The National Museum of Bermuda [NMB] is launching a new online programme “At Home with History” in an effort to stay connected during these challenging times. A spokesperson said, “The National Museum of Bermuda [NMB] is launching a new online programme in an effort to stay connected during these challenging times. “At Home with History” […] (Click to read the full article)

BELCO announced that its head office on Serpentine Road will be open Monday to Friday from 8.30am to 3.00pm for bill payments, and their bill deferment programme is still in effect. A spokesperson said, “Bermuda Electric Light Company Limited [BELCO] today announced that its head office at 27 Serpentine Road will be open Monday to Friday […] (Click to read the full article)

The Department of Community Affairs and the Bermuda Arts Council donated a combined $6,500 to the Eddie Ming Drum School and Rhythm Lab. The funds will aid in the hosting of an upcoming student workshop, which features Cuban guest percussionist Angel Luis. Minister Foggo, Eddie Ming and Angel Luis at the Ministry of Labour, Community […] (Click to read the full article)

Jugglin Jason is set to host his popular radio program “The Office Workout” on The Full 100 Radio which will air Fridays from 10am to 3pm. A spokesperson said, “The Full 100 Radio is pleased to welcome its first live DJ, Bermuda’s own Jugglin Jason, to the family with his popular radio program the ‘Office […] (Click to read the full article)

[Written by Warwick Academy student An Mei Daniels] My school, Warwick Academy, is now several days into its programme of remote learning, which commenced on Friday 20th March in response to school closures due to the Covid-19 virus. In the days leading up to the school closure, teachers immediately started training so that the remote […] (Click to read the full article)

The Bermuda National Gallery [BNG] Youth Arts Council recently launched a free digital program aimed at providing “opportunities for creative and independent thinking through an exchange of ideas and art education.” A spokesperson said, “The Bermuda National Gallery Youth Arts Council, aimed at students aged 14-17, produces art activities relevant to the teens of today. […] (Click to read the full article)

Rego Sotheby’s International Realty Bermuda shared the successful completion of their Summer Internship Program by Bermudian university undergraduates Hayley Ball, attending Trent University in Canada, and Georgia Rego, who is attending Elon University in North Carolina. During their internship, both students were able to enjoy industry specific training for multiple disciplines of real estate at […] (Click to read the full article)

While the teams sailed at the America’s Cup, young sailors also hit the water as part of the America’s Cup Endeavour Program. America’s Cup Endeavour, a youth education and community sailing initiative, allowed hundreds of young students to learn to sail in both the west end and the east end. In addition to sailing, students were also […] (Click to read the full article)

Is your organization aiming to increase the participation of minority-and women-owned businesses in state and local transportation projects? TRB will conduct a webinar on Wednesday, May 27, 2020, from 2:00 PM to 3:30 PM Eastern to discuss how to meet the goals set by the U.S. Department of Transportation Disadvantaged Business Enterprise (USDOT DBE). State and local transportation projects that receive federal funding are mandated to go through the triennial DBE goal-setting process. Make your next goals...

The Bermuda Tourism Authority [BTA] reminds local entrepreneurs that the deadline for applications to its Experience Investment Programme is on Tuesday, March 31st. A spokesperson said, “Despite Covid-19 uncertainty, the Bermuda Tourism Authority [BTA] is reminding local entrepreneurs the deadline for applications to its Experience Investment Programme closes a week today, Tuesday, March 31. “The […] (Click to read the full article)

A report from the Office of the Inspector General at the U.S. Department of Transportation

Airports and the communities they serve view robust air service as an important element for economic well-being and overall quality of life. Incentive programs are often used to encourage airlines to maintain or augment service to a community. Recent airline industry trends, including airline consolidation, use of larger aircraft, the rise of ultra-low-cost airlines, and challenges with pilot supply as well as regulatory and policy developments, have affected the significance of these programs. The TRB A...

Chicago high school junior Jessica Tansey was concerned about her classmates whose families would struggle with food insecurity during the school closure for COVID-19. At the same time, she was concerned about the restaurants in her neighborhood and the negative effect the COVID-19 shutdowns were having on them. She came up with and launched a campaign called “A Meal Today, A Meal Tomorrow” to help with both community issues.

