Background:

The impact of light-intensity physical activity (LPA) in preventing cancer mortality has been questioned. To address this concern, the present meta-analysis aimed to quantify the association between objectively-measured LPA and risk of cancer mortality.

Background:

Research on the relationship of meat, fish, and egg consumption and mortality among prostate cancer survivors is limited.

Background:

The recent expansion of treatment options in acute myeloid leukemia (AML) has necessitated a greater understanding of patient preferences for treatment benefits, about which little is known.

Although ample evidence indicates that immune cell homeostasis is an important prognostic outcome determinant in patients with cancer, few studies have examined whether it also determines cancer risk among initially healthy individuals. We performed a case–cohort study including incident cases of breast (n = 207), colorectal (n = 111), lung (n = 70), and prostate (n = 201) cancer as well as a subcohort (n = 465) within the European Prospective Investigation into Cancer and Nutrition-Heidelberg cohort. Relative counts of neutrophils, monocytes, and lymphocyte sublineages were measured by qRT-PCR. HRs and 95% confidence intervals were used to measure the associations between relative counts of immune cell and cancer risks. When relative counts of immune cell types were taken individually, a significant positive association was observed between relative counts of FOXP3+ regulatory T cells (Tregs) and lung cancer risk, and significant inverse associations were observed between relative CD8+ counts and risks of lung and breast cancer (overall and ER+ subtype). Multivariable models with mutual adjustments across immune markers showed further significant positive associations between higher relative FOXP3+ T-cell counts and increased risks of colorectal and breast cancer (overall and ER− subtype). No associations were found between immune cell composition and prostate cancer risk. These results affirm the relevance of elevated FOXP3+ Tregs and lower levels of cytotoxic (CD8+) T cells as risk factors for tumor development.Significance:This epidemiologic study supports a role for both regulatory and cytotoxic T cells in determining cancer risk among healthy individuals.See related commentary by Song and Tworoger, p. 1801

BACKGROUND AND PURPOSE:

Diffuse intrinsic pontine glioma is a lethal childhood brain cancer with dismal prognosis and MR imaging is the primary methodology used for diagnosis and monitoring. Our aim was to determine whether advanced diffusion, perfusion, and permeability MR imaging metrics predict survival and pseudoprogression in children with newly diagnosed diffuse intrinsic pontine glioma.

BACKGROUND AND PURPOSE:

Anoxic brain injury is a result of prolonged hypoxia. We sought to describe the nonquantitative arterial spin-labeling perfusion imaging patterns of anoxic brain injury, characterize the relationship of arterial spin-labeling and DWI, and evaluate the normalized diffusion-to-perfusion ratio to differentiate patients with anoxic brain injury from healthy controls.

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Grand Theft Auto V has once again taken the top spot on the EMEAA charts for week 17, 2020. XCOM: Chimera Squad is in second place, Call of Duty: Modern Warfare is in third, Alien: Isolation is in fourth, and Animal Crossing: New Horizons rounds out the top five.

Here are the top 5 best-selling titles (combined physical and digital sales) in EMEAA:

1. Grand Theft Auto V
2. XCOM: Chimera Squad
3. Call of Duty: Modern Warfare
4. Alien: Isolation
5. Animal Crossing: New Horizons

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel dedicated to gaming Let's Plays and tutorials. You can contact the author at wdangelo@vgchartz.com or on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/443399/grand-theft-auto-v-once-again-tops-the-emeaa-charts/

The millennium bug is back with a vengeance, after programmers in the 1990s simply pushed the problem back by 20 years

Lab-grown ‘meat’ often uses gelatin produced in slaughterhouses to give artificial beef a meat-like texture – but substituting soya protein can achieve that without killing animals

Two years ago, the voices of survivors of sexual harassment and assault launched an unprecedented movement the world over, using Tarana Burke’s MeToo framework. That one moment was a spark into the unknown, but the movement itself was no happy accident. It was built to fuel a reclamation of power for those who had been silenced for too long, a laborious undertaking by activists, advocates, and organizations including mine—the National Women’s Law Center, which also houses and administers the TIME’S UP Legal Defense Fund.

Since then, the #MeToo movement has enabled considerable progress, including making space for more and more people who have claims of sexual misconduct to come forward. People like Tara Reade.

But despite this dramatic cultural awakening, our institutions and systems are just beginning to stir. The lack of necessary legal and policy changes both in our government and in our workplaces, schools, houses of worship, and otherwise have created a world that very imperfectly serves the needs of survivors. Every domestic worker who is entirely unprotected by our federal and most state civil rights statutes, and every person who is classified as an independent contractor and left out of civil rights protections, have proven that our work must take on the reform and re-envisioning of the very systems that excluded them in the first place. 

Read more at The Daily Beast.

The Milky Way ate another galaxy called Gaia-Enceladus, and the waves passing through a star have shown us that it happened at most 11.6 billion years ago

Stars that are similar to the sun in every way we can measure are mostly more active than the sun, which hints that the sun’s activity may ramp up someday, risking solar eruptions

The topography and bathymetry payload for UAV

Today’s podcast has a feline bend, but we still aren’t the official Cat Fancy podcast. The full crew is here today with tons of games,...

