Having the right questions can make all the difference when getting to know a guy, whether you’re building a friendship or exploring a romantic connection. Conversations are more than just words; they’re opportunities to spark curiosity, foster understanding, and build meaningful bonds. This guide provides questions that help you move beyond small talk and create ... Read more

The post The Ultimate Guide to Questions to Ask a Guy: From Flirty to Deep appeared first on LifeHack.

Photo by Reed Naliboff  In a pivotal moment for reproductive rights in America, the Supreme Court has declined to intervene in the clash between federal emergency care law and Texas’ near-total abortion ban. This decision marks a significant setback for advocates of reproductive rights and has far-reaching implications, particularly for women of color in Texas. The […]

The post The Deepening Crisis: The Texas Abortion Ban and Its Far-Reaching Implications appeared first on Feminist Majority Foundation.

Imagine slipping into a tranquil space, the soft aroma of essential oils filling the air, as the world outside slowly fades away. For many, this is the sanctuary sought after a long week of work or dealing with chronic pain. In that moment, whether it’s the gentle caress of a Swedish massage or the deep ... Read more

The post Swedish vs. Deep Tissue – Which Massage Will Leave You More Bruised? appeared first on Star Two.

Life gets heavy. Between work, family, and scrolling through endless newsfeeds, people need an escape. But more than that, there’s a craving for something that fills up the heart and calms the mind. Creative outlets do just that, providing more than just a way to pass the time. Let’s get straight into why filling life ... Read more

The post Can Hobbies Save Your Mental Health ─ A Deep Dive into Creative Outlets appeared first on Star Two.

NASA scientists used a neural network called ExoMiner to examine data from Kepler, increasing the total tally of confirmed exoplanets in the universe.

Studies of quakes detected from the planet's surface found it in the planet's rocky outer crust.

McLaren's Lando Norris says title rival Max Verstappen "knows he did wrong" in their battle in last weekend's Mexico City Grand Prix.

Introduction India is a place full of diverse cultures and traditions that offers many fascinating experiences for curious travelers. One such experience that provides a unique glimpse into Indian culture is the classic card game Andar Bahar. With its simple yet engaging gameplay, Andar Bahar has been a beloved pastime across India for generations. For […]

    New workshop in London / remote Link - Enterprise AI workshop – Sep 2018 – in London or remote     AI / Deep Learning applications course/ mentoring program – hands-on experience with limited spaces I am pleased to announce a new course on AI Applications The course combines elements of teaching, coaching and [...]

Google DeepMind’s AlphaFold 3 is available to access by researchers around the world via open-source. Google DeepMind, the tech giant’s… Continue reading Google DeepMind opens AlphaFold 3 up to researchers worldwide

The post Google DeepMind opens AlphaFold 3 up to researchers worldwide appeared first on ReadWrite.

An underwater rover deployed by the Minderoo-UWA Deep-Sea Research Centre captured remarkable footage 3,300-meters down at the bottom of the Tonga Trench. It shows a rarely-seen bigfin squid (Magnapinna) "taking a walk" on its 13-foot tentacles. Watch below.

There have only been around 20 documented sightings of this beautifully bizarre creature in two decades. — Read the rest

The post Deep sea video of weird sea creature walking around on its 13-foot "legs" appeared first on Boing Boing.

The following article, Steve Bannon Issues 90-Second WARNING To Deep State At Trump Victory Party (Video), was first published on Conservative Firing Line.

(Natural News) Steve Bannon, one of Donald Trump’s most fired-up supporters and allies all throughout the former president’s tumultuous political career, delivered a powerful speech after Trump’s victory warning the deep state that justice is coming. Fresh out of federal prison for his involvement in the events of Jan. 6, 2021, Bannon took the stage to deliver …

Continue reading Steve Bannon Issues 90-Second WARNING To Deep State At Trump Victory Party (Video) ...

It was just a couple of weeks ago that the media was bragging about Kamala's HUGE fundraising haul.

