ap Science Confirms: You Really Can't Buy Happiness By www.washingtonpost.com Published On :: Mon, 03 Jul 2006 00:00:00 EDT When Warren Buffett announced last week that he will be giving away more than $30 billion to improve health, nutrition and education, people all over America reflected on his remarkable generosity, pondered all the noble things the gift would achieve and asked themselves what they would do if... Full Article Nation Science Confirms: You Really Can't Buy Happiness
ap Apologies Accepted? It Depends on the Offense By www.washingtonpost.com Published On :: Mon, 25 Sep 2006 00:00:00 EDT When freedom fighters in India inspired by Mahatma Gandhi turned violent in a clash with police in 1922, the nonviolent leader took personal responsibility, called off nationwide protests and starved himself for five days in a penitential fast. Gandhi was nearly alone in thinking an apology of such... Full Article Nation Apologies Accepted? It Depends on the Offense
ap Financial Hardship and the Happiness Paradox By www.washingtonpost.com Published On :: Mon, 23 Jun 2008 00:00:00 EDT The United States is awash in gloom. Overwhelming majorities of Americans say they are dissatisfied with the country's economic direction, and the intensity of unhappiness is greater than it has been in 15 years, according to a recent Washington Post-ABC News poll. The answer, pundits, politicians... Full Article Opinions Financial Hardship and the Happiness Paradox
ap Happiness on the Medal Stand? It's as Simple as 1-3-2. By www.washingtonpost.com Published On :: Mon, 18 Aug 2008 00:00:00 EDT Nearly a century ago, American middle-distance runner Abel Kiviat entered the Stockholm Olympics as the odds-on favorite to win the 1,500-meter race, an event in which he held the world record. Kiviat had the lead 1,492 meters into the race but was passed in the final eight meters by Britain's... Full Article Opinions Happiness on the Medal Stand? It's as Simple as 1-3-2.
ap Big Political Donors Just Looking for Favors? Apparently Not. By www.washingtonpost.com Published On :: Mon, 10 Nov 2008 00:00:00 EST The Center for Responsive Politics recently estimated that it cost $5.8 billion to finance the 2008 general elections. To most people that is a staggeringly large sum and evidence of the profoundly corrupting role that money plays in politics, but to some very smart political watchers, the better... Full Article Opinions Big Political Donors Just Looking for Favors? Apparently Not.
ap Who Are the Better Managers -- Political Appointees or Career Bureaucrats? By www.washingtonpost.com Published On :: Mon, 24 Nov 2008 00:00:00 EST Every time the White House changes hands between the Democrats and the Republicans, the outgoing party quickly sees the virtues of staffing government departments with competent managers. The incoming party invariably seeks to reward loyal campaign operatives with political appointments. Full Article Opinions Who Are the Better Managers -- Political Appointees or Career Bureaucrats?
ap The Computer as a Road Map to Unknowable Territory By www.washingtonpost.com Published On :: Mon, 16 Feb 2009 00:00:00 EST Last year, as the financial meltdown was getting underway, a scientist named Yaneer Bar-Yam developed a computer model of the economy. Instead of the individuals, companies and brokers that populate the real economy, the model used virtual actors. The computer world allowed Bar-Yam to do what... Full Article Opinions The Computer as a Road Map to Unknowable Territory
ap State Sociodemographic Portraits of Immigrant and U.S.-Born Parents of Young Children By www.migrationpolicy.org Published On :: Tue, 13 Dec 2016 16:53:09 -0500 These fact sheets provide a sociodemographic sketch of parents with children ages 0 to 8 in the 30 states with the largest number of immigrant families, offering data and analysis of some of the key parental characteristics to help stakeholders identify populations that could be targets for early childhood and parent-focused programs working to improve child and parent outcomes. Full Article
