Acting US director of national intelligence Richard Grenell says he spoke "with an influential Lebanese Shi'ite leader" who is "close" to coming out publicly in favor of decriminalizing homosexuality

English is often said to be a confusing language - and when it comes to homophones, we know how that notion came to be!

Homophones,...

The mol­ecule of the title Schiff base compound, C14H13N3O3·H2O, displays a trans configuration with respect to the C=N bond. The dihedral angle between the benzene and pyridine rings is 29.63 (7)°. The crystal structure features inter­molecular N—H⋯O, C—H⋯O, O—H⋯O and O—H⋯N hydrogen-bonding inter­actions, leading to the formation of a supramolecular framework. A Hirshfeld surface analysis indicates that the most important contributions to the crystal packing are from H⋯H (37.0%), O⋯H/H⋯O (23.7%)), C⋯H/H⋯C (17.6%) and N⋯H/H⋯N (11.9%) inter­actions. The title compound has also been characterized by frontier mol­ecular orbital analysis.

Protein-engineering methods have been exploited to produce a surrogate system for the extracellular neurotransmitter-binding site of a heteromeric human ligand-gated ion channel, the glycine receptor. This approach circumvents two major issues: the inherent experimental difficulties in working with a membrane-bound ion channel and the complication that a heteromeric assembly is necessary to create a key, physiologically relevant binding site. Residues that form the orthosteric site in a highly stable ortholog, acetylcholine-binding protein, were selected for substitution. Recombinant proteins were prepared and characterized in stepwise fashion exploiting a range of biophysical techniques, including X-ray crystallography, married to the use of selected chemical probes. The decision making and development of the surrogate, which is termed a glycine-binding protein, are described, and comparisons are provided with wild-type and homomeric systems that establish features of molecular recognition in the binding site and the confidence that the system is suited for use in early-stage drug discovery targeting a heteromeric α/β glycine receptor.

MICAL is an oxidoreductase that participates in cytoskeleton reorganization via actin disassembly in the presence of NADPH. Although three MICALs (MICAL1, MICAL2 and MICAL3) have been identified in mammals, only the structure of mouse MICAL1 has been reported. Here, the first crystal structure of human MICAL3, which contains the flavin-containing monooxygenase (FMO) and calponin-homology (CH) domains, is reported. MICAL3 has an FAD/NADP-binding Rossmann-fold domain for mono­oxygenase activity like MICAL1. The FMO and CH domains of both MICAL3 and MICAL1 are highly similar in structure, but superimposition of the two structures shows a different relative position of the CH domain in the asymmetric unit. Based on kinetic analyses, the catalytic efficiency of MICAL3 dramatically increased on adding F-actin only when the CH domain was available. However, this did not occur when two residues, Glu213 and Arg530, were mutated in the FMO and CH domains, respectively. Overall, MICAL3 is structurally highly similar to MICAL1, which suggests that they may adopt the same catalytic mechanism, but the difference in the relative position of the CH domain produces a difference in F-actin substrate specificity.

The performance of automated protein model building usually decreases with resolution, mainly owing to the lower information content of the experimental data. This calls for a more elaborate use of the available structural information about macromolecules. Here, a new method is presented that uses structural homologues to improve the quality of protein models automatically constructed using ARP/wARP. The method uses local structural similarity between deposited models and the model being built, and results in longer main-chain fragments that in turn can be more reliably docked to the protein sequence. The application of the homology-based model extension method to the example of a CFA synthase at 2.7 Å resolution resulted in a more complete model with almost all of the residues correctly built and docked to the sequence. The method was also evaluated on 1493 molecular-replacement solutions at a resolution of 4.0 Å and better that were submitted to the ARP/wARP web service for model building. A significant improvement in the completeness and sequence coverage of the built models has been observed.

This paper reports an Fe-added Y2O3 crucible which is capable of balancing the solution spontaneously and is employed to effectively enhance the homogeneity of YBa2(Cu1−xFex)3O7−δ single crystals.

New excavations in Indonesia and dating analyses by scientists at the Smithsonian and their colleagues show that modern humans never co-existed with Homo erectus.

The post Scientists show that modern humans never co-existed with <em>Homo erectus</em> appeared first on Smithsonian Insider.

