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Event participants

Professor Kerry Brown, Director, Lau China Institute, King's College London; Associate Fellow, Asia Programme, Chatham House
Chair: Isabel Hilton OBE, Founder and Editor, Chinadialogue

Bacterial products such as lipopolysaccharides (or endotoxin) cause systemic inflammation, resulting in a substantial global health burden. The onset, progression, and resolution of the inflammatory response to endotoxin are usually tightly controlled to avoid chronic inflammation. Members of the NF-κB family of transcription factors are key drivers of inflammation that activate sets of genes in response to inflammatory signals. Such responses are typically short-lived and can be suppressed by proteins that act post-translationally, such as the SOCS (suppressor of cytokine signaling) family. Less is known about direct transcriptional regulation of these responses, however. Here, using a combination of in vitro approaches and in vivo animal models, we show that endotoxin treatment induced expression of the well-characterized transcriptional repressor Krüppel-like factor 3 (KLF3), which, in turn, directly repressed the expression of the NF-κB family member RELA/p65. We also observed that KLF3-deficient mice were hypersensitive to endotoxin and exhibited elevated levels of circulating Ly6C+ monocytes and macrophage-derived inflammatory cytokines. These findings reveal that KLF3 is a fundamental suppressor that operates as a feedback inhibitor of RELA/p65 and may be important in facilitating the resolution of inflammation.

We put the manual derivative of the Toyota Yaris through its paces to find out if the same is worth the buy over the convenience of the CVT automatic.

Most performance cars are not designed for Indian conditions, but does the GLC 43 AMG strike the perfect balance to be usable every day of the week and satisfy the enthusiast?

Kia Seltos comes to India at a time when the auto industry is going through a massive setback in terms of sales. Based on an already perfected formula i.e. the Hyundai Creta, can the Kia Seltos make its mark and kickstart an all-new brand in India? Read our Kia Seltos review from the roads of Goa to find out!

The Maruti XL6 is a breath of fresh air when it comes to premium six-seater multi purpose vehicles in the country and its excellent at what it is designed to do.

Does the Hyundai Grand i10 Nios get what it takes to take the fight to the Swift and what are its pros and cons? Read on to find out.

There's nothing out there in the market today like the Maruti Suzuki S-Presso so we drove the automatic and manual versions of the car around Jodhpur to find out if it has what it takes to infuse some life into a declining segment and create a niche. 

Does the Skoda Kodiaq Scout bring something new to the table? Is it just a visual makeover of is there more than meets the eye? We answer these and all the other question related to this new variant of Skoda flagship SUV in India in this review.

The new Audi A6 is a step-up from the previous generation car in all aspects and didn't disappoint us in the short drive experience that we had with it.

Can the Tata Nexon Electric become your next daily driver? Read our first-drive review of India's first all-electric sub-four-meter SUV to find out!

The new Hyundai Aura has been launched at a competitive price range. With new and multiple segment-first features and extensive engine and gearbox options, the Aura presents a strong threat to the Maruti Suzuki Dzire's segment leadership. We drove the car in Indore to find out if the Hyundai Aura can topple off the existing king.

Despite reporting a fall in profits in the January-March quarter, the 10% stake sale in Reliance Jio to Facebook and the biggest-ever rights issue in India of Rs 53,000 crore that Reliance Industries announced on Friday has made brokerage firms stay firm on their ‘buy’ calls for India’s most valuable company.

According to an Indian Express report, on May 3, the Gautam Budh Nagar Police issued an order that all residents of Noida or Greater Noida, and anyone entering the city will need to download the Aarogya Setu app.

And other ways to use BACON to make your life incredible and amazing

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Alternative energy became a serious market player after the turn of the millennium. Since that time, solar, wind, smart grid and other alternative energy stocks have experienced both strong up and down trends. The forces at work driving these markets are complex, counterintuitive, and sometimes mysterious. This article looks at what has been driving the price of alternative energy markets, and as a result, alternative energy company stocks.

