The dramatic fall came before reported coronavirus cases began to surge in March, economists note, so it's only the tip of the iceberg.

San Pedro's historic waterfront market is offering discounted shrimp trays to draw in customers

The author of "We Need to Talk About Kevin" lives that perfect, self-improving quarantine life (or maybe gets drunk and watches British reality TV).

The Man Who Pays His Way: Travelling will be lonelier without trusted guidebooks

I was wrong an hour ago, to say the Golden Rule measure of borrowing was looking better than it had been in 2012. Sorry, bit rushed. Looking at the data, the chancellor is conceding that by 2011, the economy will...

(Earth Institute at Columbia University) A uniquely resilient organism all but unheard of in the Arabian Sea 20 years ago has been proliferating and spreading at an alarming pace. New research describes how the continued loss of snow over the Himalayan-Tibetan Plateau region is fueling the expansion of this destructive algal bloom.

Structural plasticity of dendritic spines is a key component of the refinement of synaptic connections during learning. Recent studies highlight a novel role for the NMDA receptor (NMDAR), independent of ion flow, in driving spine shrinkage and LTD. Yet little is known about the molecular mechanisms that link conformational changes in the NMDAR to changes in spine size and synaptic strength. Here, using two-photon glutamate uncaging to induce plasticity at individual dendritic spines on hippocampal CA1 neurons from mice and rats of both sexes, we demonstrate that p38 MAPK is generally required downstream of non-ionotropic NMDAR signaling to drive both spine shrinkage and LTD. In a series of pharmacological and molecular genetic experiments, we identify key components of the non-ionotropic NMDAR signaling pathway driving dendritic spine shrinkage, including the interaction between NOS1AP (nitric oxide synthase 1 adaptor protein) and neuronal nitric oxide synthase (nNOS), nNOS enzymatic activity, activation of MK2 (MAPK-activated protein kinase 2) and cofilin, and signaling through CaMKII. Our results represent a large step forward in delineating the molecular mechanisms of non-ionotropic NMDAR signaling that can drive shrinkage and elimination of dendritic spines during synaptic plasticity.

SIGNIFICANCE STATEMENT Signaling through the NMDA receptor (NMDAR) is vitally important for the synaptic plasticity that underlies learning. Recent studies highlight a novel role for the NMDAR, independent of ion flow, in driving synaptic weakening and dendritic spine shrinkage during synaptic plasticity. Here, we delineate several key components of the molecular pathway that links conformational signaling through the NMDAR to dendritic spine shrinkage during synaptic plasticity.

A treasure trove of new fossils unearthed in Australia reveals some raunchily-positioned bugs

The change to the Title II program will benefit Southern states, while Michigan, New York, and Pennsylvania, among others, will see their allocations shrink.

Gov. Jeb Bush has warned that Florida won't meet class-size limits without taking such steps as expanding private school vouchers, lifting restrictions on the number of charter schools, and moving to year-round schedules.

University officials, who have discouraged visits to campus and campus landmarks due to COVID-19, are increasing signage and social distancing guidance around the sites, as visitors continue to seek photographs in those areas and appear to be ignoring health care recommendations.

Our mission is to solve boredom. There are now 500 million Indians who have an internet connection, and are spending nearly five hours a day on social media and entertainment.

Meanwhile, domestic consumption of petroleum products in FY20 remained flat at 213.7 MT as sales of transportation fuels plummeted in March amid the country-wide lockdown.

State governments seem to have collected the lowest-ever inflation-adjusted monthly tax revenue in April.

At his meeting with NSA Mohib, Shringla reiterated India’s commitment to “stand with Afghanistan” as it pursues “sustainable peace and reconciliation."

A seer in Uttar Pradesh's Mathura city on Saturday demanded that the Uttarakhand government revoke its decision of postponing the opening of the Badrinath shrine and said "changing the auspicious date means inviting wrath of the deity".

HSBC pledged a new era of higher dividends on Tuesday, laying out plans to slash nearly one in five jobs...

The Bank of England warned Thursday that the British economy could suffer its deepest annual contraction in more than three centuries as a result of the coronavirus pandemic, before bouncing back next year.

from Bon Appetit. A delicious glaze. Make it often. -- posted by Vicki Kaye

Title: Type 2 Diabetes May Shrink the Brain, Study Suggests
Category: Health News
Created: 4/29/2014 9:35:00 AM
Last Editorial Review: 4/29/2014 12:00:00 AM

Title: Female Pelvis Widens, Then Shrinks Over a Lifetime, Study Finds
Category: Health News
Created: 4/25/2016 12:00:00 AM
Last Editorial Review: 4/26/2016 12:00:00 AM

Need help tracking down and completing all 120 shrines in the Legend of Zelda: Breath of the Wild? Look no further. Here's everything you need to know, from the complete list of shrines to a map with every shrine location.