The post YIKES: Kamala’s Failed Campaign Finished DEEP In Debt — Here’s The 411 appeared first on Clash Daily.

To a large extent, President-elect Donald Trump’s winning coalition came together around one absolute truth. In sum, Americans do not have a self-governing constitutional republic if we also have a […]

The post Trump Shares His 10-Step Plan to 'Shatter the Deep State' and It Will Give You Chills appeared first on The Western Journal.

Expert

Expert

A deep dive into loss and damage solutions 8 February 2022 — 1:00PM TO 2:15PM Anonymous (not verified) 31 January 2022 Online

This second event of our loss and damage series cuts through polarized debate by bringing together international experts to discuss innovative legal and financial approaches.

This event will focus on a deep dive into constructive solutions and progress made to address loss and damage.

Following the first event of this two-part series, ‘Loss and Damage – where are we now and what happens next’, this event focuses on a deep dive into constructive solutions and progress made to address loss and damage.

Loss and damage refers to harms and destruction caused by climate change impacts that cannot be avoided through mitigation or adaptation. While it has gained increasing recognition in international climate change negotiations, turning the concept of loss and damage into tangible action for climate-vulnerable countries has been contentious.

Loss and damage is interwoven with issues of fairness and equity. The issue is highly disputed due to its connection with the historical responsibility of developed countries in causing climate change, as well as associated calls for compensation from developing countries.

At COP26, Scotland became the first government to pledge funds for loss and damage for countries in the Global South. However, most climate-vulnerable countries left disappointed by the failure of the Glasgow Climate Pact to secure the establishment of a dedicated loss and damage financing facility.

Developing countries have made it clear that they will continue to push for a new financing facility in the Glasgow Dialogue, a set of international discussions on loss and damage kicking off in June. The Environment and Society Discussion Series is hosting two events on loss and damage ahead of that date.

This second event convenes a deep dive into the progress and potential on loss and damage solutions, while also examining the hurdles that are still to overcome to make loss and damage support a reality.

T. De Ryck and S. Mishra
Math. Comp. 93 (), 2643-2677.
Abstract, references and article information

In-depth coverage of proteomic analysis could enhance our understanding to the mechanism of the protein functions. Unfortunately, many highly hydrophobic proteins and low-abundance proteins, which play critical roles in signaling networks, are easily lost during sample preparation, mainly attributed to the fact that very few extractants can simultaneously satisfy the requirements on strong solubilizing ability to membrane proteins and good enzyme compatibility. Thus, it is urgent to screen out ideal extractant from the huge compound libraries in a fast and effective way. Herein, by investigating the interior mechanism of extractants on the membrane proteins solubilization and trypsin compatibility, a molecular dynamics simulation system was established as complement to the experimental procedure to narrow down the scope of candidates for proteomics analysis. The simulation data shows that the van der Waals interaction between cation group of ionic liquid and membrane protein is the dominant factor in determining protein solubilization. In combination with the experimental data, 1-dodecyl-3-methylimidazolium chloride (C12Im-Cl) is on the shortlist for the suitable candidates from comprehensive aspects. Inspired by the advantages of C12Im-Cl, an ionic liquid-based filter-aided sample preparation (i-FASP) method was developed. Using this strategy, over 3,300 proteins were confidently identified from 10³ HeLa cells (~100 ng proteins) in a single run, an improvement of 53% over the conventional FASP method. Then the i-FASP method was further successfully applied to the label-free relative quantitation of human liver cancer and para-carcinoma tissues with obviously improved accuracy, reproducibility and coverage than the commonly used urea-based FASP method. The above results demonstrated that the i-FASP method could be performed as a versatile tool for the in-depth coverage proteomic analysis of biological samples.

The U.S. Navy began its deep-sea search this week for the remains of an MH-60S Sea Hawk helicopter and the remains of five sailors who died after the aircraft crashed into waters off the San Diego coast on Aug. 31.

