Alexey I. Nesvizhskii
Oct 1, 2005; 4:1419-1440
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William M. Old
Oct 1, 2005; 4:1487-1502
Research

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The St Catherine South police are probing the fatal shooting of a fisherman in Old Harbour Bay in the parish on Sunday.

Highly engineered phytases, which sequentially hydrolyze the hexakisphosphate ester of inositol known as phytic acid, are routinely added to the feeds of monogastric animals to improve phosphate bioavailability. New phytases are sought as starting points to further optimize the rate and extent of dephosphorylation of phytate in the animal digestive tract. Multiple inositol polyphosphate phosphatases (MINPPs) are clade 2 histidine phosphatases (HP2P) able to carry out the stepwise hydrolysis of phytate. MINPPs are not restricted by a strong positional specificity making them attractive targets for development as feed enzymes. Here, we describe the characterization of a MINPP from the Gram-positive bacterium Bifidobacterium longum (BlMINPP). BlMINPP has a typical HP2P-fold but, unusually, possesses a large α-domain polypeptide insertion relative to other MINPPs. This insertion, termed the U-loop, spans the active site and contributes to substrate specificity pockets underpopulated in other HP2Ps. Mutagenesis of U-loop residues reveals its contribution to enzyme kinetics and thermostability. Moreover, four crystal structures of the protein along the catalytic cycle capture, for the first time in an HP2P, a large ligand-driven α-domain motion essential to allow substrate access to the active site. This motion recruits residues both downstream of a molecular hinge and on the U-loop to participate in specificity subsites, and mutagenesis identified a mobile lysine residue as a key determinant of positional specificity of the enzyme. Taken together, these data provide important new insights to the factors determining stability, substrate recognition, and the structural mechanism of hydrolysis in this industrially important group of enzymes.

After Ohtani's nearly unprecedented two-way success during his American League Rookie of the Year campaign last year, more clubs are looking into the possibility of having players who can both pitch and play a position. Walsh fits that bill, as he has been a power-hitting first baseman and outfielder in the Minors, but he's made 10 pitching appearances over the past three seasons as well. The Angels are experimenting with him doing both this spring and this upcoming season.

The Indiana state teachers' union is pushing to protect student and staff safety during active-shooter trainings.

The Maple Leafs called up leading Marlies scorer Alex Steeves but aren't expected to play him. He deserves a good look while other bottom-six players struggle, says Adam Proteau.

Download the data from Education Week showing how over 900 school districts provided instruction on their first day of the school year.

Local independent pharmacy to administer important immunizations Insurance Commissioner Trinidad Navarro, in collaboration with Lieutenant Governor Bethany Hall-Long and Kevin Musto, R.Ph., FAPhA, independent pharmacist with Atlantic Apothecary, has announced a COVID Vaccination and Flu Shot Clinic on Thursday, November 18 from 1:00 to 4:00PM at the Delaware Department of Insurance’s Dover Office, 1351 West […]

The video of Nagori shots has amassed almost 9 lakh views.

Read the in depth Review of Noise Shots XO Audio Video. Know detailed info about Noise Shots XO configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

Read the in depth Review of Noise Shots Rush Audio Video. Know detailed info about Noise Shots Rush configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

Positioned near the side of her head, the eye provides an expansive field of vision, while a thick layer of protective blubber shields it from harm and maintains warmth.

Body-camera video released on Monday showed the chaotic, violent moments leading to the fatal Los Angeles police shooting of an assault suspect in a clothing store, and of a 14-year-old girl caught in

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Missing or inaccessible lung function measurements, gathered over time, have the potential to stagnate or impair clinical care decisions being made. This jeopardises patient safety and often contributes to excessive resource utilisation. Data integration is fundamental to clinical decision-making and entails amalgamating lung function data from multiple sources in a user-friendly format. Despite this, current systems for recording lung function data are suboptimal, with copious gaps in the clinical picture arising from missing or inaccessible lung function measurements. This article discusses the importance of data integration for lung function, with a call to action for key stakeholders involved in the performance, management and interpretation of such tests.

Real gamblers play russian roulette with shotguns. That is the core concept of Buckshot Roulette, the Inscryption-looking game of blinksweat and bulletworry. It's been out for a while now but the developers have just added a fun extra - a 4-person multiplayer mode.

