This guidebook describes Upper Elk Meadows Research Natural Area (RNA), a 90-ha (223-ac) area that supports a mixture of coniferous forest and open, shruband herb-dominated wetlands. The major forest plant association present within Upper Elk Meadows RNA is Pacific silver fir/vine maple/coolwort foamflower (Abies amabilis/Acer circinatum-Tiarella trifoliata).

Premier League clubs will also hold a videoconference on Monday to discuss Project Restart

The Magpies teenager is out of contract in the summer and has a host of European clubs interested in his services

... about ALL ACCESS' NEWS/TALK/SPORTS section, where Editor PERRY MICHAEL SIMON delivers the most pertinent and entertaining Talk content in the business to your computer daily. You can … more

COMPASS BROADCASTING has moved the News-Talk programming of KGED-A (TALK RADIO 1680)/FRESNO to sister KXEX-A as TALK RADIO 1550 KXEX, replacing that station's Spanish Religion … more

Check out radio's most widely read show-prep resource for topics, commentary, and really stupid remarks, in the ALL ACCESS News/Talk/Sports section. It's updated by Editor and veteran … more

SANDHILL MEDIA Top 40 KAOX (NOW 107.9)/SHELLEY-IDAHO FALLS, ID will flip to News-Talk as "NEWSTALK 107.9" with former RICH BROADCASTING News-Talk KID-A-KIDG-KIDJ/IDAHO FALLS morning … more

TIMES-SHAMROCK COMMUNICATIONS Alternative WFUZ (ALT 92.1)/WILKES BARRE-SCRANTON has kicked off MAY with a new weeknight show, "MAJORITY RULES," allowing listeners to control the … more

The RADIO TELEVISION DIGITAL NEWS ASSOCIATION and FREEDOM FORUM Power Shift Project are holding a "Local Broadcasters Town Hall" online on MAY 27th to highlight the work being done … more

It even involves some serious dance moves at the end

There is a long history of exceptional walk years as well, and Adrian Beltre, who retired after the 2018 season, is a big part of it. Here is a look at 20 of the best.

Deep Learning is a branch of artificial intelligence and a subset of machine learning that focuses on networks capable of, usually, unsupervised learning from unstructured and other forms of data. It is also known as deep structured learning or differential programming. Architectures inspired by deep learning find use in a range of fields, such as...

In August 1919, the Cedar Rapids Evening Gazette opined in favor of the passage of a $5 million congressional appropriation to “investigate influenza, its cause, prevention and...

I’ve had the pleasure of serving you as sheriff of Johnson County for the past 15-plus years and the job is not one that I or anyone else should or can take lightly. The office of sheriff requires a balance of both politics and leading a very large law enforcement agency which means sometimes those two worlds can collide. In these tough situations it takes someone that believes in their co-workers, trusts their co-workers and asks them to always perform at a high level.

I’m confident that Brad Kunkel is up to the task. The sheriff must also always follow the Constitution and enforce the laws of Iowa, in addition the sheriff is responsible for the operation and oversight of the county jail. Brad’s career experience including his years working in the jail are valuable for safe and efficient jail management.

The office of sheriff requires a thoughtful approach to what is best for the citizens of Johnson County. I have worked with Brad Kunkel for over 20 years and I know he has the temperament, intelligence and integrity to excel in the office of Johnson County sheriff. I wholeheartedly believe he is the best person to take the office into the challenging time ahead.

Join me and vote for Brad Kunkel on or before June for Johnson County sheriff.

Sheriff Lonny Pulkrabek

Iowa City

In August 1919, the Cedar Rapids Evening Gazette opined in favor of the passage of a $5 million congressional appropriation to “investigate influenza, its cause, prevention and cure.”

“We all remember without effort the darkness and terror which engulfed the land last fall and winter as death stalked swiftly from seaboard to seaboard, into crowded city and unto lonely plain, sparing not the cottage of the poor nor the mansion of the rich,” the editorial said. “In four short months, influenza claimed a half million lives and pressed millions of others onto beds of sickness, suffering and helplessness. The nation’s mortality rate leapt high and with astounding speed. The nation was unprepared to cope with a disease calamity such as it has never known.”

The Gazette lamented that billions of dollars in loss were wrought by the pandemic of so-called Spanish influenza, compared with only $5 million being spent to investigate the virus.

“More has been spent in studying diseases of hogs,” the editorial argued.

