Congress's working president and three-time minister Haroon Yusuf is confident of wresting his pocket borough this time from Aam Aadmi Pary's Imran Hussain. Mr Yusuf had won from the Muslim-dominated...

India's Biggest Film Funding Platform, Film Funding Network directly connects a global network of investors, HNIs with filmmakers for funding movies, short films, TV shows.

TV Star Anushka Sen Short Film 'Sammaditthi' Is Trending On YouTube

Best Indian Short Films - Six Sigma Films

Los expertos se preguntan por qué el coronavirus es tan caprichoso. Las respuestas pueden determinar el mejor modo de protegernos y durante cuánto tiempo tendremos que hacerlo.

Joomla GMapFP component version 3.30 suffers from an arbitrary file upload vulnerability.

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From resounding applause to ostracisation and isolation.That is essentially...

Arti Zodpe is from the Tamasha (folk dance-drama) theatre in Sangli, in India’s Maharashtra state. After evening performances, some of the singers and dancers offer sex work services to the audience. “We [Tamasha sex workers] live outside of the city as people feel disturbed by the sound of our ghunghroo [anklet bracelets with bells] and […]

The post India’s Liberal Abortion Law, Nullified by Social Stigma appeared first on Inter Press Service.

From resounding applause to ostracisation and isolation.That is essentially the journey Lt. Cmdr. Robert Embleton, who served 34 years in Britain’s Royal Navy, took by ambulance when discharged from Derriford Hospital in Plymouth, southwestern England, on April 8 following his near-month sickness with Covid-19.Arriving at his retirement home, he immediately went into self-isolation with his wife of 55 years, Jean, who has shown no symptoms of the virus. Soon after, Embleton realised he was…

Hackers linked to Iran have targeted staff at U.S. drugmaker Gilead Sciences Inc in recent weeks, according to publicly-available web archives reviewed by Reuters and three cybersecurity researchers, as the company races to deploy a treatment for the COVID-19 virus.

Title: Mentally Ill Kids Face Widespread Stigma
Category: Health News
Created: 5/1/2007 2:00:00 AM
Last Editorial Review: 5/1/2007 12:00:00 AM

Title: Overweight Teens Feel Stigmatized, Bullied: Study
Category: Health News
Created: 5/1/2014 9:35:00 AM
Last Editorial Review: 5/1/2014 12:00:00 AM

APHA member Elena Ong, PHN, MS, past president and founding CEO of the Asian & Pacific Islander Caucus for Public Health, a recent APHA Executive Board member, and a past vice president of the Southern California Public Health Association, discusses discrimination against Asians in the U.S. and beyond.

N-terminal (Nt) acetylation (NTA) is an ample and irreversible cotranslational protein modification catalyzed by ribosome-associated Nt-acetyltransferases. NTA on specific proteins can act as a degradation signal (called an Ac/N-degron) for proteolysis in yeast and mammals. However, in plants, the biological relevance of NTA remains largely unexplored. In this study, we reveal that Arabidopsis (Arabidopsis thaliana) SIGMA FACTOR-BINDING PROTEIN1 (SIB1), a transcription coregulator and a positive regulator of salicylic acid-primed cell death, undergoes an absolute NTA on the initiator Met; Nt-acetyltransferase B (NatB) partly contributes to this modification. While NTA results in destabilization of certain target proteins, our genetic and biochemical analyses revealed that plant NatB-involved NTA instead renders SIB1 more stable. Given that the ubiquitin/proteasome system stimulates SIB1 degradation, it seems that the NTA-conferred stability ensures the timely expression of SIB1-dependent genes, mostly related to immune responses. Taking our findings together, here we report a noncanonical NTA-driven protein stabilization in land plants.

Extensive studies have shown that the ₁ receptor (₁R) interacts with and modulates the activity of multiple proteins with important biological functions. Recent crystal structures of ₁R as a homotrimer differ from a dimer-tetramer model postulated earlier. It remains inconclusive whether ligand binding regulates ₁R oligomerization. Here, novel nondenaturing gel methods and mutational analysis were used to examine ₁R oligomerization. In transfected cells, ₁R exhibited as multimers, dimers, and monomers. Overall, ₁R agonists decreased, whereas ₁R antagonists increased ₁R multimers, suggesting that agonists and antagonists differentially affect the stability of ₁R multimers. Endogenous ₁R in rat liver membranes also showed similar regulation of oligomerization as in cells. Mutations at key residues lining the trimerization interface (Arg119, Asp195, Phe191, Trp136, and Gly91) abolished multimerization without disrupting dimerization. Intriguingly, truncation of the N terminus reduced ₁R to apparent monomer. These results demonstrate that multiple domains play crucial roles in coordinating high-order quaternary organization of ₁R. The E102Q ₁R mutant implicated in juvenile amyotrophic lateral sclerosis formed dimers only, suggesting that dysregulation of ₁R multimeric assembly may impair its function. Interestingly, oligomerization of ₁R was pH-dependent and correlated with changes in [³H](+)-pentazocine binding affinity and B_max. Combined with mutational analysis, it is reasoned that ₁R multimers possess high-affinity and high-capacity [³H](+)-pentazocine binding, whereas monomers likely lack binding. These results suggest that ₁R may exist in interconvertible oligomeric states in a dynamic equilibrium. Further exploration of ligand-regulated ₁R multimerization may provide novel approaches to modulate the function of ₁R and its interacting proteins.

