Overcoming poor market depth and liquidity is crucial for Asia's capital markets to grow and remain attractive to investors. A coordinated approach addressing regulatory frameworks, market infrastructure, and risk management is essential for building resilient, diverse, and efficient markets.

Ancient volcanic rock from South Africa has been found to harbour primitive bacteria, which may shed light on some of the earliest forms of life on Earth

An oil company in China has started drilling a hole that would be the deepest in the country and among the deepest in the world

A drilling project in the Taklamakan desert is aiming to reach more than 11,000 metres below Earth’s surface as China explores the deep earth for resources

Companies are searching all over the world for deposits of geologic hydrogen that could be used as clean fuel, and a mine in Albania could give them clues about where to look

For decades, planetary scientists have been trying to understand the origins of two colossal geological anomalies inside our planet. New insights suggest they could be leftovers from a cosmic collision

Sea-floor nodules raise oxygen levels in the deep ocean, suggesting they may have a valuable role in ecosystems and adding to concerns about the impact of deep-sea mining

Title: 2002 Oil Spill May Shed Light on Health Problems for Deepwater Workers
Category: Health News
Created: 8/23/2010 8:10:00 PM
Last Editorial Review: 8/24/2010 12:00:00 AM

Title: Study: Aspirin Might Work Instead of Warfarin for Deep Vein Clots
Category: Health News
Created: 8/26/2014 12:35:00 PM
Last Editorial Review: 8/27/2014 12:00:00 AM

Title: Deep Brain Stimulation Safe for Older Parkinson's Patients: Study
Category: Health News
Created: 8/26/2014 12:35:00 PM
Last Editorial Review: 8/27/2014 12:00:00 AM

Title: Deepwater Horizon Oil Spill Cleanup Put Workers at Risk for Asthma
Category: Health News
Created: 8/22/2022 12:00:00 AM
Last Editorial Review: 8/22/2022 12:00:00 AM

BACKGROUND AND PURPOSE:

Intracranial vessel wall imaging is technically challenging to implement, given the simultaneous requirements of high spatial resolution, excellent blood and CSF signal suppression, and clinically acceptable gradient times. Herein, we present our preliminary findings on the evaluation of a deep learning–optimized sequence using T1-weighted imaging.

Although the progressive histologic steps leading to endometrial cancer (EndoCA), the most common female reproductive tract malignancy, from endometrial hyperplasia are well-established, the molecular changes accompanying this malignant transformation in a single patient have never been described. We had the unique opportunity to investigate the paired histologic and molecular features associated with the 12-yr development of EndoCA in a postmenopausal female who could not undergo hysterectomy and instead underwent progesterone treatment. Using a specially designed 58-gene next-generation sequencing panel, we analyzed a total of 10 sequential biopsy samples collected over this time frame. A total of eight pathogenic/likely pathogenic mutations in seven genes, APC, ARID1A, CTNNB1, CDKN2A, KRAS, PTEN, and TP53, were identified. A PTEN nonsense mutation p.W111* was present in all samples analyzed except histologically normal endometrium. Apart from this PTEN mutation, the only other recurrent mutation was KRAS G12D, which was present in six biopsy samplings, including histologically normal tissue obtained at the patient's first visit but not detectable in the cancer. The PTEN p.W111* mutant allele fractions were lowest in benign, inactive endometrial glands (0.7%), highest in adenocarcinoma (36.9%), and, notably, were always markedly reduced following progesterone treatment. To our knowledge, this report provides the first molecular characterization of EndoCA development in a single patient. A single PTEN mutation was present throughout the 12 years of cancer development. Importantly, and with potential significance toward medical and nonsurgical management of EndoCA, progesterone treatments were consistently noted to markedly decrease PTEN mutant allele fractions to precancerous levels.

Deepfakes can be close to indistinguishable from authentic video, and are now being used to perpetrate gender based abuse.

The post Deepfakes and gender based violence appeared first on rabble.ca.

ublisher Bethesda Softworks and developer MachineGames have released a gameplay deep dive video for Indiana Jones and the Great Circle that is nearly 15 minutes in length.

"From locations and puzzles to gear and combat, MachineGames Audio Director, Pete Ward, takes us on a whirlwind journey through the world of The Great Circle," reads the description to the video. "Get ready for launch with this look at Indy’s grand adventure."

View the gameplay deep dive below:

Indiana Jones and the Great Circle will launch for the Xbox Series X|S, PC via Steam and Microsoft Store, and Xbox Game Pass on December 9.

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463033/indiana-jones-and-the-great-circle-gets-gameplay-deep-dive/

Some extremely fresh vintage workwear that I bought for entirely practical reasons aside, I’m not exactly a fashion person. I have nobody to impress most days but my cat, and the only item of clothing she appears to have an opinion on is my Oodie, which is very comfortable for both of us and also smells like a chicken shop, which I imagine is more pleasant for her than me.

