Rare genetic conditions are challenging for the primary care provider to manage without proper guidelines. This clinical review is designed to assist the pediatrician, family physician, or internist in the primary care setting to manage the complexities of 16p11.2 deletion syndrome. A multidisciplinary medical home with the primary care provider leading the care and armed with up-to-date guidelines will prove most helpful to the rare genetic patient population. A special focus on technology to fill gaps in deficits, review of case studies on novel medical treatments, and involvement with the educational system for advocacy with an emphasis on celebrating diversity will serve the rare genetic syndrome population well.

BackgroundLong-term health conditions are major challenges for care systems. Social prescribing link workers have been introduced via primary care networks (PCNs) across England since 2019 to address the wider determinants of health by connecting individuals to activities, groups, or services within their local community.AimTo assess whether the rollout of social prescribing link workers was in areas with the highest need.Design and settingA retrospective study of social prescribing link workers in England from 2019 to 2023.MethodWorkforce, population, survey, and area-level data at the PCN-level from April 2020 to October 2023 were combined. Population need before the rollout of link workers was measured using reported lack of support from local services in the 2019 General Practice Patient Survey. To assess if rollout reflected need, linear regression was used to relate provision of link workers (measured by full-time equivalent [FTE] per 10 000 patients) in each quarter to population need for support.ResultsPopulations in urban, more deprived areas and with higher proportions of people from minority ethnic groups had the highest reported lack of support. Geographically these were in the North West and London. Initially, there was no association between need and provision; then from July 2022, this became negative and significant. By October 2023, a 10-percentage point higher need for support was associated with a 0.035 (95% confidence interval = −0.634 to −0.066) lower FTE per 10 000 patients.ConclusionRollout of link workers has not been sufficiently targeted at areas with the highest need. Future deployments should be targeted at those areas.

Netflix's mega-violent mega-hit series returns December 26.

Jade Ho explains what is possible for university students when they are given opportunities to learn about –and get involved with– social justice and labour issues in their own communities.

The post Students can be agents of change: Talking about activism in universities with Jade Ho appeared first on rabble.ca.

There has been fallout. Speaker Nathan Cooper is said to have decreed guests will never again be seated inside the legislative chamber.

The post Edmonton activist protests climate crisis with demonstration in AB legislature appeared first on rabble.ca.

Campaigners in Argyll and Bute are demanding a proposed tourist tax is rejected when it goes to a council vote next month.

Take-Two Interactive have sold their publishing label Private Division to an unnamed party, along with five of Private Division's "live and unreleased titles". The GTA 6 publisher have also finally confirmed that they have shut down OlliOlli World and Rollerdrome devs Roll7 together with Kerbal Space Program 2 creators Intercept Games, months after performing mass layoffs at both studios.

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Nostalgia, when you think about it, is bollocks. There has never been a better time than right this second – averaged out, and despite repeated attempts to the contrary, humanity has never been healthier, freer, or more enlightened by knowledge. It’s true of games too. For every by-committee platter of passionless map markers, there are thousands of more personal, more creative, more interesting works, all adding to the decades' worth of great stuff we can still play today.

What isn’t bollocks is the emotional pull that nostalgia, for all its lack of cold, hard reason, still manages to wield inside our warm, squishy brains. Hence, the centrepiece of Apex Legends’ Season 23 update is a mode that recreates the battle royale FPS as it was back in 2019, defaulting back to the original map and weapon arsenal while cutting the 26-strong legend roster to the earliest ten. It’s a Fortnite-style rolling back of the clock, and a passably enjoyable one, but also a reminder that the good old days weren’t always that good.

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On 19 and 20 August, the JUICE mission will make the first ever attempt to get a gravitational boost from both Earth and the moon on its way to Jupiter

If you were standing on Mars as it was hit by charged particles from the sun, you might be able to see an aurora just like on Earth

The European Space Agency is sending a probe to get a closer look at the asteroid Dimorphos, which had its orbit altered by NASA’s DART mission in 2022

Voyager 2 flew by Uranus in 1986, giving us our only up-close look at the planet – but unusual space weather just before the craft arrived has given us a misleading idea about the planet’s magnetic field

The Federal Emergency Management Agency supervisor who was fired after she told her staff to skip hurricane-damaged homes with Trump signs in their yards says it wasn't an isolated incident and is a "colossal event."

The Adison Vein Locator gives medical professionals Superman-like X-ray vision for finding patients' veins for easy insertion of needles.

… advice from former New Zealand Davis Cup player Dan Willman, who has … challenges Taranaki for the Christie Cup, the symbol of Central … place at the World Junior Davis Cup tournament in the Czech … ; Willman added. The Christie Cup has been played for since ….