ap New Brain Gain: Rising Human Capital among Recent Immigrants to the United States By www.migrationpolicy.org Published On :: Thu, 25 May 2017 12:07:54 -0400 Nearly half of immigrant adults arriving in the U.S. since 2011 have a college degree—a far higher share than a quarter-century ago, when just 27 percent did. This striking but little noted shift in the composition of recent immigrant flows, driven in part by rising migration from Asia, comes as some policymakers press for a "merit-based" immigration system. This fact sheet examines rising human capital at U.S. and state levels. Full Article
ap Credentials for the Future: Mapping the Potential for Immigrant-Origin Adults in the United States By www.migrationpolicy.org Published On :: Tue, 05 Mar 2019 13:34:43 -0500 As the U.S. workforce ages and the economy becomes ever more knowledge-based, policymakers face a key question: Do workers have the skills to meet tomorrow's demands? This report examines how immigrants and their children—the primary source of future labor-market growth—fit into the discussion. The report offers a first-ever profile of the 30 million immigrant-origin adults without a postsecondary credential. Full Article
ap Upskilling the U.S. Labor Force: Mapping the Credentials of Immigrant-Origin Workers By www.migrationpolicy.org Published On :: Fri, 08 Mar 2019 15:31:45 -0500 This webinar discusses the first-ever profile of the 30 million immigrant-origin adults in the United States who lack a postsecondary credential and offers analysis of the significant payoff credentials could bring in terms of workforce participation and wages. Full Article
ap Specificity and affinity of the N-terminal residues in staphylocoagulase in binding to prothrombin [Computational Biology] By www.jbc.org Published On :: 2020-04-24T06:08:45-07:00 In Staphylococcus aureus–caused endocarditis, the pathogen secretes staphylocoagulase (SC), thereby activating human prothrombin (ProT) and evading immune clearance. A previous structural comparison of the SC(1–325) fragment bound to thrombin and its inactive precursor prethrombin 2 has indicated that SC activates ProT by inserting its N-terminal dipeptide Ile1-Val2 into the ProT Ile16 pocket, forming a salt bridge with ProT's Asp194, thereby stabilizing the active conformation. We hypothesized that these N-terminal SC residues modulate ProT binding and activation. Here, we generated labeled SC(1–246) as a probe for competitively defining the affinities of N-terminal SC(1–246) variants preselected by modeling. Using ProT(R155Q,R271Q,R284Q) (ProTQQQ), a variant refractory to prothrombinase- or thrombin-mediated cleavage, we observed variant affinities between ∼1 and 650 nm and activation potencies ranging from 1.8-fold that of WT SC(1–246) to complete loss of function. Substrate binding to ProTQQQ caused allosteric tightening of the affinity of most SC(1–246) variants, consistent with zymogen activation through occupation of the specificity pocket. Conservative changes at positions 1 and 2 were well-tolerated, with Val1-Val2, Ile1-Ala2, and Leu1-Val2 variants exhibiting ProTQQQ affinity and activation potency comparable with WT SC(1–246). Weaker binding variants typically had reduced activation rates, although at near-saturating ProTQQQ levels, several variants exhibited limiting rates similar to or higher than that of WT SC(1–246). The Ile16 pocket in ProTQQQ appears to favor nonpolar, nonaromatic residues at SC positions 1 and 2. Our results suggest that SC variants other than WT Ile1-Val2-Thr3 might emerge with similar ProT-activating efficiency. Full Article
ap Latinos & Immigrants in Kansas City Metro Area Face Higher Health Insurance Coverage Gaps, Even as They Represent Fast-Growing Share of Workforce By www.migrationpolicy.org Published On :: Tue, 19 Nov 2019 09:31:19 -0500 WASHINGTON — Latinos and immigrants are at least twice as likely to lack health insurance coverage as the overall population in three central Kansas City metro counties, a new Migration Policy Institute (MPI) study reveals. In fact, they are four times as likely to be uninsured in Johnson County, Kansas. Full Article
