cts Flu Vaccine Protects Nursing Home Residents, Study Finds By www.medicinenet.com Published On :: Mon, 29 Aug 2022 00:00:00 PDT Title: Flu Vaccine Protects Nursing Home Residents, Study FindsCategory: Health NewsCreated: 8/25/2015 12:00:00 AMLast Editorial Review: 8/26/2015 12:00:00 AM Full Article
cts Medical Groups Endorse Early Exposure to Peanut Products for High-Risk Infants By www.medicinenet.com Published On :: Mon, 29 Aug 2022 00:00:00 PDT Title: Medical Groups Endorse Early Exposure to Peanut Products for High-Risk InfantsCategory: Health NewsCreated: 8/26/2015 12:00:00 AMLast Editorial Review: 8/27/2015 12:00:00 AM Full Article
cts Kids' Mild Brain Injury Can Have Long-Term Effects By www.medicinenet.com Published On :: Mon, 29 Aug 2022 00:00:00 PDT Title: Kids' Mild Brain Injury Can Have Long-Term EffectsCategory: Health NewsCreated: 8/24/2016 12:00:00 AMLast Editorial Review: 8/24/2016 12:00:00 AM Full Article
cts Scans Show Range of Zika-Linked Infant Brain Defects By www.medicinenet.com Published On :: Mon, 29 Aug 2022 00:00:00 PDT Title: Scans Show Range of Zika-Linked Infant Brain DefectsCategory: Health NewsCreated: 8/23/2016 12:00:00 AMLast Editorial Review: 8/24/2016 12:00:00 AM Full Article
cts Hundreds of Human, Pet Homeopathy Products Recalled By www.medicinenet.com Published On :: Mon, 29 Aug 2022 00:00:00 PDT Title: Hundreds of Human, Pet Homeopathy Products RecalledCategory: Health NewsCreated: 8/28/2018 12:00:00 AMLast Editorial Review: 8/29/2018 12:00:00 AM Full Article
cts AHA News: Mysterious Stroke at 38 Changed How Popular Speaker Connects With a Crowd By www.medicinenet.com Published On :: Mon, 29 Aug 2022 00:00:00 PDT Title: AHA News: Mysterious Stroke at 38 Changed How Popular Speaker Connects With a CrowdCategory: Health NewsCreated: 8/28/2019 12:00:00 AMLast Editorial Review: 8/29/2019 12:00:00 AM Full Article
cts People Underestimate Impact of Random Acts of Kindness By www.medicinenet.com Published On :: Thu, 25 Aug 2022 00:00:00 PDT Title: People Underestimate Impact of Random Acts of KindnessCategory: Health NewsCreated: 8/24/2022 12:00:00 AMLast Editorial Review: 8/25/2022 12:00:00 AM Full Article
cts FDA Warns Amazon, Other Vendors About Sale of Skin Tag Removal Products By www.medicinenet.com Published On :: Wed, 10 Aug 2022 00:00:00 PDT Title: FDA Warns Amazon, Other Vendors About Sale of Skin Tag Removal ProductsCategory: Health NewsCreated: 8/10/2022 12:00:00 AMLast Editorial Review: 8/10/2022 12:00:00 AM Full Article
cts Foreign Objects or Insects in the Ear By www.medicinenet.com Published On :: Wed, 3 Aug 2022 00:00:00 PDT Title: Foreign Objects or Insects in the EarCategory: Diseases and ConditionsCreated: 11/29/1998 12:00:00 AMLast Editorial Review: 8/3/2022 12:00:00 AM Full Article
cts Scotland Becomes 1st Country to Provide Free Period Products By www.medicinenet.com Published On :: Tue, 16 Aug 2022 00:00:00 PDT Title: Scotland Becomes 1st Country to Provide Free Period ProductsCategory: Health NewsCreated: 8/15/2022 12:00:00 AMLast Editorial Review: 8/16/2022 12:00:00 AM Full Article
cts Patient-managed interventions for adults with bronchiectasis: evidence, challenges and prospects By err.ersjournals.com Published On :: 2024-10-30T01:30:15-07:00 Bronchiectasis is a chronic lung condition which is characterised by recurrent chest infections, chronic sputum production and cough, and limited exercise tolerance. While bronchiectasis may be caused by various aetiologies, these features are shared by most patients with bronchiectasis regardless of the cause. This review consolidates the existing evidence on patient-managed interventions for adults with bronchiectasis, while also outlining areas for future research. Airway clearance techniques and hyperosmolar agents are key components of the bronchiectasis management and consistently recommended for clinical implementation. Questions around their prescription, such as optimal sequence of delivery, are still to be answered. Pulmonary rehabilitation and exercise are also recommended for patients with bronchiectasis. Relatively strong evidence underpins this recommendation during a clinically stable stage of the disease, although the role of pulmonary rehabilitation