A dialogue on sex, consent, ownership over bodies must be introduced from a young age so that it becomes part of a dominant narrative, say experts.

With all the unknowns about covid-19, any numbers you hear about death tolls or how long restrictions will last should be taken not just with a pinch of salt but with a sack of it

People from an ethnic minority are disproportionately affected by covid-19. Researchers say the reasons are rooted in existing social and healthcare inequalities

Australia recorded just 229 flu cases this April, compared with 18,705 last April, probably due to lockdown measures to stop the spread of the coronavirus

President Donald Trump said on Thursday his administration was considering further economic measures, possibly via executive orders, to provide help against the economic fallout from the novel coronavirus pandemic.

County officials in northern California county are threatening to sue Gov. Gavin Newsom if he doesn't ease his requirements to begin letting municipalities lift lockdown measures amid the coronavirus crisis that has fractured the global economy.

An analysis by Norwegian scientists has found a low level of heavy metals in processed fish products in the country. Commercially available items were collected from 2015 to 2018 and analyzed as composite samples for mercury, lead, arsenic, and cadmium. Levels of cadmium, lead, and arsenic were low and human exposure to these metals would... Continue Reading

Coronavirus illnesses to date may touch as little as 4 percent of meat and poultry employment, but it been enough to roil the industry over how much protection the plants need to be safe. Actions taken in tight proximity to one another by U.S. Secretary of Agriculture Sonny Perdue and U.S. District Court Judge Greg... Continue Reading

Meat production this week is up about 3 percent compared with the previous week, according to market reports by SiriusXM’s Rural Radio. That’s still off by as much as a third from a year ago. The numbers are causing some retailers to ration fresh meat purchases or risk selling out their entire supplies. The beef,... Continue Reading

MINNEAPOLIS (AP) - As coronavirus hotspots erupted at major U.S. meatpacking plants, experts criticized extremely tight working conditions that made the factories natural high risk contagion locations. But some Midwestern politicians have pointed the finger at the workers' living conditions, suggesting crowded homes bear some blame.

The comments - including ...

Revealed: records show law enforcement has called demonstrators possible ‘domestic terrorism’ threats

US law enforcement officials preparing for fresh Keystone XL pipeline protests have privately discussed tactics to stop activists “by any means” and have labeled demonstrators potential “domestic terrorism” threats, records reveal.

Internal government documents seen by the Guardian show that police and local authorities in Montana and the surrounding region have been preparing a coordinated response in the event of a new wave of protests opposing the controversial Keystone XL tar sands pipeline, which would carry crude oil from Canada to Montana, South Dakota and Nebraska.

Scientists have presented a non-contact method for detecting the state of charge and any defects in lithium-ion batteries.

Read our live coronavirus updates HERE Coronavirus: The symptoms

Follow our live coronavirus updates HERE Coronavirus: the symptoms

Follow our live Covid-19 updates HERE

Follow our live Covid-19 updates HERE

Read our live updates on coronavirus HERE Coronavirus: The symptoms

The Advertising Standards Agency (ASA) found the fast food giant had also failed to make it immediately clear its new product was dressed with an egg-based mayonnaise.

Germany plans to let small shops reopen as early as next week after a month-long coronavirus shutdown.

Coronavirus: the symptoms Read our LIVE updates on the coronavirus here

The Duke and Duchess of Sussex spent the Easter weekend helping deliver meals to vulnerable and housebound people in Los Angeles.

Matt Hancock will today be grilled by MPs as he faces questions over the UK's coronavirus response after the nationwide lockdown measures were extended for three more weeks.

Donate at virginmoneygiving.com/fund/FoodforLondonNOW

With one in four UK workers already on or facing furlough during the coronavirus pandemic, some food lovers are cooking up a storm for the NHS

A major study has deemed increasing testing and contact tracing in the community the "most promising approach" to lifting coronavirus lockdown measures in the short term.

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The UK's coronavirus lockdown measures could continue for months with the public urged to stick with the stay home guidance.

Carrie Symonds has signed a petition calling for a worldwide ban on live animal meat markets after coronavirus is thought to have emerged at a "wet market" in Wuhan, China.

Disruptive social distancing measures are expected to remain in place to combat coronavirus in the UK until a vaccine or effective treatment is available, England's chief medical officer has said.

"But as I hope we have started to set out today, if we keep doing the right things and if we consider all of the options carefully and with the right objectives in mind, I do believe there will be a way through and we will find that way through."

The adoption of "test, track and trace" could enable the coronavirus lockdown measures to be eased, Matt Hancock has said.

Matt Hancock has responded to growing frustration at the Government's refusal to offer a coronavirus lockdown exit strategy by insisting it is "still too soon" to think about lifting measures.

Many countries, including ours, are battling the question of how to lift the lockdown.