Hassan Fares, candidato a la Alcaldía de Barranquilla, dio detalles sobre las acusaciones a la Policía.

En 10AM Steve Lukather, vocalista y miembro fundador de la agrupación, confesó lo que ha representado mantenerse vigente durante cerca de 50 años en los escenarios 

La candidata para la defensoría del pueblo, hizo hincapié en las prioridades que debe tener esta entidad.

En 10AM Hoy por Hoy de Caracol Radio estuvo el alcalde de Medellín, Federico Gutiérrez, para hablar sobre la seguridad y los retos que enfrenta la ciudad.

Alfonso Medrano, presidente de la Cámara Intergemial del  Transporte, descartó en 6AM que el sector esté contemplando ir a paro, tal como lo habría asegurado el jefe de cartera de Hacienda, Ricardo Bonilla

Paloma Valencia, quien aprovechó la oportunidad para una vez más cuestionar el papel del Gobierno Nacional frente a la paz.

El general en retiro Luis Eduardo Martínez explicó en 6AM cuál es la situación actual en el municipio de Remedios, en la que se han encontrado al menos 14 cuerpos de combatientes

En 6AM Hoy por Hoy de caracol Radio estuvo la senadora Paloma Valencia, para hablar sobre una declaración que dio en donde menciona que el esfuerzo del proceso de paz de La Habana se perdió.

Ángela María Buitrago entregó detalles en 6AM de los que considera los grandes retos que tendrá que afrontar en la jefatura de la cartera de Justicia, donde remplazará a Néstor Osuna

La candidata para la defensoría del pueblo, hizo hincapié en las prioridades que debe tener esta entidad.

Tras el atentado que sufrió, Jorge Luis Pizo aseguró en 6AM que los alcaldes están desprotegidos y que han solicitado protección sin respuesta alguna.

José Manuel Restrepo estuvo en 6AM para discutir las implicaciones tras la negación del monto del presupuesto del próximo año.

En 6AM de Caracol radio estuvo Salvatore Mancuso, exjefe paramilitar, actual gestor de paz, para hablar sobre Cuál es la verdadera historia detrás de los bienes que han sido entregados para las víctimas.

Happy Halloween everyone and welcome to The Totally Throwback Thursday  show!! I’m DJ Mason and I’m going to take you back in time with  songs from the ’80s and beyond. […]

The post The Totally Throwback Thursday Show!! appeared first on KKFI.

Odido steekt boven alle Nederlandse providers uit in de recente benchmarktest van vaste internetdiensten, uitgevoerd door Umlaut. Hoewel KPN het beste scoort op het gebied van mobiele netwerken, is het Odido dat de kroon spant op het vlak van vast internet.

The following Colorado snow totals have been reported by the National Weather Service for Nov. 7-8, 2024

The following Colorado snow totals have been reported by the National Weather Service for Nov. 9 , 2024

Elected Republicans, almost all of them, are in no hurry to stop the disorder. They appear to believe what we're watching is a version of the Rodney King riots from 1992. People saw an upsetting video on the internet, they're angry, and that's understandable. But they'll calm down soon, and we can get back to cutting capital gains taxes and sanctioning Bashar al- Assad. That's their view of it. They are wrong. This is not a momentary civil disturbance. This is a serious and highly organized political movement. It is not superficial. It is deep and profound. It has vast ambitions. It is insidious; it will grow. Its goal is to end liberal democracy and challenge Western civilization itself. This is an ideological movement. The ideas that fuel it have incubated for decades on college campuses. We paid for all of it, by the way. The rest of us were so thrilled that our kids got into Duke that we decided to ignore what Duke was actually teaching them and are continuing to send big checks. That was a mistake. It was one of the greatest mistakes we've ever made. Continue reading →

Democratic politicians don't fear the mob. Notice that? Why? Because they don't need to. They control the mob. The mob operates with their permission. These are their foot soldiers. This is their militia. Continue reading →

1. Trump breidt ‘dreamteam’ uit en benoemt Elon Musk tot hoofd “ministerie voor overheidsefficiëntie": “Dit zal schokgolven sturen door het systeem”  Het Laatste Nieuws
2. Trump wijst oude bekende Ratcliffe aan als hoofd CIA | Presidentsverkiezingen VS  Het Laatste Nieuws
3. Trump plaatst Elon Musk mee aan hoofd van nieuw ministerie: “Dit gaat schokgolven door het systeem jagen”  Het Nieuwsblad
4. Miljardairs Elon Musk en Vivek Ramaswamy aan hoofd van Trumps nieuwe ministerie van ‘overheidsefficiëntie’  De Standaard
5. Trump benoemt Musk tot 'minister van overheidsefficiëntie'  De Tijd

Last night's democratic debate in Nevada got pretty damn spicy to say the least. So much so that many are calling it the most entertaining debate of the election cycle so far. Pete spoke Spanish, Warren (and every other candidate, for that matter) came out swinging against Bloomberg, and many, many other things that warranted a monumental cringe fest. 

