I agree with you. We need to think about the earth more for the future.

Руководитель Delivery Club Гюванч Донмез считает, что пандемия ускорила выполнение планов компании

People who cycle to work have a lower risk of dying, a New Zealand study has found.

For cost-benefit analysis, the usual ballpark figure for the value of a life is about $10,000,000. But I keep hearing it suggested that when it comes to fighting a disease like Covid-19, which mostly kills the elderly, this value is too high. In other words, an old life is worth less than a young life. […]

Every cricket follower fervently needs to watch real-time cricket suit. Nothing can change the excitement, delights and excitement of real-time cricket suit. Live cricket suit is of much worry for a fan during any recurring series or competitions. Every cricket… Continue Reading →

Although CEACAM1 (CC1) glycoprotein resides at the interface of immune liver injury and metabolic homeostasis, its role in orthotopic liver transplantation (OLT) remains elusive. We aimed to determine whether/how CEACAM1 signaling may affect hepatic ischemia-reperfusion injury (IRI) and OLT outcomes. In the mouse, donor liver CC1 null mutation augmented IRI-OLT (CC1-KO→WT) by enhancing ROS expression and HMGB1 translocation during cold storage, data supported by in vitro studies where hepatic flush from CC1-deficient livers enhanced macrophage activation in bone marrow–derived macrophage cultures. Although hepatic CC1 deficiency augmented cold stress–triggered ASK1/p-p38 upregulation, adjunctive ASK1 inhibition alleviated IRI and improved OLT survival by suppressing p-p38 upregulation, ROS induction, and HMGB1 translocation (CC1-KO→WT), whereas ASK1 silencing (siRNA) promoted cytoprotection in cold-stressed and damage-prone CC1-deficient hepatocyte cultures. Consistent with mouse data, CEACAM1 expression in 60 human donor liver biopsies correlated negatively with activation of the ASK1/p-p38 axis, whereas low CC1 levels associated with increased ROS and HMGB1 translocation, enhanced innate and adaptive immune responses, and inferior early OLT function. Notably, reduced donor liver CEACAM1 expression was identified as one of the independent predictors for early allograft dysfunction (EAD) in human OLT patients. Thus, as a checkpoint regulator of IR stress and sterile inflammation, CEACAM1 may be considered as a denominator of donor hepatic tissue quality, and a target for therapeutic modulation in OLT recipients.

Organ shortage continues to limit the lives of patients who require liver transplantation. While extending criteria for liver organs provides a needed resource, tissue damage from prolonged ischemic injury can result in early allograft dysfunction and consequent rejection. In this issue of the JCI, Nakamura et al. used a mouse transplantation model with prolonged ex vivo cold storage to explore liver graft protection. The authors found that liver grafts with absent carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) exhibited increased ischemia-reperfusion injury inflammation and decreased function in wild-type recipients. The authors went on to correlate CEACAM1 levels with postreperfusion damage in human liver transplant recipients. Notably, this study identified a potential biomarker for liver transplant donor graft quality.

Hepatocellular carcinoma (HCC) is clearly age-related and represents one of the deadliest cancer types worldwide. As a result of globally increasing risk factors including metabolic disorders, the incidence rates of HCC are still rising. However, the molecular hallmarks of HCC remain poorly understood. Neuropeptide Y (NPY) and NPY receptors represent a highly conserved, stress-activated system involved in diverse cancer-related hallmarks including aging and metabolic alterations, but its impact on liver cancer had been unclear. Here, we observed increased expression of NPY5 receptor (Y5R) in HCC, which correlated with tumor growth and survival. Furthermore, we found that its ligand NPY was secreted by peritumorous hepatocytes. Hepatocyte-derived NPY promoted HCC progression by Y5R activation. TGF-β1 was identified as a regulator of NPY in hepatocytes and induced Y5R in invasive cancer cells. Moreover, NPY conversion by dipeptidylpeptidase 4 (DPP4) augmented Y5R activation and function in liver cancer. The TGF-β/NPY/Y5R axis and DPP4 represent attractive therapeutic targets for controlling liver cancer progression.