The post The amazing story of adaptation and survival in our species, Homo sapiens. appeared first on Smithsonian Insider.

A new, highly speculative conjecture about the extinction of ancient humans is sure to raise critics' brows.

In this paper, for a family of second-order parabolic equation with rapidly oscillating and time-dependent periodic coefficients, we are interested in an approximate two-sphere one-cylinder inequality for these solutions in parabolic periodic homogenization, which implies an approximate quantitative propagation of smallness. The proof relies on the asymptotic behavior of fundamental solutions and the Lagrange interpolation technique.

Yang-Mills gauge theory on Minkowski space supports a Batalin-Vilkovisky-infinity algebra structure, all whose operations are local. To make this work, the axioms for a BV-infinity algebra are deformed by a quadratic element, here the Minkowski wave operator. This homotopy structure implies BCJ/color-kinematics duality; a cobar construction yields a strict algebraic structure whose Feynman expansion for Yang-Mills tree amplitudes complies with the duality. It comes with a `syntactic kinematic algebra'.

This work has been motivated by recent papers that quantify the density of values of generic quadratic forms and other polynomials at integer points, in particular ones that use Rogers' second moment estimates. In this paper we establish such results in a very general framework. Namely, given any subhomogeneous function (a notion to be defined) $f: mathbb{R}^n o mathbb{R}$, we derive a necessary and sufficient condition on the approximating function $psi$ for guaranteeing that a generic element $fcirc g$ in the $G$-orbit of $f$ is $psi$-approximable; that is, $|fcirc g(mathbf{v})| le psi(|mathbf{v}|)$ for infinitely many $mathbf{v} in mathbb{Z}^n$. We also deduce a sufficient condition in the case of uniform approximation. Here, $G$ can be any closed subgroup of $operatorname{ASL}_n(mathbb{R})$ satisfying certain axioms that allow for the use of Rogers-type estimates.

In a multitype branching process, it is assumed that immigrants arrive according to a nonhomogeneous Poisson or a generalized Polya process (both processes are formulated as a nonhomogeneous birth process with an appropriate choice of transition intensities). We show that the renormalized numbers of objects of the various types alive at time $t$ for supercritical, critical, and subcritical cases jointly converge in distribution under those two different arrival processes. Furthermore, some transient moment analysis when there are only two types of particles is provided. AMS 2000 subject classifications: Primary 60J80, 60J85; secondary 60K10, 60K25, 90B15.

In this review paper, we survey Hardy type inequalities from the point of view of Folland and Stein's homogeneous groups. Particular attention is paid to Hardy type inequalities on stratified groups which give a special class of homogeneous groups. In this environment, the theory of Hardy type inequalities becomes intricately intertwined with the properties of sub-Laplacians and more general subelliptic partial differential equations. Particularly, we discuss the Badiale-Tarantello conjecture and a conjecture on the geometric Hardy inequality in a half-space of the Heisenberg group with a sharp constant.

We give a simple proof of the strong maximum principle for viscosity subsolutions of fully nonlinear elliptic PDEs on the form $$ F(x,u,Du,D^2u) = 0 $$ under suitable structure conditions on the equation allowing for non-Lipschitz growth in the gradient terms. In case of smooth boundaries, we also prove the Hopf lemma, the boundary Harnack inequality and that positive viscosity solutions vanishing on a portion of the boundary are comparable with the distance function near the boundary. Our results apply to weak solutions of an eigenvalue problem for the variable exponent $p$-Laplacian.

Let $Nge 2$ and $ hoin(0,1/N^2]$. The homogenous Cantor set $E$ is the self-similar set generated by the iterated function system

[

left{f_i(x)= ho x+frac{i(1- ho)}{N-1}: i=0,1,ldots, N-1 ight}.

