modern

Ancient Genome Appears to Have Links to Modern Humans

Title: Ancient Genome Appears to Have Links to Modern Humans
Category: Health News
Created: 8/30/2012 4:05:00 PM
Last Editorial Review: 8/31/2012 12:00:00 AM




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Moderna Readies for Full Vaccine Approval, as Pfizer Submits Data on Booster Shot

Title: Moderna Readies for Full Vaccine Approval, as Pfizer Submits Data on Booster Shot
Category: Health News
Created: 8/26/2021 12:00:00 AM
Last Editorial Review: 8/26/2021 12:00:00 AM




modern

Analgesic Properties of Next-Generation Modulators of Endocannabinoid Signaling: Leveraging Modern Tools for the Development of Novel Therapeutics [Special Section: Cannabinoid Signaling in Human Health and Disease-Minireview]

Targeting the endocannabinoid (eCB) signaling system for pain relief is an important treatment option that is only now beginning to be mechanistically explored. In this review, we focus on two recently appreciated cannabinoid-based targeting strategies, treatments with cannabidiol (CBD) and α/β-hydrolase domain containing 6 (ABHD6) inhibitors, which have the exciting potential to produce pain relief through distinct mechanisms of action and without intoxication. We review evidence on plant-derived cannabinoids for pain, with an emphasis on CBD and its multiple molecular targets expressed in pain pathways. We also discuss the function of eCB signaling in regulating pain responses and the therapeutic promises of inhibitors targeting ABHD6, a 2-arachidonoylglycerol (2-AG)-hydrolyzing enzyme. Finally, we discuss how the novel cannabinoid biosensor GRABeCB2.0 may be leveraged to enable the discovery of targets modulated by cannabinoids at a circuit-specific level.

SIGNIFICANCE STATEMENT

Cannabis has been used by humans as an effective medicine for millennia, including for pain management. Recent evidence emphasizes the therapeutic potential of compounds that modulate endocannabinoid signaling. Specifically, cannabidiol and inhibitors of the enzyme ABHD6 represent promising strategies to achieve pain relief by modulating endocannabinoid signaling in pain pathways via distinct, nonintoxicating mechanisms of action.




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Assassin's Creed Shadows will reboot Assassin's Creed's patchy modern-day story

Put your hand up if you'd forgotten that every Assassin's Creed game is, strictly speaking, set in the present day. I know I had. That's not the actual distant past you're parkouring through. That isn't actual Renaissance architecture you're clambering on. It's a holographic Animus simulation, conjured from ancestral memories flash-frozen within your DNA - convenient, inasmuch as it means that any inconsistencies are your DNA's fault, not Ubisoft's. If the ledge-mantling animations are glitchy, that's simply because you have bad genes.

We can both be forgiven for losing sight of Assassin's Creed's modern day narrative frame. Ubisoft themselves have downplayed it since the era of Desmond Miles, the watery Peter Parker figure who served as puppetmaster protagonist for AC games up to Assassin's Creed 3. In Assassin's Creed Shadows, however, they're planning to bring back the modern day setting in a big way, though details are scanty.

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modern

Several Denisovan Populations Introgressed into Modern Humans Multiple Times: Study

The identification of a new hominin group called Denisovans was one of the most exciting discoveries in human evolution in the last decade.

The post Several Denisovan Populations Introgressed into Modern Humans Multiple Times: Study appeared first on Sci.News: Breaking Science News.




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How bad is modern life for our body clocks – and what can we do?

Modern life disrupts the circadian rhythms controlling our biology – increasing our risk of developing conditions ranging from diabetes to dementia. Lynne Peeples's new book The Inner Clock explores and offers solutions




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The Modern CIO

At the recent Gartner Symposium, there was no shortage of data and insights on the evolving role of the CIO. While the

The post The Modern CIO appeared first on Gigaom.




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Modern gizmos take some licking

You humans might be amazed to know what we dogs have figured out.