Over time, trash that has been floating in the ocean gets covered in algae and other micro-organisms

Earth's insect population has shrunk by 27 per cent in the past 30 years, researchers have found.

The once mighty northern cod stocks' growth is stalled according to DFO science. Ecosystem conditions including a lack of food are contributing factors. Fish harvesters say in the bigger picture though, the numbers are moving in the right direction.

Shriver’s contentious views on diversity thread through the story of a couple’s strained relationship with exercise

Lionel Shriver’s scabrously funny 15th novel presents a dyspeptic view of people in thrall to exercise. In 2013 Shriver’s own daily regime involved “130 press-ups, 200 side crunches, 500 sit-ups and 3,000 star jumps … The jumps take 32½ minutes, or three every two seconds”. The Motion Of The Body Through Space was written, she recently revealed, after she realised that she may be more dedicated to her exercise than to her writing.

The protagonist, Serenata Terpsichore (“rhymes with chicory”), is a 60-year-old woman from upstate New York with a beguiling voice and ruined knees. The former she puts to lucrative use as a voiceover artist and narrator of audiobooks. The latter are the result of a lifetime’s adherence to the doctrine of working out; in particular the belief that 10-mile runs are the key to longevity and good health.

We need to talk about exercise, race and gender

"Your efforts have helped to establish the Shriver Center as the authoritative international resource center on poverty law – and as a powerful voice for the most vulnerable among us. For more than three decades, you’ve fought to protect the rights and best interests of Americans in need and at risk."

An Alabama man pleaded guilty yesterday in a federal court in Gulfport, Miss., to knowingly shooting a dolphin, the Justice Department announced.

New NASA study offers first direct proof that the ozone hole is recovering thanks to the Montreal Protocol treaty and the international ban on CFCs.

Well, giant shrimp the size of your forearm are now a thing we can worry about.

Bloody red shrimp are invasive, but yummy for some native Great Lakes fish. A first-time find by Canadian researchers.

Imagine millions of these slithering out from the mud? The eggs of this alien desert crustacean remain dormant for years, waiting for a bout of rain to hatch.

Mangroves are a special ecosystem. Found all over the world, they thrive in the in-between zones of land and sea, and act as nurseries for a vast variety of animals, grocery stores for humans, a buffer between homes

The graph says it all...

A mini video series just released by the National Young Farmers Coalition illustrates the challenges and joys of starting one's own dairy farm.

Could sharing more be central to achieving the Right's biggest dream?

Russia reported 11,231 additional cases of the coronavirus disease to bring the country's tally to 177,160 since the outbreak.

Home prices have only fallen nationally once since the Great Depression, and that was after the subprime mortgage crisis and the Great Recession. Now, barely eight years after hitting bottom, and after a mighty recovery, prices are predicted to fall nationally again, down 2-3% this year, according to Zillow.

We are "worried" that humanitarian spaces for refugees may shrink if coronavirus infections within refugee camps rise, says Peter Maurer, president of the International Committee of the Red Cross. He says he also expects ICRC's funding to become "very problematic" with donor countries increasing spending on their own economies.

Market players want to know how much the European Union will provide in additional coronavirus stimulus, but the institution in charge of developing it says it's still under negotiation.

Victoria Falls, on the border of Zimbabwe and Zambia, has slowed down to a trickle after an unprecedented decline in water levels, officials have said. Data from the Zambezi River authority showed water flow at its lowest since 1995, and well under the long-term average. 

The Zambian president, Edgar Lungu, said it was a stark reminder of what climate change is doing to the environment, yet some scientists are cautious about categorically blaming the climate crisis. Harald Kling, a hydrologist at engineering firm Pöyry and a Zambezi River expert, said climate science dealt in decades, not particular years, 'so it’s sometimes difficult to say: this is because of climate change because droughts have always occurred'

• Victoria Falls dries to a trickle after worst drought in a century

Bank outlines scale of Covid-19 shock in 2020 with forecast for deepest recession in 300 years

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The Bank of England has warned the British economy could shrink by 14% this year and unemployment more than double by spring as the coronavirus causes the deepest recession in modern history.

Leaving interest rates on hold at a record low of 0.1% as the economic crisis unfolds, the central bank said economic activity across the country had fallen sharply since the onset of the global health emergency and the lockdown measures to contain its spread.

Related: Don't expect a snapback for the UK economy after lockdown is lifted | Larry Elliott

Related: Bank of England warns UK economy could shrink 14% in 2020 amid Covid-19 downturn - business live

Related: Bank of England warns UK economy could shrink 14% in 2020 amid Covid-19 downturn - business live