Editor’s Note: This article is adapted from the address Ms. Valentine delivered as the recipient of the American Diabetes Association’s (ADA’s) Outstanding Educator in Diabetes Award for 2019. She delivered the address in June 2019 at the Association’s 79th Scientific Sessions in San Francisco, CA. A webcast of this speech is available for viewing at the ADA website (professional.diabetes.org/webcast/outstanding-educator-diabetes-award-lecture%E2%80%94-most-important-thing-we-give-people-hope).

When Earth and Venus formed, they both had global magma oceans deep underground. Earth’s has turned solid by now, but Venus’s may still remain hidden

This interactive map for Assassin's Creed Odyssey will help you find everything you need, like ainigmata ostraka and tombs.

Consumer Gmail users are seeing a "Google Meet" section in the sidebar.

Hackers linked to Iran have targeted staff at U.S. drugmaker Gilead Sciences Inc in recent weeks, according to publicly-available web archives reviewed by Reuters and three cybersecurity researchers, as the company races to deploy a treatment for the COVID-19 virus.

Team RadioShack rider Gert Steegmans broke his left collarbone when a whirlwind caused him to crash during the prologue of the Paris-Nice race on Sunday.

Hackers linked to Iran have targeted staff at U.S. drugmaker Gilead Sciences Inc in recent weeks, according to publicly-available web archives reviewed by Reuters and three cybersecurity researchers, as the company races to deploy a treatment for the COVID-19 virus. In one case, a fake email login page designed to steal passwords was sent in April to a top Gilead executive involved in legal and corporate affairs, according to an archived version on a website used to scan for malicious web addresses. Ohad Zaidenberg, lead intelligence researcher at Israeli cybersecurity firm ClearSky, who closely tracks Iranian hacking activity and has investigated the attacks, said the attempt was part of an effort by an Iranian group to compromise email accounts of staff at the company using messages that impersonated journalists.

By Allan Eastman The photographs of water bombers fighting the horrendous Ft. McMurray conflagration of 2016 invoked a sudden wash of memories having to do with two of the great Canadian cultural institutions that I had the good fortune to be involved with and a bizarre set of circumstances that led from a burned out […]

Writer also said he has no plans for further episodes of 'Black Mirror'

The Kraftwerk co-founder remained a mystery even after death, but there is no doubting the impact he made with his group’s sublime, visionary music

• News: Florian Schneider, Kraftwerk co-founder, dies aged 73

Florian Schneider’s death came shrouded in a degree of secrecy. Gossip among fans about his health was first provoked at the end of April, when his fellow former Kraftwerk member Wolfgang Flür posted a sweet photo on social media of him and Schneider together in a bar, without explanation.

It had apparently been taken in 2016 – a decade and a half after Schneider and fellow founder member Ralf Hütter had served Flür with a lawsuit provoked by his autobiography I Was a Robot – and was subsequently deleted from Flür’s Facebook page. Then, a week later, another electronic musician based in Germany, the Manchester-born Mark Reeder, posted a brief eulogy; one commenter claimed that Schneider had died “several days ago”.

If only everyone was kinder we would all reap rewards

Since that moment – thanks to the work of groups like this one, and the dedication of passionate advocates like all of you – our nation has experienced remarkable, once-unimaginable progress.

The facility will be the companyâs second facility in Carlsbad specifically for its BioReliance viral and gene therapy service.

Presidential aspirant P A Sangma, who was also a former Speaker of the Lok Sabha, will be our guest at Idea Exchange on Friday, May 25. Send us your questions for him.

When it became clear in 2009 that Kim Jong Un was being groomed to be the leader of North Korea, Jung Pak was a new analyst at the Central Intelligence Agency. Her job was to analyze this then little-known young man who would take over a nuclear-armed country and keep the highest levels of the…

Pietro Nivola examines lessons from the War of 1812 and applies them to the political polarization of today.

This week marks Carnival of the Green #205, and it's being hosted by Pragmatic Environmentalism, a blog that explores urban sustainability. Thanks so much to Brenda Pike, who runs the site, for a last minute Carnival round-up. Through her blog, Brenda

Geothermal energy constantly gets overshadowed by other sources of clean energy, like wind and solar, because it's still more expensive. But with every passing year, it gets closer to its time in the spotlight.

