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Unraveling the inhibitory potential of Rosetta designed de novo cyclic peptides on PARP7 through molecular dynamics simulations

New J. Chem., 2024, 48,7347-7355
DOI: 10.1039/D4NJ00016A, Paper
Yuqi Zhu, Aamir Mehmood, Daixi Li
Cyclic peptides have the characteristics of antibodies and small molecules and have better advantages over small molecules.
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Correction: Nano-pelargonidin modulates p53/PARP/HSP 90/XRCC1 signaling axis to combat cypermethrin-induced genotoxicity and metabolic dysfunction in fish: a molecular docking predicted in vivo approach

Environ. Sci.: Nano, 2024, Advance Article
DOI: 10.1039/D4EN90017K, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Priyanka Sow, Sudatta Dey, Rishita Dey, Asmita Samadder, Sisir Nandi, Debojyoti Tarafdar, Anisur Rahman Khuda-Bukhsh
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Incisive analysis of hydrogen-bonded supramolecular architectures in designer polycyclitols: observation of some interesting self-assembly patterns

CrystEngComm, 2024, 26,1952-1961
DOI: 10.1039/D4CE00010B, Paper
Showkat Rashid, Ahmad Husain, Bilal A. Bhat, Goverdhan Mehta
This article examines C–H⋯O and O–H⋯O hydrogen-bonded patterns in polyoxygenated decalins, showcasing varied supramolecular architectures influenced by oxyfunctionalisation and surrogate carbonate groups.
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Structural diversity and tetrel bonding significance in lead(II) complexes with pyrazoylisonicotinoylhydrazone and varied anionic co-ligands

CrystEngComm, 2024, Accepted Manuscript
DOI: 10.1039/D4CE00325J, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Ghodrat Mahmoudi, Isabel Garcia-Santos, Roi Fernández-Vázquez, Rosa Maria Gomila, Alfonso Castineiras, Esmail Doustkhah, Ennio Zangrando, Antonio Frontera
Four lead(II) complexes featuring pyrazoylisonicotinoylhydrazone ligand paired with various anionic co-ligands (azido, thiocyanato, nitrito, and nitrato) were synthesized and thoroughly examined using structural, analytical, and spectroscopic techniques. These ligands, in...
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Elon Musk signals Twitter's headquarters may not stay in San Francisco

San Francisco officials said they would investigate Twitter after six former employees alleged that the company broke laws by turning its headquarters into a ‘Twitter Hotel’




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Twitter’s top content moderation executive Ella Irwin resigns

As head of Trust and Safety, Irwin helped oversee Twitter’s policies on harassment, hate speech and violent content — rules which were relaxed under new owner Elon Musk




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WhatsApp to roll out redesigned keyboard

WhatsApp redesigned keyboard will include the emoji category bar




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India’s FTAs with EU, UK, Canada may not bring in significant gains, says report

Insignificant market access, introduction of new issues, a double whammy




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CAGs of India, Chile sign MoU to support capacity building

Murmu is currently on an official visit to Chile




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​​Vietnamese Perspective on the Significance of the US-Australia Alliance in Southeast Asian Security​

​​Vietnamese Perspective on the Significance of the US-Australia Alliance in Southeast Asian Security​ ​​Vietnamese Perspective on the Significance of the US-Australia Alliance in Southeast Asian Security​

jacksonl




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The tell-tale signs of urban heat stress       

Several Indian cities sizzle under relentless temperatures this summer 




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Lithuania's Social Democratic Party signs coalition agreement




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North Korea jams GPS signals for 5th straight day: South Korea




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Guru Nanak Jayanti 2024: Know date, time and significance of festival

Guru Nanak Dev Ji, the founder of Sikhism, was the first of the ten Sikh gurus and is recognised as a philosopher, poet, and spiritual leader. He emphasised the principles of equality, compassion, and devotion to one universal God.




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Tessolve to acquire German chip design company for up to ₹400 crore

It will expand Tessolve’s European operations by adding four delivery locations across Germany and the Netherlands, including a specialized ADAS and imaging centre-of-excellence lab




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Indian IT sector lags in global RPE standards, yet digital shift signals growth potential

The Indian IT sector, while traditionally emphasising cost-effective outsourcing, is gradually evolving to enhance RPE and profitability through investments in upskilling and digital innovation




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Design, synthesis, biological evaluation and molecular docking studies of quinoline-anthranilic acid hybrids as potent anti-inflammatory drugs