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Oversimplification about integration of traditional & modern treatment systems creates confusion: Dr Kotecha

Oversimplification about integration of traditional and modern treatment systems often creates confusion among the stakeholders, and nobody understands the reality of the integration and what it is meant for, said Dr.




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Digital Will Drive Ukraine's Modernization

Technology will play a crucial role in that process. Since 2014, Ukraine has been at the forefront of the digital revolution through a journey marked by strength, adaptability, and success.  Digital transformation transcends and affects all economic sectors in Ukraine. Digital solutions have been applied in a wide range of sectors including banking and finance, agriculture and food production, and energy, to cite a few. In that regard, digital transformation is key to a well-functioning society, affecting democratic participation, education, and public services.




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Enabling an Economic Transformation of Ukraine: Recovery, Reconstruction, and Modernization

The aim of the report is to focus specifically on the critical role of private sector investment in Ukraine’s economic reconstruction, and how the private sector, both within Ukraine and internationally, can enable Ukraine to win the peace. It provides a short overview of the economic challenges facing Ukraine, including governance, the sectors that will be critical to Ukraine's reconstruction, the roles and responsibilities for the G7, EU, IFIs, and DFIs, and then recommendations for how Ukraine and its partners can best attract private sector investment.





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Many Iron Age swords may be tainted by modern forgery

Ancient weaponsmiths combined bronze and iron to fashion swords during the early Iron Age – but modern forgers glue together elements from different weapons, making it difficult for researchers to study the ancient technology




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Enhancing Dry Eye Care Through Modern Strategies

Highlights: Experts highlight the strategies that blend procedural and pharmacological therapies to optimize dry ey




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Pathology: Cornerstone of Modern Medicine

Highlights: Pathologists play an important role in diagnosing and understanding diseases International Pathologi






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Role of Virtual Reality on Mental Health Amidst Modern Stressors

Today's teens grapple with mounting stress from social media, climate issues, and pandemic disruptions, witnessing a prolonged deterioration in mental




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Interactive Whiteboards Need Of Modern Classrooms

Gone are the days when children used to sit facing those ugly-looking blackboards polluting the classroom with chalk dust. With the change in time, the needs of the students have also changed. Now they need smarter ways to study which...




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Understanding the Role of Machine Learning Feature Stores in Modern Data Infrastructure

Ravi Kiran Magham highlights the transformative role of Machine Learning Feature Stores in modern data infrastructures.




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Embracing The Modern Age Part II

Chapter A

So just what is the Modern Age, and how do we get there? First people need to educate themselves in the sense they have power over the University System. It is not the...




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Airdog’s founders are back with a precision-strike drone meant for modern warfare

The war in Ukraine has shown that warfare changes by the day. It’s also clear that the tech used to make war today is costly: While larger countries can afford legions of tanks, helicopters, and precision-strike systems, smaller nations find themselves scrambling for cheaper ways to defend themselves. Origin, a new defense tech startup out of […]

© 2024 TechCrunch. All rights reserved. For personal use only.




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Zeel Joshi, Gujarat-Based-Performer Of Culture And Modernity

Zeel always ups her social media game because she is aware of how the world works and how this generation is captivated by it. 




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Modern Interior Design - Everything You Should Know About The New-Age Interior Style

A home or space can be designed and styled into a specific design style. One of the most popular design styles that gained a lot of popularity since its inception in the early 20th century is nothing but Modern Interior design!




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Woman and Chinese modernity : the politics of reading between West and East [Electronic book] / Rey Chow.

Minneapolis, MN ; London : University of Minnesota Press, 1997.




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Widowhood in early modern Spain : protectors, proprietors, and patrons [Electronic book] / by Stephanie Fink De Backer.

Leiden ; Boston : Brill, 2010.




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Unbinding Isaac : the significance of the Akedah for modern Jewish thought [Electronic book] / Aaron Koller.

Lincoln : University of Nebraska Press, [2020]




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Top Ten Fictional Narratives in Early Modern Europe : Translation, Dissemination and Mediality [Electronic book] / ed. by Rita Schlusemann, Helwi Blom, Anna Katharina Richter, Krystyna Wierzbicka-Trwoga.

