La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

Pension Ombudsman determinations are a snap shot of issues which can and do arise in relation to the LGPS. This speedbrief looks at two recent determinations relating to the construction of the LGPS Regulations and the effect of in...

Six Pakistani security personnel, including an officer, were killed in a roadside bomb attack near the South Asian nation’s border with Iran.

Alger -Deux bombes de confection artisanale ont �t�...

(MENAFN - Jordan News Agency) Amman, May 9 (Petra) �� Minister of Planning and International Cooperation Wissam Rabadi Saturday discussed with British... ......

(MENAFN - Jordan News Agency) Amman, May 9 (Petra)- Minister of Planning and International Cooperation, Dr. Wissam Rabadi, discussed with the British ... ......

(MENAFN - CDN Newswire) Global Honeycomb Containers Market 2020 by Manufacturers, Regions, Type and Application, Forecast to 2026 recently added to th... ......

(MENAFN - Khaleej Times) The civic body in Dibba Al Fujairah has ordered the closure of three pharmacies for unreasonably increasing the price of h... ......

As coronavirus pandemic continues, Asian actors, directors and social influencers concerned over increased instances of harassment and racism.

Japan ended in last place after its leaders were rated the worst in a survey of 23 nations and regions.

The following is intended to clarify how weight can be controlled when hunger is kept at bay using a reliable, informative tool called the glycemic index.

UN High Commissioner for Human Rights Michelle Bachelet warned of a "ticking time bomb" in Syria amid an uptick of civilian attacks and human rights violations.

In response to the global financial crisis in 2008, China rolled out a massive 4 trillion yuan (US$564 billion) stimulus package.With the coronavirus posing an even greater threat to the economy, the outbreak left the top leadership with a decision to make, as the efforts in 2008 also left the nation with a mountain of debt.Before the outbreak, China had already cut the top tier of the value-added tax (VAT) rate to 13 per cent from 16 per cent in April 2019, after a one percentage point cut in…

Calls for Australian businesses to diversify away from China as their main trading partner are nothing more than a “zombie economic idea” that is being used as a political tool to expedite the decoupling of the two countries, according to a report by the Australia-China Relations Institute at the University of Technology Sydney.The debate about Australia’s over-dependence on China for its livelihood has ramped up recently, triggered by the interruption of supply chains during China’s…

President Vladimir Putin told Russians they are “invincible” when they stand together as the country on Saturday marked the 75th anniversary of the end of second world war on lockdown from the coronavirus.With the number of virus cases surging and authorities urging Russians to stay in their homes, celebrations of this year’s Victory Day were muted after the Kremlin grudgingly agreed to postpone plans for a grand parade with world leaders.Instead of columns of military hardware and thousands of…

Set out to give value and brighten the world. Champions always have energy and momentum.

A combination of three drugs suppressed the coronavirus within seven days when used on patients in Hong Kong, nearly twice as fast as a single medicine did, in a result seen as a leading hope in the fight against the pandemic, a study has found.The findings of the research, led by University of Hong Kong academics and published in The Lancet on Saturday, could signal progress in the search for a standard form of therapy for Sars-CoV-2, the virus that causes the Covid-19 disease.It discovered…

Mombasa County inspectorate officers on Monday were caught in a land dispute issue with a private investigator when they attempted to bring down an erected wall.

ROME: Italy's economic capital Milan is a virus time "bomb" at risk of erupting with residents now free to move around -- some gathering for canal-side cocktails -- after twomonths under a pandemic lockdown.The city in the northern Lombardy region is the epicentre of Italy´s outbreak, one of...

ROME: Italy’s economic capital Milan is a virus time “bomb” at risk of erupting with residents now free to move around – some gathering for canal-side cocktails – after two months under a pandemic lockdown.The city in the northern Lombardy region is the epicentre of...

ISLAMABAD: A senior member of the Prime Minister’s Office has approached the Federal Ombudsman over the ‘extreme injustice’ of out of turn allotment of second residential plots in the federal capital to a selected few in the bureaucracy in a non-transparent and unjust manner.The...