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00040D, Paper
Sidra Siddique, Khalid Hussain, Naureen Shehzadi, Muhammad Arshad, Muhammad Nadeem Arshad, Sadaf Iftikhar, Farhat Saghir, Ayisha Shaukat, Muhammad Sarfraz, Nisar Ahmed
Despite the high global prevalence, rheumatoid arthritis lacks a satisfactory treatment.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Design, synthesis, and biological application of A–D–A-type boranil fluorescent dyes

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00297K, Paper
Wei Luo, Yiling Li, Liang Wang, Yanhua Qin, Qiao Cheng, Guochang Hu, Chaoyi Yao, Xiangzhi Song
Acceptor–donor–acceptor boranil fluorescent dyes, CSU-BF-R (R = H, CH3, and OCH3), were developed with strong red fluorescence and large Stokes shifts. CSU-BF-OCH3 could selectively sense intracellular hypochlorous acid in living cells and zebrafish.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Measuring local pH at interfaces from molecular tumbling: A concept for designing EPR-active pH-sensitive labels and probes

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00167B, Paper
Open Access
Maxim A. Voinov, Nicholas Nunn, Roshan Rana, Atli Davidsson, Alex I. Smirnov, Tatyana I. Smirnova
EPR-based local pH measurements based on changes in rotational dynamics of spin-bearing molecules upon protonation.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Deep diving into design philosophies

Airbus and Boeing differ in their approach to automation




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Role of soft skills in industrial and product design career success: Preparing next generation of designers

Kushal Karwa, a thought leader in design education, emphasizes the need for integrating soft skills training into career preparation programs to help young designers thrive in real-world environments.




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Shaping the Future of Web Apps: Full Stack Developer's Expertise in API Design and Cloud Deployment

Naga Lalitha has become visible as someone who is changing the face of technology for industry verticals like supply chain and manufacturing.




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Designing for the future

For organisations, value creation and preservation are key to avoid destruction




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Designing organisations as ‘selfless’ collectives

Reducing complexity and friction between members is important




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Smashing Conf: Is Atomic Design Dead?

In his Is Atomic Design Dead? presentation at Smashing Conf New York, Brad Frost discussed the history of design systems and today's situation especially in light of very capable AI models than can generate code and designs. Here's my notes on his talk.

  • Websites started as HTML and CSS. People began to design websites in Photoshop and as the number of Web sites and apps increased, the need for managing a brand and style across multiple platforms became clear. To manage this people turned to frameworks and component libraries which resulted in more frameworks and tools that eventually got integrated into design tools like Figma. It's been an ongoing expansion...
  • There's been lots of change over the years but at the highest level, we have design systems and products that use them to enforce brand, consistency, accessibility, and more.
  • Compliance to design systems pushes from one side and product needs push from the other. There needs to be a balance but currently the gap between the two is growing. A good balance is achieved through a virtuous cycle between product and systems.
  • The atomic design system tried to intentionally define use of atoms, molecules, organisms, templates, and pages to bridge the gap between the end state of a product and a design system.
  • As an industry, we went too far in resourcing design systems and making them a standalone thing within a company. They've been isolated.
  • Design system makers can't be insular. They need to reach out to product teams and work with them. They need to be helping product teams achieve their goals.
  • What if there were one global design system with common reusable components? Isn't that what HTML is for? Yes, but it's insufficient because we're still rebuilding date pickers everywhere.
  • Open UI tracks popular design systems and what's in them. It's a start to seeing what global component needs for the Web could look like.
  • Many pattern libraries ship with an aesthetic and people need to tweak it. A global design system should be very vanilla so you can style it as much as you want.
  • The Web still has an amazing scale of communication and collaboration. We need to rekindle the ideas of the early Web. We need to share and build together to get to a common freely usable design system.
  • AI models can help facilitate design system work. Today they do an OK job but in the future, fine-tuned models may create custom components on the fly. They can also translate between one design system and another or translate across programming languages.
  • This methodology could help companies translate existing and legacy code to new modern design systems. Likewise sketches or mockups could be quickly translated directly to design system components thereby speeding up processes.
  • Combining design system specifications with large language models allows you to steer AI generations more directly toward the right kind of code and components.
  • When product experiences are more dynamic (can be built on the fly), can we adapt them to individual preferences and needs? Like custom styles or interactions.
  • AI is now part of our design system toolkit and design systems are part of our AI toolkit.
  • But the rapid onset of AI also raises higher level questions about what designers and developers should be doing in the future? We're more than rectangle creators. We think and feel which differentiates us from just production level tasks. Use your brains, your intuition, and whole self to solve real problems.