ap As Global Refugee Forum approaches, MPI Europe brief offers a road map for smart investment in refugee sponsorship programmes By www.migrationpolicy.org Published On :: Wed, 11 Dec 2019 22:29:14 -0500 BRUSSELS — Even as the number of refugees in need of protection has reached an all-time high, the resettlement spots offered by countries in 2018 were less than half the level in 2016—and future commitments may shrink further. With refugee needs high and generosity dimming, there is increasing urgency for humanitarian actors to find new ways to bring refugees to safety as well as to rebuild public interest and consensus around the importance of protection. Full Article
ap MPI Analysis of All State ESSA Accountability Plans Finds Fractured Picture of Education Policy for English Learners & Differing Approaches By www.migrationpolicy.org Published On :: Tue, 11 Feb 2020 16:45:31 -0500 WASHINGTON – Four years since the Every Student Succeeds Act (ESSA) was signed into law, all 50 states, the District of Columbia and Puerto Rico have developed accountability plans that include blueprints for serving English Learners (ELs), as well as measuring these students’ progress and being accountable for their outcomes. This marked a significant development, as EL performance was previously not well integrated with factors that determined whether a school was performing well or poorly. Full Article
ap Get Top Statistics on Immigrants in the U.S and Changing Immigration Trends; MPI Updates its Interactive Data Tools, Maps & One-Stop Resource for Key Stats By www.migrationpolicy.org Published On :: Fri, 14 Feb 2020 14:36:44 -0500 WASHINGTON — The Migration Policy Institute (MPI) today published the annual update to its data-rich article, Frequently Requested Statistics on Immigrants and Immigration in the United States, offering readers a wealth of information that can help inform understanding about an issue that is the subject of much conversation. Full Article
ap Is a U.S. Immigration System Rebuilt after 9/11 Prepared to Tackle Ever-Evolving Security Threats, Including Pandemics? Report Assesses Successes, Gaps By www.migrationpolicy.org Published On :: Thu, 09 Apr 2020 09:11:12 -0400 WASHINGTON — The U.S. immigration system was dramatically reshaped by the terrorist attacks of September 11, 2001, which shone a harsh spotlight on weaknesses in visa and immigration screening processes. From the creation of the Department of Homeland Security (DHS) to expanded national security protections in immigration and tourism policies, countless changes in the immigration arena have unfolded over the past 19 years. Full Article
ap An Uneven Landscape: The Differing State Approaches to English Learner Policies under ESSA By www.migrationpolicy.org Published On :: Wed, 29 Jan 2020 13:09:18 -0500 Experts share how states have approached Every Student Succeeds Act (ESSA) implementation, and areas where the law and state efforts to support English Learners can be improved. Full Article
ap The Patchy Landscape of State English Learner Policies under ESSA By www.migrationpolicy.org Published On :: Tue, 11 Feb 2020 10:14:34 -0500 All 50 states, the District of Columbia, and Puerto Rico have developed blueprints to meet their commitments under the Every Student Succeeds Act—including requirements that aim to raise the profile of English Learners (EL) in state accountability systems. This report breaks these plans down, comparing the significant diversity of approaches taken on everything from EL identification to tracking academic achievement. Full Article
ap Khachapuri - Georgian cheese pie By www.abc.net.au Published On :: Tue, 13 Oct 2015 15:49:00 +1100 This recipe was featured on Foodie Tuesday, a weekly segment with Raf Epstein on Drive, 774 ABC Melbourne, 3:30 PM, courtesy of Alice in Frames. www.aliceinframes.com Full Article ABC Local melbourne Lifestyle and Leisure:Recipes:All Australia:VIC:Melbourne 3000
