The Cadillac Vistiq will serve as the electric XT6 three-row SUV replacement Cadillac Vistiqs are expected to have about 300 miles of EPA-rated range The Vistiq will cost $78,790 when it arrives in 2025. Cadillac on Tuesday confirmed additional details of the Vistiq three-row electric SUV, which remains on track for a launch next year as a 2026...

India is one of Australia’s fastest growing tourism markets. Tourism businesses can realise the potential of the Indian market by learning about travellers’ culture and service expectations.

Temporary changes to the Work Bonus offer an opportunity for the visitor economy to employ mature-aged workers and overcome labour shortfalls.

A new AI-powered, imaging-based technology that creates accurate three-dimensional models of tumors, veins and other soft tissue offers a promising new method to help surgeons operate on, and better treat, breast cancers. The technology, from Illinois-based startup SimBioSys, converts routine black-and-white MRI images into spatially accurate, volumetric images of a patient’s breasts. It then illuminates Read Article

Editor’s note: The name of NIM Agent Blueprints was changed to NVIDIA Blueprints in October 2024. All references to the name have been updated in this blog. Enterprises and public sector organizations around the world are developing AI agents to boost the capabilities of workforces that rely on visual information from a growing number of Read Article

THAILAND extended a warm welcome to the first batch of visa-exempt flights from China yesterday, marking the launch of the nation’s fresh initiative to reinvigorate its Chinese tourist market. Approximately

Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.

Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.

DUBAI, United Arab Emirates — U.N. nuclear watchdog chief Rafael Grossi will visit Iran next Wednesday and start consultations with Iranian officials the following day, state media reported on Sunday. The head of the International Atomic Energy Agency said on Wednesday he might head to Iran in the coming days to discuss its disputed nuclear program and that he expected to work cooperatively with U.S. President-elect Donald Trump. Long-standing issues between Iran, the IAEA, and Western powers include Tehran barring uranium-enrichment experts from IAEA inspection teams in the country and its failure for years to explain uranium traces found at undeclared sites. Iran has also stepped up nuclear activity since 2019, after then-President Trump abandoned a 2015 deal Iran reached with world powers under which it curbed enrichment -- seen by the West as a disguised effort to develop nuclear weapons capability -- and restored tough U.S. sanctions on the Islamic Republic. Tehran is now enriching uranium to up to 60% fissile purity, close to the roughly 90% required for an atom bomb. It has enough higher-enriched uranium to produce about four nuclear bombs, if refined further, according to an IAEA yardstick. Iran has long denied any nuclear bomb ambitions, saying it is enriching uranium for civilian energy uses only. 

Former Chelsea defender, Glen Johnson has told forward, Christopher Nkunku that he would be ‘mad’ to leave Stamford Bridge amid rumours Manchester United are interested in signing him. Johnson believes Nkunku can start to have a big impact at Chelsea if he stays fit. Nkunku joined Chelsea from RB Leipzig in 2023. The Frenchman made […]

EPL: You’d be mad – Glen Johnson advises Chelsea star against leaving club for Man Utd

Lahore, Pakistan – The much-awaited Lahore Entertainment City, a project by Al Jalil Developers, celebrated its grand opening on December 11, 2023, featuring a captivating performance by the famous singer Atif Aslam. Alongside this cultural extravaganza, the event spotlighted the project’s flexible payment plan, a significant step towards making upscale living accessible to a wider ... Read more

The post Lahore Entertainment City Payment Plan Introduced At A Lavish Ceremony appeared first on Pakistan Tribune.

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Next-Generation Vision Consortium on ROK-US and the Indo-Pacific Application

United States Defense Secretary Lloyd Austin will visit Manila this week to "advance security objectives" and meet Filipino and American troops, the US State Department said on Wednesday, November 13.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

Hagai Yodan premieres a daring piano-tech concerto at Jerusalem’s 2024 Piano Festival.

Malta ESG Alliance holds ISIMGħUNA conference to bring children and national leaders together to talk about the country's future

Nazir SiyalKARACHI: Jeroen Willems, Head of Cooperation at the European Union Mission to Pakistan, called upon Speaker of the Provincial Assembly of Sindh, Syed Awais Qadir Shah, here on Tuesday. CEU Mission to Pakistan leader Jeroen was accompanied by Ms. … read more

Trump says Musk, Ramaswamy will form outside group to advise White House on government efficiency

The 15 August 2021 Taliban takeover of Afghanistan devastated the lives of millions of Afghans. But the rights and freedoms of women and girls in particular have been progressively trampled by a series of edicts that have created a virtual system of gender apartheid.

