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Exploring cancer-associated fibroblast-induced resistance to tyrosine kinase inhibitors in hepatoma cells using a liver-on-a-chip model

Lab Chip, 2024, 24,5043-5054
DOI: 10.1039/D4LC00624K, Paper
Madhu Shree Poddar, Yu-De Chu, Gaurav Pendharkar, Cheng-Hsien Liu, Chau-Ting Yeh
3D liver-on-a-chip reveals AHSG and CLEC3B to mediate cancer-associated fibroblast-induced resistance to TKIs in hepatoma cells.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Rapid low-cost assembly of modular microvessel-on-a-chip with benchtop xurography

Lab Chip, 2024, 24,5065-5076
DOI: 10.1039/D4LC00565A, Paper
Open Access
Shashwat S. Agarwal, Marcos Cortes-Medina, Jacob C. Holter, Alex Avendano, Joseph W. Tinapple, Joseph M. Barlage, Miles M. Menyhert, Lotanna M. Onua, Jonathan W. Song
Our study is a novel implementation of xurography for multi-layer microfluidic device fabrication. We demonstrate the versatility of this approach by presenting several modular 3D vessel-matrix arrangements.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Correction: Deciphering hepatoma cell resistance to tyrosine kinase inhibitors: insights from a Liver-on-a-Chip model unveiling tumor endothelial cell mechanisms

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC90093F, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Madhu Shree Poddar, Yu-De Chu, Chau-Ting Yeh, Cheng-Hsien Liu
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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A gravity-driven tissue chip to study the efficacy and toxicity of cancer therapeutics

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00404C, Paper
Open Access
Pouria Rafsanjani Nejad, Astha Lamichhane, Prasiddha Guragain, Gary Luker, Hossein Tavana
A 96-well plate format, fully-automated multi-organ tissue chip array with gravity-driven flow for cancer research.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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5-axis CNC micro-milling machine for three-dimensional microfluidics

Lab Chip, 2024, Accepted Manuscript
DOI: 10.1039/D4LC00496E, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Mitchell Modarelli, Devin Kot-Thompson, Kazunori Hoshino
The gold standard of microfluidic fabrication techniques, SU-8 patterning, requires photolithography equipment and facilities and is not suitable for 3D microfluidics. A 3D printer is more convenient and may achieve...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Real-time impedance-activated dielectrophoretic actuation for reconfigurable manipulation of single flowing particles

Lab Chip, 2024, 24,5145-5154
DOI: 10.1039/D4LC00622D, Paper
Alexis Lefevre, Cristian Brandi, Adele De Ninno, Filippo Ruggiero, Enrico Verona, Michaël Gauthier, Paolo Bisegna, Aude Bolopion, Federica Caselli
We present an original all-electrical platform that combines MIC-sensing and DEP-actuation for precise and selective trajectory control of single flowing particles.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Microstring-engineered tension tissues: a novel platform for replicating tissue mechanics and advancing mechanobiology

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00753K, Paper
Zixing Zhou, Tingting Li, Wei Cai, Xiaobin Zhu, Zuoqi Zhang, Guoyou Huang
A simple, cost-effective approach for fabricating soft microstring chips that enables precise engineering of tension tissues (METTs), advancing research in mechanobiology and biomedical applications.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Drenched in sweat, student volunteers have a bittersweet experience at sports meet in Kochi




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Over 12,000 dengue cases reported in Ernakulam since January

Sources include illegal waste dumping sites, vacant plots, and mosquito-breeding grounds like discarded containers, used tyres, and pots




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Road safety class mandatory for driving licence applicants in Ernakulam from Dec. 2

“The sessions will include new road safety guidelines in keeping with advancements in automobiles and road construction and also amendments made to the Motor Vehicles Act in the recent past”




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Union Minister Suresh Gopi inaugurates ‘Confluence-24’ in Kochi




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HC declines former Chief Secretary’s plea seeking exemption from personal appearance

Court exempts Palakkad Collector from personal appearance on condition that she will appear through virtual mode




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Science Slam brings inventions, research to common people in lucid terms

Topics presented by young researchers included science of sonar, exploration of planets outside solar system, use of nanotechnology in cancer treatment, environment-friendly alternative for food security, and use of AI to save diabetics from eye diseases




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HC allows medical termination of pregnancy of minor rape survivor

Division Bench passed the order while allowing an appeal filed against a single judge’s order declining permission. Medical board said that termination of pregnancy was most appropriate




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Detailed probe launched into fire at commercial unit near Aluva




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Government formulates ‘work from Kerala’ concept

The idea is to leverage Kerala’s unique advantages from sustainable transport facilities, clean air and water besides open-minded people.




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Once You Go Black, Rodney, Habibti and La Mcqueen please




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Gold Ride, Vivaldi, Royal Defender and Supreme Dance impress




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Siege Courageous, Desert Kingdom, Trevalius, Philosophy and Once You Go Black shine




nc

Golden Dancer and Mothers Grace impress




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Hyderabad Winter Races to commence on November 10




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India steps up critical mineral acquisition plans in Africa, challenging China’s dominance

Race for critical minerals primarily focuses on cobalt and copper – key EV battery making metals, apart from lithium.