ap Bacon wrapped mozzarella chicken breasts By www.abc.net.au Published On :: Tue, 03 Nov 2015 16:05:00 +0800 When it comes to bacon, it's everything in moderation... This recipe uses bacon as a seasoning. Full Article ABC Local southwestwa Lifestyle and Leisure:Recipes:All Health:Diet and Nutrition:Healthy recipes Australia:WA:Bunbury 6230
ap All Natural Apple Syrup By www.abc.net.au Published On :: Fri, 13 Nov 2015 14:40:00 +1100 This syrup is delicious and well worth the time involved. While it tastes sweet it is natural and sugar-free. Add a tablespoonful to any chopped fresh fruit - berries, mango, pineapple, papaya, banana, grapes - and it will balance and enhance the flavours. It's also great served over waffles, crepes or ice cream. Full Article ABC Local shepparton goulburnmurray Lifestyle and Leisure:Food and Cooking:All Lifestyle and Leisure:Recipes:All Australia:VIC:Shepparton 3630 Australia:VIC:Wodonga 3690
ap Sticky pineapple and macadamia upside-down cake By www.abc.net.au Published On :: Mon, 16 Nov 2015 12:47:00 +1100 This is what I think of as an honest cake - not tizzy, just homely, buttery and ever-so more-ish with its tender, nutty crumb and sweet, caramelised pineapple topping. I particularly love the way the sides, through some kind of magical alchemy of heat and sugar, become ever-so-slightly crunchy. There are a couple of little things I've noticed when I bake it - the first is that it cooks better and looks better when baked in a regular, not a non-stick, cake tin. And the second is that it's really important not to overload the tin with pineapple or it will release too much liquid and the centre of the cake will be soggy. Full Article ABC Local northcoast Lifestyle and Leisure:Food and Cooking:All Lifestyle and Leisure:Recipes:All Lifestyle and Leisure:Recipes:Main Australia:NSW:Lismore 2480
ap Okonomiyake - Japanese pizza with soy, honey and ginger sauce By www.abc.net.au Published On :: Mon, 16 Nov 2015 14:15:00 +0800 Referred to as a Japanese 'pizza', okonomiyaki is probably best described as a cabbage fritter. There are many versions that can include seafood, pork belly, kimchi or cheese, and either served with the sauce described or with Japanese mayonnaise. Delicious snack food, which can also be a meal. Full Article ABC Local southwestwa Lifestyle and Leisure:Recipes:All Australia:WA:Bunbury 6230
ap Apricot & Vanilla Jam By www.abc.net.au Published On :: Mon, 01 Feb 2016 18:27:00 +1100 This recipe features on Foodie Tuesday, a weekly segment with Raf Epstein on Drive , 774, 3.30pm, courtesy of Alice Zaslavsky. Full Article ABC Local melbourne Lifestyle and Leisure:Recipes:All Australia:VIC:Melbourne 3000
ap Slow-cooked pork shoulder with apples and crackling By www.abc.net.au Published On :: Tue, 29 Mar 2016 12:49:00 +1100 This recipe features on Foodie Tuesday, a weekly segment on 774 Drive with Raf Epstein, 3.30PM, courtesy of Justine Schofield. Justine's latest book is "Dinner With Justine". Full Article ABC Local melbourne Lifestyle and Leisure:Recipes:All Australia:VIC:Melbourne 3000
ap Chicken, chestnut and apple savoury crumble By www.abc.net.au Published On :: Fri, 22 Apr 2016 10:54:00 +0800 A savoury crumble seems very odd at first but makes a lot of delicious sense when you eat it! Using dried chestnuts, which are available from good Italian grocers reduces the preparation time. Full Article ABC Local southwestwa Lifestyle and Leisure:Recipes:Entree Lifestyle and Leisure:Recipes:Main Australia:WA:Pemberton 6260
ap Charred cabbage with olive and truffle tapenade By www.abc.net.au Published On :: Mon, 16 May 2016 12:44:00 +1000 Cabbage at its best. Full Article ABC Local brisbane Lifestyle and Leisure:Recipes:All Australia:QLD:Brisbane 4000
ap Mocha-Cappuccino Caramel Biscuit Cheesecake By www.abc.net.au Published On :: Mon, 23 May 2016 11:39:00 +1000 This indulgent cheesecake is as light as air, with all the ingredients of an afternoon tea rolled into one - coffee, chocolate and caramel biscuits. Full Article ABC Local widebay Lifestyle and Leisure:Recipes:All Lifestyle and Leisure:Recipes:Dessert Australia:QLD:Bundaberg 4670
