zone, SW Iran. It occurs in foraminiferal–dasycladalean wackestones and packstones, in association with Loftusia ssp., dicyclinids/cuneolinids, Neobalkhania bignoti Cherchi & Schroeder, Gyroconulina columellifera Schroeder & Darmoian, Spirolina? farsiana Schlagintweit & Rashidi, Broeckina cf. dufrenoyi (d'Archiac), other benthic foraminifers, and dasycladalean algae. Due to its elongate test and marginal chamber subdivision by aligned vertical partitions, Tarburina n. gen. can be compared with representatives of the Praerhapydionininae. The interio-marginal slit-like foramina/aperture of Tarburina represents an outstanding feature in complex porcelaneous taxa. The monospecific genus Tarburina is considered a Maastrichtian newcomer within the Late Cretaceous Global Community Maturation cycle of larger benthic foraminifera. A biostratigraphic and palaeobiogeographical restriction seems possible, as reported for many other Late Cretaceous larger benthic foraminifera.




ben

Association of early disease progression and very poor survival in the GALLIUM study in follicular lymphoma: benefit of obinutuzumab in reducing the rate of early progression




ben

An increase in MYC copy number has a progressive negative prognostic impact in patients with diffuse large B-cell and high-grade lymphoma, who may benefit from intensified treatment regimens

MYC translocations, a hallmark of Burkitt lymphoma, occur in 5-15% of diffuse large B-cell lymphoma, and have a negative prognostic impact. Numerical aberrations of MYC have also been detected in these patients, but their incidence and prognostic role are still controversial. We analyzed the clinical impact of MYC increased copy number on 385 patients with diffuse large B-cell lymphoma screened at diagnosis for MYC, BCL2, and BCL6 rearrangements. We enumerated the number of MYC copies, defining as amplified those cases with an uncountable number of extra-copies. The prevalence of MYC translocation, increased copy number and amplification was 8.8%, 15%, and 1%, respectively. Patients with 3 or 4 gene copies, accounting for more than 60% of patients with MYC copy number changes, had a more favorable outcome compared to patients with >4 copies or translocation of MYC, and were not influenced by the type of treatment received as first-line. Stratification according to the number of MYC extra-copies showed a negative correlation between an increasing number of copies and survival. Patients with >7 copies or the amplification of MYC had the poorest prognosis. Patients with >4 copies of MYC showed a similar, trending towards worse prognosis compared to patients with MYC translocation. The survival of patients with >4 copies, translocation or amplification of MYC seemed to be superior if intensive treatments were used. Our study underlines the importance of fluorescence in situ hybridization testing at diagnosis of diffuse large B-cell lymphoma to detect the rather frequent and clinically significant numerical aberrations of MYC.




ben

Benefits of Continuing RAAS Inhibitors in Advanced CKD




ben

Characteristics of high-drug-cost beneficiaries of public drug plans in 9 Canadian provinces: a cross-sectional analysis

Background:

Drugs are the fastest growing cost in the Canadian health care system, owing to the increasing number of high-cost drugs. The objective of this study was to examine the characteristics of high–drug-cost beneficiaries of public drug plans across Canada relative to other beneficiaries.

Methods:

We conducted a cross-sectional study among public drug plan beneficiaries residing in all provinces except Quebec. We used the Canadian Institute for Health Information’s National Prescription Drug Utilization Information System to identify all drugs dispensed to beneficiaries of public drug programs in 2016/17. We stratified the cohort into 2 groups: high–drug-cost beneficiaries (top 5% of beneficiaries based on annual costs) and other beneficiaries (remaining 95%). For each group, we reported total drug costs, prevalence of high-cost claims (> $1000), median number of drugs, proportion of beneficiaries aged 65 or more, the 10 most costly reimbursed medications and the 10 medications most commonly reimbursed. We reported estimates overall and by province.

Results:

High–drug-cost beneficiaries accounted for nearly half (46.5%) of annual spending, with an average annual spend of $14 610 per beneficiary, compared to $1570 among other beneficiaries. The median number of drugs dispensed was higher among high–drug-cost beneficiaries than among other beneficiaries (13 [interquartile range (IQR) 7–19] v. 8 [IQR 4–13]), and a much larger proportion of high–drug-cost beneficiaries than other beneficiaries received at least 1 high-cost claim (40.9% v. 0.6%). Long-term medications were the most commonly used medications for both groups, whereas biologics and antivirals were the most costly medications for high–drug-cost beneficiaries.