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Smart TVs from Samsung and LG monitor what you are watching even when you are using the screens to display a feed from a connected laptop or video game console

Toronto police say they have arrested 23 people after close to 100 shots were fired outside a recording studio in Toronto’s west end on Monday night – though no one was injured. 

It's a little rogue-lite, it's a bit '90s arcade, and it's surprisingly deep.

I’ve been a big fan of SIGONO’s OPUS series of narrative adventure games for a long time. If you’ve not …

Continue reading "‘OPUS: Prism Peak’, the Newest Entry in the Amazing ‘OPUS’ Series, Gets New Gameplay Screenshots"

HoYoverse’s Honkai Star Rail (Free) version 2.5 update titled “Flying Aureus Shot to Lupine Rue" was just showcased during a …

Continue reading "‘Honkai Star Rail’ Version 2.5 “Flying Aureus Shot to Lupine Rue” Update Releases on September 10th, New Trailer Showcased During Livestream"

The shootings were part of a wave of violence that erupted as the country plagued by gang violence swore in its new prime minister after a politically tumultuous process.

THIS footage of the US Open winner’s wife’s short skirt was far too long or not long enough depending on who you ask.

Emteq Labs wants eyewear to be the next frontier of wearable health technology.

The Brighton, England-based company introduced today its emotion-sensing eyewear, Sense. The glasses contain nine optical sensors distributed across the rims that detect subtle changes in facial expression with more than 93 percent accuracy when paired with Emteq’s current software. “If your face moves, we can capture it,” says Steen Strand, whose appointment as Emteq’s new CEO was also announced today. With that detailed data, “you can really start to decode all kinds of things.” The continuous data could help people uncover patterns in their behavior and mood, similar to an activity or sleep tracker.

Emteq is now aiming to take its tech out of laboratory settings with real-world applications. The company is currently producing a small number of Sense glasses, and they’ll be available to commercial partners in December.

The announcement comes just weeks after Meta and Snap each unveiled augmented reality glasses that remain in development. These glasses are “far from ready,” says Strand, who led the augmented reality eyewear division while working at Snap from 2018 to 2022. “In the meantime, we can serve up lightweight eyewear that we believe can deliver some really cool health benefits.”

Fly Vision Vectors

While current augmented reality (AR) headsets have large battery packs to power the devices, glasses require a lightweight design. “Every little bit of power, every bit of weight, becomes critically important,” says Strand. The current version of Sense weighs 62 grams, slightly heavier than the Ray-Ban Meta smart glasses, which weigh in at about 50 grams.

Because of the weight constraints, Emteq couldn’t use the power-hungry cameras typically used in headsets. With cameras, motion is detected by looking at how pixels change between consecutive images. The method is effective, but captures a lot of redundant information and uses more power. The eyewear’s engineers instead opted for optical sensors that efficiently capture vectors when points on the face move due to the underlying muscles. These sensors were inspired by the efficiency of fly vision. “Flies are incredibly efficient at measuring motion,” says Emteq founder and CSO Charles Nduka. “That’s why you can’t swat the bloody things. They have a very high sample rate internally.”

Sense glasses can capture data as often as 6,000 times per second. The vector-based approach also adds a third dimension to a typical camera’s 2D view of pixels in a single plane.

These sensors look for activation of facial muscles, and the area around the eyes is an ideal spot. While it’s easy to suppress or force a smile, the upper half of our face tends to have more involuntary responses, explains Nduka, who also works as a plastic surgeon in the United Kingdom. However, the glasses can also collect information about the mouth by monitoring the cheek muscles that control jaw movements, conveniently located near the lower rim of a pair of glasses. The data collected is then transmitted from the glasses to pass through Emteq’s algorithms in order to translate the vector data into usable information.

In addition to interpreting facial expressions, Sense can be used to track food intake, an application discovered by accident when one of Emteq’s developers was wearing the glasses while eating breakfast. By monitoring jaw movement, the glasses detect when a user chews and how quickly they eat. Meanwhile, a downward-facing camera takes a photo to log the food, and uses a large language model to determine what’s in the photo, effectively making food logging a passive activity. Currently, Emteq is using an instance of OpenAI’s GPT-4 large language model to accomplish this, but the company has plans to create their own algorithm in the future. Other applications, including monitoring physical activity and posture, are also in development.