… Junior Asia/ Oceania Davis Cup and Fed Cup final qualifying event. The … players selected for the Junior Davis Cup include Dev V. Javia, Sandeep … Gogoi (reserve). The Junior Fed Cup team includes Anisha Kashyap, Bhakti … Junior Asia/ Oceania Junior Davis Cup will begin in Kuching, Malaysia ….

… Trains for 1st Time inside Davis Cup Venue VALENCIA, Spain – World No … the Spanish national team’s Davis Cup quarterfinals against Germany. Nadal, who ….

… the opening round of the Davis Cup World Group on hard court … . Kyrgios led Australia to the Davis Cup semi-finals this year, while Zverev ….

… a big upset in his Davis Cup debut on Friday, defeating Spaniard ….

… level with France in the Davis Cup quarterfinals Friday. The 20th-ranked Fognini … all five of his previous Davis Cup matches and beat Fognini recently ….

A comet that has not been seen for more than 80,000 years is expected to be visible from Earth, potentially during two separate time periods in the next month.

Dis-Ease by Mariam Ghani uses strong visuals and compelling interviews to argue that how we see and describe disease affects how we deal with it, says Simon Ings

Medical clowns, who play with children in hospitals, may help them be discharged sooner by reducing their heart rates

Since winning the election last week, President-elect Trump has begun evaluating and rolling out his Cabinet picks, with dozens of names jockeying for some two dozen positions.

House Republicans are once again at odds with one another after conservatives threatened to protest Speaker Johnson's bid to lead the conference again.

In the bustling world of the restaurant industry, standing out is more challenging than ever. With diners increasingly turning to the internet to discover their next meal, having a strong online presence is crucial. This guide will show you practical tips and techniques to maximise your restaurant’s online visibility and enhance your SEO efforts. By […]

The post Maximising Online Visibility and SEO for Restaurants: Tips and Techniques appeared first on Chart Attack.

The gospel legend, whose new album is titled One True Vine, has a career spanning more than 60 years. She says of the record, made in collaboration with Wilco's Jeff Tweedy, "I've gone from the strictly gospel to folk to country, and here I am right back at home where I began."

1. Xi Jinping leaves for APEC meeting and state visit in Peru  CGTN
2. Peru and China to sign strengthened free-trade agreement in Xi's APEC visit  Hindustan Times
3. Amid unease over Trump 2.0, Xi Jinping heads to South America; Peru first stop  Firstpost
4. Moments in Motion | President Xi's memorable moments - Peru  Xinhua
5. Another Modi, Xi meet likely at G20 in Brazil  Deccan Chronicle

1. PM Narendra Modi to visit Nigeria, Brazil, Guyana from November 16  The Hindu
2. PM Modi to attend G20 Summit in Brazil, visit Nigeria and Guyana from November 16-20: Full schedule  The Times of India
3. PM Modi to embark on three nation visit to Nigeria, Brazil and Guyana from 16th nov  News On AIR
4. PM Modi's Africa-Latin America trip begins Sunday  The Economic Times
5. PM Modi to embark on 3-nation tour, attend G20 Leaders Summit in Brazil next week  The Indian Express

Significant visual and comfort compromises make last year's Quest 3 a better VR investment.

‘Horizon Zero Dawn Remastered’ elevates a classic with breathtaking visuals, smooth performance, and a gripping narrative on PS5 and PC

This week, Apple Arcade sees a major game update for Apple Vision Pro and a few notable updates. Castle Crumble …

Continue reading "Castle Crumble for Apple Vision Pro Is Now Available on Apple Arcade Alongside Big Updates for Puyo Puyo Puzzle Pop, Crayola Adventures, and More"

Welcome to this week’s edition of the Steam Deck Weekly. If you missed my Gundam Breaker 4 Steam Deck review, …

Continue reading "Steam Deck Weekly: Visions of Mana and More Reviews, Reynatis Preview, Age of Mythology Retold Steam Deck Impressions, News, and More"

After tackling the best party games on Switch in 2024, the recent release of Emio – The Smiling Man: Famicom …

Continue reading "The Best Switch Visual Novels and Adventure Games in 2024 – From Fata Morgana and VA-11 Hall-A to Famicom Detective Club and Gnosia"

An activist investor with a $5 billion stake in Honeywell International is calling for the company to separate its Phoenix-based aerospace division into a separate business.

Combining DNA analysis, archeological techniques, and historical records overturns some assumptions of the people of Pompeii.

If you use Chrome on your iPhone, you’re about to see some features sliding over from the Android version. Google Lens will let you add text to your image searches, and you can save files and pictures directly to Google Drive and Photos. You can get “Shopping Insights” for products you’re browsing.

Chrome for iOS now lets you add words to your Google Lens visual searches, allowing you to add nuance to your query or “perform more complex and specific searches,” as Chrome Product Manager Katia Muradyan wrote in a blog post. After activating Lens by tapping the camera icon in the Chrome search bar, you can ask questions about the object you’re snapping a pic of, and it will produce corresponding results. Google says AI Overviews will also appear for some of these search results.

