Professional drivers show a higher prevalence of obstructive sleep apnoea (OSA) compared with the general population. Furthermore, there is concern about the association between OSA and car crash risk given that drivers with OSA show an increased risk for car accidents. Despite this risk, OSA is often underdiagnosed and undertreated in this population, mainly due to lack of appropriate screening and sleep study referrals. Polysomnography (PSG), the gold standard test, is inappropriate for systematic screening because of its high expense, complexity and relative inaccessibility in this population. Therefore, there is a strong demand for good screening tools, including both subjective and objective data that may assist in early identification of possible OSA among professional drivers and, thus, aid in PSG examination referral and OSA management in an accredited sleep centre. However, there is considerable disagreement over screening methods and criteria for triggering a sleep study referral in different countries. There is also a strong need for further research in the area of OSA screening of commercial drivers in order to improve the diagnostic accuracy of screening tools and ensure that patients with OSA are accurately identified.

Although genome-wide association studies (GWAS) have identified more than 100 colorectal cancer risk loci, most of the biological mechanisms associated with these loci remain unclear. Here we first performed a comprehensive expression quantitative trait loci analysis in colorectal cancer tissues adjusted for multiple confounders to test the determinants of germline variants in established GWAS susceptibility loci on mRNA and long noncoding RNA (lncRNA) expression. Combining integrative functional genomic/epigenomic analyses and a large-scale population study consisting of 6,024 cases and 10,022 controls, we then prioritized rs174575 with a C>G change as a potential causal candidate for colorectal cancer at 11q12.2, as its G allele was associated with an increased risk of colorectal cancer (OR = 1.26; 95% confidence interval = 1.17–1.36; P = 2.57 × 10–9). rs174575 acted as an allele-specific enhancer to distally facilitate expression of both FADS2 and lncRNA AP002754.2 via long-range enhancer–promoter interaction loops, which were mediated by E2F1. AP002754.2 further activated a transcriptional activator that upregulated FADS2 expression. FADS2, in turn, was overexpressed in colorectal cancer tumor tissues and functioned as a potential oncogene that facilitated colorectal cancer cell proliferation and xenograft growth in vitro and in vivo by increasing the metabolism of PGE2, an oncogenic molecule involved in colorectal cancer tumorigenesis. Our findings represent a novel mechanism by which a noncoding variant can facilitate long-range genome interactions to modulate the expression of multiple genes including not only mRNA, but also lncRNA, which provides new insights into the understanding of colorectal cancer etiology.Significance:This study provides an oncogenic regulatory circuit among several oncogenes including E2F1, FADS2, and AP002754.2 underlying the association of rs174575 with colorectal cancer risk, which is driven by long-range enhancer–promoter interaction loops.Graphical Abstract:http://cancerres.aacrjournals.org/content/canres/80/9/1804/F1.large.jpg.

Found footage from many hours of trawling through night-drive ghost sighting videos on YouTube while on lockdown. The Golden Filter’s Stephen Hindman takes us on a haunted night-drive in the video for ‘But Please’, a new track released under his Isolating alias. ‘But Please’ appears on his new EP for Optimo Music Digital Danceforce, System. […]

The post Isolating finds himself on a haunted night-drive in ‘But Please’ appeared first on FACT Magazine.

Up until now mask-wearing had only been an unenforced suggestion by the company.

Whether it was driverless cars, lab-grown meat or faster-than-light neutrinos, some things just didn't live up to the hype in the 2010s

I don’t remember what happened this morning. There some sort of code that I type wrong. I think FFXI gets new content and then I...

Paris show features wildlife costumes to emphasise the label’s planet-friendly ethos

The singer Janelle Monáe and actor Shailene Woodley were in the front row, but two rabbits, a fox, a horse, two cows and a crocodile stole the show. People in lifesize animal costumes, of the kind more usually seen at theme park parades than at Paris fashion week, joined models for the finale of Stella McCartney’s show, swinging their new-season handbags and posing for the cameras.

The optics were fun, but the message was serious – that there are animals on almost every catwalk, it’s just that they are usually dead. The half-moon shoulder bag carried jauntily by a brown cow here was made from a vegan alternative to leather, while other bags were created from second-life plastic.

After analyzing 95 million traffic stop records, filed by officers with 21 state patrol agencies and 35 municipal police forces from 2011 to 2018, researchers concluded that 'police stops and search decisions suffer from persistent racial bias.'

SBS On Demand is streaming more than 10 hours of his features. Our isolated film critic took the bait and watched them all

Many terrible things are discussed in the maelstrom of mayhem and misery I call my inbox – terrible, terrible things, such as requests involving me needing to go somewhere, or speak to someone or do something.

But last Thursday afternoon a lovely email broke through like a ray of sunshine piercing grey clouds on a stormy day. It was an email from a publicist at SBS. The subject line read: “Binge 627 minutes of ADAM DRIVER for free.”

Restaurants and drive-in movie theatres are allowed to reopen in Las Vegas today, with casinos hoping to reopen by Memorial Day.

A team of researchers from the University of Exeter has studied potential drivers of ‘rock juggling’ in two species of otters in zoo environments. Although elusive in the wild, otters are noted to be very playful and inquisitive animals based on observations in captivity. The animals are often seen lying on their backs and batting [...]