following an exacerbation is still unclear. Additionally, self-management programmes feature prominently in bronchiectasis treatment, yet the lack of consensus regarding their definition and outcomes presents hurdles to establishing a cohesive evidence base. Moreover, cough, a cardinal symptom of bronchiectasis, warrants closer examination. Although managing cough in bronchiectasis may initially appear risky, further research is necessary to ascertain whether strategies employed in other respiratory conditions can be safely and effectively adapted to bronchiectasis, particularly through identifying patient responder populations and criteria where cough may not enhance airway clearance efficacy and its control is needed. Overall, there is a growing recognition of the importance of patient-managed interventions in the bronchiectasis management. Efforts to improve research methodologies and increase research funding are needed to further advance our understanding of these interventions, and their role in optimising patient care and outcomes. Full Article
cts Downstream Effects of Market Changes on Inhalers: Impacts on Individuals With Chronic Lung Disease By rc.rcjournal.com Published On :: 2024-10-25T05:44:13-07:00 COPD and asthma are two of the most common chronic lung diseases, affecting over 545 million people globally and 34 million in the United States. Annual health care costs related to chronic lung disease are estimated at €380 billion in the European Union, and $24–$50 billion in the United States averaging to $4,000 in out-of-pocket costs per person in the U.S. A full-text literature search was conducted for English publications between January 1, 2005–March 18, 2024. It returned over 5,000 publications that were further narrowed using key search words, resulting in 172 peer-reviewed articles. Using their experience and subject expertise, the authors further narrowed the peer-reviewed articles to 55 that were in their opinion relevant. Also, 38 recently published industry reports and news articles specific to downstream effects of inhaler market changes and the future impact were included. The literature suggests that individuals with chronic lung disease face increased challenges with access to inhaled medication due to rising medication costs, discontinuation of branded medications, introduction of generic medications not covered by insurance, exclusionary preferred drug list tactics that force health care providers into non-medical switching of medication or devices, and ongoing medication shortages. Providers experience ongoing hurdles in prescribing appropriate inhaled medications for individuals with chronic lung disease, including increased time and costs spent on administrative tasks due to inhaler denials, a loss of patient trust, and limits on their ability to prescribe appropriate inhaled medication for individuals with chronic lung disease. Full Article
cts Effects of Lung Injury and Abdominal Insufflation on Respiratory Mechanics and Lung Volume During Time-Controlled Adaptive Ventilation By rc.rcjournal.com Published On :: 2024-10-25T05:44:12-07:00 BACKGROUD:Lung volume measurements are important for monitoring functional aeration and recruitment and may help guide adjustments in ventilator settings. The expiratory phase of airway pressure release ventilation (APRV) may provide physiologic information about lung volume based on the expiratory flow-time slope, angle, and time to approach a no-flow state (expiratory time [TE]). We hypothesized that expiratory flow would correlate with estimated lung volume (ELV) as measured using a modified nitrogen washout/washin technique in a large-animal lung injury model.METHODS:Eight pigs (35.2 ± 1.0 kg) were mechanically ventilated using an Engström Carescape R860 on the APRV mode. All settings were held constant except the expiratory duration, which was adjusted based on the expiratory flow curve. Abdominal pressure was increased to 15 mm Hg in normal and injured lungs to replicate a combination of pulmonary and extrapulmonary lung injury. ELV was estimated using the Carescape FRC INview tool. The expiratory flow-time slope and TE were measured from the expiratory flow profile.RESULTS:Lung elastance