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Finance Minister is now final authority to grade CPSEs

Proposals for upgrade or downgrade CPSEs need no longer be referred to Cabinet Secretariat and Public Enterprises Service Board




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Cabinet clears ₹2,254 crore for national forensic infra enhancement scheme

Under this scheme, the MHA will establish campuses of the National Forensic Sciences University and central forensic science laboratories in the country




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Union Cabinet announces economic decisions worth over ₹2.88-lakh crore

These include the MSP hike for 14 Kharif crops, Varanasi airport expansion, and a new major port at Vadhavan




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Govt hikes NDRF risk and hardship allowance by 40%: Amit Shah

Union Home Minister Amit Shah made the announcement at the Flag-in ceremony of the NDRF’s Mountaineering Expedition Vijay, emphasising the crucial role NDRF plays in national and international disaster response




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Govt announces guidelines for funding testing facilities under National Green Hydrogen Mission

With a budget of ₹200 crore till FY26, the scheme aims to support the development of standards and regulatory frameworks in the Green Hydrogen sector.




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Two pre-Independence era acts to be re-enacted: Aircraft Act and Boilers Act get modern overhaul

In the upcoming Lok Sabha session, the Government will re-enact the Aircraft Act of 1934, introduce the Coffee Promotion Bill, and revamp the Indian Boilers Act of 1923 to modernise regulations and support the ‘Make in India’ initiative




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Oil Ministry announces plans for energy security fund

The Minister highlighted the importance of creating an energy security fund and exploring rare earth minerals




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Budget 2024: ₹5,000 monthly internship allowance announced for 1 crore youth

Internship scheme aims to create job opportunities in top 500 companies over next five years




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Disaster management Bill tabled in LS; Opposition says Bill encroaches on States’ jurisdiction

Centre asserts that there is no interference in the rights of the States as disaster management is the first responsibility of the States.




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Entering a decade of financial inclusion: PMJDY reaches 53 crore beneficiaries and ₹2.28 lakh crore in deposits

The scheme has largely been women-centric with 29.48 crore beneficiaries while 35.27 crore of total accounts are from rural and semi-urban branches




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Andhra to announce new industrial, liquor policies soon

Pharma, automobiles, mining, energy and shipping, likely to be given special thrust by the State Government




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Govt to provide financial assistance to North Eastern States for hydro power development

This scheme has an outlay of ₹4,136 crore to be implemented from FY25 to FY32




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Defence Ministry cautions firms using Chinese parts for drones

Ministry dashes off a letter to industry bodies asking them to sensitise manufacturers against using Chinese parts for drones




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NFRA-ICAI tussle over key audit standard overhaul: CA Institute Council to meet on Sep 17 to discuss future strategy

ICAI to debate NFRA’s plan to overhaul audit standard SA600, fearing concentration of market in few hands




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Centre Notifies NaBFID as a ‘Public Financial Institution’

NaBFID expects its total sanctions loan book to touch ₹2 lakh crore by March 2025, while disbursements are likely to be around ₹ 1 lakh crore



  • Money & Banking

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Finance Ministry notifies new rules for compounding under FEMA

The new rules aim to further promote ease of investment




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Govt to launch another PLI scheme for speciality steel: Steel Secy

Speciality steel is an area where more needs to be done, says Steel Secretary Sandeep Poundrik




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Parliamentary panel expresses concern over CCI budget cuts

Panel seeks updates on pending competition cases, CCI’s backlog, and progress of the Draft Digital Competition Bill targeting the digital market




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GoM for freeing health insurance for senior citizens, all policies up to ₹5-lakh cover from GST burden

GoM suggests rate hike on high-end wrist watches, shoes; GST on packaged water to be cut




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Invoice Management System may add compliance for GST assesses, say tax experts

First GSTR-2B based on IMS to be generated for October on November 14.




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No merger of 50% DA into basic, as finance ministry issues order payment for 53% DA

DA to central government employees was enhanced from 50 per cent to 53 per cent of the basic pay with effect from July 1, 2024




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PM E-DRIVE: Government starts disbursal of incentives amounting to ₹320 crore in first month of scheme

Total 28,81,436 units of EVs to be incentivised with an outlay of ₹10,900 crore in the next 2 years




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Aviation Minister proposes over 50 helicopter emergency medical units along highways

This initiative aims to enhance rapid medical assistance, particularly in remote areas, and align with global healthcare standards




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GoI invites proposals for establishing Centres of Excellence under Green Hydrogen Mission

This initiative, launched by the Ministry of New and Renewable Energy, aims to position India as a global leader in Green Hydrogen technologies by enhancing research in production, storage, and utilization




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Kawasaki Ninja ZX-6R Launched




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2024 Land Rover Discovery Sport launched




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Punching above its weight

The Tata Punch.ev looks impressive on paper, but how good is it?




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Hero Mavrick 440: Unconventional?

Hero MotoCorp’s new flagship is a bucketful of rights and only a few wrongs