BACKGROUND The live attenuated BPZE1 vaccine candidate induces protection against B. pertussis and prevents nasal colonization in animal models. Here we report on the responses in humans receiving a single intranasal administration of BPZE1.METHODS We performed multiple assays to dissect the immune responses induced in humans (n = 12) receiving BPZE1, with particular emphasis on the magnitude and characteristics of the antibody responses. Such responses were benchmarked to adolescents (n = 12) receiving the complete vaccination program of the currently used acellular pertussis vaccine (aPV). Using immunoproteomics analysis, potentially novel immunogenic B. pertussis antigens were identified.RESULTS All BPZE1 vaccinees showed robust B. pertussis–specific antibody responses with regard to significant increase in 1 or more of the following parameters: IgG, IgA, and memory B cells to B. pertussis antigens. BPZE1–specific T cells showed a Th1 phenotype, and the IgG exclusively consisted of IgG1 and IgG3. In contrast, all aPV vaccines showed a Th2-biased response. Immunoproteomics profiling revealed that BPZE1 elicited broader and different antibody specificities to B. pertussis antigens as compared with the aPV that primarily induced antibodies to the vaccine antigens. Moreover, BPZE1 was superior at inducing opsonizing antibodies that stimulated ROS production in neutrophils and enhanced bactericidal function, which was in line with the finding that antibodies against adenylate cyclase toxin were only elicited by BPZE1.CONCLUSION The breadth of the antibodies, the Th1-type cellular response, and killing mechanisms elicited by BPZE1 may hold prospects of improving vaccine efficacy and protection against B. pertussis transmission.TRIAL REGISTRATION ClinicalTrials.gov NCT02453048, NCT00870350.FUNDING ILiAD Biotechnologies, Swedish Research Council (Vetenskapsrådet), Swedish Heart-Lung Foundation.

It’s no secret that I love Japan. I mean, I really, really love Japan. I felt more at home in Tokyo than I ever have anywhere else, and I think about going back all. the. time. I’m even thinking about it right now. You’re probably reading this right now because, at the very least, some tiny part of you is curious about whether you should do it. It might be the tiiiiiiiniest little part, but I’m sure it’s there. Maybe you don’t want to admit it because it seems pretty impossible, and yeah, I will admit that if you have a job that you don’t want to leave, strong family ties, kids, pets, or no money (among other things), it must seem like a distant what-if that will never happen. Here’s the thing. If you’re really, honestly interested, then make it happen. Because guess what? You freaking can make it happen, and don’t let anybody tell you no. If you’re coming up with a “But…” right now, I’ll stop you right there! “But I have kids/pets…” Figure out how to take them with you, because you can! “But I don’t want to leave my job…” Take a sabbatical for a year, look into transfers to a branch abroad, look for a better job in the same field in Japan, or look into whether this job is really worth giving up on this dream (maybe it isn’t). “But I can’t speak the language…” So? I moved to Japan and didn’t speak a word. Some people learn before they go, some people learn while they’re there (me), and some people never learn (I don’t recommend this). I could go on forever, but the whole world is at your fingers if you really want it! I seriously believe that. It’s not always easy, but if you want something badly enough, don’t you owe it to yourself to at least try? Anyways, let me give you the top reasons why I think that you should give living in Japan a try! 1. Living in a different culture opens your eyes. This especially is true if you immerse yourself in as much of the culture as you can. Make Japanese friends, learn about what people do on a daily basis and what they believe in. Try doing things in ways that are new to you. Try new foods! Mochi is the schiz, by the way! Once you’ve experienced doing new things, it will change how you do things even if you return back home. I will always have a no-shoes policy in my house (it’s so much cleaner!), I absolutely CRAVE a train system (if only!), and I have a newfound respect for walking and cycling. I never did this when I was little, but now, if I can, I walk! 2. You’ll have a fresh start. In your new home in Japan, you won’t have any of the drama that surrounded you in your old one. Thanks to the internet, we can still keep in touch with friends and family, but being a few thousand miles away from them will keep a lot of the drama to a minimum. Take a chance to stretch your wings and see what kind of person you are when you have the freedom to be you without their judgement. Trust me, it takes a weight off being in a new place where nobody knows who you used to be (or who they thought you used to be). Oh, and you know what? I bet that you will love yourself more than you ever did before. 3. Japan is a magical place! Seriously. Cherry blossoms, gorgeous temples and “castles” (I wouldn’t call them castles, but they’re called that nonetheless, and they’re really cool anyway), a rich history filled with Samurai and ninjas (who doesn’t love ninjas?), seasonal treats, and an entire culture that grew up reading manga. How does this not sound like an amazing place to live?!  And no offense to any other country, but Japanese trains come quickly, go almost everywhere, are extremely punctual, and pretty clean, which makes them (Tokyo especially) easily #1 in the world in public transportation. Now that sounds magical to me. 4. Universal Health Care. If you’re American like me, this will make a HUGE difference in your life. Trust me. If you come from pretty much any other 1st world nation, it probably won’t matter as much, though. But at least it’s good! 5. Japan is safer than where you came from. There’s no gun violence. There’s very low crime in general. You can walk in the dead of night in the seediest parts of town, as a woman, alone, and still feel perfectly safe from other people. From earthquakes is another matter, but you’ll get used to them really fast, and Japan is built to withstand all but the biggest. 6. Wa. There is a concept called wa in Japanese society, which essentially promotes practicing peace and harmony in your daily life. Wa is obvious in everything from traditional architecture and decor to the way that people act around each other– courteousness, quiet, and respect are what you expect most from your neighbors. You’re never going to wake up to your neighbors blaring music at 3am having a raucous party. Even drunken people wandering the street are more polite than not (although most of them just sort of stumble home or sit down where they are for the night– but remember, Japan is safe so they only thing they have to worry about is getting chilly). We could all use a little bit of harmony in our lives, and that’s something that Japan taught me to value. I’m surprised that yoga isn’t more popular, since they’re pretty in tune with each other. 7. All the new gadgets, and all of the old culture. Sure, Silicon Valley is where a lot of new apps are coming out, but if you want lots of little weird but useful gadgets to make your life easier (or more interesting), take a stroll through Akihabara. Plus, there are tons of cheap versions of what you’re used to, like large-capacity flash drives and SD cards. And I would be remiss in not mentioning the used electronics! Smartphones! Right next to small neighborhood temples, btw. It’s the only place to find Ayanami Rei in a kimono, wandering the street. The best of both worlds! 8. MANGA AND ANIME EVERYWHERE. This should be your main reason. This should be enough of a reason. Not only is it available everywhere, but events abound. If you wanted, you could go to an anime-related event every weekend of the year. Also, let’s not forget that it’s the only place to see all of the anime movies released in the theater, go to the official events (like Jump Festa, Comicket, World Cosplay Summit, and Anime Japan, among others), and see the musicals, seiyuu radio shows, and stage plays. If this isn’t reason enough, you’re probably in the wrong place. 9. It’s cheaper than you think. I lived in Tokyo, and then I moved back to the US, thinking that because I was living in a place often called “The Most Expensive City In The World,” it would be cheaper here. Nope.. Apartment rents, even in small cities, are at least the price that I was paying in Tokyo (~$600/mo). And try finding that in LA. So far I haven’t had any luck, and especially not in the areas that are actually sort-of-kind-of safe. Food is also about on-par with the US, especially domestic food. Considering that it’s an island, it’s actually really, really cheap. Food in Hawaii cost sometimes 3-4 times what I was able to get it for in Japan. Then, when you factor in healthcare, which is pretty cheap (what you pay for the insurance is based on your income, and then it covers 80% of all your bills — this is a simplification, but generally holds true), and transportation costs (you don’t need a car, therefore no gas, no insurance, no car maintenance fees), it’s downright cheap. Even living in Tokyo. 10. You will never run out of things to do. In nearly a decade, I never ran out of cool things to do. Can you say the same about the city that you live in now? Thought so. Ah man, I kinda feel ready to jump back on a plane and move across the ocean… three cats and all! Somebody hold me back… resistance is fading……………….  