ISLAMABAD: A senior member of the Prime Minister’s Office has approached the Federal Ombudsman over the ‘extreme injustice’ of out of turn allotment of second residential plots in the federal capital to a selected few in the bureaucracy in a non-transparent and unjust manner.The...

ISLAMABAD: A senior member of the Prime Minister’s Office has approached the Federal Ombudsman over the ‘extreme injustice’ of out of turn allotment of second residential plots in the federal capital to a selected few in the bureaucracy in a non-transparent and unjust manner. The...

The global response to COVID-19 should also be a springboard for action on climate change resilience so we can narrow the divide between rich and poor and keep everyone safe.

The Government of Palau will draw down on a $15 million policy-based loan from ADB's Disaster Resilience Program to help finance the country’s response to the novel coronavirus disease (COVID-19) pandemic.

ADB today announced the release of a $6 million grant from its Pacific Disaster Resilience Program (Phase 2) to help finance the Government of the Marshall Islands’ response to the novel coronavirus disease (COVID-19) pandemic.

ADB President Masatsugu Asakawa and Pakistan’s Federal Minister for Economic Affairs and ADB Governor Makhdoom Khusro Bukhtiar today discussed how ADB can scale up its support for the government’s response to the COVID-19...

The Asian Development Bank (ADB) has provided a guarantee for a $25 million trade loan to the State Pharmaceuticals Corporation of Sri Lanka (SPC) to purchase medical supplies as part of the country’s response to the novel ....

Dentons is now the largest global law firm in Argentina and the first truly Pan-Latin American and the Caribbean firm in the history of the legal profession.

CES 2020, LAS VEGAS – JANUARY 6, 2020 – Turn up the volume, because the latest speaker in the JBL portables portfolio is here and it does not disappoint. JBL’s Boombox 2 provides JBL Original Pro Sound with big bass, clear mids and smooth highs in an...

No matter how deep we dig, life has always found a way to survive. The remarkable story of these impossible microbes can teach us about how life evolved

Notorious for making us sick, viruses are weird, undead organisms – but new insights are revealing they may have created life's glorious complexity in the first place

Two more firms are eyeing a share of Reliance Industries Ltd's $65-billion digital unit Jio Platforms, according to Bloomberg News, setting them up to be a part of a growing list of firms that have recently invested in the Indian company.

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ABSTRACT

Recognition modes of individual T cell receptors (TCRs) are well studied, but factors driving the selection of TCR repertoires from primary through persistent human virus infections are less well understood. Using deep sequencing, we demonstrate a high degree of diversity of Epstein-Barr virus (EBV)-specific clonotypes in acute infectious mononucleosis (AIM). Only 9% of unique clonotypes detected in AIM persisted into convalescence; the majority (91%) of unique clonotypes detected in AIM were not detected in convalescence and were seeming replaced by equally diverse "de novo" clonotypes. The persistent clonotypes had a greater probability of being generated than nonpersistent clonotypes due to convergence recombination of multiple nucleotide sequences to encode the same amino acid sequence, as well as the use of shorter complementarity-determining regions 3 (CDR3s) with fewer nucleotide additions (i.e., sequences closer to germ line). Moreover, the two most immunodominant HLA-A2-restricted EBV epitopes, BRLF1₁₀₉ and BMLF1₂₈₀, show highly distinct antigen-specific public (i.e., shared between individuals) features. In fact, TCRα CDR3 motifs played a dominant role, while TCRβ played a minimal role, in the selection of TCR repertoire to an immunodominant EBV epitope, BRLF1. This contrasts with the majority of previously reported repertoires, which appear to be selected either on TCRβ CDR3 interactions with peptide/major histocompatibility complex (MHC) or in combination with TCRα CDR3. Understanding of how TCR-peptide-MHC complex interactions drive repertoire selection can be used to develop optimal strategies for vaccine design or generation of appropriate adoptive immunotherapies for viral infections in transplant settings or for cancer.