COLOGNE, Germany, Nov. 1, 2024 — DeepL has announced it will be among the first to commercially deploy the Nvidia DGX SuperPOD with DGX GB200 systems. The Nvidia DGX SuperPOD, […]

The post DeepL to Debut Nvidia DGX SuperPOD with DGX GB200 Systems in Europe appeared first on HPCwire.

Wisconsin's Ronnie Porter established a new scoring high and Serah Williams and Carter McCray posted double-doubles in win over Georgetown Sunday.

Umut Güçlü
Jul 8, 2015; 35:10005-10014
BehavioralSystemsCognitive

Systemic study of pathogenic pathways and interrelationships underlying genes associated with Alzheimer's disease (AD) facilitates the identification of new targets for effective treatments. Recently available large-scale multiomics datasets provide opportunities to use computational approaches for such studies. Here, we devised a novel disease gene identification (digID) computational framework that consists of a semi-supervised deep learning classifier to predict AD-associated genes and a protein–protein interaction (PPI) network-based analysis to prioritize the importance of these predicted genes in AD. digID predicted 1,529 AD-associated genes and revealed potentially new AD molecular mechanisms and therapeutic targets including GNAI1 and GNB1, two G-protein subunits that regulate cell signaling, and KNG1, an upstream modulator of CDC42 small G-protein signaling and mediator of inflammation and candidate coregulator of amyloid precursor protein (APP). Analysis of mRNA expression validated their dysregulation in AD brains but further revealed the significant spatial patterns in different brain regions as well as among different subregions of the frontal cortex and hippocampi. Super-resolution STochastic Optical Reconstruction Microscopy (STORM) further demonstrated their subcellular colocalization and molecular interactions with APP in a transgenic mouse model of both sexes with AD-like mutations. These studies support the predictions made by digID while highlighting the importance of concurrent biological validation of computationally identified gene clusters as potential new AD therapeutic targets.

Ruth Glacier’s Great Gorge is quite simply one of the continent’s most awe-inspiring sights. At 2,000 feet and over ten miles long, it’s one of the deepest canyons in the world.

This time-lapse video shows researchers collecting samples inside a South African gold mine. (by Gaetan Borgonie)

After five people perished on a controversial submersible dive to the wreckage of the Titanic in June, we got to thinking about what genuine undersea exploration looks like. In this episode, we speak with Tony Perrottet, who profiled the late OceanGate CEO Stockton Rush for Smithsonian magazine in 2019, about our ancient fascination with exploring hostile environments. Then we’re joined by Susan Casey, who has written four best-selling books about the ocean and its creatures, the newest of which is The Underworld: Journeys to the Depths of the Ocean. Susan tells us why understanding the ocean is key to humanity’s survival, and how, while serious research and shipwreck tourism may have some overlap, they remain two very different things. Read Tony Perrottet’s June 2019 (https://www.smithsonianmag.com/innovation/worlds-first-deep-diving-submarine-plans-tourists-see-titanic-180972179/) Smithsonian (https://www.smithsonianmag.com/innovation/worlds-first-deep-diving-submarine-plans-tourists-see-titanic-180972179/) profile (https://www.smithsonianmag.com/innovation/worlds-first-deep-diving-submarine-plans-tourists-see-titanic-180972179/) of Stockton Rush. Learn more about Tony and his work at his site (http://tonyperrottet.com/) . Read an excerpt from Susan Casey’s new book, The Underworld: Journeys to the Depths of the Ocean (https://www.smithsonianmag.com/science-nature/inside-the-nerve-racking-dive-to-an-active-submarine-volcano-180982687/) . Learn more about Susan and her work at her site (https://susancasey.com/) . There’s More to That is a production of Smithsonian magazine and PRX Productions. From the magazine, our team is Chris Klimek, Debra Rosenberg and Brian Wolly. From PRX, our team is Jessica Miller, Adriana Rosas Rivera, Genevieve Sponsler, Terence Bernardo, and Edwin Ochoa. The Executive Producer of PRX Productions is Jocelyn Gonzales. Episode artwork by Emily Lankiewicz (contains elements by Madelgarius (https://commons.wikimedia.org/wiki/File:Titan_(mod%C3%A9lisation_sketchup_-_twilight_render_-_Gimp).jpg) , via Wikimedia Commons under CC BY-SA 4.0) Music by APM Music.