Disney has announced that it will be producing a new Robin Hood movie.

Yes, that Robin Hood.

read more

Plus more ways to support comics creators and new authors launching their books worldwide while social distancing!

The post Social Distancing Roundup: JOHN WICK Livestream, Neil Gaiman reads CORALINE, and an X-MEN ’92 watchalong appeared first on The Beat.

IBM and Telestream announced today at IBC 2017 a game-changing solution for high-speed capture and production of live, broadcast quality video from remote locations for faster production turnaround. Telestream Vantage powered by Aspera combines Aspera’s FASPStream high-speed streaming technology and Telestream Lightspeed Live Capture media processing platform to enable production teams to work on live video feeds from remote locations in near real time.

IBM today announced that it will help deliver a tailored fan experience through the IBM Cloud at Atlanta’s new Mercedes-Benz Stadium, scheduled to open later this month.

Today IBM and Eurobank announced the first cloud-based digital platform for online international commercial trading. Using IBM's industry-leading Digital Experience software, with advanced cloud capabilities and social offerings, Eurobank is uniting exporters and importers from around the globe to enhance international trade operations and increase transactions.

IBM today announced that Vissensa, a UK-based managed service provider (MSP), has taken delivery of the IBM Enterprise Cloud System, which will help the company offer new and improved cloud services to its customers.

As businesses increasingly recognize the opportunity to increase productivity, improve customer experiences and deliver new products and services through intelligent automation, Blue Prism and IBM have joined forces to deliver a secure, scalable and easy-to-use Digital Workforce for enterprises worldwide, such as Walgreens.

Today IBM unveiled the seventh annual IBM 5 in 5 – a list of innovations that have the potential to change the way people work, live and interact during the next five years.