One Platform, Many Uses

Nduka believes Emteq’s glasses represent a “fundamental technology,” similar to how the accelerometer is used for a host of applications in smartphones, including managing screen orientation, tracking activity, and even revealing infrastructure damage.

Similarly, Emteq has chosen to develop the technology as a general facial data platform for a range of uses. “If we went deep on just one, it means that all the other opportunities that can be helped—especially some of those rarer use cases—they’d all be delayed,” says Nduka. For example, Nduka is passionate about developing a tool to help those with facial paralysis. But a specialized device for those patients would have high unit costs and be unaffordable for the target user. Allowing more companies to use Emteq’s intellectual property and algorithms will bring down cost.

In this buckshot approach, the general target for Sense’s potential use cases is health applications. “If you look at the history of wearables, health has been the primary driver,” says Strand. The same may be true for eyewear, and he says there’s potential for diet and emotional data to be “the next pillar of health” after sleep and physical activity.

How the data is delivered is still to be determined. In some applications, it could be used to provide real-time feedback—for instance, vibrating to remind the user to slow down eating. Or, it could be used by health professionals only to collect a week’s worth of at-home data for patients with mental health conditions, which Nduka notes largely lack objective measures. (As a medical device for treatment of diagnosed conditions, Sense would have to go through a more intensive regulatory process.) While some users are hungry for more data, others may require a “much more gentle, qualitative approach,” says Strand. Emteq plans to work with expert providers to appropriately package information for users.

Interpreting the data must be done with care, says Vivian Genaro Motti, an associate professor at George Mason University who leads the Human-Centric Design Lab. What expressions mean may vary based on cultural and demographic factors, and “we need to take into account that people sometimes respond to emotions in different ways,” Motti says. With little regulation of wearable devices, she says it’s also important to ensure privacy and protect user data. But Motti raises these concerns because there is a promising potential for the device. “If this is widespread, it’s important that we think carefully about the implications.”

Privacy is also a concern to Edward Savonov, a professor of electrical and computer engineering at the University of Alabama, who developed a similar device for dietary tracking in his lab. Having a camera mounted on Emteq’s glasses could pose issues, both for the privacy of those around a user and a user’s own personal information. Many people eat in front of their computer or cell phone, so sensitive data may be in view.

For technology like Sense to be adopted, Sazonov says questions about usability and privacy concerns must first be answered. “Eyewear-based technology has potential for a great future—if we get it right.”

The victims were identified as Shamshad and Faizan Qasri from Bihar's Batya Zila

In Iceland scientists plan to drill down to magma to understand it and use it for energy production.

Antônio Vinicius Gritzbach had recently agreed to hand over information about the Primeiro Comando da Capital group.

Andrés Bracamonte, known as Pillín, was gunned down near his club's stadium in Rosario.

Shot from village Timila in Ranikhet Tehsil of Uttarakhand

Canadian vaccination programs could eliminate medlinkcervical cancer/medlink by switching to a 1-dose gender-neutral medlinkhuman papillomavirus/medlink

Innovative semaglutide hydrogel may revolutionize diabetes treatment by reducing the need for injections to just once a month, improving patient convenience.

Last week, Kamala's team shared a video in which she was seen dressed in a rainbow flag jacket as part of her campaign. Orry took to the comments section and dropped a vomit emoji. He commented, "You're either a Trump supporter or you hate America."

Creator of the iPod, Nest Labs founder, and investor Tony Fadell took a shot at OpenAI CEO Sam Altman on Tuesday during a spirited interview at TechCrunch Disrupt 2024 in San Francisco. Speaking about his understanding of the longer history of AI development before the large language model (LLM) craze and the serious issues with […]

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Time is running out on one of the biggest opportunities in Disrupt history. We stop accepting applications to the Startup Battlefield 200 tonight, August 5, at precisely 11:59 p.m. PDT. No more deadline extensions, no last-minute exceptions. Nada. Zip. Zilch. Lollygagger alert: Drop what you’re doing and go apply to the Startup Battlefield 200 right […]

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