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The Indianapolis Metropolitan Police Department on Thursday night released more information about an exchange of gunfire that it says occurred between fatal shooting victim Dreasjon Reed and police.

Dreasjon Reed, 21, was shot and killed following an Indianapolis police pursuit that was broadcast in part on Facebook Live.

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Vin Diesel stars as Bloodshot as Valiant Comics finally makes it to the big screen.

Favorites have won 99 of 318 races (31 percent) in the Breeders’ Cup.

• I tested a roughly $33,000 Polaris Slingshot R, a three-wheeled "autocycle."
• The three-wheeler category includes vehicles from Can-Am and Harley-Davidson, offering a motorcycle experience in a less demanding package.
• My Slingshot R had a new, Polaris-developed, 203-horsepower engine and an automatic transmission.
• In all but three US states, no motorcycle license is required to operate the Slingshot (New York, Massachusetts, and Alaska continue to require the motorcycle certification).
• The Slingshot is insanely fun, with a modest learning curve — it's a great alternative to a two-wheeler, although the price is definitely steep for the Slingshot R.
• Visit Business Insider's homepage for more stories.

Motorcycles are cool, but they aren't for everybody. Fortunately, there are some alternatives out there that offer an equally compelling, open-air experience.

One of the most popular is the the Polaris Slingshot, manufactured by the Minnesota-based powersports company. Until recently, Slingshots were available only with manual transmissions and GM-sourced engines, but for 2020, Polaris has updated the autocycle with an in-house motor and an automatic.

The automatic transmission in particular really broadens the Slingshot's potential. So I was excited to sample the machine, which I first saw about five years ago.

Polaris was kind enough to loan me a tester for a few weeks. Here's how it went:

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The Polaris Slingshot is a three-wheeled autocycle/motorcycle that Polaris industries has produced since 2014. My 2020 Slingshot R tester cost about $33,000 and was outfitted in a menacing red-and-black paint job.

The cheapest Slingshot is about $20,000.

This wasn't my first crack at a Slingshot. Polaris brought the vehicle to Insider's New York offices when the vehicle first launched.

And I generally have a gander at the Slingshot when I visit the annual New York motorcycle show.

The Slingshot is classified as either a motorcycle or an autocycle, depending on which state it's being operated in.

Yep, it looks like the Batmobile. Or Batcycle. Hard to avoid feeling like a superhero when you're behind the wheel. In all but three US states, no motorcycle license is required to drive the Slingshot. In New Jersey, you are required to wear a helmet.

Up front, you have 18-inch forged aluminum wheels, with an 20-incher at the back. The brakes have two-piece composite rotors.

Permanent open-air motoring isn't for everybody. Polaris does sell and older model, the Grand Touring, which has a cockpit canopy. The Polaris R has a waterproof interior and drain holes in the floorboards, should you get caught in bad weather.

My tester was the top-level "R" trim, complete with dual roll bars for drier and passenger.

Let's talk fender fairings! The Slingshot's are dramatic and large — I was reminded of Chevy Corvettes while driving this thing. Like a motorcycle, there's no rear-view mirror, so you have to adjust slightly to using the sideviews.

There's a new engine under the hood. Previously, Polaris used a 2.4-liter, four-cylinder GM-sourced Ecotech motor, making up to 175 horsepower. But my R had a ProStar four, also at 2.4-liters, cranking out 203 horsepower with a five-speed automatic transmission (a manual remains available). It's an in-house engine that was impressive in action.

The top speed is limited at 125 mph, and the 0-60mph run, according to Polaris and confirmed by yours truly, is about five seconds.

The four-banger redlines at 8,500 rpm and even with the automatic transmission does a pretty fair imitation of proper motorcycle acceleration. The auto is a tad crunchy, but in this context, that's a plus. It keeps you aware of what the engine is doing.

The rear wheel — fat and wide — is yoked to the motor and transmission with a belt drive. The suspension is surprisingly compliant, but you do have to be mindful of bumps, potholes, and manhole covers if you want to preserve you lower spine.

Polaris says the interior has been upgraded for 2020. No one would call it premium, but for a vehicle like this, it's rather comfortable.

The steering wheel is leather-wrapped, multifunctioned, and flat-bottomed to make getting into and out of the driver's seat easier.

The instrument cluster is a basic analog affair with a central digital display. The red button to on the right steering-wheel spoke allows you to switch between Comfort and Slingshot modes (the latter being the high-performance option).

The bucket seats are waterproof and extremely well-bolstered, with three-point seat belts.