It works by a customer buying one gift card at a nearby restaurant, and the restaurant agreeing to donate a second gift card to Tansey’s high school, which is then given to a school family in need. While some of the larger restaurant chains are able to commit to matching gift cards dollar-for-dollar, many smaller restaurants are donating gift cards worth a percentage of the one purchased to help out. Tansey said, “If we can connect restaurants and students with one solution, maybe it can make a difference for everybody. I want to get all of us thinking about how to bring communities together to support each other during rough times.”

UC San Diego Health launches pilot project using drones to move medical samples, supplies and documents between Jacobs Medical Center, Moores Cancer Center and the Center for Advanced Laboratory Medicine, speeding delivery of services and patient care currently managed through ground transport.

IL-17–producing RORγt+ γδ T cells (γδT17 cells) are innate lymphocytes that participate in type 3 immune responses during infection and inflammation. Herein, we show that γδT17 cells rapidly proliferate within neonatal lymph nodes and gut, where, upon entry, they upregulate T-bet and coexpress IL-17, IL-22, and IFN-γ in a STAT3- and retinoic acid–dependent manner. Neonatal expansion was halted in mice conditionally deficient in STAT5, and its loss resulted in γδT17 cell depletion from all adult organs. Hyperactive STAT5 mutant mice showed that the STAT5A homolog had a dominant role over STAT5B in promoting γδT17 cell expansion and downregulating gut-associated T-bet. In contrast, STAT5B preferentially expanded IFN-γ–producing γδ populations, implying a previously unknown differential role of STAT5 gene products in lymphocyte lineage regulation. Importantly, mice lacking γδT17 cells as a result of STAT5 deficiency displayed a profound resistance to experimental autoimmune encephalomyelitis. Our data identify that the neonatal microenvironment in combination with STAT5 is critical for post-thymic γδT17 development and tissue-specific imprinting, which is essential for infection and autoimmunity.

Facioscapulohumeral muscular dystrophy (FSHD) results from expression of the full-length double homeobox 4 (DUX4-FL) retrogene in skeletal muscle. However, even in cases of severe FSHD the presence of DUX4 is barely detectable. In this issue of the JCI, Bosnakovski et al. used an inducible, muscle-specific human DUX4 to reproduce the low-level, sporadic DUX4 expression of human FSHD muscle as well the myopathology seen in human FSHD disease. Notably, dysregulated fibroadipogenic progenitors accumulated in affected muscles, thus providing a mechanism for the replacement of muscle by fibrosis and fat.

The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing worldwide. Although gene-environment interactions have been implicated in the etiology of several disorders, the impact of paternal and/or maternal metabolic syndrome on the clinical phenotypes of offspring and the underlying genetic and epigenetic contributors of NAFLD have not been fully explored. To this end, we used the liver-specific insulin receptor knockout (LIRKO) mouse, a unique nondietary model manifesting 3 hallmarks that confer high risk for the development of NAFLD: hyperglycemia, insulin resistance, and dyslipidemia. We report that parental metabolic syndrome epigenetically reprograms members of the TGF-β family, including neuronal regeneration–related protein (NREP) and growth differentiation factor 15 (GDF15). NREP and GDF15 modulate the expression of several genes involved in the regulation of hepatic lipid metabolism. In particular, NREP downregulation increases the protein abundance of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) and ATP-citrate lyase (ACLY) in a TGF-β receptor/PI3K/protein kinase B–dependent manner, to regulate hepatic acetyl-CoA and cholesterol synthesis. Reduced hepatic expression of NREP in patients with NAFLD and substantial correlations between low serum NREP levels and the presence of steatosis and nonalcoholic steatohepatitis highlight the clinical translational relevance of our findings in the context of recent preclinical trials implicating ACLY in NAFLD progression.