]

Let $s=dim_H E$ be the Hausdorff dimension of $E$, and let $mu=mathcal H^s|_E$ be the $s$-dimensional Hausdorff measure restricted to $E$. In this paper we describe, for each $xin E$, the pointwise lower $s$-density $Theta_*^s(mu,x)$ and upper $s$-density $Theta^{*s}(mu, x)$ of $mu$ at $x$. This extends some early results of Feng et al. (2000). Furthermore, we determine two critical values $a_c$ and $b_c$ for the sets

[

E_*(a)=left{xin E: Theta_*^s(mu, x)ge a ight}quad extrm{and}quad E^*(b)=left{xin E: Theta^{*s}(mu, x)le b ight}

] respectively, such that $dim_H E_*(a)>0$ if and only if $a<a_c$, and that $dim_H E^*(b)>0$ if and only if $b>b_c$. We emphasize that both values $a_c$ and $b_c$ are related to the Thue-Morse type sequences, and our strategy to find them relies on ideas from open dynamics and techniques from combinatorics on words.

Given a standard graded polynomial ring over a commutative Noetherian ring $A$, we prove that the cohomological dimension and the height of the ideals defining any of its Veronese subrings are equal. This result is due to Ogus when $A$ is a field of characteristic zero, and follows from a result of Peskine and Szpiro when $A$ is a field of positive characteristic; our result applies, for example, when $A$ is the ring of integers.

For an odd prime $p$, we determined the Brown-Peterson cohomology of $BPU_n$ in dimensions $-(2p-2)leq ileq 2p+2$, where $BPU_n$ is the classifying space of the projective unitary group $PU_n$. We construct a family of $p$-torsion classes $eta_{p,k}in BP^{2p^{k+1}+2}(BPU_n)$ for $p|n$ and $kgeq 0$ and identify their images under the Thom map with well understood cohomology classes in $H^*(BPU_n;mathbb{Z}_{(p)})$.

In this paper we study manifolds $M_{Sigma}$ with fibered singularities, more specifically, a relevant space $Riem^{psc}(X_{Sigma})$ of Riemannian metrics with positive scalar curvature. Our main goal is to prove that the space $Riem^{psc}(X_{Sigma})$ is homotopy invariant under certain surgeries on $M_{Sigma}$.

Image dehazing is an ill-posed problem that has been extensively studied in the recent years. The objective performance evaluation of the dehazing methods is one of the major obstacles due to the lacking of a reference dataset. While the synthetic datasets have shown important limitations, the few realistic datasets introduced recently assume homogeneous haze over the entire scene. Since in many real cases haze is not uniformly distributed we introduce NH-HAZE, a non-homogeneous realistic dataset with pairs of real hazy and corresponding haze-free images. This is the first non-homogeneous image dehazing dataset and contains 55 outdoor scenes. The non-homogeneous haze has been introduced in the scene using a professional haze generator that imitates the real conditions of hazy scenes. Additionally, this work presents an objective assessment of several state-of-the-art single image dehazing methods that were evaluated using NH-HAZE dataset.

This paper reviews the NTIRE 2020 Challenge on NonHomogeneous Dehazing of images (restoration of rich details in hazy image). We focus on the proposed solutions and their results evaluated on NH-Haze, a novel dataset consisting of 55 pairs of real haze free and nonhomogeneous hazy images recorded outdoor. NH-Haze is the first realistic nonhomogeneous haze dataset that provides ground truth images. The nonhomogeneous haze has been produced using a professional haze generator that imitates the real conditions of haze scenes. 168 participants registered in the challenge and 27 teams competed in the final testing phase. The proposed solutions gauge the state-of-the-art in image dehazing.

Homomorphic encryption (HE) allows direct computations on encrypted data. Despite numerous research efforts, the practicality of HE schemes remains to be demonstrated. In this regard, the enormous size of ciphertexts involved in HE computations degrades computational efficiency. Near-memory Processing (NMP) and Computing-in-memory (CiM) - paradigms where computation is done within the memory boundaries - represent architectural solutions for reducing latency and energy associated with data transfers in data-intensive applications such as HE. This paper introduces CiM-HE, a Computing-in-memory (CiM) architecture that can support operations for the B/FV scheme, a somewhat homomorphic encryption scheme for general computation. CiM-HE hardware consists of customized peripherals such as sense amplifiers, adders, bit-shifters, and sequencing circuits. The peripherals are based on CMOS technology, and could support computations with memory cells of different technologies. Circuit-level simulations are used to evaluate our CiM-HE framework assuming a 6T-SRAM memory. We compare our CiM-HE implementation against (i) two optimized CPU HE implementations, and (ii) an FPGA-based HE accelerator implementation. When compared to a CPU solution, CiM-HE obtains speedups between 4.6x and 9.1x, and energy savings between 266.4x and 532.8x for homomorphic multiplications (the most expensive HE operation). Also, a set of four end-to-end tasks, i.e., mean, variance, linear regression, and inference are up to 1.1x, 7.7x, 7.1x, and 7.5x faster (and 301.1x, 404.6x, 532.3x, and 532.8x more energy efficient). Compared to CPU-based HE in a previous work, CiM-HE obtain 14.3x speed-up and >2600x energy savings. Finally, our design offers 2.2x speed-up with 88.1x energy savings compared to a state-of-the-art FPGA-based accelerator.

