Hauppauge, NY, January 13, 2014 – The Ross MegaShear Ultra-High Shear Mixer is designed for homogenizing dispersions and disintegrating large solid particles or droplets suspended in liquid. 

Event Begins: Thursday, November 14, 2024 3:00pm
Location: East Hall
Organized By: Topology Seminar - Department of Mathematics

The Torelli group is the subgroup of the mapping class group of a surface acting trivially on the first homology of the surface. The first rational homology of the Torelli group is known for a closed surface of genus 2 by work of Mess, and for closed surfaces of genus at least 3 by work of Johnson. We will discuss forthcoming work with Putman that computes the second rational homology of the Torelli group for all closed surfaces of genus at least 6. In particular, we will show that this homology group is an algebraic representation of the symplectic group. Combined with the work of Kupers and Randal-Williams, this partially resolves Church and Farb's conjecture that the rational homology of the Torelli group is representation stable over the symplectic group.

In the week before the US presidential election on 5 November 2024, it is the artists who are calling the tune – impulsive, powerful and mighty, as only music can be.

Serwis Internetowy Nieruchomości ROTUNDA.

Fr. John shares his homily from the Sunday of All Saints.

In this episode, Fr John Parker address same-sex marriage and homosexuality, in response to the frenzy of discussion on these topics today in the public sphere.

In this final episode on the “Light from the Psalter,” we consider see how Psalm 1’s righteous man is fulfilled in the final three Psalms, where humanity leads the praises of creation, bringing together the God-given faculties of reason, sub-creativity, and worship. We are helped by Genesis 1-2, Isaiah 6, and Revelation 4-5, and by l fathers. In two week’s time, we will begin a new series “Light From (and Upon) the Readable Books,” in which we will consider the significance of those Old Testament books that are ignored or even rejected by some.

In this podcast Steve references an article he wrote for AGAIN Magazine on the Orthodox Church and same sex attraction. In it he shares the results of several interviews with Orthodox men and women who shared their backgrounds and experiences as homosexuals before and after becoming Orthodox Christians.

In Part Two Steve answers email from listeners in a Question/Answer format.

One of the extremely complicated issues with which Orthodox parents must contend these days is that of homosexuality. How do we talk to our kids about same-sex desires and relationships and how do we do so with the sensitivity, nuance, and frankness that the topic requires? At the request of Carole Buleza, the Director of the Antiochian Department of Christian Education, Bobby Maddex once again interviews Dr. Philip Mamalakis, an Assistant Professor of Pastoral Care at Holy Cross Greek Orthodox School of Theology, about how to talk about marriage, intimacy, and homosexuality with your children. This is part two!

One of the extremely complicated issues with which Orthodox parents must contend these days is that of homosexuality. How do we talk to our kids about same-sex desires and relationships and how do we do so with the sensitivity, nuance, and frankness that the topic requires? At the request of Carole Buleza, the Director of the Antiochian Department of Christian Education, Bobby Maddex interviews Dr. Philip Mamalakis, an Assistant Professor of Pastoral Care at Holy Cross Greek Orthodox School of Theology, about how to talk about marriage, intimacy, and homosexuality with your children.

Port Vale eject a home fan at Tuesday's EFL Trophy tie with Wrexham for alleged homophobic abuse.

The fan is barred from attending any matches for two seasons, following an investigation.

The terrazzo-inspired visuals are constructed in 18” x 36” format with color selections specifically curated for healthcare, education and office environments.

Some new information about Homo floresiensis, from a talk given by Colin Groves at the National Museum of Australia on Feb 12th.

Human tRNA (uracil-5-)-methyltransferase 2 homolog A (TRMT2A) is the dedicated enzyme for the methylation of uridine 54 in transfer RNA (tRNA). Human TRMT2A has also been described as a modifier of polyglutamine (polyQ)-derived neuronal toxicity. The corresponding human polyQ pathologies include Huntington's disease and constitute a family of devastating neuro­degenerative diseases. A polyQ tract in the corresponding disease-linked protein causes neuronal death and symptoms such as impaired motor function, as well as cognitive impairment. In polyQ disease models, silencing of TRMT2A reduced polyQ-associated cell death and polyQ protein aggregation, suggesting this protein as a valid drug target against this class of disorders. In this paper, the 1.6 Å resolution crystal structure of the RNA-recognition motif (RRM) from Drosophila melanogaster, which is a homolog of human TRMT2A, is described and analysed.

