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When does private no longer mean private? Implications of a challenge to the SFC’s accessing of digital devices in an investigation

The Hong Kong Court has recently confirmed the Securities and Futures Commission (“SFC”)’s powers to seize, search and compel access to digital devices rejecting challenges to such powers based on privacy grounds. Data privacy is a...




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Law & Business 2017. Key changes. Trends and challenges

We are pleased to present to you our brochure which reviews the changes in the Polish law that we believe will have a major impact on business in Poland in 2017.



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Support around Covid-19 Challenges

Most of the questions we are receiving in the clean energy sector around Covid-19 relate to maintaining project continuity and the impact of Covid-19 on the work force, raising and defending Force Majeure and how best to approach discussions with f...




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UAE- Bentley Institute announces Digital Infrastructure Student Idea Challenge 2020

(MENAFN - Dubai PR Network) 7 May 2020 - Bentley Institute, a leading organization advancing infrastructure professions by empowering practitioners, s... ......




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Coronavirus is added challenge for group homes: How they are dealing with pandemic

Here is how staff and residents of group homes for people with disabilities are coping during COVID-19 in the Southern Tier of New York. ......




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Conhece a nossa equipa do Hall of Fame!

No âmbito das celebrações do nosso 81º aniversário, fizemos um pedido. Ao longo da semana, desafiamos aos nossos sócios e adeptos para votarem...




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SDGs: the Challenge to Improve Lives After the COVID-19 Crisis

Alexander Trepelkov is Officer-in-Charge of the Division for Sustainable Development Goals (SDGs) at the UN’s Department of Economic and Social Affairs (DESA)

The post SDGs: the Challenge to Improve Lives After the COVID-19 Crisis appeared first on Inter Press Service.




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Ceremonial Hall, the most spectacular room of Dolmabahçe

Dolmabahçe Palace has been astonishing visitors with its stunning architecture and breathtaking designs but the most astounding room it houses is the Ceremonial Hall.




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Challenging IT implementations - a UK reminder about the fundamentals for success

Sanderson Limited v Simtom Food Products Limited [2019] EWHC 442 (TCC) Summary Whatever the sector, IT transformation can deliver superior services, development of dynamic business models, increased customer satisfaction, returns and cost savings. ...




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Coronavirus - key legal challenges and solutions for the international energy industry

Overview On 30 January 2020, the World Health Organization (WHO) declared a Public Health Emergency of International Concern (PHEIC) in response to the spread of the Wuhan coronavirus, the sixth time that the WHO has made this declaration since adop...




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Coronavirus - Dealing with the financial services regulatory challenges - Ireland

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Education briefing - Challenging times for the new Ofsted inspection regime

The new regime One of the most significant changes to the academies and further education sectors in 2019 was the introduction of the Education Inspection Framework (EIF) which Ofsted implemented in September 2019. The stated aim of this change was ...




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Zimbabwe’s Afforestation Challenge

“I have never planted a tree in my life,” laughs Jairos Saunyama, a tobacco farmer, revelling at the absurdity of the question of whether he is involved in the country’s afforestation efforts. Sawunyama is one of thousands of farmers who are blamed by local conservationists for turning the country’s forests into deserts and dust bowls. […]

The post Zimbabwe’s Afforestation Challenge appeared first on Inter Press Service.




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Closed bookstores and libraries remain a challenge for bibliophiles

Japan is a nation of bibliophiles and while bookstores saw a spike in sales as schools closed due to the outbreak of COVID-19, publishers now ...




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COVID-19 - Porous Kenya-Somalia Border a Challenge for Wajir

[Nation] The porous Kenya-Somalia border is proving a challenge in management of the Covid-19 coronavirus disease for counties such as Wajir.




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German monitor: antisemitic incidents have increased since Halle shooting


In the Halle attack, two people were killed near the synagogue when the alleged gunman could not enter the building.




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Is Scripture Sufficient to Meet Modern Cultural Challenges?

Twenty-first century evangelists and missionaries are confronted with a vastly different world to that of the early church. In the realms of communication and technology, the changes are immense. And in the eyes of many church growth proponents, a lot of modern advancements have left the Bible looking older than ever.

READ MORE




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Road filled with challenges for mental health team

Chronic shortage of psychiatrists, inadequate funding and societal ignorance among challenges




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Coronavirus: Hong Kong’s High Court tosses Pakistan returnee’s challenge to mandatory quarantine at government facility

The High Court has thrown out a Hong Kong resident’s challenge to his quarantine status, dismissing his application for a writ of habeas corpus over his mandatory isolation at a government-run facility.Accountant Syed Agha Raza Shah, who tested negative for Covid-19 upon his return, was sent to the Chun Yeung Estate in Fo Tan for a 14-day stay after returning from Pakistan via Qatar with about 200 other Hong Kong residents on April 29.On Thursday, he applied for a writ of habeas corpus…




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Former Child Bride Holds Pakistan to Account for Wrongful Imprisonment in Historic Legal Challenge

A former Pakistani child bride, who was wrongly accused of killing her husband at 13 and subsequently spent almost two decades in prison, is making history by being the first victim of a miscarriage of justice to seek compensation from the state, say legal human rights experts.   This March, Rani Tanveer, who was released in […]

The post Former Child Bride Holds Pakistan to Account for Wrongful Imprisonment in Historic Legal Challenge appeared first on Inter Press Service.