“We’re ready to testify before the QuadComm as victims of extrajudicial killings,” Rosenda Lemita said, stressing that they want Duterte and those responsible to face investigation. For these families, the government’s “nanlaban” excuse is not just for the drug war but also for silencing activists.

Philippine institutions and governance structures must be strengthened as part of any effort to reform the country's financial supervisory structure.

vital is vision chapter 1

Voyager 2 flew by Uranus in 1986, giving us our only up-close look at the planet – but unusual space weather just before the craft arrived has given us a misleading idea about the planet’s magnetic field

Title: England to Lift Travel Restrictions for Vaccinated Visitors
Category: Health News
Created: 1/24/2022 12:00:00 AM
Last Editorial Review: 1/25/2022 12:00:00 AM

Title: CDC Revises Death Estimates From Flu
Category: Health News
Created: 8/26/2010 2:10:00 PM
Last Editorial Review: 8/27/2010 12:00:00 AM

Title: Eye Pigment May Help Vision in Hazy Conditions
Category: Health News
Created: 8/28/2014 9:35:00 AM
Last Editorial Review: 8/28/2014 12:00:00 AM

Title: Health Tip: Exercise While Watching Television
Category: Health News
Created: 8/29/2014 7:35:00 AM
Last Editorial Review: 8/29/2014 12:00:00 AM

Title: Climate Change May Bring More ER Visits, Deaths, Study Says
Category: Health News
Created: 8/21/2015 12:00:00 AM
Last Editorial Review: 8/24/2015 12:00:00 AM

Title: CDC Advises Pregnant Women to Avoid Miami Beach Due to Zika
Category: Health News
Created: 8/19/2016 12:00:00 AM
Last Editorial Review: 8/22/2016 12:00:00 AM

Title: School Kids Need Supervision After Classes End
Category: Health News
Created: 8/26/2018 12:00:00 AM
Last Editorial Review: 8/27/2018 12:00:00 AM

Title: Tourist With Measles Visited Southern California Attractions
Category: Health News
Created: 8/26/2019 12:00:00 AM
Last Editorial Review: 8/26/2019 12:00:00 AM

Title: Regular Vaccines Advised With Multiple Sclerosis
Category: Health News
Created: 8/28/2019 12:00:00 AM
Last Editorial Review: 8/29/2019 12:00:00 AM

Title: 'Virtual' Museum Visits Are Good Medicine for Seniors
Category: Health News
Created: 8/16/2022 12:00:00 AM
Last Editorial Review: 8/16/2022 12:00:00 AM

Introduction:

High-quality primary care can reduce avoidable emergency department visits and emergency hospitalizations. The availability of electronic medical record (EMR) data and capacities for data storage and processing have created opportunities for predictive analytics. This systematic review examines studies which predict emergency department visits, hospitalizations, and mortality using EMR data from primary care.

Visible particle is an important issue in the biopharmaceutical industry, and it may occur across all the stages in the life cycle of biologics. Upon the occurrence of visible particles, it is often necessary to conduct chemical identification and root cause analysis to safeguard the safety and efficacy of the biotherapeutic products. In this article, we present a number of typical particles and relevant root cause analysis in the categories of extrinsic, intrinsic, and inherent particles that are commonly encountered in the biopharma industry. In particular, the optical images of particles obtained both in situ and after isolation are provided, along with spectral and elemental information. The particle identification was carried out with multiple microscopic and microspectroscopic techniques, including stereo optical microscopy, Fourier-transform infrared microscopy, confocal Raman microscopy, scanning electron microscopy, and energy dispersive X-ray spectroscopy. Both commercial and in-house spectral databases were used for comparison and identification. In addition to particle identification, we placed significant efforts on the root cause analysis of the addressed particles with the intention to provide a relatively whole picture of the particle-related issues and practical references to particle mitigation for our peers in the biopharmaceutical industry.