Just less than a year earlier, The Evening Gazette did not see “darkness and terror” coming. A front page, above-the-fold story Sept. 25, 1918, asked: “Spanish Influenza just the old-fashioned grippe?” “Grippe” is an old-time term for the flu, by the way.

“As a matter of fact, in the opinion of City Physician Beardsley, and a good many other Cedar Rapids men in the same profession, Spanish influenza is just another name for the regular old fashioned influenza and is no different from the influenza we have always had. A bad cold is a bad cold, and a worse cold is grippe, which covers a multitude of things ...,” The Gazette reported, optimistically.

An earlier strain of influenza in the spring of 1918 had been less virulent and deadly. But the second wave was no ordinary grippe.

By mid-October, according to reports in The Evening Gazette, influenza caseloads exploded. On Oct. 12, 1918, the local health board shut down pool rooms, billiard halls and bowling alleys. It pleaded with store owners to avoid allowing crowds to linger. On Oct. 16, stores were ordered to discontinue any special sales that might draw more shoppers.

Restrictions tightened as the pandemic worsened.

Death notices were stacking up on Gazette pages, in rows reminiscent of small tombstones. Many victims were cut down in the prime of life by a virus that struck young, healthy people hardest. Mothers and fathers died, leaving young children. Soldiers serving in World War I died far away from home. Visitors to town never returned home.

Young brothers died and were mourned at a double funeral. A sister who came to care for a sick brother died, and so did her brother.

Ray Franklin Minburn, 24, died of influenza, leaving behind six sisters and two brothers. “Mr. Minburn was a faithful son, a devoted companion, a good neighbor,” concluded his death announcement on Oct. 21, 1918.

On the same page that day came news, tucked among the tombstones, reporting that Iowa Gov. William Harding had recovered from influenza, in the midst of his reelection campaign, and was back in the office. You might remember Harding as the governor who banned German and other languages during World War I and who was nearly impeached for bribery in 1919.

Not far from Harding’s update came news from the prison in Anamosa that “whisky and quinine” were being deployed to attack the grippe.

The pages of The Evening Gazette also were dotted with advertisements for supposed cures and treatments.

“Danger of infection from influenza or any contagious disease can be eliminated by using preventive measures,” prescribed by Ruby S. Thompson, chiropractor and naturopathic physician. Those included “Sulphur-vapor baths, Carlsbad mineral bath.”

You could build up your blood using “Gude’s Pepto-Mangan,” the “Red Blood Builder.” Keep your strength up with Horlick’s Malted Milk.

One ad looked exactly like a news story, carrying the bold headline “Druggists still asked to conserve stocks of VapoRub needed in ‘flu’ districts.” In a tiny notation at the end of the “story” were the words “The Vicks Chemical Co.”

That August 1919 Gazette editorial I mentioned makes me wonder what we’ll be writing in a year or so after our current pandemic.

Death stalking us swiftly from seaboard to seaboard in an unprepared nation, preceded by the casual insistence it’s no worse than the seasonal flu, sounds eerily familiar in 2020. More attention is being paid to hogs than the health of humans working in meatpacking plants.

Will we be writing in 2021 how reopening states and counties too soon led to our own second wave? Here in Iowa, reopening began before we had a fully working predictive model to chart the pandemic’s course and before new testing efforts had a chance to ramp up. Will decisions made without crucial information look smart in 2021? Or will we wish we’d waited just a couple more weeks?

What of the protesters demanding liberation? What about the president, running for reelection in a nation harmed by his crisis mismanagement? What will a new normal look like?

Will there be newspapers around to editorialize in the aftermath? After all, most of the pitches for fake cures are online now, some even extolled at White House briefings.

And will we be better prepared next time? I bet editorial writers in 1919 figured we’d have this pandemic response thing down to a science by now.

Little did they know that in 2020 we’d have so little respect for science. And after a century-plus, the darkness and terror apparently slipped our minds.

(319) 398-8262; todd.dorman@thegazette.com

One in five people will have some kind of mental illness in their lifetime. Yet despite how common these conditions are — as common as silver cars, and more common than being left-handed — stigma remains the greatest barrier to individuals seeking help regarding their mental illness.

May is Mental Health Awareness Month. This serves as a great opportunity for our community to begin eliminating stigma by starting conversations and increasing understanding about mental illness.