So please enjoy the following roast-y memes from the night and you can watch a more in-depth recap of it here!

If you haven't been living under a rock for the past week, you're probably familiar with the Four Seasons Total Landscaping drama that occurred earlier this week in Philadelphia. On November 7th, President Trump tweeted that a press conference would be held at the Four Seasons in the Pennsylvania capital. Eight minutes later, Trump tweeted an update - that the conference would actually be taking place at Four Seasons Total Landscaping in the same city. 

The tweets led to a great deal of speculation as to whether the administration had intended to book the hotel. The speculation grew when it became clear that the location, between a sex shop and a crematorium, was probably not their first choice. After Rudy Giuliani spoke to crowds about voter fraud, and even used a convicted sex offender as a witness, the occasion was largely seen as a massive blunder. And as expected, the memes began flowing freely. We've put together some of our favorite examples from the last week, but we're willing to bet this press conference will be talked about for quite a while. Here's hoping Four Seasons Total Landscaping is enjoying the free publicity. 

https://www.gamefly.com/browse/store/ps5-store-usedbestsellers

NFS unbound is $20
PGA Tour 2023 $20

Some decent prices here, if you’ve never purchased from GameFly you get a mint case and guaranteed disc. The cases often include any original codes if applicable. I’ve purchased a few games from GameFly and would recommend them for some decent savings on physical

All PS5 prices but some Xbox are actually better and even Switch has a couple finds. Happy hunting Cag’s!

Have you ever craved the flavors of a Big Mac but wanted something more substantial and comforting for dinner? This Big Mac Tater Tot Casserole is the perfect hearty casserole for busy weeknights! Combining all the classic tastes of the beloved fast-food burger with the warmth and heartiness of a casserole, this recipe is sure to make your whole family happy. Whether you’re looking for an easy...

The post Big Mac Tater Tot Casserole appeared first on Dear Crissy.

Professional women’s basketball is a cesspool of mediocrity full of women gatekeeping so the sport can’t change. Fortunately, incoming rookie Caitlin Clark is worth more than the entire WNBA due to her sponsorships. This means that unlike other players, Clark doesn’t work for the WNBA she works for her sponsors and her fans. Also, Clark […]

The post WNBA is totally annoying, here’s how to fix it for Caitlin Clark’s arrival appeared first on Penelope Trunk Careers.

Complete with a Shiver and 26" wheels.
( Photos: 7, Comments: 159 )

Tottenham boss Ange Postecoglou says their inconsistent start is down to him rather than his players after a fifth Premier League defeat.

agilePHM We are launching a new product called agilePHM In Industrial IoT, I have been working with PHM  (Prognostics and Health Management) for a while and it is a well known discipline Prognostics and Health management(PHM)  is an engineering discipline focused on predicting the time at which a system or a component will no longer perform its intended [...]

Richard Moeckel and Richard Montgomery
J. Amer. Math. Soc. 38 (), 225-241.
Abstract, references and article information

Synapse loss is associated with motor and cognitive decline in multiple neurodegenerative disorders, and the cellular redistribution of tau is related to synaptic impairment in tauopathies, such as Alzheimer's disease and frontotemporal dementia. Here, we examined the cellular distribution of tau protein species in human tau overexpressing line 66 mice, a transgenic mouse model akin to genetic variants of frontotemporal dementia. Line 66 mice express intracellular tau aggregates in multiple brain regions and exhibit sensorimotor and motor learning deficiencies. Using a series of anti-tau antibodies, we observed, histologically, that nonphosphorylated transgenic human tau is enriched in synapses, whereas phosphorylated tau accumulates predominantly in cell bodies and axons. Subcellular fractionation confirmed that human tau is highly enriched in insoluble cytosolic and synaptosomal fractions, whereas endogenous mouse tau is virtually absent from synapses. Cytosolic tau was resistant to solubilization with urea and Triton X-100, indicating the formation of larger tau aggregates. By contrast, synaptic tau was partially soluble after Triton X-100 treatment and most likely represents aggregates of smaller size. MS corroborated that synaptosomal tau is nonphosphorylated. Tau enriched in the synapse of line 66 mice, therefore, appears to be in an oligomeric and nonphosphorylated state, and one that could have a direct impact on cognitive function.

