Waiting is the hardest part. In the fall of 2023, HPCwire wrote about the new diverging Xeon processor strategy from Intel. Instead of a on-size-fits all approach; Intel has opted […]

The post Granite Rapids HPC Benchmarks: I’m Thinking Intel Is Back (Updated) appeared first on HPCwire.

Genetic-testing lab 23andMe plans to cut its workforce by 40% and end its therapeutics program in an effort to cut costs, the company announced Monday.

The therapy helps the brain work more efficiently and lifts depression.

Many people who want to be healthy often try to eat a balanced diet and get regular exercise. However, most foods today simply do not contain the nutrition they did in the past. If your goal is to improve your physical and mental health, your body may still require essential nutrients. IV nutrition therapy is […]

The post Exploring the Impact of IV Nutrition Therapy on Mental Health first appeared on What is Psychology?.

EMDR therapy, also known as Eye Movement Desensitization and Reprocessing therapy, is an integrative and all-inclusive psychotherapy model used to treat mental conditions and trauma. This approach has been researched extensively in recent years and confirmed to be an effective way to tackle mental challenges. EMDR therapy was reportedly developed in the 1980’s by an […]

The post What are The Different Phases of EMDR Therapy? first appeared on What is Psychology?.

Are you a clinician looking to master CBT for Perfectionism? Or, learn more about the CBT model of perfectionism below. CBT Model of Perfectionism Perfectionism is not the same thing as conscientiousness. For example, in a recent study of older adults, perfectionism was both associated with increased risk of mortality whereas conscientiousness was associated with […]

The post Cognitive Behavioral Therapy Model of Perfectionism appeared first on Dr Alice Boyes.

The core beliefs that cause the most common problems fall into the following 3 categories. These core beliefs commonly underlie depression and anxiety. Helpless Core Beliefs such as: “I’m incompetent” “I’m needy” “I’m weak” “I’m defective, I don’t measure up” “I’m a failure” Unlovable Core Beliefs such as: “I’m unlovable” “I’m different” “I’m bound to […]

The post How To Change Negative Core Beliefs: A Straightforward Guide to Cognitive Behavioral Therapy (CBT) appeared first on Dr Alice Boyes.

Chief technology officers are facing an unprecedented test of digital preparedness due to the coronavirus pandemic, struggling with shortfalls of available learning devices and huge Wi-Fi access challenges.

Chief technology officers are facing an unprecedented test of digital preparedness due to the coronavirus pandemic, struggling with shortfalls of available learning devices and huge Wi-Fi access challenges.

A former high school athletic standout and homecoming king, Pedro Garcia III “could connect with anybody,” no matter the language, said a teaching colleague in Cozad, Neb.

The demand for substitute teacher positions is outpacing the supply, and the quality of those applying is a concern in many places.

Nephron Pharmaceuticals, a drug manufacturing company in West Columbia, S.C., recently hired 650 current and retired teachers through a new program designed to provide educators with additional income.

Chief technology officers are facing an unprecedented test of digital preparedness due to the coronavirus pandemic, struggling with shortfalls of available learning devices and huge Wi-Fi access challenges.

An audit of the early-childhood education offerings in Minnesota finds complexity and fragmentation as well as a lack of data about program effectiveness.

Emma Lingan and Eric Cruikshank discuss Washington Capitals center Dylan Strome, the Bruins and Red Wings coaches, Kirill Kaprizov's next contract and much more.

Steven F. Grieco
Nov 9, 2022; 42:8439-8449
Symposium and Mini-Symposium

Yulia Lerner
Feb 23, 2011; 31:2906-2915
BehavioralSystemsCognitive

We recently demonstrated that transient attenuation of Toll-like receptor 4 (TLR4) in dorsal root ganglion (DRG) neurons, can both prevent and reverse pain associated with chemotherapy-induced peripheral neuropathy (CIPN), a severe side effect of cancer chemotherapy, for which treatment options are limited. Given the reduced efficacy of opioid analgesics to treat neuropathic, compared with inflammatory pain, the cross talk between nociceptor TLR4 and mu-opioid receptors (MORs), and that MOR and TLR4 agonists induce hyperalgesic priming (priming), which also occurs in CIPN, we determined, using male rats, whether (1) antisense knockdown of nociceptor MOR attenuates CIPN, (2) and attenuates the priming associated with CIPN, and (3) CIPN also produces opioid-induced hyperalgesia (OIH). We found that intrathecal MOR antisense prevents and reverses hyperalgesia induced by oxaliplatin and paclitaxel, two common clinical chemotherapy agents. Oxaliplatin-induced priming was also markedly attenuated by MOR antisense. Additionally, intradermal morphine, at a dose that does not affect nociceptive threshold in controls, exacerbates mechanical hyperalgesia (OIH) in rats with CIPN, suggesting the presence of OIH. This OIH associated with CIPN is inhibited by interventions that reverse Type II priming [the combination of an inhibitor of Src and mitogen-activated protein kinase (MAPK)], an MOR antagonist, as well as a TLR4 antagonist. Our findings support a role of nociceptor MOR in oxaliplatin-induced pain and priming. We propose that priming and OIH are central to the symptom burden in CIPN, contributing to its chronicity and the limited efficacy of opioid analgesics to treat neuropathic pain.