The mechanisms by which prostate cancer shifts from an indolent castration-sensitive phenotype to lethal castration-resistant prostate cancer (CRPC) are poorly understood. Identification of clinically relevant genetic alterations leading to CRPC may reveal potential vulnerabilities for cancer therapy. Here we find that CUB domain-containing protein 1 (CDCP1), a transmembrane protein that acts as a substrate for SRC family kinases (SFKs), is overexpressed in a subset of CRPC. Notably, CDCP1 cooperates with the loss of the tumor suppressor gene PTEN to promote the emergence of metastatic prostate cancer. Mechanistically, we find that androgens suppress CDCP1 expression and that androgen deprivation in combination with loss of PTEN promotes the upregulation of CDCP1 and the subsequent activation of the SRC/MAPK pathway. Moreover, we demonstrate that anti-CDCP1 immunoliposomes (anti–CDCP1 ILs) loaded with chemotherapy suppress prostate cancer growth when administered in combination with enzalutamide. Thus, our study identifies CDCP1 as a powerful driver of prostate cancer progression and uncovers different potential therapeutic strategies for the treatment of metastatic prostate tumors.

Cornel West and Tavis Smiley criticize President Barack Obama for being to the right of even President Richard Nixon. Continue reading →

Bernie Sanders would have already won this nominating contest if we had received an accurate accounting of the vote. It is deeply troubling the Senator would be sending out surrogates to talk about his allegiance to the Democratic party and Clinton in general in the face of the Party instituting theft against its own constituents. It is no mystery HOW to win. Count the votes and contest fraud. A tough Sane Progressive call out. Continue reading →

Bernie Sanders and Jane Sanders are mere actors serving as pressure valves which release from time to time all excess heat emanating from failed policies, scandals, and the worsening economic conditions, so that a catastrophic systems’ collapse can be prevented. They are sheepdogs for Hillary Clinton, preventing progressives from supporting a third party progressive candidate and to herd them back into the corral of the Democratic Party. Continue reading →

Grow a spine. Bernie Sanders, when are you going to risk losing your friendship with the Democrats to help your country? When are you going to risk doing that? You had a stupid secret agreement not to attack Hillary Clinton, and you stayed by it, and then when the country needed you to do something with your movement, you told them to go work for the Machine. And now you're telling them to back Chuck Schumer. Continue reading →

Bernie Sanders' voting record is not progressive. It has been reported on Facebook that Bernie has voted 98% of the time in agreement with Senate Democrats and 93% of the time in agreement with Hillary Clinton. And here is Bernie Sanders' illustrious "progressive" voting record...LOL. Show this to all his crazed cult followers who claim he is a progressive and has done so much for us...LOL. Continue reading →

IBM Watson Health and Tiatros Inc, a digital health company, today announced that the Tiatros-enabled post-traumatic stress disorder programs achieved up to 73% completion rate for veterans who begin the PTSD sessions. The Tiatros Post Traumatic Growth for Veterans is a Tiatros psychotherapy program designed as a secure social network to support veterans suffering from post-traumatic stress disorder. The program connects veterans with their peers online, in a platform that is designed to reduce barriers to access and deliver evidence-based cognitive behavioral therapy that is personalized to each individual, with help from Watson APIs.

La enfermedad de Parkinson es un trastorno neurológico degenerativo crónico que afecta a una de cada 100 personas mayores de 60 años. Se estima que más de 5 millones de personas en el mundo tienen Parkinson y el número está aumentando con la población actual que envejece.

Después de un mes de haber iniciado la consultoría pro-bono de IBM, denominada Corporate Service Corps (CSC), el día de hoy se hizo entrega de los resúmenes ejecutivos a cada uno de los Directores de las organizaciones receptoras de este apoyo: DIF-Dirección de Innovación Guadalajara, Cuerpos de Paz-AIPROMADES, Asociación Nacional de Bancos de Alimentos (BAMX).

Vodafone New Zealand, a leading telecommunications services provider, and IBM (NYSE: IBM) today announced a partnership to deliver the Digital Vodafone 2021 program in New Zealand. The vision for Digital Vodafone 2021 is to create the most engaging digital customer experience by adopting agile as a way of working, embracing new technologies and simplifying business models. The program is supported by IBM iX, one of the world’s largest digital agencies and global business design partners.