increased with induced lung injury from 29.3 ± 7.3 cm H2O/L to 39.9 ± 15.1cm H2O/L, and chest wall elastance increased with increasing intra-abdominal pressures (IAPs) from 15.3 ± 4.1 cm H2O/L to 25.7 ± 10.0 cm H2O/L in the normal lung and 15.8 ± 6.0 cm H2O/L to 33.0 ± 6.2 cm H2O/L in the injured lung (P = .39). ELV decreased from 1.90 ± 0.83 L in the injured lung to 0.67 ± 0.10 L by increasing IAP to 15 mm Hg. This had a significant correlation with a TE decrease from 2.3 ± 0.8 s to 1.0 ± 0.1 s in the injured group with increasing insufflation pressures (ρ = 0.95) and with the expiratory flow-time slope, which increased from 0.29 ± 0.06 L/s2 to 0.63 ± 0.05 L/s2 (ρ = 0.78).CONCLUSIONS:Changes in ELV over time, and the TE and flow-time slope, could be used to demonstrate evolving lung injury during APRV. Using the slope to infer changes in functional lung volume represents a unique, reproducible, real-time, bedside technique that does not interrupt ventilation and may be used for clinical interpretation. Full Article
cts Effects of Ultrasonic Use on Hearing Loss in Dental Hygienists: A matched pairs design study By jdh.adha.org Published On :: 2024-10-15T09:18:41-07:00 Purpose Dental professionals are exposed to hazardous noise levels on a daily basis in clinical practice. The purpose of this study was to compare the hearing status of dental hygienists who utilize ultrasonic scalers in the workplace compared to age-matched control participants (non-dental hygienists) who were not exposed to ultrasonic noise.Methods A convenience sample of nineteen dental hygienists (experimental) and nineteen non-dental hygienists (control) was recruited for this study. A matched pairs design was utilized; participants in each group were matched based on age and gender to eliminate confounding variables. The testing procedure consisted of an audiologist performing a series of auditory tests including otoacoustic emissions test, pure-tone audiometry, and tympanometry on the experimental and control groups.Results In the right ear, there were notable differences from 1000 Hz – 10,000 Hz and in the left ear from 6000 Hz – 10,000 Hz, with higher hearing thresholds in the experimental group of dental hygienists. While 56% of the univariate tests conducted on how many days were worked per week showed statistical significance, the regression line slope indicated those that worked more days had better hearing statuses. The variables for years in practice for dental hygienists, how many of those years were full-time employment, and how many years the dental hygienist had used an ultrasonic scaling device, also had many significant univariate tests for the experimental group only. These variables were more likely to serve as proxies representing true noise exposure. The paired t-test between the groups demonstrated statistically significant differences between the experimental and control group at 9000 Hz in both ears.Conclusion While results from this study demonstrated various qualitative differences in hearing status of the control group (non-dental hygienists) and experimental group (dental hygienists), age was found to be the most critical variable. Furthermore, this data demonstrated differences in hearing status based on various frequencies between dental hygienists and age-matched controls that should be further explored with a larger population. Full Article
cts Deciphering visceral instincts: a scientific quest to unravel food choices from molecules to mind [Special Section: Symposium Outlook] By genesdev.cshlp.org Published On :: 2024-10-16T07:18:56-07:00 The study of biological mechanisms, while crucial, cannot fully explain complex phenomena like the instinct to eat. The mind–body connection, as exemplified by the concept of "voodoo death," highlights the profound influence of belief and cultural context on physiology. Indigenous knowledge systems further emphasize the interconnectedness of humans with their environment. Recent discoveries in gut–brain communication reveal the intricate neural circuits that drive our visceral desires, but a holistic approach that integrates both physiological mechanisms and the subjective experience of life, informed by diverse cultural perspectives, will be essential to truly understand what it means to be alive. Full Article