Compounds of the formula (I) or (I'), where R1 is a hydrogen atom or C1-C4-alkyl and R'1 is C1-C4-alkyl; X1 and X2 are each, independently of one another, a secondary phosphine group; R2 is hydrogen, R01R02R03Si—, C1-C18.acyl substituted by halogen, hydroxy, C1-C8-alkoxy or R04R05N—, -or R06—X01—C(O)—; R01, R02 and R03 are each, independently of one another, C1-C12-alkyl, unsubstituted or C1-C4-alkyl or C1-C4-alkoxy-substituted C6-C10-aryl or C7-C12-aralkyl; R04 and R05 are each, independently of one another, hydrogen, C1-C12-alkyl, C3-C8-cycloalkyl, C6-C10-aryl or C7-C12-aralkyl, or R04 and R05 together are trimethylene, tetramethylene, pentamethylene or 3-oxapcntylene; R06 is C1-C18-alkyl, unsubstituted or C1-C4-alkyl- or C1-C4-alkoxy-substituted C3-C8-cycloalkyl, C6-C10-aryl or C7-C12-aralkyl; X01 is —O— or —NH—; T is C6-C20-arylene; v is 0 or an integer from 1 to 4; and * denotes a mixture of racemic or enantiomerically pure diastereomers or pure racemic or enantiomerically diastereomers, are excellent chiral ligands for metal complexes as enantioselective catalysts for the hydrogenation of prochiral organic compounds.

The present invention relates to a process for the production of a ready-to-use epoxy composition having a filler content of at least 55 vol.-%, relative to the complete ready-to-use epoxy composition, which comprises: providing a liquid A, which comprises at least one epoxy resin,providing a liquid B, which comprises at least one curing agent,providing a solid component C, which comprises at least one filler,wherein in a first step one of the liquids A or B is filled in a mixing container,in a second step the solid component C is deposited on top of the liquid in the mixing container,in a third step the remaining liquid A or B is deposited on top of the solid component C, andin a fourth step the components are mixed to obtain the ready-to-use epoxy composition.

The present invention relates to methods for making oxidation resistant homogenized polymeric materials and medical implants that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and annealing the anti-oxidant doped UHMWPE in a super critical fluid, and materials used therein.

A single software project in an integrated development environment (IDE) may be built for multiple target environments in a single build episode. Multiple different output artifacts may be generated by the build process for each of the target environments. The output artifacts are then deployed to the target environments, which may be homogeneous or heterogeneous environments. The same source project may be used to generate multiple output artifacts for the same target environment.

A persistent-mode High Temperature Superconductor (HTS) shim coil is provided having at least one rectangular shaped thin sheet of HTS, wherein the thin sheet of HTS contains a first long portion, a second long portion parallel to first long portion, a first end, and a second end parallel to the first end. The rectangular shaped thin sheet of high-temperature superconductor has a hollow center and forms a continuous loop. In addition, the first end and the second end are folded toward each other forming two rings, and the thin sheet of high-temperature superconductor has a radial build that is less than 5 millimeters (mm) and able to withstand very strong magnetic field ranges of greater than approximately 12 Tesla (T) within a center-portion of a superconducting magnet of a superconducting magnet assembly.

The present invention relates to a process for recovery of homogeneous metal hydride catalyst from a reactor stream as catalyst suitable for recycle to a reactor comprising the steps of: removing a stream from a reactor, said stream comprising the homogeneous metal hydride catalyst; contacting the stream with a solid acidic absorbent under process conditions which allow at least some of the metal to become bound to the absorbent; subjecting the metal bound to the absorbent, under process conditions which allow desorption of the metal, to a fluid stripping medium comprising hydrogen and solvent; and recovering the active metal hydride catalyst.

