Title: Ancient Genome Appears to Have Links to Modern Humans
Category: Health News
Created: 8/30/2012 4:05:00 PM
Last Editorial Review: 8/31/2012 12:00:00 AM

Title: Moderna Readies for Full Vaccine Approval, as Pfizer Submits Data on Booster Shot
Category: Health News
Created: 8/26/2021 12:00:00 AM
Last Editorial Review: 8/26/2021 12:00:00 AM

Targeting the endocannabinoid (eCB) signaling system for pain relief is an important treatment option that is only now beginning to be mechanistically explored. In this review, we focus on two recently appreciated cannabinoid-based targeting strategies, treatments with cannabidiol (CBD) and α/β-hydrolase domain containing 6 (ABHD6) inhibitors, which have the exciting potential to produce pain relief through distinct mechanisms of action and without intoxication. We review evidence on plant-derived cannabinoids for pain, with an emphasis on CBD and its multiple molecular targets expressed in pain pathways. We also discuss the function of eCB signaling in regulating pain responses and the therapeutic promises of inhibitors targeting ABHD6, a 2-arachidonoylglycerol (2-AG)-hydrolyzing enzyme. Finally, we discuss how the novel cannabinoid biosensor GRAB_eCB2.0 may be leveraged to enable the discovery of targets modulated by cannabinoids at a circuit-specific level.

Put your hand up if you'd forgotten that every Assassin's Creed game is, strictly speaking, set in the present day. I know I had. That's not the actual distant past you're parkouring through. That isn't actual Renaissance architecture you're clambering on. It's a holographic Animus simulation, conjured from ancestral memories flash-frozen within your DNA - convenient, inasmuch as it means that any inconsistencies are your DNA's fault, not Ubisoft's. If the ledge-mantling animations are glitchy, that's simply because you have bad genes.

We can both be forgiven for losing sight of Assassin's Creed's modern day narrative frame. Ubisoft themselves have downplayed it since the era of Desmond Miles, the watery Peter Parker figure who served as puppetmaster protagonist for AC games up to Assassin's Creed 3. In Assassin's Creed Shadows, however, they're planning to bring back the modern day setting in a big way, though details are scanty.

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The identification of a new hominin group called Denisovans was one of the most exciting discoveries in human evolution in the last decade.

The post Several Denisovan Populations Introgressed into Modern Humans Multiple Times: Study appeared first on Sci.News: Breaking Science News.

Modern life disrupts the circadian rhythms controlling our biology – increasing our risk of developing conditions ranging from diabetes to dementia. Lynne Peeples's new book The Inner Clock explores and offers solutions

At the recent Gartner Symposium, there was no shortage of data and insights on the evolving role of the CIO. While the

The post The Modern CIO appeared first on Gigaom.

You humans might be amazed to know what we dogs have figured out.

Oversimplification about integration of traditional and modern treatment systems often creates confusion among the stakeholders, and nobody understands the reality of the integration and what it is meant for, said Dr.

Jan 10, 2023

Technology will play a crucial role in that process. Since 2014, Ukraine has been at the forefront of the digital revolution through a journey marked by strength, adaptability, and success.  Digital transformation transcends and affects all economic sectors in Ukraine. Digital solutions have been applied in a wide range of sectors including banking and finance, agriculture and food production, and energy, to cite a few. In that regard, digital transformation is key to a well-functioning society, affecting democratic participation, education, and public services.

Jan 10, 2023

The aim of the report is to focus specifically on the critical role of private sector investment in Ukraine’s economic reconstruction, and how the private sector, both within Ukraine and internationally, can enable Ukraine to win the peace. It provides a short overview of the economic challenges facing Ukraine, including governance, the sectors that will be critical to Ukraine's reconstruction, the roles and responsibilities for the G7, EU, IFIs, and DFIs, and then recommendations for how Ukraine and its partners can best attract private sector investment.

Ancient weaponsmiths combined bronze and iron to fashion swords during the early Iron Age – but modern forgers glue together elements from different weapons, making it difficult for researchers to study the ancient technology

Highlights: Experts highlight the strategies that blend procedural and pharmacological therapies to optimize dry ey

Highlights: Pathologists play an important role in diagnosing and understanding diseases International Pathologi

Al Murunah’s unique approach to climate adaptation and development combines nature-based solutions with agricultural water management interventions and a gender perspective.

The post Modern tools and ancient smarts first appeared on International Water Management Institute (IWMI).

Farmers in the Gomal Zam Dam Command Area are learning to adopt climate change-resilient cultivation techniques.

The post IWMI modernizes agricultural practices in Pakistan first appeared on International Water Management Institute (IWMI).

Today's teens grapple with mounting stress from social media, climate issues, and pandemic disruptions, witnessing a prolonged deterioration in mental

Gone are the days when children used to sit facing those ugly-looking blackboards polluting the classroom with chalk dust. With the change in time, the needs of the students have also changed. Now they need smarter ways to study which...

Ravi Kiran Magham highlights the transformative role of Machine Learning Feature Stores in modern data infrastructures.

Chapter A

So just what is the Modern Age, and how do we get there? First people need to educate themselves in the sense they have power over the University System. It is not the...

The war in Ukraine has shown that warfare changes by the day. It’s also clear that the tech used to make war today is costly: While larger countries can afford legions of tanks, helicopters, and precision-strike systems, smaller nations find themselves scrambling for cheaper ways to defend themselves. Origin, a new defense tech startup out of […]

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Zeel always ups her social media game because she is aware of how the world works and how this generation is captivated by it. 

A home or space can be designed and styled into a specific design style. One of the most popular design styles that gained a lot of popularity since its inception in the early 20th century is nothing but Modern Interior design!

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