Zoo and Aquarium Association Uses IBM Technology to Support Endangered Species Programme

Hello! Everyone who is waiting for the print release of Chapter 2, here is a progress report! The Deimos mini-smut-comic is finished, which is great, and I'm now in the middle of working on the Cain and Abel mini-smut-comic… which I have been waiting FOREVER to do! I'm so glad to get my black claws into this. So hold tight, my sweethearts, these goodies are on their way to you! I'll make more announcements as things develop!

Thank you so much for your patience! -Hamlet

The last data has been sent out, but our work on Nebula - the final phase of data analysis - is picking up steam. However, not all ideas are good ideas. Read about Multiplet scoring: back to the drawing board.

Preventivní opatření proti nákaze covid-19 zasáhla jak firmy všech velikostí, tak živnostníky. Jenže právě osoby samostatně výdělečně činné patří podle vlády ke skupinám, které krize vyvolaná pandemií nejvíce ohrozí. Zejména pak ty, kteří mají živnost jako hlavní zdroj příjmů a nemají ji jako přivýdělek k zaměstnání. Jak je stát podpoří?

I have finally obtained the first batch of the printed "Programming Algorithms" books and will shortly be sending them to the 13 people who asked for a hardcopy.

Here is a short video showing the book "in action":

If you also want to get a copy, here's how you do it:

1. Send the money to my PayPal account: $30 if you want normal shipping or $35 if you want a tracking number. (The details on shipping are below).
2. Shoot me an email to vseloved@gmail.com with your postal address.
3. Once I see the donation, I'll go to the post office and send you the book.
4. Optionaly step: if you want it to be signed, please, indicate it in your letter.

Shipping details: As I said originally, the price of the dead-tree version will be $20+shipping. I'll ship via the Ukrainian national post. You can do the fee calculation online here (book weight is 0.58 kg, size is 23 x 17 x 2 cm): https://calc.ukrposhta.ua/international-calculator. Alas, the interface is only in Ukrainian. According to the examples I've tried, the cost will be approximately $10-15. To make it easier, I've just settled on $10 shipping without a tracking number of $15 if you want a tracking number. Regardless of your country. I don't know how long it will take - probably depends on the location (I'll try to inquire when sending).

The book was already downloaded more than 1170 times (I'm not putting the exact number here as it's constantly growing little by little). I wish I knew how many people have, actually, read it in full or in part. I've also received some error corrections (special thanks goes to Serge Kruk), several small reviews and letters of encouragement. Those were very valuable and I hope to see more :)

Greetings from the far away city of Lima, Peru!
I loved this part: "Only losers don't comment their code, and comments will be used extensively"
Thank you so much for putting this comprehensive collection of highly important data structures, i'm already recommending this to two of my developers, which I hope i'll induce into my Lisp addiction.
--Flavio Egoavil

And here's another one:

Massively impressive book you've written! I've been a Lisp programmer for a long time and truly appreciate the work put in here. Making Lisp accessible for more people in relation to practical algorithms is very hard to do. But you truly made it. You'll definitely end up in the gallery of great and modern Lisp contributions like "Land of Lisp" and "Let Over Lambda". Totally agree with your path to focus on practical algorithmic thinking with Lisp and not messing it up with macros, oop and other advanced concepts.
--Lars Hård

Thanks guys, it's really appreciated!

If you feel the same or you've liked the book in some respect and have found it useful, please, continue to share news about it: that definitely helps attract more readers. And my main goal is to make it as widely read as possible...

If your referral marketing program is not bringing in the desired results, then you’re probably not doing it right. A well-oiled referral marketing program can ...

The post 13 Reliable Tips to Take Your Referral Marketing Program to the Next Level appeared first on Saleschase Stories.

Yep, it on!

Let's talk about Blockchain. Goal is to use this forum topic to highlight its usefulness to programming language theory and practice. If you're familiar with existing research efforts, please share them here. In addition, feel free to generate ideas for how Blockchain could improve languages and developer productivity.