The United States is experiencing a significant shift in its energy landscape. Last year, utility-scale wind and solar power combined for 47 percent of new generation capacity in the U.S. Based on this expansion, 11 states now generate more than 10 percent of their electricity from solar, wind, and geothermal power, with three of these states — Iowa, South Dakota, and Kansas — exceeding 20 percent. In 2014, California became the first state in the nation to garner 5 percent of its electricity from utility-scale solar. When including hydropower, four states —Idaho, Washington, Oregon, and South Dakota — now exceed 70 percent renewables generation.

A truck driver has been freed from his vehicle and is being airlifted to hospital after a crash in Eastern Bay of Plenty.Emergency services were called to a report that a truck crashed at the intersection of State Highway 30 and...

A truck driver is in a critical condition after being trapped for more than four hours after his truck rolled near Rotorua this morning. Police were notified of a truck that rolled and was in a ditch at 9:33am on the intersection...

Mohamed assured that it’s a countrywide drive, and not an exclusively Rift Valley project.

The coronavirus in Japan has brought not just an epidemic of infections, but also an onslaught of bullying and discrimination against the sick, their families and health workers.A government campaign to raise awareness seems to be helping, at least for medical workers. But it’s made only limited headway in countering the harassment and shunning that may be discouraging people from seeking testing and care and hindering the battle against the pandemic.When Arisa Kadono tested positive and was…

Ride-along and interview Nokia's Aaron Dannenbring

Jan 19 - In an exclusive interview with Reuters Global Editor-at-Large Chrystia Freeland, GE CEO Jeffrey Immelt says a large and educated workforce is fueling China's strength and not simply a deflated yuan.

Changing global and political landscapes have made the kind of broad and bipartisan agreements reached in the 1970s seem impossible.

- 5 MIN READ -

The post How Data-driven Personalized Learning is Propelling the Learning Industry Forward appeared first on e-Learning Feeds.

A driver tried to throw NZ$50,000 worth of cocaine out of his van while police were chasing him but ended up with cocaine all over the inside of the vehicle after forgetting to actually open the window.A photo of the man's expensive...

When watching Formula One, it can be easy to forget these drivers are taking their lives in their own hands.

There’s no guarantee you’ll find a race track to drive during the pandemic, but Porsche will be ready whenever you can hit the course. It recently updated its Track Precision app for iOS (via Autoblog) with CarPlay support to make lap data much more...

KKR has about $58 billion in dry powder for new investments.

The post KKR sees Asia portfolio as driver for growth amid virus crisis appeared first on DealStreetAsia.

Red Bull drivers Mark Webber and Sebastian Vettel suffered mixed emotions during qualifying for the Italian Grand Prix after finishing fourth and sixth fastest respectively

Read what the teams and drivers had to say after the Italian Grand Prix at Monza

Driver and team reaction after the action-packed Canadian Grand Prix

Jean-Eric Vergne set the quickest time of the first morning of the Young Driver Test in Abu Dhabi

A list of who is driving for which teams and when during the Young Driver Test in Abu Dhabi

Nico Rosberg admitted he only had himself to blame after failing front row of the grid for the first time in 13 races in a wet qualifying session in Malaysia

A round-up of the drivers' thoughts after the Australian Grand Prix in Melbourne

The boss of the Australian Grand Prix Ron Walker has labelled Formula One drivers "lazy prima donnas" after they complained about low light levels at this year's race

Formula One drivers and team bosses have expressed their sympathy for the paying spectators who turned up in appalling conditions at Suzuka on Saturday only to see qualifying postponed until Sunday morning

Driver and team reaction after the Japanese Grand Prix

Driver and team reaction after the first practice sessions for the Korean Grand Prix

All the driver's reaction after the Monaco Grand Prix

A quick look at how the 24 drivers got on during the Monaco Grand Prix