This aside, I found myself taking a whole bunch of Dragon Age: The Veilguard screenshots as I played just to capture the RPG’s various outfits. They are ridiculous. Incredibly intricate and detailed, as well as being obscenely impractical for the most part. I do not like any of them in the sense I would wear them, but I like all of them in the sense that they display artists allowed to run free like caffeinated weasels and indulge their every whim.

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Let’s try and get you up to speed on the fascinating oddity that is simulation game Ecosystem, on the off chance that Nate's coverage of it hasn't stuck with you like an unwelcome brain parasite you’re nonetheless unwilling to get removed for fear of the lingering emptiness it might cause (he once described an eel as “a quaver with erectile dysfunction”). Broadly speaking, this game is Spore’s evolutionary-biology-degree-having cousin. It’s been in early access for about three years now, but with the latest "Crustacean" update, it’s just hit 1.0. Once again, carcinization has come for all things.

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A faint glow from all of the galaxies that have ever existed fills the cosmos, and NASA's New Horizons spacecraft has made the best measurement ever of just how faint it is

AlphaProof, an AI from Google DeepMind, came close to matching the top participants in a prestigious competition for young mathematicians

It can be difficult to spot AI generated videos known as deepfakes, but there are ways to spot one if you know what to look for

Experiments show that viewers can usually identify video deepfakes of famous politicians – but fake audio and text are harder to detect

Tigerair has again cancelled flights in and out of Denpasar, and there is no sign of the dispute being resolved.

Scientists have found a new building block of life deep in the cold darkness of interstellar space.

As our submersible descended, the waters grew darker around us. Looming teeth, some as long as a man’s leg, skirted the edge of our floodlights. The captain was sure this area held caves filled with golden bounty, but to those creatures of the deep it was our flesh and blood that were the true prizes… […]

Samples from the asteroid Ryugu contain key ingredients in the biological cookbook.

"You’ve taken this idea way too far," a mentor told Prof. Fei-Fei Li.

‘Singham Again’ had an ensemble cast which includes Ajay Devgn, Akshay Kumar, Ranveer Singh, Tiger Shroff, Kareena Kapoor Khan, Deepika Padukone, Arjun Kapoor and Jackie Shroff

Canadians are watching the U.S. election results with trepidation, knowing they have no control over the outcome that will still affect them. Polling shows Vice-President Kamala Harris and former president Donald Trump are neck-and-neck. 

Recently-released dolls tied to the new Wicked movie inadvertently carry the address of an adult website.

A heart attack unleashes immune cells that stimulate neurons in the brain, leading to restorative slumber

For people with diabetes, glucose monitors are a valuable tool to monitor their blood sugar. The current generation of these biosensors detect glucose levels with thin, metallic filaments inserted in subcutaneous tissue, the deepest layer of the skin where most body fat is stored.

Medical technology company Biolinq is developing a new type of glucose sensor that doesn’t go deeper than the dermis, the middle layer of skin that sits above the subcutaneous tissue. The company’s “intradermal” biosensors take advantage of metabolic activity in shallower layers of skin, using an array of electrochemical microsensors to measure glucose—and other chemicals in the body—just beneath the skin’s surface.

Biolinq just concluded a pivotal clinical trial earlier this month, according to CEO Rich Yang, and the company plans to submit the device to the U.S. Food and Drug Administration for approval at the end of the year. In April, Biolinq received US $58 million in funding to support the completion of its clinical trials and subsequent submission to the FDA.

Biolinq’s glucose sensor is “the world’s first intradermal sensor that is completely autonomous,” Yang says. While other glucose monitors require a smartphone or other reader to collect and display the data, Biolinq’s includes an LED display to show when the user’s glucose is within a healthy range (indicated by a blue light) or above that range (yellow light). “We’re providing real-time feedback for people who otherwise could not see or feel their symptoms,” Yang says. (In addition to this real-time feedback, the user can also load long-term data onto a smartphone by placing it next to the sensor, like Abbott’s FreeStyle Libre, another glucose monitor.)

More than 2,000 microsensor components are etched onto each 200-millimeter silicon wafer used to manufacture the biosensors.Biolinq

Biolinq’s hope is that its approach could lead to sustainable changes in behavior on the part of the individual using the sensor. The device is intentionally placed on the upper forearm to be in plain sight, so users can receive immediate feedback without manually checking a reader. “If you drink a glass of orange juice or soda, you’ll see this go from blue to yellow,” Yang explains. That could help users better understand how their actions—such as drinking a sugary beverage—change their blood sugar and take steps to reduce that effect.

Biolinq’s device consists of an array of microneedles etched onto a silicon wafer using semiconductor manufacturing. (Other glucose sensors’ filaments are inserted with an introducer needle.) Each chip has a small 2-millimeter by 2-millimeter footprint and contains seven independent microneedles, which are coated with membranes through a process similar to electroplating in jewelry making. One challenge the industry has faced is ensuring that microsensors do not break at this small scale. The key engineering insight Biolinq introduced, Yang says, was using semiconductor manufacturing to build the biosensors. Importantly, he says, silicon “is harder than titanium and steel at this scale.”