ap Greek cauliflower with a minted maple and tamarind sauce By www.abc.net.au Published On :: Thu, 23 Jun 2016 13:11:00 +1000 150g panko crumbs 1 clove of crushed garlic 1 tsp. ground ginger 2 tsps. curry powder 1 tsp. ground cumin 2 tsps. ground coriander 1 tsp. black mustard seeds 1 tsp. chilli flakes 2 tsps. caster sugar Pinch of salt 3 free range eggs, beaten 100g plain flour with a pinch of salt 1 cauliflower, broken in to small florets Sunflower oil for deep frying Sauce: Handful of chopped parsley Handful of chopped coriander leaves Handful of chopped mint leaves 1 tbsp. tamarind paste 1 tsp. maple syrup 1 tbsp. olive oil 2 tsps. lime juice Pinch of salt 2 tbsps. water Full Article ABC Local widebay Lifestyle and Leisure:Recipes:All Australia:QLD:Bundaberg 4670
ap French spiced beetroot and apple jam By www.abc.net.au Published On :: Fri, 05 Aug 2016 11:49:00 +1000 2 granny smith apples, coarsely grated 2 beetroots 1/4 tsp. ground clove 2 star anise 1/2 nutmeg finely grated 200ml balsamic vinegar 150g caster sugar Full Article ABC Local widebay Lifestyle and Leisure:Recipes:All Australia:QLD:Bundaberg 4670
ap BBQ Moreton Bay bugs with asparagus, butter, lemon and capers By www.abc.net.au Published On :: Mon, 10 Oct 2016 10:56:00 +1000 A simple summer seafood dish! Full Article ABC Local brisbane Lifestyle and Leisure:Recipes:All Australia:QLD:Brisbane 4000
ap Seared Tasmanian salmon, fennel, caper, parsley By www.abc.net.au Published On :: Mon, 21 Nov 2016 11:28:00 +1000 Salmon and fennel at its best. Full Article ABC Local brisbane Lifestyle and Leisure:Recipes:All Australia:QLD:Brisbane 4000
ap Indian mango kulfi with maple, oat and ginger crumb By www.abc.net.au Published On :: Thu, 30 Mar 2017 12:05:00 +1000 Mango kulfi: 1 cup condensed milk 60g butter 1 tsp. vanilla extract 250 ml (1 cup) mango puree, frozen mangos are fine Oat-ginger crumb: 1/2 cup coconut oil 20g butter 125 ml 1/2 cup maple syrup 90 g (1 cup) rolled oats 1 tbsp. ground ginger 1/4 cup desiccated coconut Full Article ABC Local widebay Lifestyle and Leisure:Recipes:All Australia:QLD:Bundaberg 4670
ap Japanese sweet ginger meatballs By www.abc.net.au Published On :: Thu, 15 Jun 2017 13:41:00 +1000 1 bunch of spring onions, finely chopped 250 g minced beef 250 g minced pork 20 g grated ginger 1 egg 2 tsps. roasted sesame oil 1 tbsp. cornflour, plus extra for dusting sunflower oil, for shallow frying 1 tbsp. white sesame seeds salt and ground white pepper For the sweet ginger sauce: 30 g grated ginger 3 tbsps. soy sauce 125 ml dashi stock or 1 tsp instant dashi powder mixed with water 2 tbsps. sugar 3 tbsps. mirin 3 tbsps. rice vinegar 1 tsp cornflour Full Article ABC Local widebay Lifestyle and Leisure:Recipes:All Australia:QLD:Bundaberg 4670
ap Goat's Curd Bavarois with Cardamom Apples By www.abc.net.au Published On :: Thu, 29 Jun 2017 06:38:00 +1000 Exotic, different, really cool flavours, pared-back dessert and it's not too sweet. Enjoy! Full Article ABC Local northcoast Lifestyle and Leisure:Food and Cooking:All Lifestyle and Leisure:Recipes:All Lifestyle and Leisure:Recipes:Main Australia:NSW:Lismore 2480
ap Sammy and Bishoo spark India collapse By www.abc.net.au Published On :: Tue, 08 Nov 2011 07:32:00 +1100 Darren Sammy and Devendra Bishoo shared five wickets to trigger India's collapse on the second day of the opening Test against the West Indies in New Delhi. Full Article
ap Williams apologises to Tiger for slur By www.abc.net.au Published On :: Tue, 08 Nov 2011 13:09:00 +1100 Tiger Woods says he was hurt by a racist slur from his former caddie Steve Williams, who referred to him as a "black arsehole". Full Article