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Masaba Gupta: Not your everyday wedding designer

Up, close and personal with Masaba Gupta on wedding outfits and life choices




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Helsinki: The Scandinavian design capital

If you love great design and architecture, Finland’s capital is right up your alley




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Rethinking writing instruction in the age of AI [electronic resource]: a universal design for learning approach Randy Laist ; with contributions from Nicole Brewer, Cynthia J. Murphy, and Dana Sheehan

Lynnfield, Massachusetts CAST [2024]




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Groups and graphs, designs and dynamics / edited by R. A. Bailey, Peter J. Cameron, Yaokun Wu.

Cambridge ; New York, NY : Cambridge University Press, 2024.




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From elementary to advanced: rational design of single component phosphorescence organogels for anti-counterfeiting applications

Mater. Chem. Front., 2024, 8,3577-3586
DOI: 10.1039/D4QM00498A, Research Article
Huamiao Lin, Yi Shi, Yan Li, Shuzhan Chen, Wei Wang, Peng Geng, Jiaying Yan, Shuzhang Xiao
In this work, we designed and synthesized two non-conventional organogels (DBF-dAc and DBF-dPh). DBF-dPh organogels emitted long-lasting room-temperature phosphorescence with a visible afterglow and multi-layered anti-counterfeiting capabilities.
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Alissa Walker: I'm a Design Journalist, But I'm also a Transit Geek | WIRED 2012 | WIRED

Alissa Walker took to the stage during a session of Wired 2012 entitled "The future of the city" to share the passion she has for her namesake activity: walking.




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Signal Technology Foundation's Brian Acton in Conversation with Steven Levy

Executive Chairman of Signal Technology Foundation Brian Acton spoke with WIRED's Steven Levy as part of WIRED25, WIRED's second annual conference.




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How Porsche and Lucasfilm Teamed Up to Create a New Star Wars Starship | The Designer Alliance | WIRED Brand Lab

BRANDED CONTENT | Produced by WIRED Brand Lab for Porsche | Want to see the fastest ride in the galaxy? Meet the Tri-Wing S-91X Pegasus, the newest starfighter in the Star Wars universe. Watch as designers from Porsche and LucasFilm race the clock to bring together two iconic brands and create this one-of-a-kind vehicle. See Star Wars: #TheRiseofSkywalker December 20.




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WIRED25 2020: Dr. Celia Hodent and Drew Blackard on Video Game Design

Dr. Celia Hodent, Drew Blackard, and Irene Au joined the WIRED25 event to discuss how cognitive science, UX research, and dark patterns play into video game design.




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The Sound Design of Mank

David Fincher wanted to recall the look and feel of movies from the 1930s, but in a subtle way. For the sound design, that meant finding a range of characteristics that would remind the audience of old-fashioned sound.




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Using AI as a creative tool with artist and stage designer Es Devlin | WIRED Live

Artist and stage designer Es Devlin has created stage sculptures for Beyoncé, Billie Eilish, the WEEKND and U2 and now at WIRED Live, she discusses her approach to creativity; AI as a creative tool; and the future of live experiences. "The practice has changed beyond recognition."




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Sustainability in architecture and design with Bjarke Ingels | WIRED Live

Bjarke Ingels, Founder and Creative Director, BIG - Bjarke Ingels Group, defines architecture as the art and science of making cities and buildings fit with the way we want to live our lives. At WIRED Live 2020, he explains the importance of sustainability in architecture and design. "Sustainable buildings are not only better for the environment, but for the lives of the people living in them."




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The Drop In: Creative Collaborations at Work | Designer Sophia Chang on Creating a More Equitable Sneaker Experience

Produced by WIRED Brand Lab with Dropbox | Illustrator and designer Sophia Chang talks about her mission to empower women within sneaker culture and using Dropbox to collaborate.




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How Disney Designed a Robotic Spider-Man

The stunts we love to watch in movies like 'Spider-Man: Homecoming' usually rely on a combination of green screen, stunt performers, and computer-generated models. Stunts like these can be dangerous, especially when performed live...over and over. At the new Avengers Campus at Disneyland Resorts, radical stunts are being performed everyday by a robotic acrobat. Disney Imagineers Tony Dohi and Morgan Pope sit down with WIRED to talk about how they designed this amazing stuntronic robot.




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Dune Costume Designers Break Down Dune’s Stillsuits

In 'Dune,' inhabitants of the desert planet wear full-body stillsuits for their survival. These stillsuits capture moisture and recycle it into drinking water. Jacqueline West and Bob Morgan, costume designers on 'Dune,' explain how they approached designing the suits for the film.




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Tech Support - James Dyson Answers Design Questions From Twitter

James Dyson answers the internet's burning questions about design and inventions. How does Dyson's bladeless fan work? What do you do if you have an invention idea? Why are hand dryers so loud? How does suction work? James answers all these questions and much more!