It is well known that Hirshfeld surfaces provide an easy and straightforward way of analysing inter­molecular inter­actions in the crystal environment. The use of atomic Hirshfeld surfaces has also demonstrated that such surfaces carry information related to chemical bonds which allow a deeper evaluation of the structures. Here we briefly summarize the approach of atomic Hirshfeld surfaces while further evaluating the kind of information that can be retrieved from them. We show that the analysis of the metal-centre Hirshfeld surfaces from structures refined via Hirshfeld Atom Refinement (HAR) allow accurate evaluation of contacts of type M⋯H, and that such contacts can be related to the overall shape of the surfaces. The com­pounds analysed were tetra­aqua­bis­(3-carb­oxy­propionato)metal(II), [M(C4H3O4)2(H2O)4], for metal(II)/M = manganese/Mn, cobalt/Co, nickel/Ni and zinc/Zn. We also evaluate the sensitivity of the surfaces by an investigation of seemingly flat surfaces through analysis of the curvature functions in the direction of C—C bonds. The obtained values not only demonstrate variations in curvature but also show a correlation with the hybridization of the C atoms involved in the bond.

Here, it is investigated how optical properties of single scatterers in interacting multi-particle systems influence measurable structure factors. Both particles with linear gradients of their scattering length density and core–shell structures evoke characteristic deviations between the weighted sum 〈S(Q)〉 of partial structure factors in a multi-component system and experimentally accessible measurable structure factors SM(Q). While 〈S(Q)〉 contains only the structural information of self-organizing systems, SM(Q) is additionally influenced by the optical properties of their constituents, resulting in features such as changing amplitudes, additional peaks in the low-wavevector region or splitting of higher-order maxima, which are not related to structural reasons. It is shown that these effects can be systematically categorized according to the qualitative behaviour of the form factor in the Guinier region, which enables assessing the suitability of experimentally obtained structure factors to genuinely represent the microstructure of complex systems free from any particular model assumption. Hence, a careful data analysis regarding size distribution and optical properties of single scatterers is mandatory to avoid a misinterpretation of measurable structure factors.

The two most abundant CaCO3 polymorphs, calcite and aragonite, are universally recognized for the richness of their morphology to which different twins make relevant contributions. The epitaxial transformation calcite ↔ aragonite has long been debated. While the twinning has been thoroughly treated, the homo-epitaxy occurring within each of these minerals has, inexplicably, been overlooked to date, both experimentally and theoretically. Twinning can be deceptive to the point where it can be mistaken for homo-epitaxy, thus making the proposed growth mechanism in the crystal aggregate wrong. Within the present work, the first aim is a theoretical investigation of the homo-epitaxies among the three {10.4}-cleavage, {01.2}-steep and {01.8}-flat rhombohedra of calcite. Accordingly, the specific adhesion energies were calculated between facing crystal forms, unequivocally showing that the {01.2}/{01.8} homo-epitaxy competes with the generation of both {01.2} and {01.8} contact twins. Secondly, the calculation of the specific adhesion energy was extended to consider homo-epitaxy for the {10.4} rhombohedron. The two-dimensional geometric lattice coincidence has been tried for the {00.1} pinacoidal form as well.

ROSS inline high shear mixers from 1 through 250 HP accelerate mixing, emulsification and homogenization in both recirculation and continuous modes.

Event Begins: Wednesday, November 13, 2024 4:00pm
Location: East Hall
Organized By: Algebraic Geometry Seminar - Department of Mathematics

Joint work with Ailsa Keating (Cambridge). We prove the homological mirror symmetry conjecture of Kontsevich for K3 surfaces in the following form: The Fukaya category of a projective K3 surface is equivalent to the derived category of coherent sheaves on the mirror, which is a K3 surface of Picard rank 19 over the field of formal Laurent series. This builds on prior work of Seidel (who proved the theorem in the case of the quartic surface), Sheridan, Lekili--Ueda, and Ganatra--Pardon--Shende.

I will try to keep prerequisites to a minimum, in particular, I will not assume prior knowledge of the Fukaya category.