Interpretation:

High–drug-cost beneficiaries were characterized by the use of expensive medications and polypharmacy relative to other beneficiaries. Interventions and policies to help reduce spending need to consider both of these factors.




ben

Levonadifloxacin, a Novel Benzoquinolizine Fluoroquinolone, Modulates Lipopolysaccharide-Induced Inflammatory Responses in Human Whole-Blood Assay and Murine Acute Lung Injury Model [Pharmacology]

Fluoroquinolones are reported to possess immunomodulatory activity; hence, a novel benzoquinolizine fluoroquinolone, levonadifloxacin, was evaluated in lipopolysaccharide-stimulated human whole-blood (HWB) and mouse acute lung injury (ALI) models. Levonadifloxacin significantly mitigated the inflammatory responses in an HWB assay through inhibition of proinflammatory cytokines and in the ALI model by lowering lung total white blood cell count, myeloperoxidase, and cytokine levels. The immunomodulatory effect of levonadifloxacin, along with promising antibacterial activity, is expected to provide clinical benefits in the treatment of infections.




ben

Encephalitozoon cuniculi Genotype III Evinces a Resistance to Albendazole Treatment in both Immunodeficient and Immunocompetent Mice [Experimental Therapeutics]

Of four genotypes of Encephalitozoon cuniculi, E. cuniculi genotype II is considered to represent a parasite that occurs in many host species in a latent asymptomatic form, whereas E. cuniculi genotype III seems to be more aggressive, and infections caused by this strain can lead to the death of even immunocompetent hosts. Although albendazole has been considered suitable for treatment of Encephalitozoon species, its failure in control of E. cuniculi genotype III infection has been reported. This study determined the effect of a 100x recommended daily dose of albendazole on an Encephalitozoon cuniculi genotype III course of infection in immunocompetent and immunodeficient mice and compared the results with those from experiments performed with a lower dose of albendazole and E. cuniculi genotype II. The administration of the regular dose of abendazole during the acute phase of infection reduced the number of affected organs in all strains of mice and absolute counts of spores in screened organs. However, the effect on genotype III was minor. Surprisingly, no substantial effect was recorded after the use of a 100x dose of albendazole, with larger reductions seen only in the number of affected organs and absolute counts of spores in all strains of mice, implying variations in albendazole resistance between these Encephalitozoon cuniculi genotypes. These results imply that differences in the course of infection and the response to treatment depend not only on the immunological status of the host but also on the genotype causing the infection. Understanding how microsporidia survive in hosts despite targeted antimicrosporidial treatment could significantly contribute to research related to human health.




ben

Beneficial Agents for Patients With Type 2 Diabetes and Cardiovascular Disease or Obesity: Utilization in an Era of Accumulating Evidence

This study was an analysis of a national sample of U.S. medical office visits from 2014 to 2016, a period when evidence of effectiveness was emerging for a variety of beneficial type 2 diabetes agents with regard to potential reduction in diabetes comorbidities. Ideal therapy was defined as an American Diabetes Association–identified beneficial agent plus metformin. The associations between atherosclerotic cardiovascular disease or obesity and use of these agents were explored.




ben

Age at Diagnosis and Patient Preferences for Treatment Outcomes in AML: A Discrete Choice Experiment to Explore Meaningful Benefits

Background:

The recent expansion of treatment options in acute myeloid leukemia (AML) has necessitated a greater understanding of patient preferences for treatment benefits, about which little is known.

Methods:

We sought to quantify and assess heterogeneity of the preferences of AML patients for treatment outcomes. An AML-specific discrete choice experiment (DCE) was developed involving multiple stakeholders. Attributes included in the DCE were event-free survival (EFS), complete remission (CR), time in the hospital, short-term side effects, and long-term side effects. Continuously coded conditional, stratified, and latent-class logistic regressions were used to model preferences of 294 patients with AML.

Results:

Most patients were white (89.4%) and in remission (95.0%). A 10% improvement in the chance of CR was the most meaningful offered benefit (P < 0.001). Patients were willing to trade up to 22 months of EFS or endure 8.7 months in the hospital or a two-step increase in long-term side effects to gain a 10% increase in chance of CR. Patients diagnosed at 60 years or older (21.6%) more strongly preferred to avoid short-term side effects (P = 0.03). Latent class analysis showed significant differences of preferences across gender and insurance status.

Conclusions:

In this national sample of mostly AML survivors, patients preferred treatments that maximized chance at remission; however, significant preference heterogeneity for outcomes was identified. Age and gender may affect patients' preferences.