Now, more than ever before, it is important to talk about mental illness. Many of us could be feeling increased anxiety, stress and feelings of isolation due to the COVID-19 outbreak and social distancing requirements. For those Iowans who already live with a mental illness, this pandemic could be causing symptoms to compound.

A recent study released by a team at Iowa State University states that increased unemployment and social isolation measures related to COVID-19 could result in an increase in suicide rates of close to 50,000 individuals.

Despite the challenges created by the COVID-19 pandemic, there still is help available: Telehealth services during this crisis is critical. Our state leaders, Iowa Insurance Commissioner Doug Ommen and Gov. Kim Reynolds responded immediately by encouraging health providers, insurers and businesses to work together to remove barriers and ensure telehealth is accessible.

Your Life Iowa, a state-operated service, offers referrals for problems related to alcohol, drugs, gambling, mental health or suicidal thoughts and can be contacted by phone, text or online chat 24/7.

Between March 1 and April 19, Your Life Iowa received nearly 500 contacts related to COVID-19 and traffic on the website — YourLifeIowa.org — is up 27 percent. Crisis lines and mental health counselors around the state and country are also reporting an uptick in patients reaching out for resources or virtual counseling. This is important progress.

However, the greatest barrier for those in need of mental health services is stigma.

If you know someone who is struggling, be a voice of support. The silence around mental illness is preventing our fellow Iowans — our friends, neighbors, co-workers and family members — from feeling better. By breaking down the stigma around mental illness, we can help them access the resources and treatment they deserve.

If someone opened up to you about their mental illness, would you know what to say? Do you have a general understanding of the most common mental illnesses? Do you know how to support loved ones dealing with mental illness? There are free resources available at MakeItOK.org/Iowa to learn more.

You can also read stories of Iowans who live with mental illness, take a pledge to end mental illness stigma and learn more about how you can get more involved with Make It OK through ambassador trainings, upcoming events and workplace programming.

Together, we can end the stigma and Make It OK.

Jami Haberl, Iowa Healthiest State Initiative; Lori Weih, UnityPoint Health — St. Luke’s Hospital; Tricia Kitzmann, Linn County Public Health and Mona McCalley-Whitters, Ph.D., NAMI Linn County.

In August 1919, the Cedar Rapids Evening Gazette opined in favor of the passage of a $5 million congressional appropriation to “investigate influenza, its cause, prevention and cure.”

“We all remember without effort the darkness and terror which engulfed the land last fall and winter as death stalked swiftly from seaboard to seaboard, into crowded city and unto lonely plain, sparing not the cottage of the poor nor the mansion of the rich,” the editorial said. “In four short months, influenza claimed a half million lives and pressed millions of others onto beds of sickness, suffering and helplessness. The nation’s mortality rate leapt high and with astounding speed. The nation was unprepared to cope with a disease calamity such as it has never known.”

The Gazette lamented that billions of dollars in loss were wrought by the pandemic of so-called Spanish influenza, compared with only $5 million being spent to investigate the virus.

“More has been spent in studying diseases of hogs,” the editorial argued.

Just less than a year earlier, The Evening Gazette did not see “darkness and terror” coming. A front page, above-the-fold story Sept. 25, 1918, asked: “Spanish Influenza just the old-fashioned grippe?” “Grippe” is an old-time term for the flu, by the way.

“As a matter of fact, in the opinion of City Physician Beardsley, and a good many other Cedar Rapids men in the same profession, Spanish influenza is just another name for the regular old fashioned influenza and is no different from the influenza we have always had. A bad cold is a bad cold, and a worse cold is grippe, which covers a multitude of things ...,” The Gazette reported, optimistically.

An earlier strain of influenza in the spring of 1918 had been less virulent and deadly. But the second wave was no ordinary grippe.

By mid-October, according to reports in The Evening Gazette, influenza caseloads exploded. On Oct. 12, 1918, the local health board shut down pool rooms, billiard halls and bowling alleys. It pleaded with store owners to avoid allowing crowds to linger. On Oct. 16, stores were ordered to discontinue any special sales that might draw more shoppers.

Restrictions tightened as the pandemic worsened.

Death notices were stacking up on Gazette pages, in rows reminiscent of small tombstones. Many victims were cut down in the prime of life by a virus that struck young, healthy people hardest. Mothers and fathers died, leaving young children. Soldiers serving in World War I died far away from home. Visitors to town never returned home.