Today IBM formally unveiled the fifth annual "Next Five in Five" – a list of innovations that have the potential to change the way people work, live and play over the next five years: • You'll beam up your friends in 3-D • Batteries will breathe air to power our devices • You won’t need to be a scientist to save the planet • Your commute will be personalized • Computers will help energize your city

ANZ, Commonwealth Bank, IBM Scentre Group and Westpac have jointly launched a live pilot for Lygon, a new digital platform using blockchain technology to transform the way businesses obtain and manage bank guarantees that are often required as part of a retail property lease.

IBM Australia (NYSE: IBM) has been awarded a multimillion dollar contract with NBN Co Limited to implement and manage the core business and operational support systems required to operate Australia’s National Broadband Network (NBN).

Tasmania’s St Virgil’s College has signed a two-year agreement with IBM to equip staff and students with Apple iPads and Mobile Device Management (MDM) software as part of its digital education delivery commitment.

IBM has announced the availability of its cloud container service in its Australian data centres, delivered out of Sydney and Melbourne, on IBM Cloud.

IBM (NYSE: IBM) today announced that the University of Melbourne, a world class research university, has selected IBM to design and install a high efficiency, high density cooling solution to support new IT initiatives such as Cloud and Research computing, in its new data centre, Data Hall 2.

【動画配信】Rakuten TV 　2月3日 雪組千秋楽 LIVE配信 　『ONCE UPON A TIME IN AMERICA』 　宝塚大劇場公演 フィナーレ以降 ・プレミアムプラン加入...

New advertising streams for global news organisations uncovered by AI

記憶がしっかりと残ってる間に暦タメLiveのことについてかこうと思います*\(^o^)/*ツイッターにて質問等も募集したので参考にしながらかいていきますね(^○^)見てない方も楽しめるように、まず自分が演じた役を書いておきますね。まずはじめに妙林尼戦国時代の女性。おんな城主です。土方歳三新撰組副長。上杉謙信の影武者徳川慶喜徳川最後の将軍。を演じました????今回の舞台で一番大変だった点を話しますと、なんといっても徳川慶喜メインのお話。台本は完璧に覚えていってたので初日から本を持つということはありませんでした。それで演出家さんも大爆笑だったので、一番はじめの稽古と千秋楽の芝居がほぼ変わらなかった印象です。なので相手のセリフ、自分のセリフに慣れないということ、笑いを自分からとりにいかない事、これを大事にやっていました。笑わせようという意図が見えると見る側は冷めるもの。そのバランスを大切にしていました。本自体が面白かったから、それをただ信じてやりました。昨日の打ち上げで脚本家さん演出家さんから徳川慶喜は本当ハマリ役でキャスティングで蓮くんの時点であれはもう成功だったと言ってもらえたので良かったんだと思います！ここまでみると大変じゃないじゃんと思われるかもしれません。練習したら良くなる芝居とそうじゃない芝居がありまして、徳川慶喜のお話は稽古を飛ばされるほど新鮮さを大事にしていた感じです。写真の面白さ、鈴木拡樹のノリツッコミの美味さがあったので自信もってできました????演じてみたい武将はいますか？については、やはり岡崎ということで徳川家康はいつか演じてみたいです。毎日のように岡崎城をみて育ちました。家康の生まれた地という事を誇りに思っています。あと正直なんの役でもいいというのが本音で、知らない事を知るという事は凄く楽しいことなので、役との出会いがあるだけで満足です。新撰組の衣装の写真はこれしかなかった((((；ﾟДﾟ続きをみる

『著作権保護のため、記事の一部のみ表示されております。』

We've gotten some requests to provide an RSS feed for the website, and I'm happy to say it's now ready to go! You can subscribe to the feed with your favorite reader and get updated whenever we post a new comic page or news post.

Also, HamletMachine's been cranking away on the extra material for the print version of the first chapter of Starfighter, and we're getting close to having everything together. Hopefully soon we'll have an estimate of when it will be available. Thanks to everyone for your support! -Thisbe

Touring the homes of all the dead who have ever lived Even the ones long gone burned buried torn down vanished Wandering halls Opening rooms Crossing borders to see all the places the dead have been Trying to learn what it means to remain present after the body has gone It is not something  I have thought […]

No doubt — this is a crazy, scary, sad, worrying time for everyone. Most of us are sheltering in place and trying our best to adjust to a new reality. While we are not performing heroic deeds like all the frontline healthcare workers and first responders, grocery store employees and delivery drivers, we can all … Continue reading nine cool things on a tuesday (stay home, save lives edition)

1. Strategic oil storage to be full by mid-May: Dharmendra Pradhan  Livemint
2. India's fuel demand nearly halves in April amid national lockdown  Hindustan Times
3. Dharmendra Pradhan hints at new gas policy, says low oil prices no answer  Zee News
4. India has ample crude oil reserves: Pradhan  The Tribune India
5. India's Fuel Consumption Falls 46% To Lowest Since 2007  NDTV Profit
6. View Full coverage on Google News