Impact:

Survivor preferences for outcomes can inform patient-focused drug development and shared decision-making. Further studies are necessary to investigate the use of DCEs to guide treatment for individual patients.




ben

Hệ thống ngân hàng TPHCM thông báo thanh lý 29 nền đất liền kề bến xe Miền Tây Bình Tân

Hệ thống ngân hàng TP. HCM trân trọng thông báo đến quý khách hàng. Phát mãi 39 nền đất và 10 nền đất xây biệt thự Bình Tân liền kề bến xe Miền Tây Aeon Bình Tân TP. HCM.Quý khách đăng ký để nhận thông tin và thời gian phát mãi tại phòng phát mãi tài sản (0901 679 578) chi nhánh ...




ben

Bán khách sạn góc 2MT P. Bến Nghé, Q1 diện tích 1000m2, 2 hầm 20 tầng. Giá: 1300 tỷ

Bán gấp siêu phẩm khách sạn góc 2 mặt tiền, phường Bến Nghé, Quận 1.Diện tích: 25m x 40m.Kết cấu: 2 hầm 20 tầng.Vị trí: Tọa lạc tại vị trí vô cùng đắc địa, ngay phố đi bộ Nguyễn Huệ, gần các khách sạn nổi tiếng như: Times Square, Caravelle, Sheraton,...Giá bán chỉ: 1300 tỷ.Liên h...




ben

Phòng làm việc hợp phong thủy giúp sự nghiệp bền vững

Phong thủy học cho rằng, tất cả mọi vật đều có nguồn năng lương riêng còn gọi là khí, bạn có thể sử dụng khí để đem đến tài lộc, may mắn, cơ hội cho mình. Do đó, vận dụng khí này vào phòng làm việc như thế nào là điều rất quan trọng đối với sự nghiệp của bạn.




ben

Hà Nội phê duyệt quy hoạch bến xe mới quy mô 7,4ha tại Đông Anh

Bến xe khách mới tại Hà Nội có quy mô 7,4ha, nằm tại nút giao giữa quốc lộ 3 và đường Vành đai 3 theo quy hoạch thuộc xã Uy Nỗ, huyện Đông Anh.




ben

TP.HCM: Đề xuất làm metro Bến Thành - Tân Kiên vốn 68.000 tỷ đồng

UBND TP.HCM vừa gửi Bộ Kế hoạch và Đầu tư xem xét, trình Thủ tướng dự án Metro Bến Thành - Tân Kiên (số 3A) với chiều dài 20km, tổng mức đầu tư 68.000 tỷ đồng.




ben

CTY CPDT & PT BDS BỀN VỮNG THIÊN HƯNG SG




ben

Four-star hotel for sale, facade on 12 Ly Tu Trong, Ben Nghe ward, District 1 - near Japan Town

Four-Star hotel for sale, facade on 12 Ly Tu Trong, Ben Nghe ward, District 1, HCMC - Address: Corner Le Thanh Ton st - Chu Manh Trinh st - Area: 20.71 x 29.35m - Recognized area: 608.8 m2 - Structure: 3 basements 20 floors 4 elevators 135 private rooms - Location: near Nguyen Hu...




ben

Benefits of selling home with a real estate agent

Selling home with help from a real estate agent is the ultimate option of many home sellers to promote a fast, smooth sale with a higher price. The following infographic shows the specific benefits you could get when you sell your home with an agent.




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VIB HT phát mãi 25 nền đất gần bến xe Miền Tây Bình Tân, TP. HCM, sổ riêng xem ngay, HT vay 70%

Ngân hàng VIB TP. HCM thanh lý 25 nền đất thổ cư và nhà phố khu vực quận Bình Tân, gần bến xe Miền Tây, siêu thị Aeon Bình Tân.1 - Vị trí vàng. - Nằm trên đại lộ Trần Văn Giàu rộng 60m - nối dài đường Số 7, đây là tuyến đường chính lưu thông ở khu Bình Tân, dễ dàng di chuyển về c...




ben

CHINH CHỦ BÁN GẤP 3 NỀN ĐẤT LIỀN KỀ ĐỐI DIỆN BỆNH VIỆN CHỢ RẪY 2 TIỆN KINH DOANH DA NGÀNH NGHỀ

CHINH CHỦ BÁN GẤP 3 NỀN ĐẤT LIỀN KỀ ĐỐI DIỆN BỆNH VIỆN CHỢ RẪY 2, đường 20m, Sổ hồng riêng, Xây dựng tự do, Tiện xây kinh doanh, Làm văn phòng, Gần Aeon Mall Tên Lửa. - DT: 5x28.4m, 142m2, giá 4.260 tỷ/nền đường 20m - Đất ở đô thị, không khống chế thời gian xây dựng, xây x...




ben

China’s rover has discovered what lies beneath the moon’s far side

China’s Yutu-2 rover has used radar to peer 40 metres under the surface of the far side of the moon and revealed how past impacts have shaped its geology




ben

Trial questions benefits of organic nitrates for bone health

A new study found that organic nitrates do not have clinically relevant effects on bone mineral density or bone turnover in postmenopausal women, and the medications caused significant side effects.