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Coronavirus is accelerating eight challenging mega trends

We are about to experience the next 20 years in 12 months, and we need to get ready for it, according to a former British foreign secretary.




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'The greatest challenge': Asia catches coronavirus' second wave

Beijing has imposed new restrictions on an upscale diplomats district home to 3.5 million people, as it guards a second wave of coronavirus cases.




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Fiscal budget 2020-21 under process: Centre faces mammoth challenges to find ways out for revenue

ISLAMABAD: The Centre will have to face serious challenges to support day to day expenditures after paying defence and debt servicing bills from available resources, as the fiscal budget 2020-21 is...

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Fiscal budget 2020-21 under process: Centre faces mammoth challenges to find ways out for revenue

ISLAMABAD: The Centre will have to face serious challenges to support day to day expenditures after paying defence and debt servicing bills from available resources, as the fiscal budget 2020-21 is...

[[ This is a content summary only. Visit my website for full links, other content, and more! ]]




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The challenges of COVID-19

COVID-19, the deadly pandemic, is moving at a fast pace, killing thousands of people worldwide in its wake every day. The confirmed cases of coronavirus have topped 3.4 million worldwide while over...

[[ This is a content summary only. Visit my website for full links, other content, and more! ]]




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Fiscal budget 2020-21 under process: Centre faces mammoth challenges to find out ways for revenue

ISLAMABAD: The Centre will have to face serious challenges to support day to day expenditures after paying defence and debt servicing bills from available resources, as the fiscal budget 2020-21 is...

[[ This is a content summary only. Visit my website for full links, other content, and more! ]]




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Covid-19 challenges: Imran stresses out-of-box solutions

ISLAMABAD: Prime Minister Imran Khan Friday said out-of-box solutions were needed to meet the present day economic challenges in the wake of COVID-19 situation.He was chairing a meeting to review the economic situation and future outlook of economy in the wake of COVID-19 situation. A detailed...




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COVID-19 challenges: Imran stresses out-of-box solutions

ISLAMABAD: Prime Minister Imran Khan Friday said out-of-box solutions were needed to meet the present day economic challenges in the wake of COVID-19 situation.He was chairing a meeting to review the economic situation and future outlook of economy in the wake of COVID-19 situation.A detailed...




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COVID-19 challenges: PM Imran Khan stresses out-of-box solutions

ISLAMABAD: Prime Minister Imran Khan Friday said out-of-box solutions were needed to meet the present day economic challenges in the wake of COVID-19 situation.He was chairing a meeting to review the economic situation and future outlook of economy in the wake of COVID-19 situation.A detailed...




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Small business solutions for pandemic challenges -- by Lotte Schou-Zibell

Crafting small business support efforts to specific country circumstances could help save millions of livelihoods in poor communities and fortify economies against future shocks.




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Golfer Greg Norman’s Colorado ranch — featuring seven lakes, a dance hall and 11,600 acres — can be yours for $50 million

Surrounded by the White River National Forest, the 11,600-acre Seven Lakes Ranch located in the Meeker Valley is up for sale three years removed from extensive renovations.




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Microchip Solves Interoperability Challenges of Delivering up to 90 Watts of Power Over Ethernet Wiring

Microchip Solves Interoperability Challenges of Delivering up to 90 Watts of Power Over Ethernet Wiring




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ADB Announces $6 Million Grant to Help Marshall Islands Combat COVID-19

ADB today announced the release of a $6 million grant from its Pacific Disaster Resilience Program (Phase 2) to help finance the Government of the Marshall Islands’ response to the novel coronavirus disease (COVID-19) pandemic.




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Japan to Support ADB Developing Member Countries' Response to COVID-19 Challenges

ADB has provided several targeted interventions to support its developing member countries in combating the effects of the COVID-19 pandemic from its early stages. In support of ADB’s effort, the Government of Japan is...




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Learning from the Challenges of the Melamchi Water Supply in Kathmandu

Nepal has 2.7% of the earth’s freshwater, yet the people of Kathmandu, Nepal’s most developed region, struggle with scarce water supply.




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COVID-19: Responding to the Present Crisis, Preparing for Future Challenges

ADB is formulating an aggressive set of actions to protect the poor, the vulnerable, and wider populations across Asia and the Pacific. And to ensure economies will rebound as swiftly as possible.




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With Australian-ADB investment, clean water is flowing in Marshall Islands’ Ebeye

Thanks to investment from Australia and ADB, a new clean water plant in Ebeye, in the north-west corner of the Marshall Islands, is changing lives.