The Monte Conca cave system in Sicily is showing signs of being altered by pollution from above.

A new global simulation model offers the first long-term look at how urbanization -- the growth of cities and towns -- will unfold in the coming decades. The research team projects the total amount of urban areas on Earth can grow anywhere from 1.8 to 5.9-fold by 2100, building approximately 618,000 square miles.

Lorry driver Maurice Robinson has admitted the manslaughter of 39 people who were found dead in a refrigerated trailer in Essex.

Read our live updates on coronavirus HERE Coronavirus: The symptoms

Read our live coronavirus updates HERE

Follow our live Covid-19 updates HERE Coronavirus: The symptoms

Coronavirus: the symptoms Read our LIVE updates on the coronavirus here

Follow our live Covid-19 updates HERE Coronavirus: The symptoms

Follow our live coronavirus updates HERE Coronavirus: The symptoms

The family of a London bus driver who died with Covid-19 said today a lack of protective equipment for public transport workers and delays to improving safety had "cost lives".

Four police officers have died after being hit by a truck when they stopped to detain a speeding driver on an Australian motorway, officials said.

A man who claimed he had coronavirus before spitting at a bus driver is west London has pleaded guilty to common assault.

Home Secretary Priti Patel revealed that police have been called to respond to some "extraordinarily dangerous driving" as car lovers take advantage of the quieter roads "as their own personal race track".

A five-star luxury hotel in London has been spreading a little joy amid the coronavirus outbreak by serving up free meals for key workers.

A teenager who allegedly spat at a bus driver in south-east London during the coronavirus lockdown has been arrested.

The number of speeding drivers caught by traffic police has risen by nearly eight-fold compared with last year, the Met revealed today.

A man has been jailed for spitting at a London bus driver and a police officer.

Bus drivers paid their respects to a colleague who died with coronavirus symptoms as his funeral cortege passed through the depot where he had worked for almost 20 years.

A dating app is providing London bus drivers with free face bandanas, amid fears of a lack adequate personal protective equipment (PPE) for frontline transport staff.

A new survey suggests people think the behaviour of drivers and cyclists has deteriorated since the start of the coronavirus pandemic.

Drive-thru restaurants such as McDonald's are "made for social distancing", Environment Secretary George Eustice has said.

The state accuses the ride-hailing apps of flouting a labor law by classifying drivers as independent contractors instead of employees.

Visual challenges remain before autonomous cars are ready for the masses.

'It looks like they were just spraying bullets across my property'

Michael Condron played Bowen Marsh in the fantasy epic

The advert will air during Friday's 'Gogglebox'

• Alex Wurz calls measures to deal with coronavirus ‘immaculate’
  
• ‘F1 can be pioneer’ for other sports to follow, says GPDA chief

The Grand Prix Drivers’ Association is confident the precautions being taken by Formula One mean the sport stands every chance of resuming as planned in Austria on 5 July.

Alex Wurz, chairman of the GPDA, will reassure his members that Formula One has put the safety of everyone involved at the forefront of its plans to return to racing after attending a meeting with F1 and the FIA on Friday.

Lyft users must self-certify that they are following CDC guidelines related to COVID-19.

Nintendo, Sony, Microsoft seek exemption from threatened Chinese tariffs.

A Danish club have come up with a novel way to allow fans to watch games together when football returns behind closed doors – by setting up drive-in screenings.

Welcome to the Evening Standard's LIVE coverage as the coronavirus crisis continues to heavily impact sport across the globe.

Social distancing rules will ‘kill cities’, experts warn – and the future of mass transit hangs in the balance

This is the second feature in our Life after lockdown series, which looks at how Covid-19 could change Australia for good

Before the pandemic struck, Sara Blazey made the same three-hour commute to work, three days a week, for the better part of 12 years. The 63-year-old family lawyer from the Blue Mountains works for a domestic violence legal advice hotline in Parramatta and it used to be that she would wake at 7am, drive seven minutes to Hazelbrook station and from there catch the 7.17am train to Parramatta before making the same one-and-a-half hour trip home in the evening.

With the pandemic, all that would change. Domestic violence support services such as the one Blazey worked for were declared “essential” services, meaning they could keep operating despite restrictions. To ensure they could do so safely, the organisation did what some commentators long thought impossible and began to transition its employees into working from home.

It's not just multi-manufacturer racing leagues like NASCAR going digital during the COVID-19 pandemic. Porsche is livestreaming its Mobil 1 Supercup Virtual Edition starting on April 4th at 10AM Eastern, when drivers take to a digital version of the Spanish Circuit de Barcelona-Catalunya for two races in 911 GT3 Cup cars. The iRacing-based series will have 31 drivers, 22 of which are full-time Supercup racers -- the nine others are factory and young professional drivers fielded by big-name sponsors like TAG Heuer and Vodafone.

Drivers being cheated out of wages and not being reimbursed for expenses causes California to lose out on payroll taxes, attorney Shannon Liss-Riordan argues in a new legal challenge to Uber's practices.

Responding to a new California labor law, Uber making concessions drivers have long sought. But it may change the service in ways that displease drivers and riders alike.