ben

Skin-to-skin 'kangaroo care' shows important benefits for premature babies

A world-first study has demonstrated significant benefits to a premature baby's heart and brain function when held by the parent in skin-to-skin contact. Parent-infant skin-to-skin care (SSC) or kangaroo care, started in the late 1970s in Columbia when incubators to keep babies warm were not available. It is now widely recognized as a beneficial component of holistic care provided for pre-term infants.




ben

Ben Crump: Ahmaud Arbery killing reminiscent of lynching

Justice in case of 25-year-old black male delayed amid COVID-19 response. Apparently in Georgia bowling and tattooing are more essential.





ben

VCs see opportunities for gaming infrastructure startups and incumbents

As the infrastructure for developing games becomes more advanced, studios have turned to buying best-in-class technology from others instead of building everything from scratch (often with inferior quality). This shift underpinned Unity’s rise as the most popular game engine. The current focus on games as ever-evolving social hubs that can remain popular for a decade […]




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Diets do help you lose weight - but the benefits usually don't last

Atkins, Paleo or Zone – whichever diet you follow, you’ll probably only lose a bit of weight, and improvements to your cholesterol may disappear within a year




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How to get the health benefits of nature when you’re stuck inside

Going out into the natural world is good for your health and mind, and you can still get some of the same benefits even when stuck inside, says Graham Lawton




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Dr. Ben Carson: America's economy can reopen 'imminently' by following coronavirus health guidelines, data

America can take its next steps toward reopening by placing an emphasis on emerging health data and closely examining how early states are performing, Housing and Urban Development Secretary Dr. Ben Carson asserted Saturday.



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ben

This Earth Day, we must stop the fossil fuel money pipeline | Bill McKibben

Taking down the fossil fuel industry requires taking on the institutions that finance it. Even during a pandemic, this movement is gaining steam

1970 was a simpler time. (February was a simpler time too, but for a moment let’s think outside the pandemic bubble.)

Simpler because our environmental troubles could be easily seen. The air above our cities was filthy, and the water in our lakes and streams was gross. There was nothing subtle about it. In New York City, the environmental lawyer Albert Butzel described a permanently yellow horizon: “I not only saw the pollution, I wiped it off my windowsills.” Or consider the testimony of a city medical examiner: “The person who spent his life in the Adirondacks has nice pink lungs. The city dweller’s are black as coal.” You’ve probably heard of Cleveland’s Cuyahoga River catching fire, but here’s how the former New York governor Nelson Rockefeller described the Hudson south of Albany: “One great septic tank that has been rendered nearly useless for water supply, for swimming, or to support the rich fish life that once abounded there.” Everything that people say about the air and water in China and India right now was said of America’s cities then.

Continue reading...




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Big Oil is using the coronavirus pandemic to push through the Keystone XL pipeline | Bill McKibben

The oil industry saw its opening and moved with breathtaking speed to take advantage of this moment

I’m going to tell you the single worst story I’ve heard in these past few horrid months, a story that combines naked greed, political influence peddling, a willingness to endanger innocent human beings, utter blindness to one of the greatest calamities in human history and a complete disregard for the next crisis aiming for our planet. I’m going to try to stay calm enough to tell it properly, but I confess it’s hard.

The background: a decade ago, beginning with indigenous activists in Canada and farmers and ranchers in the American west and midwest, opposition began to something called the Keystone XL pipeline, designed to carry filthy tar sands oil from the Canadian province of Alberta to the Gulf of Mexico. It quickly became a flashpoint for the fast-growing climate movement, especially after Nasa scientist James Hansen explained that draining those tar sands deposits would be “game over” for the climate system. And so thousands went to jail and millions rallied and eventually Barack Obama bent to that pressure and blocked the pipeline. Donald Trump, days after taking office, reversed that decision, but the pipeline has never been built, both because its builder, TC Energy, has had trouble arranging the financing and permits, and because 30,000 people have trained to do nonviolent civil disobedience to block construction. It’s been widely assumed that, should a Democrat win the White House in November, the project would finally be gone for good.

Continue reading...




ben

Titans' Ben Jones commends Ryan Tannehill for helping him out after wind storm

Tennessee Titans quarterback Ryan Tannehill stepped up for a teammate who was in need.




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In a Tunnel Beneath Alaska, Scientists Race to Understand Disappearing Permafrost

What lies inside the icy cavern seems more and more like a captive, rare animal, an Earth form that might soon be lost




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Benthos in the Antarctic Weddell Sea in decline

Over the past quarter-century, changes in Antarctic sea-ice cover have had profound impacts on life on the ocean floor.