The study of biological mechanisms, while crucial, cannot fully explain complex phenomena like the instinct to eat. The mind–body connection, as exemplified by the concept of "voodoo death," highlights the profound influence of belief and cultural context on physiology. Indigenous knowledge systems further emphasize the interconnectedness of humans with their environment. Recent discoveries in gut–brain communication reveal the intricate neural circuits that drive our visceral desires, but a holistic approach that integrates both physiological mechanisms and the subjective experience of life, informed by diverse cultural perspectives, will be essential to truly understand what it means to be alive.

ABSTRACTIntroduction:Emergency contraceptive pills (ECPs) are effective and can be used safely at any age repeatedly within the same cycle. They are often favored by youth yet are underutilized. Private facilities can increase ECP access but present barriers including cost. Identifying effective public-sector ECP distribution models can help ensure equitable access. The Malawi Ministry of Health developed a strategy to improve ECP access in 2020. We documented ECP provision through select public, youth-serving channels recommended by the strategy: general and youth-specific outreach, paid and unpaid community health workers (CHWs), and youth clubs.Methods:We conducted this mixed methods study from November 2022–March 2023 in 2 rural districts (Mchinji and Phalombe) implementing the strategy. We conducted qualitative interviews with 10 national stakeholders, 46 providers, and 24 clients aged 15–24 years about ECP service delivery. Additionally, 25 providers collected quantitative tally data about clients seeking ECPs. We analyzed qualitative data using grounded theory and quantitative data descriptively.Results:Stakeholders and providers reported ECP uptake increased in geographies where the strategy was implemented, especially among youth. Providers documented 3,988 client visits for ECPs over 3 months. Of these visits, 26% were from male clients, 36% were from clients aged younger than 20 years, and 64% received ECPs for the first time. Across channels, youth club leaders and unpaid CHWs reported the most client visits per provider and served the youngest clients. However, no ECPs were dispensed during 29% of visits due to stock-outs. While many providers were supportive of youth accessing ECPs, most held unfavorable attitudes toward repeat use.Conclusion:ECP access should be expanded through provision in the studied channels, especially youth clubs and CHWs. However, to meet demand, the supply chain must be strengthened. We recommend addressing providers’ attitudes about repeat use to ensure informed method choice.

The phase 3 VISION trial demonstrated that [¹⁷⁷Lu]Lu-PSMA-617 prolonged progression-free survival and overall survival (OS) in prostate-specific membrane antigen [PSMA]–positive metastatic castration-resistant prostate cancer (mCRPC) patients who progressed on taxane-based chemotherapy and androgen receptor–signaling inhibitors (ARSIs). The U.S. expanded-access program (EAP; NCT04825652) was opened to provide access to [¹⁷⁷Lu]Lu-PSMA-617 for eligible patients until regulatory approval was obtained. This study aimed to evaluate the efficacy and safety profile of [¹⁷⁷Lu]Lu-PSMA-617 within the EAP and compare the results with those from the VISION trial. Methods: Patients enrolled in the EAP at 4 institutions in the United States with available toxicity and outcome data were included. Outcome measures included OS, a prostate-specific antigen (PSA) response rate (RR) of at least 50%, and incidences of toxicity according to Common Terminology Criteria for Adverse Events version 5.0. Differences in baseline characteristics, outcome data, and toxicity between the EAP and VISION were evaluated using t testing of proportions and survival analyses. Results: In total, 117 patients with mCRPC who received [¹⁷⁷Lu]Lu-PSMA-617 within the EAP between May 2021 and March 2022 were eligible and included in this analysis. Patients enrolled in the EAP were more heavily pretreated with ARSI (≥2 ARSI regimens: 70% vs. 46%; P < 0.001) and had worse performance status at baseline (Eastern Cooperative Oncology Group score ≥ 2: 19% vs. 7%; P < 0.001) than VISION patients. EAP and VISION patients had similar levels of grade 3 or higher anemia (18% vs. 13%; P = 0.15), thrombocytopenia (13% vs. 8%; P = 0.13), and neutropenia (3% vs. 3%; P = 0.85) and similar PSA RRs (42% vs. 46%; P = 0.50) and OS (median: 15.1 vs. 15.3 mo; P > 0.05). Conclusion: Patients with PSMA-positive mCRPC who received [¹⁷⁷Lu]Lu-PSMA-617 within the EAP were later in their disease trajectory than VISION patients. Patients enrolled in the EAP achieved similar PSA RRs and OS and had a safety profile similar to that of the VISION trial patients.