The Slingshot's tubular frame is apparent in the doorless frame.

Not really much cargo capacity here, although I did use the Slingshot for a grocery-store run and quick jaunt to Target to buy a basketball.

There is a place to stow a smartphone, located just above the push-button gear selector.

The Slingshot also has push-button start-stop.

The glove compartment is the only other storage available ...

... And it's actually pretty roomy. One could stash a rain jacket in there, for example.

The RideCommand infotainment system is basic — but good! On a vehicle such as this, I wasn't expecting much, but the audio setup sounded decent, the screen was responsive, and Bluetooth and USB connectivity was on-par with what you'd find in any modern automobile.

There's even GPS navigation, which can display a map and provide turn-by-turn guidance.

The ride-mode selector is doubled in the infotainment system.

So what's the verdict?

I love three-wheelers. They aren't as cool as two-wheeled motorbikes, but they provide easy access to open-air motoring, and the driving/riding experience is much more engaging than what you find in convertible automobiles.

For anybody who dislikes the impracticality of motorcycles but wants to partake of the open-road lifestyle, machines like the Slingshot (the Can-Am Spyder and the Harley-Davidson Freewheeler, to name two) are ideal.

Not for nothing, they also offer aging riders a chance to yank their helmets and biker jackets out of storage to pursue moderately safer riding. With the Slingshot, gearing-up isn't necessary.

The trade-off, of course, is price. The Slingshot R that I tested costs more than an entry-level car or SUV. So, an expensive plaything. But there's nothing wrong with that. Everybody needs a hobby.

No doubt about it, the Slingshot captures attention. I lost count of how many little kids a stopped in their tracks as I tooled around the Jersey suburbs. The last vehicle that provoked such astonishment was the Lamborghini Huracán Performante. If you become a Slingshotter, prepare to be pointed at and asked for photo-ops.

Driving-wise, the Slingshot scratches an itch: on the road, the experience is unexpurgated — you don't have to be constantly vigilant, as you would on a bike, but you do need to remain aware. Highway trips are demanding. And noisy. And exhilarating. The Slingshot R is also fast and torque-y and the power goes to the single back wheel, so the while the two-wheeled front is stable, the back end can get pretty wiggly, especially in Slingshot mode, if you stomp the throttle.

I had iffy springtime Northeast weather to contend with, so I took the Slingshot out only on warm and sunny days; the rest of the time, I parked it in my garage. But the vehicle can handle being rained on, and one could also buy a cover to protect it from the elements. To be honest, however, I think it's a better choice in warm, dry climates. 

The performance is aggressively go-kart-y. This thing will make you a better drive, thanks to its point-and-shoot steering, crisp suspension, and easy access to power. It's insanely fun on curves and into corners. But it's also worthy of short road trips. In fact, the relative comfort was a shocker: I took the Slingshot out for a few hours one day and suffered no ill-effects to my lower back.

Drawback? The design is thoroughly sporty, so if you don't go in for that, the Slingshot might not be your bag. It isn't a throwback, nor is it at all steam-punky. 

It also isn't a motorcycle, in that there aren't any handlebars, you don't throw a leg, and the single wheel takes up the rear. 

But the Slingshot is a absolute blast, and if you're a weekend warrior who wants to carve up a canyon or a country road without having the grapple with a motorcycle's demands — and you don't mind dropping some dollars — the Slingshot is perfect.

If you have kids with mobile devices, create a central home charging station in a place like your bedroom. Before the kids go to bed at night, have them put their mobile devices there so they are not tempted to play with them when they should be sleeping.

Politicians, celebrities and people speaking out on social media are angrily demanding the arrest of two white men in the shooting death of an unarmed black jogger in Georgia.

It took hundreds of exposures and a complex method of removing occlusions, but this "lucky" shot is the result: a depiction of the hot regions lurking under Jupiter's uppermost clouds.

The picture was captured in infared by the Gemini North Telescope in Hawaii, and is one of the sharpest observations of the planet ever made from the ground. To achieve the resolution, scientists used a technique called "lucky imaging" which scrubs out the blurring effect of looking through Earth's turbulent atmosphere. This method involves acquiring multiple exposures of the target and only keeping those segments of an image where that turbulence is at a minimum.

The following article, BREAKING: 43-Yr-Old Father Of 9, Dollar Store Sec Guard, Shot DEAD While Allegedly Trying To Enforce MI Gov Whitmer’s Face Covering Exec Order, was first published on 100PercentFedUp.com.