As one tasty example: Blockchain helps to formalize thinking about mutual knowledge and common knowledge, and potentially think about sharing intergalactic computing power through vast distributed computing fabrics. If we can design contracts in such a way that maximizes the usage of mutual knowledge while minimizing common knowledge to situations where you have to "prove your collateral", third-party transactions could eliminate a lot of back office burden. But, there might be benefits in other areas of computer science from such research, as well.

Some language researchers, like Mark S. Miller, have always dreamed of Agoric and the Decades-Long Quest for Secure Smart Contracts.

Some may also be aware that verification of smart contracts is an important research area, because of the notorious theft of purse via logic bug in an Ethereum smart contract.

MSI komt met inruilprogramma voor upgrade naar Z490-moederbord  Hardware InfoHele verhaal bekijken via Google Nieuws

‘Sentiment mining’ – i.e. trying to gauge the Public’s attitude towards an institution, product, firm (etc. etc.) though automatic analysis of Social Media posts (etc. etc.) is now considered an essential tool for market researchers and ‘reputation managers’. But there are problems. One of which is sarcasm. Given its prevalence, serious errors can be introduced […]

I’m pretty excited to get back to stitching this morning! I love developing an embroidery project and seeing how my …

Sarah Mitchell Programme Director for the Active and Independent Living Improvement Programme and Susan Kelso AHP Lead for Early Intervention (Scottish Government) spoke to Iriss.fm about the programme and the LifeCurve Survey.

The Active and Independent Living Improvement Programme (AILIP) was officially launched on April 26th by Shona Robison MSP, Cabinet Secretary for Health and Sport. The vision for Scotland as outlined in the Health and Social care Delivery Plan is to have a Scotland with high quality services that have a focus on prevention, early intervention and supported self management.

The AILIP will be a key contributor to delivering that vision.

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Music Credit: Something Elated by Broke For Free

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NFPA's 2017 Conference & Expo features presentations informed by research and practice and reflect thought leadership in the field. Sessions address new areas this year such as: effective and efficient enforcement, building electrical safety

The short answer: everyone.     Hot work is one of the leading causes of industrial fire. According to the NFPA report Structure Fires Started by Hot Work - September 2016, U.S. fire departments responded to an average of 4,440

This evaluation report is based on feedback from people living with dementia and carers who received an Individual Award from the Life Changes Trust. The Individual Awards Pilot Scheme was run in Argyll & Bute and Edinburgh in 2014-15 and aimed to provide a small amount of additional financial empowerment to a number of individuals whose lives have been affected by dementia, to help improve their well-being and quality of life. A secondary aim of the pilot scheme was to find out what people would spend the Award on when given relatively broad choice, and what benefit that might bring in the short and medium terms.

Systematic review produced by the EPPI-Centre in 2015.This systematic review aimed to evaluate the effect of HAART and ARV monotherapy on liver disease progression and liver-related mortality in individuals co-infected with HIV and hepatitis C, including in patients with haemophilia.

In 2006 Mencap produced a comprehensive review of short break provision. Now, 10 years on, they are revisiting the support available for family carers to see whether recent policy initiatives and investment have delivered the much-needed change. A total of 264 family carers responded to their survey on short breaks provision and experiences of caring. They also sent Freedom of Information requests to all 152 local authorities in England that provide social care services. This report looks at short breaks provision in a climate of cuts to central and local government budgets. It examines the extent to which these cuts have impacted on the lives of people with a learning disability and their family carers. It also looks at the state of affairs for family carers of children and young people across the full spectrum of learning disability; from people with mild and moderate learning disabilities, to people with severe and profound disabilities.

MSI has announced an upgrade program if you are going to be purchasing one of their upcoming Z490 motherboards. This program is valid on motherboards purchased May 6th through June 15th.

The post MSI Announces Upgrade Program for Z490 Motherboards appeared first on ThinkComputers.org.

Have you tried the conventional route to building your Vemma Nutrition Program already? Friends and family? Three foot rule? Business cards? Shopping malls? Lets face it the list goes on. If you truly want to generate more leads than you can handle, or what I call an abundance of leads for your Vemma Nutrition Program then you need to listen very closely and take notes I am going to expose 3 big mistakes you are making.