cts Effects of Compound Probiotics on Pharmacokinetics of Cytochrome 450 Probe Drugs in Rats [Articles] By dmd.aspetjournals.org Published On :: 2024-10-16T09:02:03-07:00 Compound probiotics have been widely used and commonly coadministered with other drugs for treating various chronic illnesses, yet their effects on drug pharmacokinetics remain underexplored. This study elucidated the impact of VSL#3 on the metabolism of probe drugs for cytochrome P450 enzymes (P450s), specifically omeprazole, tolbutamide, midazolam, metoprolol, phenacetin, and chlorzoxazone. Male Wistar rats were administered drinking water containing VSL#3 or not for 14 days and then intragastrically administered a P450 probe cocktail; this was done to investigate the host P450’s metabolic phenotype. Stool, liver/jejunum, and serum samples were collected for 16S ribosomal RNA sequencing, RNA sequencing, and bile acid profiling. The results indicated significant differences in both α and β diversity of intestinal microbial composition between the probiotic and vehicle groups in rats. In the probiotic group, the bioavailability of omeprazole increased by 269.9%, whereas those of tolbutamide and chlorpropamide decreased by 28.1% and 27.4%, respectively. The liver and jejunum exhibited 1417 and 4004 differentially expressed genes, respectively, between the two groups. In the probiotic group, most of P450 genes were upregulated in the liver but downregulated in the jejunum. The expression of genes encoding metabolic enzymes and drug transporters also changed. The serum-conjugated bile acids in the probiotic group were significantly reduced. Shorter duodenal villi and longer ileal villi were found in the probiotic group. In summary, VSL#3 administration altered the gut microbiota, host drug–processing gene expression, and intestinal structure in rats, which could be reasons for pharmacokinetic changes. SIGNIFICANCE STATEMENT This study focused on the effects of the probiotic VSL#3 on the pharmacokinetic profile of cytochrome P450 probe drugs and the expression of host drug metabolism genes. Compared with previous studies, the present study provides a comprehensive explanation for the host drug metabolism profile modified by probiotics, combined here with the bile acid profile and histopathological analysis. Full Article
cts Quantitatively Predicting Effects of Exercise on Pharmacokinetics of Drugs Using a Physiologically Based Pharmacokinetic Model [Articles] By dmd.aspetjournals.org Published On :: 2024-10-16T09:02:03-07:00 Exercise significantly alters human physiological functions, such as increasing cardiac output and muscle blood flow and decreasing glomerular filtration rate (GFR) and liver blood flow, thereby altering the absorption, distribution, metabolism, and excretion of drugs. In this study, we aimed to establish a database of human physiological parameters during exercise and to construct equations for the relationship between changes in each physiological parameter and exercise intensity, including cardiac output, organ blood flow (e.g., muscle blood flow and kidney blood flow), oxygen uptake, plasma pH and GFR, etc. The polynomial equation P = aiHRi was used for illustrating the relationship between the physiological parameters (P) and heart rate (HR), which served as an index of exercise intensity. The pharmacokinetics of midazolam, quinidine, digoxin, and lidocaine during exercise were predicted by a whole-body physiologically based pharmacokinetic (WB-PBPK) model and the developed database of physiological parameters following administration to 100 virtual subjects. The WB-PBPK model simulation results showed that most of the observed plasma drug concentrations fell within the 5th–95th percentiles of the simulations, and the estimated peak concentrations (Cmax) and area under the curve (AUC) of drugs were also within 0.5–2.0 folds of observations. Sensitivity analysis showed that exercise intensity, exercise duration, medication time, and alterations in physiological parameters significantly affected drug pharmacokinetics and the net effect depending on drug characteristics and exercise conditions. In conclusion, the pharmacokinetics of drugs during exercise could be quantitatively predicted using the developed WB-PBPK model and database of physiological parameters. SIGNIFICANCE STATEMENT This study simulated real-time changes of human physiological parameters during exercise in the WB-PBPK model and comprehensively investigated pharmacokinetic changes during exercise following oral and intravenous administration. Furthermore, the factors affecting pharmacokinetics during exercise were also revealed. Full Article