ap Efficacy and Safety of Dapagliflozin in the Elderly: Analysis From the DECLARE-TIMI 58 Study By care.diabetesjournals.org Published On :: 2020-01-20T12:00:30-08:00 OBJECTIVE Data regarding the effects of sodium–glucose cotransporter 2 inhibitors in the elderly (age ≥65 years) and very elderly (age ≥75 years) are limited. RESEARCH DESIGN AND METHODS The Dapagliflozin Effect on Cardiovascular Events (DECLARE)–TIMI 58 assessed cardiac and renal outcomes of dapagliflozin versus placebo in patients with type 2 diabetes. Efficacy and safety outcomes were studied within age subgroups for treatment effect and age-based treatment interaction. RESULTS Of the 17,160 patients, 9,253 were <65 years of age, 6,811 ≥65 to <75 years, and 1,096 ≥75 years. Dapagliflozin reduced the composite of cardiovascular death or hospitalization for heart failure consistently, with a hazard ratio (HR) of 0.88 (95% CI 0.72, 1.07), 0.77 (0.63, 0.94), and 0.94 (0.65, 1.36) in age-groups <65, ≥65 to <75, and ≥75 years, respectively (interaction P value 0.5277). Overall, dapagliflozin did not significantly decrease the rates of major adverse cardiovascular events, with HR 0.93 (95% CI 0.81, 1.08), 0.97 (0.83, 1.13), and 0.84 (0.61, 1.15) in age-groups <65, ≥65 to <75, and ≥75 years, respectively (interaction P value 0.7352). The relative risk reduction for the secondary prespecified cardiorenal composite outcome ranged from 18% to 28% in the different age-groups with no heterogeneity. Major hypoglycemia was less frequent with dapagliflozin versus placebo, with HR 0.97 (95% CI 0.58, 1.64), 0.50 (0.29, 0.84), and 0.68 (0.29, 1.57) in age-groups <65, ≥65 to <75, and ≥75 years, respectively (interaction P value 0.2107). Safety outcomes, including fractures, volume depletion, cancer, urinary tract infections, and amputations were balanced with dapagliflozin versus placebo, and acute kidney injury was reduced, all regardless of age. Genital infections that were serious or led to discontinuation of the study drug and diabetic ketoacidosis were uncommon, yet more frequent with dapagliflozin versus placebo, without heterogeneity (interaction P values 0.1058 and 0.8433, respectively). CONCLUSIONS The overall efficacy and safety of dapagliflozin are consistent regardless of age. Full Article
ap Performance of the ESC 0/1-h and 0/3-h Algorithm for the Rapid Identification of Myocardial Infarction Without ST-Elevation in Patients With Diabetes By care.diabetesjournals.org Published On :: 2020-01-20T12:00:30-08:00 OBJECTIVE Patients with diabetes mellitus (DM) have elevated levels of high-sensitivity cardiac troponin (hs-cTn). We investigated the diagnostic performance of the European Society of Cardiology (ESC) algorithms to rule out or rule in acute myocardial infarction (AMI) without ST-elevation in patients with DM. RESEARCH DESIGN AND METHODS We prospectively enrolled 3,681 patients with suspected AMI and stratified those by the presence of DM. The ESC 0/1-h and 0/3-h algorithms were used to calculate negative and positive predictive values (NPV, PPV). In addition, alternative cutoffs were calculated and externally validated in 2,895 patients. RESULTS In total, 563 patients (15.3%) had DM, and 137 (24.3%) of these had AMI. When the ESC 0/1-h algorithm was used, the NPV was comparable in patients with and without DM (absolute difference [AD] –1.50 [95% CI –5.95, 2.96]). In contrast, the ESC 0/3-h algorithm resulted in a significantly lower NPV in patients with DM (AD –2.27 [95% CI –4.47, –0.07]). The diagnostic performance for rule-in of AMI (PPV) was comparable in both groups: 0/1-h (AD 6.59 [95% CI –19.53, 6.35]) and 0/3-h (AD 1.03 [95% CI –7.63, 9.7]). Alternative cutoffs increased the PPV in both algorithms significantly, while improvements in NPV were only subtle. CONCLUSIONS Application of the ESC 0/1-h algorithm revealed comparable safety to rule out AMI comparing patients with and without DM, while this was not observed with the ESC 0/3-h algorithm. Although alternative cutoffs might be helpful, patients with DM remain a high-risk population in whom identification of AMI is challenging and who require careful clinical evaluation. Full Article
