Bone marrow transplantation, now often known as haematopoietic stem cell transplantation (HSCT), is a complex choreographed procedure used to treat both acquired and inherited disorders of the bone marrow. It has proven invaluable as therapy for haematological and immunological disorders, and more recently in the treatment of metabolic and enzyme disorders. As the number of performed transplants grows annually, and with patients enjoying improved survival, a knowledge of both early and late complications of HSCT is essential for respiratory trainees and physicians in practice. This article highlights the spectrum of respiratory complications, both infectious and non-infectious, the timeline of their likely occurrence, and the approaches used for diagnosis and treatment, keeping in mind that more than one entity may occur simultaneously. As respiratory issues are often a leading cause of short- and long-term morbidity, consideration of a combined haematology/respiratory clinic may prove useful in this patient population.

Chronic pulmonary aspergillosis has a range of manifestations from indolent nodules to semi-invasive infection. Patients may be asymptomatic or have chronic symptoms such as cough and weight loss or present with life-threatening haemoptysis. The physician can choose from a range of available therapies including medical therapy with antifungals, minimally invasive therapy with intracavitary antifungal therapy and surgery involving open thoracotomy or video-assisted thoracoscopic surgery. The patients with the most severe forms of pulmonary infection may not be surgical candidates due to their underlying pulmonary condition. The management of haemoptysis can include tranexamic acid, bronchial artery embolisation, antifungals or surgery. There are few controlled studies to inform clinicians managing complex cases, so a multidisciplinary approach may be helpful.

Jun 2, 2024

Ethnic cleansing is not only a modern phenomenon. The medieval Catholic Church saw non-Christians as a threat and facilitated the ethnoreligious cleansing of Muslim and Jewish communities across Western Europe. Three conditions made this possible: The rising power of the papacy as a supranational religious authority; its dehumanization of non-Christians; and competition among Catholic Western European monarchs that left them vulnerable to papal-clerical demands to eradicate non-Christians. These findings revise our understanding twentieth- and twenty-first-century ethnic cleansing in places like Cambodia, Iraq, Myanmar, the Soviet Union, and Syria.

Northwestern Mutual will support the fight against childhood cancer by hosting lemonade stands nationwide as part of Alex�s Lemonade Days (June 12-14). Join the fight and build your own lemonade stand.

Senior party figures faced pressure to explain their handling of McMonagle's departure.

IWMI has been awarded the 2020 Water Award from the Prince Albert II of Monaco Foundation in recognition of the institute’s outstanding research for finding water solutions for sustainable development.

The post IWMI receives the 2020 Water Award from the Prince Albert II of Monaco Foundation first appeared on International Water Management Institute (IWMI).

Hot flashes and other menopausal symptoms are becoming more and more treatable with nonhormone alternatives, especially for women whose health prevents them from taking hormones.

Recent advancements in artificial intelligence (AI) have led to the development of a promising algorithm by Anumana, in collaboration with Janssen Research

medlinkPulmonary hypertension/medlink is a critical condition that often results in heart failure and death for many patients. In search of innovative

Aryan Bangar, formerly son of cricketer Sanjay Bangar, now identifies as a transwoman and goes by the name of Anaya.

Abingdon, Oxon ; New York, NY : Routledge, 2023.

Manchester : Manchester University Press, [2016]

Abingdon, Oxon ; New York, NY : Routledge, 2020.

Manchester : Manchester University Press, [2020]

Manchester : Manchester University Press, [2016]

Over the weekend, Akanksha was evicted. Good riddance.

Nitibha wins the Immunity Medallion and Bigg Boss puts relationships at test in the new nomination task, discovers Divya Nair.

Priyanka tries all tricks to turn Manu and Manveer against Mona, but Mona stands like a rock in her path!

There were many twists in the show over the weekend.

Mona knows how to make hay even when the sun is not in her favour.

In a house where relationships change at the drop of a hat, this episode's big reveal pulls skeletons out of the closet.

Last night's episode was a reminder that there is nothing in the house that cannot be reversed observes Divya Nair.

Pictures from the engagement episode.

A look at the pictures.

A look at pictures from the wedding.

A look at the awards night.

Ganpati celebrations are on in full swing!

Lightman, Alan P., 1948- author

Dominic Monaghan and Billy Boyd answer the web's most searched questions about themselves and 'The Lord of the Rings.' What is Dominic Monaghan doing right now? How tall is Billy Boyd? Why is Peregrin Took called Pippin? What kinds of accents do Merry and Pippin have? Dominic and Billy Boyd answer all these questions and much more! The Friendship Onion drops every Tuesday across all audio players as well as a video version on The Friendship Onion YouTube channel.

Sudipto Das on the relevance of scientist and polymath Sir Jagadish Chandra Bose in the contemporary world

Winner of the Tokyo Paralympics gold three years ago, Avani, 22, shot a superb 249.7 to erase her own Paralympic record of 249.6 set in the Japanese capital three years ago

As the Bundesliga prepares to restart on May 16, the former Arsenal midfielder believes the league could have waited before ending the French season

All the driver's reaction after the Monaco Grand Prix

Robert Kubica has played down the chances of a repeat of his Monaco performance at this weekend's Singapore Grand Prix

Chronic obstructive pulmonary disease, COPD, is a progressive lung disease that makes breathing hard. It can turn fatal if not properly treated. Smoking and exposure to air pollution are considered as some of the main causes of COPD. Some

The bacterial type VI secretion system (T6SS) secretes many toxic effectors to gain advantage in interbacterial competition and for eukaryotic host infection. The cognate immunity proteins of these effectors protect bacteria from their own effectors. PldB is a T6SS trans-kingdom effector in Pseudomonas aeruginosa that can infect both prokaryotic and eukaryotic cells. Three proteins, PA5086, PA5087 and PA5088, are employed to suppress the toxicity of PldB-family proteins. The structures of PA5087 and PA5088 have previously been reported, but the identification of further distinctions between these immunity proteins is needed. Here, the crystal structure of PA5086 is reported at 1.90 Å resolution. A structural comparison of the three PldB immunity proteins showed vast divergences in their electrostatic potential surfaces. This interesting phenomenon provides an explanation of the stockpiling mechanism of T6SS immunity proteins.