Will the mainstream media report about the senseless death of a 43-year-old father of nine, who would have been alive today if it were not for VP wannabe, Gretchen Whitmer's executive order that forced him to respond to a customer not wearing a face mask? 

Continue reading: BREAKING: 43-Yr-Old Father Of 9, Dollar Store Sec Guard, Shot DEAD While Allegedly Trying To Enforce MI Gov Whitmer’s Face Covering Exec Order ...

Alexey I. Nesvizhskii
Oct 1, 2005; 4:1419-1440
Tutorial

William M. Old
Oct 1, 2005; 4:1487-1502
Research

Expert

Nikita Prianichnikov
Mar 10, 2020; 0:TIR119.001720v1-mcp.TIR119.001720
Technological Innovation and Resources

Ion mobility can add a dimension to LC-MS based shotgun proteomics which has the potential to boost proteome coverage, quantification accuracy and dynamic range.  Required for this is suitable software that extracts the information contained in the four-dimensional (4D) data space spanned by m/z, retention time, ion mobility and signal intensity. Here we describe the ion mobility enhanced MaxQuant software, which utilizes the added data dimension. It offers an end to end computational workflow for the identification and quantification of peptides and proteins in LC-IMS-MS/MS shotgun proteomics data. We apply it to trapped ion mobility spectrometry (TIMS) coupled to a quadrupole time-of-flight (QTOF) analyzer. A highly parallelizable 4D feature detection algorithm extracts peaks which are assembled to isotope patterns. Masses are recalibrated with a non-linear m/z, retention time, ion mobility and signal intensity dependent model, based on peptides from the sample. A new matching between runs (MBR) algorithm that utilizes collisional cross section (CCS) values of MS1 features in the matching process significantly gains specificity from the extra dimension. Prerequisite for using CCS values in MBR is a relative alignment of the ion mobility values between the runs. The missing value problem in protein quantification over many samples is greatly reduced by CCS aware MBR.MS1 level label-free quantification is also implemented which proves to be highly precise and accurate on a benchmark dataset with known ground truth. MaxQuant for LC-IMS-MS/MS is part of the basic MaxQuant release and can be downloaded from http://maxquant.org.

The police are probing the shooting of two homeless persons along Church Street in downtown Kingston. The incident, which happened about 10:10 Thursday morning, drew a large gathering. The Gleaner understands that both injured persons were rushed...

Jan 1, 2013; 31:46-46
Patient Information

Average educational indebtedness of graduating students from U.S. dental schools has increased an average of 3.5% annually between 2000 and 2018 after adjusting for inflation.

International dental school graduates in U.S. dental schools

Advanced dental education program enrollment by gender

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[1856]

London (6, Pall Mall) : Published ... by Henry Graves, & Comp.y, May 10th, 1856.

A few nights after one of their players was injured by a dirty hit, the Johnstown Jets plotted to exact some revenge on Buffalo's Greg Neeld. An all-out brawl broke out during warmups and the North American Hockey League game was postponed, much to the dismay of ownership and presumably the fans at a sold-out War Memorial Arena. It just so happened that director George Roy Hill was in the arena that night, cameras rolling.

In many areas, practitioners need to analyze large data sets that challenge conventional single-machine computing. To scale up data analysis, distributed and parallel computing approaches are increasingly needed. Here we study a fundamental and highly important problem in this area: How to do ridge regression in a distributed computing environment? Ridge regression is an extremely popular method for supervised learning, and has several optimality properties, thus it is important to study. We study one-shot methods that construct weighted combinations of ridge regression estimators computed on each machine. By analyzing the mean squared error in a high-dimensional random-effects model where each predictor has a small effect, we discover several new phenomena. Infinite-worker limit: The distributed estimator works well for very large numbers of machines, a phenomenon we call 'infinite-worker limit'. Optimal weights: The optimal weights for combining local estimators sum to more than unity, due to the downward bias of ridge. Thus, all averaging methods are suboptimal. We also propose a new Weighted ONe-shot DistributEd Ridge regression algorithm (WONDER). We test WONDER in simulation studies and using the Million Song Dataset as an example. There it can save at least 100x in computation time, while nearly preserving test accuracy.

Ontario's police watchdog says an OPP officer didn't break the law when he shot and killed a man running at him with an aluminum bat in November 2019.

For all the sporting moments Mark Blinch has captured through his lens for nearly two decades, there is only one he has taken the trouble to hang in his home.

With ‘Four More Shots Please!,’ India Gets Its Own ‘Sex and the City’  The New York Times