Archives, Room Use Only - TK5741.N47 1921

Archives, Room Use Only - TK5262.C65 1925

Since striking out on my own, much of my time’s been dedicated to, well, the book. But I’ve also been fortunate enough to collaborate a bit with Filament Group on one of their projects: namely, a large-scale engagement that requires a responsive approach.

Needless to say, I am having the time of my life.

We’re also learning a lot, too. A lot of discussions about approach and execution have come up, largely because processes for a lot of this stuff don’t exist yet. That will, with a bit of hard work and community discussion, change over time. Still, there has been a lot of brilliant stuff created so far.

Here’s just one example:

The goal of this technique is to deliver optimized, contextual image sizes for responsive layouts that utilize dramatically different image sizes at different resolutions. Ideally, this approach will allow developers to start with mobile-optimized images in their HTML and specify a larger size to be used for users with larger screen resolutions — without requesting both image sizes, and without UA sniffing.

Check out the script, download it, and kick the tires a bit—feedback and tweaks are most welcome.

I realize that there are always going to be philosophical differences around responsive web design. But for me, the solutions-driven discussions are always going to be infinitely more interesting to me than the alternative.

Former Patriots executive Mike Lombardi still won't rule out New England signing Cam Newton at some point despite Bill Belichick indicating he plans to roll with the current QB group he has now.

The 'Namaste Trump' event is based on the lines of 'Howdy Modi' programme that was addressed by Narendra Modi and Trump during the PM's trip to Houston last September.

The inmates at the relief camp said the rioters were all locals and not outsiders. They also said they will only return when authorities assure them of safety.

Nikhil, son of former Chief Minister H D Kumaraswamy, tied the nuptial knot with Revathi, the grand-niece of former Karnataka housing minister M Krishnappa.The marriage was solemnised at Kumaraswamy's Kethaganahalli farmhouse at Bidadi in the neighbouring Ramanagara district, a JD-S stronghold.

Hizbul chief Syed Salahuddin claims responsibility for Handwara attack, adm...

Mixed response to State Govt move on labour reforms

Hapless woman’s case exposes poor distress response mechanism in State

This post explains a hidden gem in the XMLHttpRequest standard that simplifies fetching and parsing JSON data through Ajax.

The COVID-19 outbreak exposed “shortcomings” in China’s public healthcare system, a top health official admitted on Saturday, saying that reforms are

A group headed to Bhubaneswar is now housed in shelters

The State government may have permitted industrial units to reopen, but an interaction with MSME bodies brought to light the acute logistical problem

Despite these times of distress, the Bannerghatta Biological Park’s (BBP) animal adoption programme has been generating a good response. On Saturday,

Esports: Wehrlein ends Guenther's run of virtual Formula E success

The electric car company told employees to report to work Friday, but a county official said Tesla did not meet the requirements for resuming production.

A "product grid" demo using - CSS Grid - Clip Path - Conic Gradient, and more.

Autor:
Erschienen
BSB-Signatur Clm 18565

URN: urn:nbn:de:bvb:12-bsb00131315-7
URL: http://daten.digitale-sammlungen.de/~db/0013/bsb00131315/images/

Obama cast the US response to the virus as an outgrowth of tribalism as he sought to emphasise the urgency of the November election

Small-animal physiology studies are typically complicated, but the level of complexity is greatly increased when performing live-animal X-ray imaging studies at synchrotron and compact light sources. This group has extensive experience in these types of studies at the SPring-8 and Australian synchrotrons, as well as the Munich Compact Light Source. These experimental settings produce unique challenges. Experiments are always performed in an isolated radiation enclosure not specifically designed for live-animal imaging. This requires equipment adapted to physiological monitoring and test-substance delivery, as well as shuttering to reduce the radiation dose. Experiment designs must also take into account the fixed location, size and orientation of the X-ray beam. This article describes the techniques developed to overcome the challenges involved in respiratory X-ray imaging of live animals at synchrotrons, now enabling increasingly sophisticated imaging protocols.

Authors of a paper that includes a new crystal-structure determination are expected to not only report the structural results of inter­est and their inter­pretation, but are also expected to archive in computer-readable CIF format the experimental data on which the crystal-structure analysis is based. Additionally, an IUCr/checkCIF validation report will be required for the review of a submitted paper. Such a validation report, automatically created from the deposited CIF file, lists as ALERTS not only potential errors or unusual findings, but also suggestions for improvement along with inter­esting information on the structure at hand. Major ALERTS for issues are expected to have been acted on already before the submission for publication or discussed in the associated paper and/or commented on in the CIF file. In addition, referees, readers and users of the data should be able to make their own judgment and inter­pretation of the underlying experimental data or perform their own calculations with the archived data. All the above is consistent with the FAIR (findable, accessible, inter­operable, and reusable) initiative [Helliwell (2019). Struct. Dyn. 6, 05430]. Validation can also be helpful for less experienced authors in pointing to and avoiding of crystal-structure determination and inter­pretation pitfalls. The IUCr web-based checkCIF server provides such a validation report, based on data uploaded in CIF format. Alternatively, a locally installable checkCIF version is available to be used iteratively during the structure-determination process. ALERTS come mostly as short single-line messages. There is also a short explanation of the ALERTS available through the IUCr web server or with the locally installed PLATON/checkCIF version. This paper provides additional background information on the checkCIF procedure and additional details for a number of ALERTS along with options for how to act on them.