ap Association Between the Use of Antidepressants and the Risk of Type 2 Diabetes: A Large, Population-Based Cohort Study in Japan By care.diabetesjournals.org Published On :: 2020-03-20T11:50:34-07:00 OBJECTIVE This study aimed to reveal the associations between the risk of new-onset type 2 diabetes and the duration of antidepressant use and the antidepressant dose, and between antidepressant use after diabetes onset and clinical outcomes. RESEARCH DESIGN AND METHODS In this large-scale retrospective cohort study in Japan, new users of antidepressants (exposure group) and nonusers (nonexposure group), aged 20–79 years, were included between 1 April 2006 and 31 May 2015. Patients with a history of diabetes or receipt of antidiabetes treatment were excluded. Covariates were adjusted by using propensity score matching; the associations were analyzed between risk of new-onset type 2 diabetes and the duration of antidepressant use/dose of antidepressant in the exposure and nonexposure groups by using Cox proportional hazards models. Changes in glycated hemoglobin (HbA1c) level were examined in groups with continuous use, discontinuation, or a reduction in the dose of antidepressants. RESULTS Of 90,530 subjects, 45,265 were in both the exposure and the nonexposure group after propensity score matching; 5,225 patients (5.8%) developed diabetes. Antidepressant use was associated with the risk of diabetes onset in a time- and dose-dependent manner. The adjusted hazard ratio was 1.27 (95% CI 1.16–1.39) for short-term low-dose and 3.95 (95% CI 3.31–4.72) for long-term high-dose antidepressant use. HbA1c levels were lower in patients who discontinued or reduced the dose of antidepressants (F[2,49] = 8.17; P < 0.001). CONCLUSIONS Long-term antidepressant use increased the risk of type 2 diabetes onset in a time- and dose-dependent manner. Glucose tolerance improved when antidepressants were discontinued or the dose was reduced after diabetes onset. Full Article
ap Epigenetic Link Between Statin Therapy and Type 2 Diabetes By care.diabetesjournals.org Published On :: 2020-03-20T11:50:34-07:00 OBJECTIVE To investigate the role of epigenetics in statins’ diabetogenic effect comparing DNA methylation (DNAm) between statin users and nonusers in an epigenome-wide association study in blood. RESEARCH DESIGN AND METHODS Five cohort studies’ participants (n = 8,270) were classified as statin users when they were on statin therapy at the time of DNAm assessment with Illumina 450K or EPIC array or noncurrent users otherwise. Associations of DNAm with various outcomes like incident type 2 diabetes, plasma glucose, insulin, and insulin resistance (HOMA of insulin resistance [HOMA-IR]) as well as with gene expression were investigated. RESULTS Discovery (n = 6,820) and replication (n = 1,450) phases associated five DNAm sites with statin use: cg17901584 (1.12 x 10–25 [DHCR24]), cg10177197 (3.94 x 10–08 [DHCR24]), cg06500161 (2.67 x 10–23 [ABCG1]), cg27243685 (6.01 x 10–09 [ABCG1]), and cg05119988 (7.26 x 10–12 [SC4MOL]). Two sites were associated with at least one glycemic trait or type 2 diabetes. Higher cg06500161 methylation was associated with higher fasting glucose, insulin, HOMA-IR, and type 2 diabetes (odds ratio 1.34 [95% CI 1.22, 1.47]). Mediation analyses suggested that ABCG1 methylation partially mediates the effect of statins on high insulin and HOMA-IR. Gene expression analyses showed that statin exposure and ABCG1 methylation were associated with ABCG1 downregulation, suggesting epigenetic regulation of ABCG1 expression. Further, outcomes insulin and HOMA-IR were significantly associated with ABCG1 expression. CONCLUSIONS This study sheds light on potential mechanisms linking statins with type 2 diabetes risk, providing evidence on DNAm partially mediating statins’ effects on insulin traits. Further efforts shall disentangle the molecular mechanisms through which statins may induce DNAm changes, potentially leading to ABCG1 epigenetic regulation. Full Article
