Nine people died in the January 26 helicopter crash.

He did something really sweet for his late daughter.

The program focuses on "critical importance of self-care."

She battled depression after the birth of her third child.

Take a peek inside their fairy tale romance.

Is your organization aiming to increase the participation of minority-and women-owned businesses in state and local transportation projects? TRB will conduct a webinar on Wednesday, May 27, 2020, from 2:00 PM to 3:30 PM Eastern to discuss how to meet the goals set by the U.S. Department of Transportation Disadvantaged Business Enterprise (USDOT DBE). State and local transportation projects that receive federal funding are mandated to go through the triennial DBE goal-setting process. Make your next goals...

"I fell into transportation domain by chance, pursuing my interests in software and data. And although I kept working in these fields, TRB taught me about transportation and how my software and data expertise could help solve transportation problems," says Nikola Ivanov, Director of Operations at the University of Maryland’s Center for Advanced Transportation Technology (CATT) Laboratory. "Through TRB, I’ve met hundreds of brilliant experts, all of whom help me make a difference in people’s everyday live...

TRB's Airport Cooperative Research Program (ACRP) Research Report 155: Guidebook for Advanced Computerized Maintenance Management System Integration at Airports explores the use of a Computerized Maintenance Management System (CMMS) to manage a variety of assets across a number of different airport systems. This report develops guidance on the steps necessary to implement a CMMS, factors for consideration in prioritizing which systems should be included in the CMMS using a phased approach, and the steps ...

V posledních týdnech se aktivně zapojuji do snah získat podporu pro kreativní průmysly, zasažené koronakrizí. Mailů a diskuzních příspěvků, u nichž mám pocit, že jsou citací z legendárního projevu Miloše Jakeše na Červeném Hrádku, mám plnou schránku.

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BACKGROUND The anti–programmed cell death 1 (anti–PD-1) antibody pembrolizumab is clinically active against non–small cell lung cancer (NSCLC). In addition to T cells, human natural killer (NK) cells, reported to have the potential to prolong the survival of patients with advanced NSCLC, also express PD-1. This study aimed to investigate the safety and efficacy of pembrolizumab plus allogeneic NK cells in patients with previously treated advanced NSCLC.METHODS In total, 109 enrolled patients with a programmed death ligand 1 (PD-L1) tumor proportion score (TPS) of 1% or higher were randomly allocated to group A (n = 55 patients given pembrolizumab plus NK cells) or group B (n = 54 patients given pembrolizumab alone). The patients received i.v. pembrolizumab (10 mg/kg) once every 3 weeks and continued treatment until the occurrence of tumor progression or unacceptable toxicity. The patients in group A continuously received 2 cycles of NK cell therapy as 1 course of treatment.RESULTS In our study, patients in group A had longer survival than did patients in group B (median overall survival [OS]: 15.5 months vs. 13.3 months; median progression-free survival [PFS]: 6.5 months vs. 4.3 months; P < 0.05). In group A patients with a TPS of 50% or higher, the median OS and PFS was significantly longer. Moreover, the patients in group A treated with multiple courses of NK cell infusion had better OS (18.5 months) than did those who received a single course of NK cell infusion (13.5 months).CONCLUSIONS Pembrolizumab plus NK cell therapy yielded improved survival benefits in patients with previously treated PD-L1+ advanced NSCLC.TRIAL REGISTRATION ClinicalTrials.gov NCT02843204.FUNDING This work was supported by grants from the National Natural Science Foundation of China (NSFC) – Guangdong Joint Foundation of China (no. U1601225); the NSFC (no. 81671965); the Guangdong Provincial Key Laboratory Construction Project of China (no. 2017B030314034); and the Key Scientific and Technological Program of Guangzhou City (no. 201607020016).

JONES: You talked about the person we always talk about, Donald Trump. Let's talk about the person we never talk about, we just heard from. Bernie Sanders has incredible momentum. He's had almost a media blackout. We -- I mean, he's almost never the subject of the main conversation. But out in the country, you see a lot of Bernie Sanders support. He got more contributions, individual donors, than anybody in American history. That by itself lets you know something's going on. I think he's going to win Iowa. He may win New Hampshire. Continue reading →

At the International Supercomputing Conference in Frankfurt, The Weather Company, an IBM Business, today announced a plan to help improve weather prediction globally via a new collaboration with the University Corporation for Atmospheric Research (UCAR) and the National Center for Atmospheric Research (NCAR), a federally funded research and development center for the atmosphere and Earth’s geospace systems.

IBM and the University of California San Diego have announced a multi-year project to enhance quality of life and independence for aging populations through the new Artificial Intelligence for Healthy Living Center (AIHL), located on the campus of UC San Diego. The groundbreaking center will bring together the technology, artificial intelligence and life sciences knowledge of IBM and UC San Diego to promote critical research and applications in two thematic areas: Healthy Aging and the Human Microbiome.