In fungi, the mitochondrial respiratory chain complexes (complexes I–IV) are responsible for oxidative phosphorylation, as in higher eukaryotes. Cryo-EM was used to identify a 200 kDa membrane protein from Neurospora crassa in lipid nanodiscs as cytochrome c oxidase (complex IV) and its structure was determined at 5.5 Å resolution. The map closely resembles the cryo-EM structure of complex IV from Saccharomyces cerevisiae. Its ten subunits are conserved in S. cerevisiae and Bos taurus, but other transmembrane subunits are missing. The different structure of the Cox5a subunit is typical for fungal complex IV and may affect the interaction with complex III in a respiratory supercomplex. Additional density was found between the matrix domains of the Cox4 and Cox5a subunits that appears to be specific to N. crassa.

The effects of relative humidity on a tetragonal crystal form of hen egg white lysozyme are studied via in situ laboratory X-ray powder diffraction.

The Panoramic Survey Telescope & Rapid Response System (Pan-STARRS) PS1 telescope has discovered an asteroid about 150 feet in diameter that will come within 4 million miles of Earth in mid-October.

The post Rapid Response telescope system spots first potentially hazardous asteroid appeared first on Smithsonian Insider.

Recently, after examining hundreds of photos taken by camera traps set-up to monitor clouded leopards in the park, three Smithsonian researchers say Khao Yai also is quite popular with a different kind of visitor: poachers.

The post Poachers at large in Thailand’s nature reserves despite ranger outposts appeared first on Smithsonian Insider.

Microbes that live in rice paddies, northern peat bogs and other previously unexpected environments are among the bacteria that can generate highly toxic methylmercury, researchers […]

The post Toxic methylmercury-producing microbes more widespread than realized appeared first on Smithsonian Insider.

It has all the hallmarks of a paleontological crime scene: a massive graveyard along a remote desert highway containing the fossil bones of at least […]

The post Algae assassin found responsible for whale mass grave in Chile appeared first on Smithsonian Insider.

The bush dog is one of the most enigmatic of the world’s canid species, seldom seen throughout its range in Central and South America. New […]

The post Elusive bush dog widespread in Panama appeared first on Smithsonian Insider.

Javad Fahanik-babaei, Bahareh Rezaee, Maryam Nazari, Nihad Torabi, Reza Saghiri, Remy Sauve, and Afsaneh Eliassi

We have determined the electropharmacological properties of a new potassium channel from brain mitochondrial membrane by planar lipid bilayer method. Our results showed the presence of a channel with a conductance of 150 pS at potentials between 0 and –60 mV in 200 cis/50 trans mM KCl solutions.

The channel was voltage-independent, with an open probability value ~0.6 at different voltages. ATP did not affect current amplitude and Po at positive and negative voltages. Notably, adding iberiotoxin, charybdotoxin, lidocaine, and margatoxin had no effect on the channel behavior. Similarly, no changes were observed by decreasing the cis-pH to 6. Interestingly, the channel was inhibited by adding sodium in a dose dependent manner. Our results also indicated a significant increase in mitochondrial complex IV activity and membrane potential and decrease in complex I activity and mitochondrial ROS production in the presence of sodium ions.

We propose that inhibition of mitochondrial K⁺ transport by Na ions on K⁺ channel opening may be important for cell protection and ATP synthesis.

Many traits unique to humans were long thought to have originated in the genus Homo between 2.4 and 1.8 million years ago in Africa. A […]

The post Human Evolution Rewritten: We owe our existence to our ancestor’s flexible response to climate change appeared first on Smithsonian Insider.

Appendices B4 and B5 of Cayron [Acta Cryst. (2019), A75, 411–437] contain equations involving the point group and the metric tensor in which the equality symbol should be substituted by the inclusion symbol.

Two grass species that had been relatively rare in the plots, Spartina patens and Distichlis spicata, began to respond vigorously to the excess nitrogen. Eventually the grasses became much more abundant. Nitrogen ultimately changed the composition of the ecosystem as well as its capacity to store carbon.

The post Scientists find excess nitrogen favors plants that respond poorly to rising CO2 appeared first on Smithsonian Insider.

Smithsonian plant physiologist Bert Drake has studied one wetland's response to climate change for more than two decades. He gives a tour of the field experiment and explains some of the findings.

The post On the Chesapeake Bay, Smithsonian plant physiologist Bert Drake has been studying one wetland’s response to climate change for more than two decades. appeared first on Smithsonian Insider.

Smooth and shiny, the tough body of the South African beetle Pedinorrhina trivittata, a flower eater, appears to be a non-inviting surface for pollen grains […]

The post Caught on camera: Despite hard shells pollen sticks to South African beetles appeared first on Smithsonian Insider.

As mangrove trees lose ground to deforestation and urban sprawl, one development seems to be giving them a boost: climate change. Fewer winter cold snaps […]

The post Mangroves creep north in response to warmer temperatures appeared first on Smithsonian Insider.