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How an Architect Redesigns NYC Streets

Claire Weisz, founder of W X Y + architecture + urban design, walks us through three different street redesigns that her team has done in New York City. Claire explains why they made the changes they made, and what ultimately makes for a "better" street.




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How This Humanoid Robot Diver Was Designed

A robotic diving system that looks like a Transformer? OceanOneK can go to depths that would kill a human diver. It can also handle delicate objects without breaking them. Using a haptic system, humans can use OceanOneK as an avatar, allowing humans to dive in areas we never previously could. WIRED spoke with Professor Oussama Khatib to understand how he and his team designed, built and tested this robotic diver.




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Obsessed - This Craftsman Designs & Builds 100% Wooden Puzzle Boxes

Kagen Sound is an artisan of remarkable skill, engineering and constructing incredibly intricate puzzle boxes made entirely of wood. WIRED brings you inside his workshop as he breaks down the design process behind his wonderful creations, and the woodworking skill he leverages to make everything snap together perfectly.




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Tech Support - Urban Designer Answers City Planning Questions From Twitter

Former Chief Urban Designer of The City of New York Alexandros Washburn joins WIRED to answer the internet's burning questions about city planning. How does the New York City Subway compare to others worldwide? What are the pros and cons of rent control initiatives? Which city can lay claim to being "smartest" in the world? Or has the best airport? What challenges will the urban designers of tomorrow need to meet? Alexandros Washburn answers these questions and many more on City Planning Support.




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Tech Support - Urban Designer Answers More City Planning Questions

Former Chief Urban Designer of The City of New York Alex Washburn returns to WIRED to answer another round of the internet's burning questions about city planning. How should cities accommodate electric bikes? Can urban planning mitigate over-gentrification? How can urban planning prevent crimes? What does the future of public transportation in urban centers look like? Can a city ever reach population capacity? How's it possible for a city to run out of water? Alex Washburn answers these questions and many more on City Planning Support, Vol. 2. Director: Justin Wolfson Director of Photography: Constantine Economides Editor: Richard Trammell Expert: Alex Washburn Line Producer: Joseph Buscemi Associate Producer: Brandon White Production Manager: Peter Brunette Production Coordinator: Rhyan Lark Casting Producer: Nicholas Sawyer Camera Operator: Christopher Eustache Sound Mixer: Sean Paulsen Production Assistant: Kalia Simms Post Production Supervisor: Christian Olguin Post Production Coordinator: Ian Bryant Supervising Editor: Doug Larsen Additional Editor: Jason Malizia Assistant Editor: Billy Ward




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Theoretical Insights and Design of MXene for Aqueous Batteries and Supercapacitors: Status, Challenges, and Perspectives

Nanoscale Horiz., 2024, Accepted Manuscript
DOI: 10.1039/D4NH00305E, Review Article
Jun Zhao, Ninggui Ma, Tairan Wang, Yuhang Wang, Bochun Liang, Yaqin Zhang, Shuang Luo, Yu Xiong, Qianqian Wang, Jun Fan
Aqueous batteries and supercapacitors are promising electrochemical energy storage systems (EESS) due to their low cost, environmental friendliness, and high safety. However, aqueous EESS development faces challenges like narrow electrochemical...
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Correlated excitonic signatures of individual van der Waals NiPS3 antiferromagnet nanoflakes

Nanoscale Horiz., 2024, Advance Article
DOI: 10.1039/D4NH00390J, Communication
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Vigneshwaran Chandrasekaran, Christopher R. DeLaney, Cong Tai Trinh, David Parobek, Christopher A. Lane, Jian-Xin Zhu, Xiangzhi Li, Huan Zhao, Marshall A. Campbell, Laura Martin, Edward F. Wyckoff, Andrew C. Jones, Matthew M. Schneider, John Watt, Michael T. Pettes, Sergei A. Ivanov, Andrei Piryatinski, David H. Dunlap, Han Htoon
Optical spectroscopy on individual nano-flakes of NiPS3 2D-antiferromagnet reveals correlated excitons arising from entangled charge, spin, orbital, and lattice degrees of freedom, similar to bulk NiPS3 but at a completely different energy range.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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On the design of cell membrane-coated nanoparticles to treat inflammatory conditions

Nanoscale Horiz., 2024, Advance Article
DOI: 10.1039/D4NH00457D, Review Article
Andreia Marinho, Salette Reis, Cláudia Nunes
Cell membrane-coated nanoparticles (CMCNPs) offer targeted and effective treatment for chronic inflammatory conditions by mimicking natural cell interactions and enhancing immune evasion.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Signature sambar, very long dosas and delicious filter coffee

Coimbatore’s legendary Annapoorna Hotel can teach marketers a lesson or two