What’s the world record for deepest vertical dig? Go ahead, take a guess. We bet you won’t come close to the surprising answer unearthed in this one-minute video by Ask Smithsonian host, Eric Schulze. Then, stick around to find out what scientists found lurking below.

The discovery of worms and snails confirms that these still-mysterious, dark hotspots of life extend beyond what’s visible above the crust

SolidWorks 3D mechanical design and COSMOS design analysis software play key roles in developing regulator that reached more than 1,000 feet deep

An OM worker and local team of believers visit indigenous Cabecar communities in the mountains of Talamanca, Costa Rica.

Dig into what two leading Democratic presidential candidates have to say in their platforms about charter schools with Education Week's detailed analysis.

Dig into what two leading Democratic presidential candidates have to say in their platforms about charter schools with Education Week's detailed analysis.

SA's financial regulator is investigating allegations that agents of online brokerage Banxso, whose licence has been suspended, contacted clients claiming it has been "cleared".

In a very special Steinhoff edition of SA Money Report, we examine the SA Reserve Bank’s recent surprise moves against former CEO Markus Jooste.

Indiana Jones and the Great Circle received a gameplay deep dive Monday that detailed more of the game’s combat, exploration and puzzles. Publisher Bethesda also shed more light on the premise of the story that sees Indy join the chase for a priceless stolen relic.

Google DeepMind has silently open-sourced its frontier artificial intelligence (AI) model that can predict the interaction between proteins and other molecules. Dubbed AlphaFold 3, the large language model is the successor of AlphaFold 2, whose research led to the creators of the large language model (LLM) Demis Hassabis and John Jumper getting the Nobel Prize in Chemistry in 2024.

Rohit Shetty shared that it was his conscious choice to not cast Ranveer and Deepika together in a scene, as it might have received backlash

Arshdeep Singh has batted at No. 8 for India in the T20I series against South Africa.

In early October, Deepinder Goyal shared a post showing various moments from their day as delivery agents

[Daily Maverick] Office of the Chief Justice reveals Constitutional Court has been unable to sit because of unreliable water supply. This article is free to read.Sign up for free or sign in to continue reading.Unlike our competitors, we don't force you to pay to read the news but we do need your email address to make your experience better.Create your free account or sign in FAQ | Contact Us Nearly there! Create a password to finish signing up with us: You want to receive First Thing, our flagship daily newsletter. Opt

[COSATU] The Congress of South African Trade Unions (COSATU) is deeply concerned by the Minister for Communications and Digital Technologies, Mr. S. Malatsi's sudden withdrawal of the South African Broadcasting Corporation (SABC) SOC Ltd Bill from Parliament where it was being engaged upon by the National Assembly's Portfolio Committee: Communications and Digital Technologies.

The Australian Government is proud to announce the upgrading of the Agreement Establishing the ASEAN-Australia-New Zealand Free Trade Area (AANZFTA).

FCMB Bank (UK) Limited, an independently incorporated subsidiary of First City Monument Bank Limited (which is a member of FCMB Group Plc), has introduced its Personal and Business banking proposition in London, United Kingdom and Lagos, Nigeria at an impressive ceremony attended by the top echelon of the business community within and from outside the […]

FCMB Bank (UK) Limited Launches Personal and Business Banking Proposition to Deepen Inclusiveness

We are currently seeing the worst refugee crisis since World War II, and developed countries are not doing nearly enough to help those in need.