Representational picture

California: A year after introducing the ability to send or request money on Android app, Gmail is finally extending its pay friends feature to its iOS users.

As part of the new update version 5.0.180422, iOS users will be able to send and request money from Gmail, Cnet reports.

In addition to that, iOS users will also be able to snooze emails. The feature makes the email disappear for a while and then show up later as a fresh email.

Catch up on all the latest Crime, National, International and Hatke news here. Also download the new mid-day Android and iOS apps to get latest updates

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As part of its redesigning spree, Google has provided a surprise makeover to its Drive.

The Google Drive now appears to take major inspiration from the recently redesigned Gmail app. There are no new features, but the appearance has been tweaked to match with other Google products.

To begin with, the Drive interface background has been changed from gray to white for a neater look. The boxes and icons have also been given rounded corners and a taller appearance than before, Engadget reports.

In addition to that, the Drive logo is now placed prominently on the top left corner of the interface. The icons have also been shuffled a bit.

The latest changes to Google Drive will start reflecting in some time as the company is gradually rolling out the redesign.

Irrfan's passing is a huge loss for the entire film fraternity, but I have lost a dear friend today. We were destined to be friends. I was 19 when I first met him at the National School of Drama, where I was a few years junior to him. Since then, Irrfan has played different roles in my life — sometimes he was a pal, other times, an elder brother. There were times when he would push me to work harder, like a mentor.

Not many know that he was a part of my first directorial venture in Mumbai — a show called Hum Bambai Nahin Jayenge for Business India TV (BITV). Shekhar Kapur was the creative head of the channel, and asked me to direct the show. I reached out to Irrfan, who had come to Mumbai four years before me, and that was the beginning [of our professional collaboration]. We worked on several serials for Star Bestsellers, and finally collaborated on Haasil (2003).

Tigmanshu Dhulia

He was a gentle human being who was so evolved in his ideas. He was an outdoor guy who expressed concern for the environment. In fact, he used to love flying kites. Whenever we needed time to prepare for a shot, we used to hand him a kite. He would happily indulge in it till we were ready. He was a charming, happy-go-lucky guy.

Over the last few months, we could not speak regularly because he had stopped using his cell phone. So, I would keep in touch with his wife Sutapa. I visited him at the hospital on Tuesday. He was unconscious but breathing; it was heart-wrenching to see him like that. Right now, I am numb; it will take time to process his loss. I will miss a friend with whom I could have any discussion without the fear of being judged. I will miss hearing his insightful views and taking his advice on matters.

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Renowned bass guitarist Matthew Seligman, who played with late music icon David Bowie at Live Aid in 1985, has died after a battle with Coronavirus. He was 64.

Seligman is best known for his role in the new wave scene in the 1980s. He was a member of The Soft Boys and The Thompson Twins, also collaborating with Thomas Dolby.

Dolby, 61, confirmed Seligman's death and said a candlelight vigil to remember the star would be held on YouTube live on April 19, reports dailymail.co.uk. "Matthew would want us to remember the good times and have a party," Dolby said.

Seligman had been battling COVID-19 for two weeks and had been on a ventilator at a hospital in London. He leaves behind son Deji, daughter Lily, and Mami, his partner, and Lily's mother. He was born in Cyprus and raised in England. The bassist first came to prominence as a founding member of Bruce Woolley and the Camera Club, and the psychedelic group The Soft Boys.

Seligman gained a reputation as a session musician and collaborated with Morrissey, Tori Amos, Sinead O'Connor, and David Bowie. He even played at Bowie's iconic 1985 performance at Live Aid to an audience of billions and also featured on his next two albums.

The Soft Boys member Robyn Hitchcock paid tribute to his former bandmate, saying: "Everybody goes, but none of us was expecting Matthew to leave us so abruptly, forever. I'm profoundly grateful to have played music with him - you could really see his face light up like a full moon when he listened back to a take he enjoyed."

"Onstage he would lope and lurch and pace when the music moved him. Matthew is, was, and always will be one of the greats, Hitchcock added.

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Poverty takes a toll on health in many ways. It often causes malnutrition and hunger, creates barriers to access basic resources, and can also impact

Drought in California has been in the headlines frequently these last three years, with startling pictures of empty reservoirs, rivers and canals, wildfires, disappearing snowpack and dry earth. Yet these dramatic effects have not stopped the agricultural sector from growing.

Lauren Greenfield’s documentary about the Philippines’ former First Lady is comic as well as horrific

Funding bodies face a choice between established manufacturers and biotech upstarts

It is easy to take advantage of frightened people who have accepted infringements on freedom