En 10AM Hoy por Hoy de Caracol Radio estuvo la representante a la Cámara, Carolina Giraldo, para hablar sobre la prohibición de las terapias de conversión en Colombia.

An email containing a racist trope had already leaked.

I’m traveling for the long weekend. Either I’m having bad luck with the epic heat waves or there have been a lot of epic heat waves, because again the short road trip threatens to be tyrannized by the hot air. It did at least touch 100°F this time, so at least it is a proper respectable heat wave. We are in a place called Hocking Hills, whose AirBnB has these OBX-style stickers that say “HHO”, which could either be confusingly “Hills, HOcking,” or perhaps “Hocking Hills, Ohio”, but not “Hocking hills OHio” as one might expect. I plan to stick the sticker upside-down for “OHH”, as in “Ohh yeah, I need to write a post on Tom 7 Radar for the month of August, and I need to do it on this mediocre wi-fi which Google Internet Speed Test describes as ‘fine’ while everyone else drinks beers outside.” Fair enough: This is a self-imposed curse and one that’s easily tended to at any time during the month.

During the month: I worked again on making my own video codec, which is a very bad way to spend one’s time, but I don’t think there are any modern lossless codecs that would be suitable for my use case. And I do like a data compression project because of the inherent benchmarkability. The use case is for the increasingly common situation where I have a program generating a series of video frames (e.g. BoVeX is making an animation), which I usually do by writing a sequence of PNG files to disk. I’m way ahead of PNG files so far even without doing any inter-frame stuff, which is not impressive, but does make me feel like it’s at least not totally pointless. (Still, it’s quite pointless: Sure I can make these files smaller at significant cost of complexity and encoding times, but these animations typically use space similar to like one second of 4K 60fps XF-AVC footage.)

Sometimes programming your own lossless video codec is a bit too fast-paced so you need to write a Wikipedia article from scratch about Clairton Coke Works by digging through newspaper archives. I haven't even gotten to the last 30 years of its history yet! I also rounded out the Cyrillic in FixederSys though I don't think I've uploaded a new version of that yet. As usual I did some hacking on secret projects.

UHH, elsewise, I did finish off Animal Well which I liked very much. My spoilerless advice to you is: Don't try to 100% this game without at least looking at a spoiler-controlled guide! But I did have fun once I felt like I was stuck-ish finishing the remaining postgame puzzles. I have also been playing Chippy, a bullet-hell twin-stick shooter that is quite hard (I usually feel good at this genre) and has several new good ideas in it. It's essentially all boss fights, and the chief innovation is that you fight the giant bosses by disconnecting pieces of them. I'm on the last boss so I will probably finish that one soon. As I have confessed many times, I like dumb first-person shooter games, and I played through Trepang 2 this month as well. It does have a few moments, but it was mostly pretty dumb, like I wanted. And then I started Touhou Luna Nights, which is a "Metroidvania" fan-game with great pixel art and music.

OK, I should get back to this vacation!

Pierre Lairez, Eric Pichon-Pharabod and Pierre Vanhove
Math. Comp. 93 (), 2985-3025.
Abstract, references and article information

N. Lebedeva and A. Petrunin
St. Petersburg Math. J. 35 (), 473-476.
Abstract, references and article information

The dominant role of CaV2 voltage-gated calcium channels for driving neurotransmitter release is broadly conserved. Given the overlapping functional properties of CaV2 and CaV1 channels, and less so CaV3 channels, it is unclear why there have not been major shifts toward dependence on other CaV channels for synaptic transmission. Here, we provide a structural and functional profile of the CaV2 channel cloned from the early-diverging animal Trichoplax adhaerens, which lacks a nervous system but possesses single gene homologues for CaV1–CaV3 channels. Remarkably, the highly divergent channel possesses similar features as human CaV2.1 and other CaV2 channels, including high voltage–activated currents that are larger in external Ba2+ than in Ca2+; voltage-dependent kinetics of activation, inactivation, and deactivation; and bimodal recovery from inactivation. Altogether, the functional profile of Trichoplax CaV2 suggests that the core features of presynaptic CaV2 channels were established early during animal evolution, after CaV1 and CaV2 channels emerged via proposed gene duplication from an ancestral CaV1/2 type channel. The Trichoplax channel was relatively insensitive to mammalian CaV2 channel blockers ω-agatoxin-IVA and ω-conotoxin-GVIA and to metal cation blockers Cd2+ and Ni2+. Also absent was the capacity for voltage-dependent G-protein inhibition by co-expressed Trichoplax Gβγ subunits, which nevertheless inhibited the human CaV2.1 channel, suggesting that this modulatory capacity evolved via changes in channel sequence/structure, and not G proteins. Last, the Trichoplax channel was immunolocalized in cells that express an endomorphin-like peptide implicated in cell signaling and locomotive behavior and other likely secretory cells, suggesting contributions to regulated exocytosis.