Young brothers died and were mourned at a double funeral. A sister who came to care for a sick brother died, and so did her brother.

Ray Franklin Minburn, 24, died of influenza, leaving behind six sisters and two brothers. “Mr. Minburn was a faithful son, a devoted companion, a good neighbor,” concluded his death announcement on Oct. 21, 1918.

On the same page that day came news, tucked among the tombstones, reporting that Iowa Gov. William Harding had recovered from influenza, in the midst of his reelection campaign, and was back in the office. You might remember Harding as the governor who banned German and other languages during World War I and who was nearly impeached for bribery in 1919.

Not far from Harding’s update came news from the prison in Anamosa that “whisky and quinine” were being deployed to attack the grippe.

The pages of The Evening Gazette also were dotted with advertisements for supposed cures and treatments.

“Danger of infection from influenza or any contagious disease can be eliminated by using preventive measures,” prescribed by Ruby S. Thompson, chiropractor and naturopathic physician. Those included “Sulphur-vapor baths, Carlsbad mineral bath.”

You could build up your blood using “Gude’s Pepto-Mangan,” the “Red Blood Builder.” Keep your strength up with Horlick’s Malted Milk.

One ad looked exactly like a news story, carrying the bold headline “Druggists still asked to conserve stocks of VapoRub needed in ‘flu’ districts.” In a tiny notation at the end of the “story” were the words “The Vicks Chemical Co.”

That August 1919 Gazette editorial I mentioned makes me wonder what we’ll be writing in a year or so after our current pandemic.

Death stalking us swiftly from seaboard to seaboard in an unprepared nation, preceded by the casual insistence it’s no worse than the seasonal flu, sounds eerily familiar in 2020. More attention is being paid to hogs than the health of humans working in meatpacking plants.

Will we be writing in 2021 how reopening states and counties too soon led to our own second wave? Here in Iowa, reopening began before we had a fully working predictive model to chart the pandemic’s course and before new testing efforts had a chance to ramp up. Will decisions made without crucial information look smart in 2021? Or will we wish we’d waited just a couple more weeks?

What of the protesters demanding liberation? What about the president, running for reelection in a nation harmed by his crisis mismanagement? What will a new normal look like?

Will there be newspapers around to editorialize in the aftermath? After all, most of the pitches for fake cures are online now, some even extolled at White House briefings.

And will we be better prepared next time? I bet editorial writers in 1919 figured we’d have this pandemic response thing down to a science by now.

Little did they know that in 2020 we’d have so little respect for science. And after a century-plus, the darkness and terror apparently slipped our minds.

(319) 398-8262; todd.dorman@thegazette.com

A couple weeks ago, I saw a tweet come through my Twitter timeline from my buddy Tim Smith, a designer and podcaster saying, “2014 was my worst year in freelance. My business revenue declined by ~10k.” I immediately related, but hesitated to reply. Who wants to talk about their failures? Business being slow is actually pretty […]

This brand new All-Encompassing Creative Toolkit contains a variety of resources that take the hard work out of creating stunning visual effects. From ready-made assets you can copy/paste into your artwork to pro-grade tools that provide the building blocks you need to create original designs, these resources make it possible to create work in totally […]

The post Add New Effects to Your Design Work with This Creative Toolkit appeared first on Spoon Graphics.

In this Chalkboard Text Vector tutorial, I’ll show you how to create a chalkboard vector effect with some gradients, a bristle brush, and some freebies from Vector Mill! This chalkboard text vector effect tutorial is relatively simple and can be applied to many other Illustrator projects. Use this effect for logo creation, back to school backgrounds, […]

The post 20 Minute Tut! Create Your Own Customized Chalkboard Text Vector appeared first on Vectips.

We're back and this week, we're talking to Avatar's colorful frontman Johannes Eckerström. If you've ever seen the band live,...

The post Squared Circle Pit #54 - AVATAR Frontman Johannes Eckerström Talks Wrestling Unlocking His Love of Metal Frontmen appeared first on Metal Injection.

Comic artist Box Brown is the guest on the show this week. We kick things off talking about his comic...

The post Squared Circle Pit #55 - Comic Artist Box Brown Talks AEW vs. NXT appeared first on Metal Injection.

We're back and super excited to welcome the Hot Topic senior buyer Joe Enriquez to the show. Joe tells the...