Isolated polynucleotides and polypeptides and recombinant DNA constructs particularly useful for altering agronomic characteristics of plants under nitrogen limiting conditions, compositions (such as plants or seeds) comprising these recombinant DNA constructs, and methods utilizing these recombinant DNA constructs. The recombinant DNA construct comprises a polynucleotide operably linked to a promoter functional in a plant, wherein said polynucleotide encodes an LNT1 polypeptide.

A high-pressure homogenizer including: a fixed body (7) housing a rotating crankshaft (10);a motor (3) for driving the crankshaft (10);a reduction gear unit (4) interconnected between the crankshaft and transmission elements (5, 6), characterized in that the reduction gear unit (4) is an epicyclic reduction gear unit. Preferably there is provided a lubricant feed line (15) which passes through the fixed body and reaches the epicyclic reduction gear unit (4). Preferably the epicyclic reduction gear unit (4) is constructed integrally with the fixed body (4).

A machine for the homogenization and thermal treatment of liquid and semi-liquid food products, for example ice creams, whipped cream, creams, chocolate, yogurt and the like, comprises a containment tank for the mixture and a centrifugal pump put in fluid communication with the bottom of the containment tank for drawing mixture from the tank and putting it back into the tank, heating and cooling means acting at the pump for heating and cooling the mixture in transit in the pump. The heating and cooling means comprise a thermal machine with reversible thermodynamic cycle and using carbon dioxide as refrigerant.

Provided in some embodiments are antibodies comprising a heavy chain having no native interchain cysteine amino acids, a light chain having no native interchain cysteine amino acids, and having no native interchain disulphide linkages between the heavy chain and the light chain. Also provided in certain embodiments are antibodies comprising a heavy chain having no native interchain cysteine amino acids, a light chain having no native interchain cysteine amino acids, and having no native interchain disulphide linkages between the heavy chain and the light chain where the native interchain cysteine amino acids have been replaced by amino acids having no thiol moiety.

Provided are a propylene homopolymer composition for a capacitor film, which can provide a film with excellent high-temperature voltage resistance and excellent thin-film stretchability, a method for producing the same, and a capacitor film. The propylene homopolymer composition for a capacitor film contains 50 to 99% by mass of a propylene homopolymer (A1) having predetermined characteristics and 1 to 50% by mass of a propylene homopolymer (B1) having predetermined characteristics, and has (i) a melt flow rate (MFR) of 1.0 to 10.0 g/10 min and (ii) a chlorine content of 2 ppm by mass or less.

Compositions and methods for detecting Trichomonas vaginalis are provided.

A MAN used homophobic slurs and threatened to "spread coronavirus" towards two Southampton police officers after he broke a window.

A MAN used homophobic slurs and threatened to "spread coronavirus" towards two Southampton police officers after he broke a window.

IT SEEMS almost impossible to watch a newly released silent film now, but new film 12th Man is all about proving the impossible, possible.

Gay and lesbian culture has been long associated with the city, often to the detriment of LGBT people in rural Victoria who felt they could never be accepted.

Close to the heart of gay rights campaigner Rodney Croome are two flags made from the dresses of drag queens who fought police in the Stonewall riots in New York. They'll now be preserved in a collection of memorabilia documenting the battle to change society's views.

[h/t Stephan Hurtubise]  

Ryan Murphy and Ian Brennan rewrite the history of Hollywood in Netflix's "Hollywood," a progressive fantasy of motion pictures in 1947.

Pierre Colmez, Gabriel Dospinescu and Wiesława Nizioł
J. Amer. Math. Soc. 33 (2019), 311-362.
Abstract, references and article information

K. D. Cherednichenko, Yu. Yu. Ershova, A. V. Kiselev and S. N. Naboko
Trans. Moscow Math. Soc. 80 (2020), 251-294.
Abstract, references and article information

V. V. Ryzhikov
Trans. Moscow Math. Soc. 80 (2020), 83-94.
Abstract, references and article information