Homologous recombination (HR) repairs DNA double-strand breaks using intact homologous sequences as template DNA. Broken DNA and intact homologous sequences form joint molecules (JMs), including Holliday junctions (HJs), as HR intermediates. HJs are resolved to form crossover and noncrossover products. A mismatch repair factor, MLH3 endonuclease, produces the majority of crossovers during meiotic HR, but it remains elusive whether mismatch repair factors promote HR in nonmeiotic cells. We disrupted genes encoding the MLH3 and PMS2 endonucleases in the human B cell line, TK6, generating null MLH3−/− and PMS2−/− mutant cells. We also inserted point mutations into the endonuclease motif of MLH3 and PMS2 genes, generating endonuclease death MLH3DN/DN and PMS2EK/EK cells. MLH3−/− and MLH3DN/DN cells showed a very similar phenotype, a 2.5-fold decrease in the frequency of heteroallelic HR-dependent repair of restriction enzyme–induced double-strand breaks. PMS2−/− and PMS2EK/EK cells showed a phenotype very similar to that of the MLH3 mutants. These data indicate that MLH3 and PMS2 promote HR as an endonuclease. The MLH3DN/DN and PMS2EK/EK mutations had an additive effect on the heteroallelic HR. MLH3DN/DN/PMS2EK/EK cells showed normal kinetics of γ-irradiation–induced Rad51 foci but a significant delay in the resolution of Rad51 foci and a 3-fold decrease in the number of cisplatin-induced sister chromatid exchanges. The ectopic expression of the Gen1 HJ re-solvase partially reversed the defective heteroallelic HR of MLH3DN/DN/PMS2EK/EK cells. Taken together, we propose that MLH3 and PMS2 promote HR as endonucleases, most likely by processing JMs in mammalian somatic cells.

Earlier in the service I read from the first chapter of Romans what is really a very, very shocking portion of Scripture just to remind you that Romans cha

Organic anion transporting polypeptides (OATP, gene symbol SLCO) are well-recognized key determinants for the absorption, distribution, and excretion of a wide spectrum of endogenous and exogenous compounds including many antineoplastic agents. It was therefore proposed as a potential drug target for cancer therapy. In our previous study, it was found that low-dose X-ray and carbon ion irradiation both upregulated the expression of OATP family member OATP1A2 and in turn, led to a more dramatic killing effect when cancer cells were cotreated with antitumor drugs such as methotrexate. In the present study, the underlying mechanism of the phenomenon was explored in breast cancer cell line MCF-7. It was found that the nonreceptor tyrosine kinase v-YES-1 Yamaguchi sarcoma viral oncogene homolog 1 (YES-1) was temporally coordinated with the change of OATP1A2 after irradiation. The overexpression of YES-1 significantly increased OATP1A2 both at the mRNA and protein level. The signal transducer and activator of transcription 3 (STAT3) pathway is likely the downstream target of YES-1 because phosphorylation and nuclear accumulation of STAT3 were both enhanced after overexpressing YES-1 in MCF-7 cells. Further investigation revealed that there are two possible binding sites of STAT3 localized at the upstream sequence of SLCO1A2, the encoding gene of OATP1A2. Electrophoretic mobility shift assay and chromatin immunoprecipitation analysis suggested that these two sites bound to STAT3 specifically and the overexpression of YES-1 significantly increased the association of the transcription factor with the putative binding sites. Finally, inhibition or knockdown of YES-1 attenuated the induction effect of radiation on the expression of OATP1A2.

The Central Council for Research in Ayurvedic Sciences - Captain Srinivasa Murthy Central Ayurveda Research Institute (CSMCARI) and Commissionerate of

English is often said to be a confusing language - and when it comes to homophones, we know how that notion came to be!

Homophones,...