IMPORTANCE Several lines of evidence suggest that TCRα and TCRβ repertoires play a role in disease outcomes and treatment strategies during viral infections in transplant patients and in cancer and autoimmune disease therapy. Our data suggest that it is essential that we understand the basic principles of how to drive optimum repertoires for both TCR chains, α and β. We address this important issue by characterizing the CD8 TCR repertoire to a common persistent human viral infection (EBV), which is controlled by appropriate CD8 T cell responses. The ultimate goal would be to determine if the individuals who are infected asymptomatically develop a different TCR repertoire than those that develop the immunopathology of AIM. Here, we begin by doing an in-depth characterization of both CD8 T cell TCRα and TCRβ repertoires to two immunodominant EBV epitopes over the course of AIM, identifying potential factors that may be driving their selection.

ABSTRACT

Middle East respiratory syndrome coronavirus (MERS-CoV) can cause severe and fatal acute respiratory disease in humans and remains endemic in the Middle East since first being identified in 2012. There are currently no approved vaccines or therapies available for MERS-CoV. In this study, we evaluated parainfluenza virus 5 (PIV5)-based vaccine expressing the MERS-CoV envelope spike protein (PIV5/MERS-S) in a human DPP4 knockin C57BL/6 congenic mouse model (hDPP4 KI). Following a single-dose intranasal immunization, PIV5-MERS-S induced neutralizing antibody and robust T cell responses in hDPP4 KI mice. A single intranasal administration of 10⁴ PFU PIV5-MERS-S provided complete protection against a lethal challenge with mouse-adapted MERS-CoV (MERS_MA6.1.2) and improved virus clearance in the lung. In comparison, single-dose intramuscular immunization with 10⁶ PFU UV-inactivated MERS_MA6.1.2 mixed with Imject alum provided protection to only 25% of immunized mice. Intriguingly, an influx of eosinophils was observed only in the lungs of mice immunized with inactivated MERS-CoV, suggestive of a hypersensitivity-type response. Overall, our study indicated that PIV5-MERS-S is a promising effective vaccine candidate against MERS-CoV infection.

IMPORTANCE MERS-CoV causes lethal infection in humans, and there is no vaccine. Our work demonstrates that PIV5 is a promising vector for developing a MERS vaccine. Furthermore, success of PIV5-based MERS vaccine can be employed to develop a vaccine for emerging CoVs such as SARS-CoV-2, which causes COVID-19.

BACKGROUND Pregnant patients from rural counties of Western North Carolina face additional barriers when accessing comprehensive perinatal substance use disorders care at Project CARA as compared to patients local to the program in Buncombe County. We hypothesized regional patients would be less engaged in care.

METHOD Using a retrospective cohort design, univariate analyses (², t-test; P < .05) compared patients' characteristics, engagement in care, and delivery outcomes. Engagement in care, the primary outcome, was operationalized as: attendance at expected, program-specific prenatal and postpartum visits, utilization of in-house counseling, community-based and/or inpatient substance use disorders treatment, and maternal urine drug screen at delivery negative for illicit substances.

RESULTS Regional patients (n = 324) were more likely than Buncombe County patients (n = 284) to have opioid [209 (64.5%) versus 162 (57.0%)] or amphetamine/methamphetamine use disorders (25 [7.7%] versus 13 [4.6%]), but less likely to have cannabis use (19 [5.9%] versus 38 [13.4%]; P = .009) and concurrent psychiatric disorders (214 [66.0%] versus 220 [77.5%]; P = .002). Engagement at postpartum visits was the significantly different outcome between patients (110/221 [49.8%] versus 146/226 [64.6%]; P = .002).

LIMITATIONS Outcomes were available for 66.8% of regional and 79.6% of Buncombe County patients of one program in one predominately white, non-Hispanic region of the state.

CONCLUSION Contrary to our hypothesis, regional and Buncombe County women engaged in prenatal care equally. However, a more formal transition into the postpartum period is needed, especially for regional women. A "hub-and-spokes" model that extends delivery of perinatal substance use disorders care into rural communities may be more effective for engagement retention.