The feature shares some common ground with an Apple Intelligence feature for iPhone 16 owners in iOS 18.2, which is currently in beta. Visual Intelligence lets you point your camera at something and get info about it, including asking ChatGPT questions about it or searching for it on Google.

Chrome for iPhone now has a feature that lets you save a file directly to Google Drive or Google Photos, sparing you from using your phone’s internal storage. When saving files from Chrome, you’ll see a new option to save the file to Drive. Similarly, when browsing a photo you want to save, long-press on it, and you’ll see a new “Save in Google Photos” option in the context menu. Of course, the feature requires you to be signed into a Google account.

Chrome for iOS also adds a feature that pops up a mini-map when you click on an address. Look for an underlined link to specific addresses; clicking on it will take you to the mini-map without leaving the browser.

Finally, Google is adding Shopping Insights for US users. The company frames it as a way to help you find great prices on items you’re shopping for, but it’s hard to imagine this feature exists strictly from the kindness of Google's heart. Regardless, you’ll soon see a “Good Deal Now” alert in Chrome’s address bar when browsing for products for which it’s available. You’ll see details like price history / tracking and buying options if you tap it.

Cadillac is adding to its fleet of EVs with a new luxury SUV. The 2026 Cadillac Vistiq is a three-row, all-electric SUV that will hit showrooms and dealerships sometime next summer with a starting price of $78,790.

The Vistiq’s dual-motor, all-wheel drive system runs on a 102 kWh battery pack with a range of 300 miles that produces 615 horsepower and 650 pound-feet of torque. The Vistiq also supports vehicle-to-home (V2H) bidirectional charging capabilities: it can charge at home, and also deliver electricity to your house during a power outage. Using the features requires buying the GM Energy V2H bundle though.

The SUV’s design borrows aesthetically from other Cadillac EVs. Like the Lyriq, it has flush door handles, and features similar looking lights and side panels. It also matches the Lyriq’s 300 mile range. The “swept-back windshield” and “Black Crystal Shield grill” evoke the Escalade IQ.

Of course, the Vistiq's power and price are different from its Cadillac EV's. The new Cadillac EV SUV is less expensive than an Escalade IQ ($129,990) but more than a Lyriq ($58,595), and the Escalade IQ has a higher peak battery range at 450 miles.

The Vistiq comes with a 23-speaker AKG7 Studio Audio system with Dolby Atmos. The Android-powered infotainment system is baked into a 33-inch high resolution LED display. The Verge also reported that the new EV’s navigation system uses Google Maps and can run other apps from the Google Play Store.

Apple CarPlay and Android Auto won’t be available in Cadillac’s newest EV. General Motors is phasing out Apple CarPlay and Android Auto from its EVs and plans to go with Android Automotive. GM’s Executive Director of Digital Cockpit Experience Edward Kummer said in a Reuters interview that the carmaker didn’t want any features in its EVs “that are dependent on a person having a cellphone.”

The initial buzz for Apple’s mixed-reality headset has died down, but new apps and experiences are still arriving for consumers who plunked down $3,500. The UK broadcaster Channel 4 just dropped a dedicated streaming app for the headset, which lets users watch stuff in “ground-breaking cinema-style.”

Channel 4 is the first UK broadcaster to take this step. The app leverages the tech inside the headset to overlay streaming content on the real world, which allows for a “full-screen viewing experience” of stuff like The Great British Bake Off and Taskmaster, in addition to multi-screen view.

Speaking of Taskmaster, the broadcaster also announced an environment based on the comedy game show. Environments on the AVP transform the world around the user, so people can watch Taskmaster while sitting in a room inspired by Taskmaster (cue that Xzibit Yo Dawg meme.) Other streaming apps have their own environments. Paramount+ offers one based on SpongeBob Squarepants and Disney+ now includes one set in Iceland.

This app doesn’t feature access to the recently-released Taskmaster VR experience. That one’s still tied to Steam VR and Meta Quest. By most accounts, it’s a pretty bad game, so the Vision Pro isn’t missing much.

Les Islanders ont une lourde tâche qui les attend ce soir.

Canada has launched a tourist drive but will tensions with China doom it to fail?

Japanese PM Shinzo Abe will arrive in Sydney tomorrow for a weekend meeting with Malcolm Turnbull.

Whilst the timeline set for adhering to the revised Schedule M of the Drugs and Cosmetics Act ends on December 31 for pharmaceutical companies with a turnover of less than Rs. 250 crore, the union ministry's

Nvision Biomedical Technologies and Invibio Biomaterial Solutions have announced that the FDA has granted clearance of the first 3D-Printed PEEK Interbody System made from PEEK-OPTIMA.