cts Effects of Dual Inhibition at Dopamine Transporter and {sigma} Receptors in the Discriminative-Stimulus Effects of Cocaine in Male Rats [Behavioral Pharmacology] By jpet.aspetjournals.org Published On :: 2024-10-18T07:04:15-07:00 Previous studies demonstrated that sigma receptor (R) antagonists alone fail to alter cocaine self-administration despite blocking various other effects of cocaine. However, R antagonists when combined with dopamine transporter (DAT) inhibitors substantially decrease cocaine self-administration. To better understand the effects of this combination, the present study examined the effects of R antagonist and DAT inhibitor combinations in male rats discriminating cocaine (10 mg/kg, i.p.) from saline injections. The DAT inhibitors alone [(–)-2-β-carbomethoxy-3-β-(4-fluorophenyl)tropane 1,5-naphthalenedisulfonate monohydrate (WIN 35,428) and methylphenidate] at low (0.1-mg/kg) doses that were minimally active failed to shift the dose-effect function for discriminative-stimulus effects of cocaine to the left more than 2-fold. At 0.32 mg/kg the DAT inhibitors alone shifted the cocaine dose-effect function leftward 24- or 6.6-fold, respectively. The R antagonists (BD1008, BD1047, and BD1063) failed to fully substitute for cocaine, although BD1008 and BD1047 substituted partially. At 10 mg/kg, BD1008, BD1047, or BD1063 alone shifted the cocaine dose-effect function leftward less than 6.0-fold. In combination with 0.1 mg/kg WIN 35,428, the 10 mg/kg doses of R antagonists shifted the cocaine dose-effect function from 12.3- to 36.7-fold leftward, and with 0.32 mg/kg WIN 35,428 from 14.3- to 440-fold leftward. In combination with 0.1 mg/kg methylphenidate, those R antagonist doses shifted the cocaine dose-effect function from 5.5- to 55.0-fold leftward, and with 0.32 mg/kg methylphenidate from 10.5- to 48.1-fold leftward. The present results suggest that dual DAT/R inhibition produces agonist-like subjective effects that may promote decreases in self-administration obtained in previous studies. SIGNIFICANCE STATEMENT There is currently no approved medication for treating stimulant abuse, although dopamine uptake inhibitors in combination with sigma receptor (R) antagonists decrease cocaine self-administration in laboratory animals. The present study assessed how this combination alters the discriminative-stimulus effects of cocaine in male rats. Results suggest that concurrent dopamine uptake inhibition and R antagonism together may promote decreases in self-administration, possibly by mimicking the subjective effects extant when subjects cease continued cocaine self-administration. Full Article
cts Alternative Reinforcers Enhance the Effects of Opioid Antagonists, but Not Agonists, on Oxycodone Choice Self-Administration in Nonhuman Primates [Behavioral Pharmacology] By jpet.aspetjournals.org Published On :: 2024-10-18T07:04:15-07:00 Clinical reports suggest that the most effective strategies for managing opioid use disorder comprise a comprehensive treatment program of both pharmacological and nonpharmacological approaches. However, the conditions under which these combinations are most effective are not well characterized. This study examined whether the presence of an alternative reinforcer could alter the efficacy of Food and Drug Administration–approved opioid antagonist or agonist medications, as well as the nonopioid flumazenil, in decreasing oxycodone choice self-administration in nonhuman primates. Adult squirrel monkeys (n = 7; four females) responded under concurrent second-order fixed-ratio (FR)-3(FR5:S);TO45s schedules of reinforcement for intravenous oxycodone (0.1 mg/kg) or saline on one lever and 30% sweetened condensed