Berlin ; Boston : De Gruyter, [2023]




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Subjects of modernity : Time-space, disciplines, margins [Electronic book] / Saurabh Dube.

Manchester : Manchester University Press, [2017]




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Stereotypes and stereotyping in early modern England : Puritans, papists and projectors [Electronic book] / ed. by Koji Yamamoto.

Manchester : Manchester University Press, [2022]




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The senses in early modern England, 1558-1660 [Electronic book] / ed. by Simon Smith, Amy Kenny, Jacqueline Watson.

Manchester : Manchester University Press, [2020]




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Popol vuh : the Mayan book of the dawn of life [Electronic book] / translated by Dennis Tedlock ; with commentary based upon the ancient knowledge of the modern Quiché Maya.

[Place of publication not identified] : [eBookIt.com], [1996]




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Pageantry and Power : A cultural history of the early modern Lord Mayor's Show 1585-1639 [Electronic book] / Tracey Hill.

Manchester : Manchester University Press, [2017]




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Modernism and Religion : Between Mysticism and Orthodoxy [Electronic book] / Jamie Callison.

Edinburgh : Edinburgh University Press, [2023]




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Modern Etruscans : Close Encounters with a Distant Past [Electronic book] / Chiara Zampieri, Martina Piperno.

[s.l.] : Universitaire Pers Leuven, 2023.




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Modern Central Asia : a primary source reader [Electronic book] / Yuriy Malikov.

Lanham : Lexington Books, [2020]




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Das Mittelmeer und die deutsche Literatur der Vormoderne : Transkulturelle Perspektiven [Electronic book] / hrsg. von Falk Quenstedt.

Berlin ; Boston : De Gruyter, [2023]




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The marketplace of print : pamphlets and the public sphere in early modern England [Electronic book] / Alexandra Halasz.

Cambridge : Cambridge University Press, 2006.




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Male witches in early modern Europe [Electronic book] / Andrew Gow, Lara Apps.

Manchester : Manchester University Press, [2018]




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Making and unmaking in early modern English drama : Spectators, aesthetics and incompletion [Electronic book] / Chloe Porter.

Manchester : Manchester University Press, [2014]




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Islamic Law in Early Modern Iran : Sharīʿa Court Practice in the Sixteenth to Twentieth Centuries [Electronic book] / Zahir Bhalloo.

Berlin ; Boston : De Gruyter, [2023]




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In search of social democracy : Responses to crisis and modernisation [Electronic book] / ed. by John Callaghan, Martin McIvor, Ben Jackson, Nina Fishman.

Manchester : Manchester University Press, [2017]




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Improper modernism : Djuna Barnes's bewildering corpus [Electronic book] / Daniela Caselli.

Abingdon : Routledge, 2016.




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Humanism and Protestantism in early modern English education [Electronic book] / Ian M. Green.

Abingdon, Oxon ; New York, NY : Routledge, 2016.




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Gottfried Kellers Moderne. Kellers Welten : Territorien - Ordnungen - Zirkulationen [Electronic book] / hrsg. von Sebastian Meixner.

Berlin ; Boston : De Gruyter, [2023]




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A global history of early modern violence [Electronic book] / ed. by Erica Charters, Peter H. Wilson, Marie Houllemare.

Manchester : Manchester University Press, [2021]




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Fragmenting modernism : Ford Madox Ford, the novel and the Great War [Electronic book] / Sara Haslam.

Manchester : Manchester University Press, [2018]




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Enthusiast! : Essays on Modern American literature [Electronic book] / David Herd.

Manchester : Manchester University Press, [2017]




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The Enlightenment and religion : The myths of modernity [Electronic book] / S. Barnett.

Manchester : Manchester University Press, [2018]




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Engine of modernity : The omnibus and urban culture in nineteenth-century Paris [Electronic book] / Masha Belenky.

Manchester : Manchester University Press, [2020]