Miniaturization allows for sensing closer to the surface of the skin, where there is a high level of metabolic activity. That makes the shallow depth ideal for monitoring glucose, as well as other important biomarkers, Yang says. Due to this versatility, combined with the use of a sensor array, the device in development can also monitor lactate, an important indicator of muscle fatigue. With the addition of a third data point, ketones (which are produced when the body burns fat), Biolinq aims to “essentially have a metabolic panel on one chip,” Yang says.

Using an array of sensors also creates redundancy, improving the reliability of the device if one sensor fails or becomes less accurate. Glucose monitors tend to drift over the course of wear, but with multiple sensors, Yang says that drift can be better managed.

One downside to the autonomous display is the drain on battery life, Yang says. The battery life limits the biosensor’s wear time to 5 days in the first-generation device. Biolinq aims to extend that to 10 days of continuous wear in its second generation, which is currently in development, by using a custom chip optimized for low-power consumption rather than off-the-shelf components.

The company has collected nearly 1 million hours of human performance data, along with comparators including commercial glucose monitors and venous blood samples, Yang says. Biolinq aims to gain FDA approval first for use in people with type 2 diabetes not using insulin and later expand to other medical indications.

This article appears in the August 2024 print issue as “Glucose Monitor Takes Page From Chipmaking.”

SINGAPORE – The police are investigating deepfake nude photos of Singapore Sports School (SSP) students that were created and spread by other students. In response to queries from The Straits Times, school principal Ong Kim Soon said SSP is “aware of the incident involving the creation and sharing of deepfake photos by our student-athletes”. “The school does not condone such harmful behaviour,” he said, adding that it has launched an investigation and lodged a police report. The police, in response to queries from ST, confirmed that a report was lodged and investigations are ongoing. A reader who identified himself as a parent of a victim had alerted ST in an e-mail on Nov 12 about the deepfake nude images that were being circulated. “Many parents of affected female students in Singapore Sports School are making police reports about deepfake nude photos of their daughters generated by male students from the school,” the parent said. When contacted, the parent said that female teachers were also targeted, and that the school has offered affected students counselling.

Jun 10, 2024

As India concluded the world’s largest election on June 5, 2024, with over 640 million votes counted, observers could assess how the various parties and factions used artificial intelligence technologies – and what lessons that holds for the rest of the world.

May 14, 2024

In a semester-long series, HKS Professor Tarek Masoud interviewed Middle East scholars and policymakers—from a Trump administration strategist to Palestinian intellectuals—on their vastly different views on the war.

These students think they are boarding an ordinary school bus, but when they depart, a virtual reality experience �transports� them to the surface of Mars.

Hennessy V.S new ad creative celebrates the true story of Auguste Piccard, the first man to reach the stratosphere, and his son Jacques, the first man to reach the deepest depths of the ocean.

Компания Google DeepMind опубликовала исходные тексты системы машинного обучения AlphaFold 3, предназначенной для предсказания трёхмерной структуры белков и моделирования взаимодействия белков с другими типами молекул. За создание алгоритмов машинного обучения, реализованных во второй версии AlphaFold, в этом году присуждена Нобелевская премия по химии. Связанный с AlphaFold 3 инструментарий написан на Python и C++, и распространяется под лицензией CC BY-NC-SA 4.0. Натренированные модели предоставляются на основе пользовательского соглашения. Отдельно запущен сервер, позволяющий экспериментировать с AlphaFold 3 в online-режиме.

Hey y’all. Here’s a relaxing image! I need that hammock plus some pillows, a blanket, and noise cancelling everything. Today feels like being up to my neck in icy maple syrup: unpleasant and I can’t move very quickly. And in a moment of complete hilarity, I scheduled my annual physical for today. Wonder what my blood pressure will be like? (I think I can hear my blood pressure medication doing pushups in the other room, … Continue reading Deep Breaths. Fuzzy Things. →

Campaigner Kate Isaacs describes the horror of seeing her face digitally edited into an adult film.

The medlinkdengue/medlink outbreak in West Bengal has escalated significantly, surpassing 50,000 reported cases. While the health department hasn't

A recent investigation by The BMJ revealed that scammers are increasingly using deepfakes to impersonate well-known UK television doctors in order to promote bogus health products on social media.

State, National Long Term Care Leaders to Warn of Growing Threat to Washington Seniors' Care in Wake of Legislative Sess

The identity of the confusion and self-perception is always super heroes face a common problem. Because he has super powers; he was not an ordinary man. As Superman series of important works, Man of Steel elaborates further on these...

Legendary leg-spinner Anil Kumble has expressed his wish for Yash Dayal, Vyshak Vijaykumar, and Ramandeep Singh to get a chance to play for India

Deepika Padukone spotted in Barbie Girl avatar at MAMI.

Deepika Padukone plays the role of an acid attack survivor Laxmi Agarwal in Chhapaak.

Salman Khan, Sudeep, Prabhudeva and other members from Dabangg 3 were in Chennai on Monday, 16 December, to promote the movie.