The post Squared Circle Pit #56 - Hot Topic's Joe Enriquez talks AEW, ECW and Thrash Metal appeared first on Metal Injection.

We're so excited to finally have British death match legend Jimmy Havoc on the show. We talked about how he...

The post Squared Circle Pit #57 - Jimmy Havoc Talks Death Match Wrestling appeared first on Metal Injection.

Every time we contribute to an open source project, in any way, we are answering an important question: Why don’t I walk away and start a new fork? I’ve been working in and with and around open source software for the better part of 15 years, and over that time I’ve seen the rise of […]

The post Walking Away and the Ethos of Open Source appeared first on MOR10.

By Julia Conley Common Dreams “Nature is not a ‘nice to have’—it is our life-support system.” Scientists from around the world issued a stark warning to humanity Tuesday in a semi-annual report on the Earth’s declining biodiversity, which shows that … Continue reading →

By Julia Conley Common Dreams “Nature is not a ‘nice to have’—it is our life-support system.” Scientists from around the world issued a stark warning to humanity Tuesday in a semi-annual report on the Earth’s declining biodiversity, which shows that … Continue reading →

Although the performance of today's speech recognition systems is impressive, the experience for many is still one of errors, corrections, frustration and abandoning speech in favour of alternative interaction methods. We take a closer look at speech and find out why speech recognition is so difficult.

I take a closer look at some unavoidable challenges to effective speech recognition, and I discuss why you may want to think twice before designing dialogue that is 'conversational' and 'natural'. I also offer five important questions that I think should form the basis of any VUI design kick-off meeting.

Adam offers advice to caregivers of a loved one with TBI and/or PTSD — from simply trying to see how that person's life has changed to helping him get involved in confidence-boosting activities.

Including version 4.6 it was quite difficult to add custom bulk actions to the WordPress admin pages. In version 4.7 […]

We study an equivariant extension of the Batalin-Vilkovisky formalism for quantizing gauge theories. Namely, we introduce a general framework to encompass failures of the quantum master equation, and we apply it to the natural equivariant extension of AKSZ solutions of the classical master equation (CME). As examples of the construction, we recover the equivariant extension of supersymmetric Yang-Mills in 2d and of Donaldson-Witten theory.

Over the years, performance evaluation has become essential in computer vision, enabling tangible progress in many sub-fields. While talking-head video generation has become an emerging research topic, existing evaluations on this topic present many limitations. For example, most approaches use human subjects (e.g., via Amazon MTurk) to evaluate their research claims directly. This subjective evaluation is cumbersome, unreproducible, and may impend the evolution of new research. In this work, we present a carefully-designed benchmark for evaluating talking-head video generation with standardized dataset pre-processing strategies. As for evaluation, we either propose new metrics or select the most appropriate ones to evaluate results in what we consider as desired properties for a good talking-head video, namely, identity preserving, lip synchronization, high video quality, and natural-spontaneous motion. By conducting a thoughtful analysis across several state-of-the-art talking-head generation approaches, we aim to uncover the merits and drawbacks of current methods and point out promising directions for future work. All the evaluation code is available at: https://github.com/lelechen63/talking-head-generation-survey.

With all due respect to Greta Thunberg and Billie Eilish, nobody had a better 2019 than Baby Yoda. The real star of the Disney+ flagship Star Wars series The Mandalorian, the little green puppeteering/CGI marvel (aka "the Child") might be the most adorable creature ever created.…

Virtually every musician starts out trying to copy their heroes.…

Another First Friday is here, and you can correctly assume that it will be all online once again. The May 1 Virtual First Friday is from 10 am to midnight.…

The chafing.…

Erin Haskell Gourde isn't afraid to mix it up a little.…

A method for preparation of an aryl poly(oxalkyl) quaternary ammonium compound is provided, said method comprising steps of: 1) reacting a phenol with a dihalopolyalkylene ether under the action of a phase transfer catalyst, to obtain an arylpoly(oxalkyl) halide; 2) reacting said arylpoly(oxalkyl) halide with an amination reagent under the action of a phase transfer catalyst, to obtain an arylpoly(oxalkyl) amine; 3) reacting said arylpoly(oxalkyl) amine with an alkylation reagent, to obtain an aryl poly(oxalkyl) quaternary ammonium compound; wherein R1 is H or a C1 to C16 alkyl group, located in the ortho, meta or para position; n is an integer of 2 to 6; R2 is H or a C1 to C16 alkyl group; R3 is H or a C1 to C16 alkyl group; R4 is a C1 to C16 alkyl group; X1 is Br or Cl; X is Cl, Br, or I. The preparation method according to the present invention requires low temperature and low pressure, the reaction time is short, and an overall yield can reach 75%. The operation is simple, the cost is low, and the product can be separated easily and have a purity of pharmaceutical grade, thereby facilitating the large-scale production.

