NSW Police says officers were called to a house in Erina last night in response to a domestic dispute between neighbours and found flames coming from the window.
NSW government-owned energy supplier Essential Energy is expected to cut 165 across regional New South Wales, according to the Electrical Trades Union.
Groups that were planning to ask Colorado voters for money and new laws in November are seeking rule changes after the coronavirus brought their efforts to a screeching halt.
Facebook will soon let you know if you saw or interacted with dangerous coronavirus misinformation on the site.
The federal stimulus checks go to people with Social Security numbers, leaving out millions who work in the U.S. without permission, but who pay taxes.
A program for one-time assistance to undocumented workers affected by the pandemic is a start, but California must do much more.
Governments across the U.S. have simply not saved enough to deal with coronavirus-induced budget shortfalls. They need to start taxing the rich more.
It is well known that tobacco smoking kills. But it also exacerbates poverty, contributes to world hunger by diverting prime land away from food production, damages the environment and reduces economic productivity. Second hand smoking also affects other people’s lives. Despite many attempts to prevent it, a global tobacco control treaty became international law in 2005.
However, challenges still remain as tobacco companies try to hit back, for example, by targeting developing nations, increasing advertising at children and women, attempting to undermine global treaties and influence trade talks, etc.
This update includes updated stats, as well as more information on the above issues.
The Public Investment Corporation has terminated the employment contract of Executive Head of Listed Investments Fidelis Madavo, it said in a statement on Monday.
Background: Patients with NHL who are treated with rituximab may develop resistant disease, often associated with changes in expression of CD20. The next generation β-particle emitting radioimmunoconjugate 177Lu-lilotomab-satetraxetan (Betalutin®) was shown to up-regulate CD20 expression in different rituximab-sensitive NHL cell lines and to act synergistically with rituximab in a rituximab-sensitive NHL animal model. We hypothesized that 177Lu-lilotomab-satetraxetan may be used to reverse rituximab-resistance in NHL. Methods: The rituximab-resistant Raji2R and the parental Raji cell lines were used. CD20 expression was measured by flow cytometry. ADCC was measured by a bioluminescence reporter assay. The efficacies of combined treatments with 177Lu-lilotomab-satetraxetan (150MBq/kg or 350MBq/kg) and rituximab (4x10mg/kg) were compared with those of single agents or saline in a Raji2R-xenograft model. Cox-regression and the Bliss independence model were used to assess synergism. Results: Rituximab-binding in Raji2R cells was 36±5% of that in the rituximab-sensitive Raji cells. 177Lu-lilotomab-satetraxetan treatment of Raji2R cells increased the binding to 53±3% of the parental cell line. Rituximab ADCC-induction in Raji2R cells was 20±2% of that induced in Raji cells, while treatment with 177Lu-lilotomab-satetraxetan increased the ADCC-induction to 30±3% of the Raji cells, representing a 50% increase (p<0.05). The combination of rituximab with 350MBq/kg 177Lu-lilotomab-satetraxetan synergistically suppressed Raji2R tumor growth in athymic Foxn1nu mice. Conclusion: 177Lu-lilotomab-satetraxetan has the potential to reverse rituximab-resistance; it increases binding and ADCC-activity in-vitro and can synergistically improve anti-tumor efficacy in-vivo.
SCOTLAND'S capital is coming to terms with the "heart-breaking" news that its summer festivals will not go ahead this year - costing the city hundreds of millions of pounds.
Income Tax Deadlines Extended State Tax Due Dates Remain Unchanged Last week, the Delaware Division of Revenue (DOR) announced that the deadlines for taxpayers to file certain personal and corporate income tax returns and payments had been extended to July 15, 2020 due to “rolling conformity” with federal income tax rules adopted by the […]
At least 13 states hike VAT on petrol/diesel since mid-March, many make liquor costlier with new imposts.
Grappling with low revenues following the outbreak of Covid-19 and the subsequent lockdown, the UP government hiked the value added tax (VAT) on petrol and diesel and increased the excise duty on liquor.
The NCAA approved a waiver that will allow schools to spend below the minimum level on athletic scholarships required to compete in Division I in response to the coronavirus pandemic.
The extent to which payments in lieu of notice (PILONs) may attract tax has for a long time been a complex issue and one which has not always received consistent treatment by HM Revenue and Customs. The issue is straightforward if the payment is ma...