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Google hits back at IBM's quantum supremacy challenge

Google engineers have spoken out about their claims of quantum supremacy, questioning IBM’s challenges and revealing some of their big plans for coming years




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Opera star sings Britain's VE Day hits from an empty Albert Hall

Welsh mezzo-soprano Katherine Jenkins will stream a concert from an empty Royal Albert Hall on Friday evening, as locked-down Britain marks the 75th anniversary of "Victory in Europe" Day.




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Spiders think with their webs, challenging our ideas of intelligence

With the help of their webs, spiders are capable of foresight, planning, learning and other smarts that indicate they may possess consciousness




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Shallow Mexican seabed traps tsunamis so they strike land repeatedly

A tsunami kept pinging back and forth for three days after being triggered by the 8 September 2017 Mexico earthquake, posing even more risk to human life




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Self-driving cars find use in challenging times

After being sidelined as a non-essential business, some self-driving car companies can put their vehicles back on the roads to make food and other deliveries - a win-win scenario that allows them to continue testing their nascent technology.




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Spiders think with their webs, challenging our ideas of intelligence

With the help of their webs, spiders are capable of foresight, planning, learning and other smarts that indicate they may possess consciousness




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Type 2 Diabetes in Kids a Challenge to Control

Title: Type 2 Diabetes in Kids a Challenge to Control
Category: Health News
Created: 5/1/2012 11:01:00 AM
Last Editorial Review: 5/1/2012 12:00:00 AM




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White House to Challenge Ruling on Unlimited Access to 'Morning-After' Pill

Title: White House to Challenge Ruling on Unlimited Access to 'Morning-After' Pill
Category: Health News
Created: 5/2/2013 10:35:00 AM
Last Editorial Review: 5/2/2013 12:00:00 AM




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Study Challenges Salt Guidelines for Kids

Title: Study Challenges Salt Guidelines for Kids
Category: Health News
Created: 4/27/2015 12:00:00 AM
Last Editorial Review: 4/28/2015 12:00:00 AM




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The Danger of Internet Challenges

A child psychologist advises parents to address the threat of internet challenges with continual, preemptive conversations with kids -- and with special phone settings.




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Challenges with Adherence to Clinical Practice Guidelines: Lessons for Implementation Science




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Neutralizing Monoclonal Antibodies against the Gn and the Gc of the Andes Virus Glycoprotein Spike Complex Protect from Virus Challenge in a Preclinical Hamster Model

ABSTRACT

Hantaviruses are the etiological agent of hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS). The latter is associated with case fatality rates ranging from 30% to 50%. HCPS cases are rare, with approximately 300 recorded annually in the Americas. Recently, an HCPS outbreak of unprecedented size has been occurring in and around Epuyén, in the southwestern Argentinian state of Chubut. Since November of 2018, at least 29 cases have been laboratory confirmed, and human-to-human transmission is suspected. Despite posing a significant threat to public health, no treatment or vaccine is available for hantaviral disease. Here, we describe an effort to identify, characterize, and develop neutralizing and protective antibodies against the glycoprotein complex (Gn and Gc) of Andes virus (ANDV), the causative agent of the Epuyén outbreak. Using murine hybridoma technology, we generated 19 distinct monoclonal antibodies (MAbs) against ANDV GnGc. When tested for neutralization against a recombinant vesicular stomatitis virus expressing the Andes glycoprotein (GP) (VSV-ANDV), 12 MAbs showed potent neutralization and 8 showed activity in an antibody-dependent cellular cytotoxicity reporter assay. Escape mutant analysis revealed that neutralizing MAbs targeted both the Gn and the Gc. Four MAbs that bound different epitopes were selected for preclinical studies and were found to be 100% protective against lethality in a Syrian hamster model of ANDV infection. These data suggest the existence of a wide array of neutralizing antibody epitopes on hantavirus GnGc with unique properties and mechanisms of action.

IMPORTANCE Infections with New World hantaviruses are associated with high case fatality rates, and no specific vaccine or treatment options exist. Furthermore, the biology of the hantaviral GnGc complex, its antigenicity, and its fusion machinery are poorly understood. Protective monoclonal antibodies against GnGc have the potential to be developed into therapeutics against hantaviral disease and are also great tools to elucidate the biology of the glycoprotein complex.




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A rational approach to e-cigarettes: challenging ERS policy on tobacco harm reduction

We wish to thank J. Britton and co-workers for responding to our editorial and giving us an opportunity to clarify our position as well as correct a few misunderstandings. We definitely share the same goal, which is to relieve Europe and the rest of the world from the terrible results of the tobacco epidemic. We also do not "blankly oppose e-cigarettes"; however, we strongly advocate against a harm reduction strategy including e-cigarettes as well as heated tobacco products [1]. As clinicians we all see reluctant smokers where e-cigarettes can be tried as a last resort for getting off cigarette smoking, but that is of little relevance for a general harm reduction strategy. We also agree that the UK has achieved a lot in the area of smoking cessation but would argue that this has been achieved by impressive tobacco control, not by the use of e-cigarettes, and that a country such as Australia, which has banned nicotine-containing e-cigarettes, has achieved similar results.