A branched hetero polyfunctional polyoxyalkylene compound represented by the following formula (1): wherein Z represents a hydroxyl group-removed residue of pentaerythritol or dipentaerythritol, OA1 and OA2 represent an oxyalkylene group having 2 to 4 carbon atoms, L1, L2 and L3 represent an alkylene group or an alkylene group that contains an ester bond, a urethane bond, an amide bond, an ether bond, a carbonate bond, a secondary amino group or a urea bond, X and Y are different from each other and represent a functional group capable of a chemical reaction; m and n are an average number of moles of the oxyalkylene group added, m represents 5 to 1,000, n represents 0 to 1,000, and p, q and r represent 0 or 1; and s1 is an integer of 2 or more and s1+s2=4 or 6.

A process for preparing alkylated p-phenylenediamine having the steps of reacting aniline and nitrobenzene in presence of a complex base catalyst to obtain 4-aminodiphenylamine intermediates, hydrogenating the 4-aminodiphenylamine intermediates to 4-aminodiphenylamine in presence of a hydrogenation catalyst, and reductively alkylating the 4-aminodiphenylamine to alkylated p-phenylenediamine.

Disclosed is a process for preparing an aryloxyalkylene amine compound via an aminoethylation reaction comprising: a) reacting an aromatic hydroxyl compound in the presence of a basic catalyst with a 2-oxazolidinone compound of the formula II to form an intermediate reaction product; wherein R3 is selected from the group consisting of hydrogen or lower alkyl having 1 to 6 carbon atoms, R4 is selected from the group consisting of hydrogen, straight or branched chain alkyl having from one to six carbon atoms, phenyl, alkaryl, or arylalkyl; and b) reacting the intermediate product of step a) with a polyalkylene polyamine.

The invention relates to a method for preparing ring-halogenated N,N-dialkylbenzylamines and intermediates obtainable therefrom for preparing agrochemicals and pharmaceutically active ingredients.

A process for producing C10-C26 monobranched fatty acids or alkyl esters thereof which includes isomerizing unsaturated C10-C26 fatty acids or alkyl esters thereof in the presence of a catalyst which comprises both a zeolite and a Lewis base. The zeolite can be reused after simple separation from the reaction products without having to regenerate. The process is particularly suitable for producing highly monobranched fatty acids or alkyl esters thereof.

The invention relates to the use of a composition of A) at least one quaternary ammonia compound comprising at least one organic radical bonded to the ammonia nitrogen atom and optionally comprising heteroatoms and having 1 to 36 carbon atoms, and B) at least one amine alkoxylate ester of formula (1) or a salt thereof, where A, B are, independently of each other, a C2- through C5-alkylene radical R1, a C8- through C24-alkyl radical or alkenyl radical R2, R3, R4 independent of each other, H, or a C8- through C24-acyl radical, with the stipulation that at least one of the radicals R2, R3 or R4 stands for a C8- through C24-acyl radical, and x, y, z, independently of each other, stand for a whole number from 0 through 50, with the stipulation that x+y+z is a whole number from 1 through 100, in quantities of 10 through 5000 g/tonne of ore as a collector in silicate floation.

This invention relates to an improved process for the preparation of green fatty acid methyl esters (FAME; commonly called as biodiesel) from different triglyceride oils using mixed metal oxides derived from layered double hydroxides (referred here as LDHs) as reusable solid heterogeneous base catalysts. This process uses very low alcohohoil molar ratio and catalyst and/or products are easily separable after the reaction through simple physical processes. The properties of thus obtained biodiesel meet the standard biodiesel values and can directly be used as transport fuel.

This invention relates to novel 5-[(hydroxymethyl)aryl]-substituted pyrrolo[2,1-f][1,2,4]triazin-4-amines of formula (I), to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for treating angiogenesis-related disorders, in particular angiogenesis-related ocular disorders.