The precise regulation of Ca²⁺ signals plays a crucial role in the physiological functions of neurons. Here, we investigated the rapid effect of glucocorticoids on Ca²⁺ signals in cultured hippocampal neurons from both female and male rats. In cultured hippocampal neurons, glucocorticoids inhibited the spontaneous somatic Ca²⁺ spikes generated by Kv2.1-organized Ca²⁺ microdomains. Furthermore, glucocorticoids rapidly reduced the cell surface expressions of Kv2.1 and Ca_V1.2 channels in hippocampal neurons. In HEK293 cells transfected with Kv2.1 alone, glucocorticoids significantly reduced the surface expression of Kv2.1 with little effect on K⁺ currents. In HEK293 cells transfected with Ca_V1.2 alone, glucocorticoids inhibited Ca_V1.2 currents but had no effect on the cell surface expression of Ca_V1.2. Notably, in the presence of wild-type Kv2.1, glucocorticoids caused a decrease in the surface expression of Ca_V1.2 channels in HEK293 cells. However, this effect was not observed in the presence of nonclustering Kv2.1S586A mutant channels. Live-cell imaging showed that glucocorticoids rapidly decreased Kv2.1 clusters on the plasma membrane. Correspondingly, Western blot results indicated a significant increase in the cytoplasmic level of Kv2.1, suggesting the endocytosis of Kv2.1 clusters. Glucocorticoids rapidly decreased the intracellular cAMP concentration and the phosphorylation level of PKA in hippocampal neurons. The PKA inhibitor H89 mimicked the effect of glucocorticoids on Kv2.1, while the PKA agonist forskolin abrogated the effect. In conclusion, glucocorticoids rapidly suppress Ca_V1.2-mediated Ca²⁺ signals in hippocampal neurons by promoting the endocytosis of Kv2.1 channel clusters through reducing PKA activity.

A new book reveals striking images from six decades of the beloved Wildlife Photographer of the Year competition

From the visits of Prince Charles and theGlobal Indigenous Youth Caucus (GIYC) to headquarters, to the Director-General’s ongoing visit to crisis-stricken parts of Africa, and the release of new FAO [...]

Cellist Yo-Yo Ma talks with the founder of the Girls Computing League about the promise of her generation

Researchers are able to track Venus flytrap plants that were stolen from protected areas

Credit: Smithsonian Digital Studio

Transitions: Photographs by Robert Creamer

A slowed-down recording, made as part of a scientific study, shows one dog quickly mimicking another canine's expression during playtime in a park in Palermo. (Video courtesy Elisabetta Palagi)

Two of the preeminent researchers of gene therapy hope to improve their patients' sight in an experimental operation (Stephen Voss/WPN)

A museum in Portland, Oregon highlights the multi-layered path of 3D imagery, from stereoscopes of the American West to blockbuster movies

A close look reveals how the famed photographer altered his glass negatives, creating the popular image of Native Americans that still exists today

Smithsonian magazine commissioned Drew Gardner for a project that connects Black Americans today to their lost ancestry. Read about Gardner’s project and process, as well as more details about the subjects of this incredible series here: https://www.smithsonianmag.com/history/descendants-black-civil-war-heroes-wear-heritage-pride-180983397/ Video produced by Sierra Theobald. Special thanks to Drew Gardner Additional credits: Emma MacBeath, WikiTree US Black Heritage project; Ottawa Goodman, research and coordinator; Sam Dole, Penumbra Foundation; Elizabeth Zuck, set design; Calvin Osbourne, props and costume; Angela Huff, hair and make up; Diego Huerta, Lexia Krebs, behind-the-scenes filming; background prints by Fujifilm USA

Deep in the jungles of Brazil, photographer Steve Winter explains how he managed to capture stunning images of one of the world's top predators. Read more about jaguars at http://www.smithsonianmag.com/video/Photographing-the-Elusive-Jaguar.html

The National Gallery of Art organized a comprehensive exhibit of Robert Frank's work (Images courtesy of: National Gallery of Art; Produced by: Diane Bolz and Brian Wolly)

In the years before digital cameras, the process of getting shots from the field to the printers was incredibly complicated and dangerous. Video by Adam Grossman | Good Dog Media

Read more at http://www.smithsonianmag.com/arts-culture/Herman-Leonards-Eye-for-Jazz.html With just a camera as his ticket, Herman Leonard captured jazz icons performing on and off stage.

Read more at http://www.smithsonianmag.com/specialsections/womens-history/The-Writers-Eye.html Scholars and friends of Eudora Welty discuss how her hobby influenced her later works.

After his start capturing the horrors of the Civil War for Mathew Brady's studio, 19th century photographer Timothy O'Sullivan uncovered the beauty of the great expanses of the American west

Read more at http://www.smithsonianmag.com/history-archaeology/We-Have-Liftoff.html Photographer David Burnett focused his camera on the many tourists who flocked to Florida in 1969 to watch the launch of Apollo 11 (Produced by Molly Roberts; Photographs by David Burnett/Contact Press Images).

Cardiac MRI of an animal that has undergone photosynthetic therapy. CREDIT: Stanford University School of Medicine, Department of Cardiothoracic Surgery