CHENNAI: Thousands of unauthorised buildings in the state are facing demolition after the Madras high court on Monday quashed two government orders that proposed to legalise illegal structures built till July 1, 2007. The first bench comprising Chief Justice R K Agrawal and Justice M Sathyanaryanan said: “But for the lackadaisical attitude on the part of the authorities, such an alarming and mushrooming growth of unauthorized and illegal constructions would not have come into place.” The bench was delivering verdict on two PILs against October 30, 2012 government orders extending amnesty schemes for illegal buildings constructed between 1999 and July 1, 2007. “The state government and statutory authorities concerned are […]
Paclitaxel has been considered to cause OATP1B-mediated drug-drug interactions at therapeutic doses; however, its clinical relevance has not been demonstrated. This study aimed to elucidate in vivo inhibition potency of paclitaxel against OATP1B1 and OATP1B3 using endogenous OATP1B biomarkers. Paclitaxel is an inhibitor of OATP1B1 and OATP1B3, with Ki of 0.579 ± 0.107 and 5.29 ± 3.87 μM, respectively. Preincubation potentiated its inhibitory effect on both OATP1B1 and OATP1B3, with Ki of 0.154 ± 0.031 and 0.624 ± 0.183 μM, respectively. Ten patients with non–small cell lung cancer who received 200 mg/m2 of paclitaxel by a 3-hour infusion were recruited. Plasma concentrations of 10 endogenous OATP1B biomarkers—namely, coproporphyrin I, coproporphyrin III, glycochenodeoxycholate-3-sulfate, glycochenodeoxycholate-3-glucuronide, glycodeoxycholate-3-sulfate, glycodeoxycholate-3-glucuronide, lithocholate-3-sulfate, glycolithocholate-3-sulfate, taurolithocholate-3-sulfate, and chenodeoxycholate-24-glucuronide—were determined in the patients with non–small cell lung cancer on the day before paclitaxel administration and after the end of paclitaxel infusion for 7 hours. Paclitaxel increased the area under the plasma concentration-time curve (AUC) of the endogenous biomarkers 2- to 4-fold, although a few patients did not show any increment in the AUC ratios of lithocholate-3-sulfate, glycolithocholate-3-sulfate, and taurolithocholate-3-sulfate. Therapeutic doses of paclitaxel for the treatment of non–small cell lung cancer (200 mg/m2) will cause significant OATP1B1 inhibition during and at the end of the infusion. This is the first demonstration that endogenous OATP1B biomarkers could serve as surrogate biomarkers in patients.
Endogenous biomarkers can address practical and ethical issues in elucidating transporter-mediated drug-drug interaction (DDI) risks of anticancer drugs clinically. We could elucidate a significant increment of the plasma concentrations of endogenous OATP1B biomarkers after a 3-hour infusion (200 mg/m2) of paclitaxel, a time-dependent inhibitor of OATP1B, in patients with non–small cell lung cancer. The endogenous OATP1B biomarkers are useful to assess the possibility of OATP1B-mediated DDIs in patients and help in appropriately designing a dosing schedule to avoid the DDIs.
The Prime Minister reportedly poured caution on easing current lockdown measures during discussion with senior Government colleagues
Sydney's famous Bondi Beach reopened to swimmers and surfers today, five weeks after it was shut over the coronavirus pandemic.
Ryanair has said it expects up to 3,000 jobs to be lost as part of a restructuring of the airline.
California's governor has announced that the six-week lockdown of America's most populous state will be relaxed within days as the daily coronavirus death toll across the United States fell to its lowest level in a month.
Producers have reportedly found it impossible to arrange filming amid the coronavirus pandemic
For the latest episode of At Home With...JP Saxe opens up about his song with girlfriend Julia Michaels and challenges Amira Hashish to sing her verse of If The World Was Ending
Borussia Dortmund sporting director Michael Zorc says he is "completely relaxed" over the future of Manchester United target Jadon Sancho.
Waverley council in Sydney’s eastern suburbs has reopened Bondi, Bronte and Tamarama beaches to swimmers and surfers between 7am and 5pm on weekdays. The beaches were closed as Australia’s coronavirus restrictions came into force. They are to remain closed on weekends, and only the water is ‘open’, with sunbathing, walking and jogging on the beach not allowed
STRUGGLING parents say they don’t know how they will scrape together enough cash to pay for school uniforms, shoes and fees after being stripped of the Schoolkids Bonus.
Australian business are presented with a new set of rules on how to manage workplaces during the coronavirus pandemic, as Prime Minister Scott Morrison says he would "love to see a return to work across the board".
Colleyville city leaders went further than the Texas governor, allowing restaurants and salons to reopen this week. Residents remain conflicted.
The aggressive nationalism of China's diplomats matches the swagger of Xi Jinping's China, which is determined to deflect blame for the coronavirus.
The United States has filed a lawsuit against New York attorney Thomas B. Pruzan, d/b/a the Pruzan Law Firm, seeking to put an end to Mr. Pruzans repeated failure to timely deposit and pay the employment and unemployment taxes due from his law firm, as well as his failure to timely file employment and unemployment tax returns with the Internal Revenue Service.
A federal court in Boston issued a preliminary injunction ordering Excel Home Care Inc. and Diane E. Porter of Tewksbury, Mass., to comply with federal tax withholding requirements and to timely pay all future employment and unemployment tax liabilities.
Former UBS banker, Bradley Birkenfeld of Weymouth, Mass., has been sentenced to 40 months incarceration by Judge William J. Zloch in Fort Lauderdale, Fla. On June 19, 2008, Birkenfeld pleaded guilty to conspiring to defraud the United States.