ap Predicting 10-Year Risk of End-Organ Complications of Type 2 Diabetes With and Without Metabolic Surgery: A Machine Learning Approach By care.diabetesjournals.org Published On :: 2020-03-20T11:50:34-07:00 OBJECTIVE To construct and internally validate prediction models to estimate the risk of long-term end-organ complications and mortality in patients with type 2 diabetes and obesity that can be used to inform treatment decisions for patients and practitioners who are considering metabolic surgery. RESEARCH DESIGN AND METHODS A total of 2,287 patients with type 2 diabetes who underwent metabolic surgery between 1998 and 2017 in the Cleveland Clinic Health System were propensity-matched 1:5 to 11,435 nonsurgical patients with BMI ≥30 kg/m2 and type 2 diabetes who received usual care with follow-up through December 2018. Multivariable time-to-event regression and random forest machine learning models were built and internally validated using fivefold cross-validation to predict the 10-year risk for four outcomes of interest. The prediction models were programmed to construct user-friendly web-based and smartphone applications of Individualized Diabetes Complications (IDC) Risk Scores for clinical use. RESULTS The prediction tools demonstrated the following discrimination ability based on the area under the receiver operating characteristic curve (1 = perfect discrimination and 0.5 = chance) at 10 years in the surgical and nonsurgical groups, respectively: all-cause mortality (0.79 and 0.81), coronary artery events (0.66 and 0.67), heart failure (0.73 and 0.75), and nephropathy (0.73 and 0.76). When a patient’s data are entered into the IDC application, it estimates the individualized 10-year morbidity and mortality risks with and without undergoing metabolic surgery. CONCLUSIONS The IDC Risk Scores can provide personalized evidence-based risk information for patients with type 2 diabetes and obesity about future cardiovascular outcomes and mortality with and without metabolic surgery based on their current status of obesity, diabetes, and related cardiometabolic conditions. Full Article
ap Inoreader mobile apps updated to support Automatic Night Mode, Microblogs, Sort by Magic and popularity indicators. By blog.inoreader.com Published On :: Thu, 20 Feb 2020 09:05:38 +0000 Hey, it’s been quite some time without updates on this front, but our latest updates to our Android and iOS… Full Article Uncategorized
ap An Uneven Landscape: The Differing State Approaches to English Learner Policies under ESSA By www.migrationpolicy.org Published On :: Wed, 19 Feb 2020 10:14:45 -0500 Experts share how states have approached Every Student Succeeds Act (ESSA) implementation, areas where the law and state efforts to support English Learners can be improved, and findings from the compendium, The Patchy Landscape of State English Learner Policies under ESSA. Full Article
ap Millions Will Feel Chilling Effects of U.S. Public-Charge Rule That Is Also Likely to Reshape Legal Immigration By www.migrationpolicy.org Published On :: Thu, 08 Aug 2019 12:09:29 -0400 The public-charge rule issued by the Trump administration in August 2019 will have profound effects on future immigration and on use of public benefits by millions of legal noncitizens and their U.S.-citizen family members. Complex standards for determining when an immigrant is likely to become a public charge could cause a significant share of the nearly 23 million noncitizens and U.S. citizens in benefits-using immigrant families to disenroll, as this commentary explains. Full Article
ap Health Insurance Test for Green-Card Applicants Could Sharply Cut Future U.S. Legal Immigration By www.migrationpolicy.org Published On :: Thu, 10 Oct 2019 11:55:01 -0400 A new Trump administration action requiring intending immigrants to prove they can purchase eligible health insurance within 30 days of arrival has the potential to block fully 65 percent of those who apply for a green card from abroad, MPI estimates. Full Article
ap Evaluating the Effect of U-500 Insulin Therapy on Glycemic Control in Veterans With Type 2 Diabetes By clinical.diabetesjournals.org Published On :: 2015-01-01 Joseph A. GranataJan 1, 2015; 33:14-19Feature Articles Full Article
ap Medical Nutrition Therapy: A Key to Diabetes Management and Prevention By clinical.diabetesjournals.org Published On :: 2010-12-01 Sara F. MorrisDec 1, 2010; 28:12-18Feature Articles Full Article
ap Therapeutic Inertia is a Problem for All of Us By clinical.diabetesjournals.org Published On :: 2019-04-01 Stephen BruntonApr 1, 2019; 37:105-106Editorials Full Article