W Gamble
Nov 1, 1978; 19:1068-1070
Articles

Expert

Olha Prykhodko and Kostiantyn Ralchenko
Theor. Probability and Math. Statist. 111 (), 123-135.
Abstract, references and article information

Claudio Macci and Barbara Pacchiarotti
Theor. Probability and Math. Statist. 111 (), 21-43.
Abstract, references and article information

Paweł Hitczenko and Nick Wormald
Proc. Amer. Math. Soc. 152 (), 5411-5427.
Abstract, references and article information

Xiaoshang Jin
Proc. Amer. Math. Soc. 152 (), 5327-5337.
Abstract, references and article information

Members of the B-cell lymphoma (BCL-2) protein family regulate mitochondrial outer membrane permeabilization (MOMP), a phenomenon in which mitochondria become porous and release death-propagating complexes during the early stages of apoptosis. Pro-apoptotic BCL-2 proteins oligomerize at the mitochondrial outer membrane during MOMP, inducing pore formation. Of current interest are endogenous factors that can inhibit pro-apoptotic BCL-2 mitochondrial outer membrane translocation and oligomerization. A mitochondrial-derived peptide, Humanin (HN), was reported being expressed from an alternate ORF in the mitochondrial genome and inhibiting apoptosis through interactions with the pro-apoptotic BCL-2 proteins. Specifically, it is known to complex with BAX and BID. We recently reported the fibrillation of HN and BAX into β-sheets. Here, we detail the fibrillation between HN and BID. These fibers were characterized using several spectroscopic techniques, protease fragmentation with mass analysis, and EM. Enhanced fibrillation rates were detected with rising temperatures or pH values and the presence of a detergent. BID fibers are similar to those produced using BAX; however, the structures differ in final conformations of the BCL-2 proteins. BID fibers display both types of secondary structure in the fiber, whereas BAX was converted entirely to β-sheets. The data show that two distinct segments of BID are incorporated into the fiber structure, whereas other portions of BID remain solvent-exposed and retain helical structure. Similar analyses show that anti-apoptotic BCL-xL does not form fibers with humanin. These results support a general mechanism of sequestration of pro-apoptotic BCL-2 proteins into fibers by HN to inhibit MOMP.

NSun2 is an RNA methyltransferase introducing 5-methylcytosine into tRNAs, mRNAs, and noncoding RNAs, thereby influencing the levels or function of these RNAs. Autotaxin (ATX) is a secreted glycoprotein and is recognized as a key factor in converting lysophosphatidylcholine into lysophosphatidic acid (LPA). The ATX-LPA axis exerts multiple biological effects in cell survival, migration, proliferation, and differentiation. Here, we show that NSun2 is involved in the regulation of cell migration through methylating ATX mRNA. In the human glioma cell line U87, knockdown of NSun2 decreased ATX protein levels, whereas overexpression of NSun2 elevated ATX protein levels. However, neither overexpression nor knockdown of NSun2 altered ATX mRNA levels. Further studies revealed that NSun2 methylated the 3'-UTR of ATX mRNA at cytosine 2756 in vitro and in vivo. Methylation by NSun2 enhanced ATX mRNA translation. In addition, NSun2-mediated 5-methylcytosine methylation promoted the export of ATX mRNA from nucleus to cytoplasm in an ALYREF-dependent manner. Knockdown of NSun2 suppressed the migration of U87 cells, which was rescued by the addition of LPA. In summary, we identify NSun2-mediated methylation of ATX mRNA as a novel mechanism in the regulation of ATX.

Oxylipins are potent lipid mediators involved in a variety of physiological processes. Their profiling has the potential to provide a wealth of information regarding human health and disease and is a promising technology for translation into clinical applications. However, results generated by independent groups are rarely comparable, which increases the need for the implementation of internationally agreed upon protocols. We performed an interlaboratory comparison for the MS-based quantitative analysis of total oxylipins. Five independent laboratories assessed the technical variability and comparability of 133 oxylipins using a harmonized and standardized protocol, common biological materials (i.e., seven quality control plasmas), standard calibration series, and analytical methods. The quantitative analysis was based on a standard calibration series with isotopically labeled internal standards. Using the standardized protocol, the technical variance was within ±15% for 73% of oxylipins; however, most epoxy fatty acids were identified as critical analytes due to high variabilities in concentrations. The comparability of concentrations determined by the laboratories was examined using consensus value estimates and unsupervised/supervised multivariate analysis (i.e., principal component analysis and partial least squares discriminant analysis). Interlaboratory variability was limited and did not interfere with our ability to distinguish the different plasmas. Moreover, all laboratories were able to identify similar differences between plasmas. In summary, we show that by using a standardized protocol for sample preparation, low technical variability can be achieved. Harmonization of all oxylipin extraction and analysis steps led to reliable, reproducible, and comparable oxylipin concentrations in independent laboratories, allowing the generation of biologically meaningful oxylipin patterns.

TROY, Mich., Oct. 17, 2024 — Altair, a global leader in computational intelligence, is proud to announce its collaboration with Motivo, a product engineering firm for clients in the mobility, […]

The post Altair’s HPC and Simulation Solutions Advance Motivo’s Aerospace Prototyping appeared first on HPCwire.

Nov. 11, 2024 — Forschungszentrum Jülich and its partners in the QSolid project have begun operating Germany’s first prototype quantum computer featuring optimized qubit quality. This prototype lays the groundwork […]

The post Jülich Leads QSolid Quantum Prototype Toward Hybrid HPC Integration for Industry and Research appeared first on HPCwire.