milk or water on the other. Doses of naltrexone (0.00032–1.0 mg/kg), nalbuphine (0.32–10 mg/kg), buprenorphine (0.0032–0.032 mg/kg), methadone (0.32–1.0 mg/kg), or flumazenil (1–3.2 mg/kg) were administered intramuscularly prior to oxycodone self-administration sessions that occurred with either milk or water as the alternative. Naltrexone, a μ-opioid receptor antagonist, was >30-fold more potent when milk was available compared with water and abolished oxycodone intake (injections/session) while concomitantly increasing milk deliveries at the highest dose tested. Pretreatment with the low-efficacy μ-agonist nalbuphine was most effective in the presence of milk compared with water, decreasing oxycodone preference to <50% of control values. The higher efficacy μ-agonists, methadone and buprenorphine, and the benzodiazepine antagonist flumazenil did not appreciably alter the reinforcing potency of oxycodone under either condition. These results suggest that antagonist medications used in combination with alternative reinforcers may be an effective strategy to curtail opioid abuse–related behaviors. SIGNIFICANCE STATEMENT Clinical treatment programs for opioid use disorder use a combination of pharmacological and nonpharmacological approaches. However, the conditions under which these combinations are most effective have not been fully characterized. This study examined whether the effectiveness of μ-opioid medications to decrease oxycodone self-administration is altered in the presence of an alternative reinforcer. The results suggest that alternative reinforcers enhance the effects of antagonist or low-efficacy partial agonists, suggesting they may be a more effective strategy to curtail opioid use. Full Article
cts Cannabinoid 2 Receptor Activation Protects against Diabetic Cardiomyopathy through Inhibition of AGE/RAGE-Induced Oxidative Stress, Fibrosis, and Inflammasome Activation [Special Section: Cannabinoid Signaling in Human Health and Disease] By jpet.aspetjournals.org Published On :: 2024-10-18T07:04:15-07:00 Oxidative stress, fibrosis, and inflammasome activation from advanced glycation end product (AGE)–receptor of advanced glycation end product (RAGE) interaction contribute to diabetic cardiomyopathy (DCM) formation and progression. Our study revealed the impact of β-caryophyllene (BCP) on activating cannabinoid type 2 receptors (CB2Rs) against diabetic complication, mainly cardiomyopathy and investigated the underlying cell signaling pathways in mice. The murine model of DCM was developed by feeding a high-fat diet with streptozotocin injections. After the development of diabetes, the animals received a 12-week oral BCP treatment at a dose of 50 mg/kg/body weight. BCP treatment showed significant improvement in glucose tolerance and insulin resistance and enhanced serum insulin levels in diabetic animals. BCP treatment effectively reversed the heart remodeling and restored the phosphorylated troponin I and sarcoplasmic/endoplasmic reticulum Ca2+ ATPase 2a expression. Ultrastructural examination showed reduced myocardial cell injury in DCM mice treated with BCP. The preserved myocytes were found to be associated with reduced expression of AGE/RAGE in DCM mice hearts. BCP treatment mitigated oxidative stress by inhibiting expression of NADPH oxidase 4 and activating phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/nuclear factor erythroid 2–related factor 2 (Nrf2) signaling. Also, BCP suppressed cardiac fibrosis and endothelial-to-mesenchymal transition in DCM mice by inhibiting transforming growth factor β (TGF-β)/suppressor of mothers against decapentaplegic (Smad) signaling. Further, BCP treatment suppressed nucleotide-binding domain, leucine-rich–containing family, pyrin domain–containing-3 (NLRP3) inflammasome activation in DCM mice and alleviated cellular injury to the pancreatic tissues evidenced by significant elevation of the number of insulin-positive cells. To demonstrate a CB2R-dependent mechanism of BCP, another group of DCM mice were pretreated with AM630, a CB2R antagonist. AM630 was observed to abrogate the beneficial effects of BCP in DCM mice. Taken together, BCP demonstrated the potential to protect the myocardium and pancreas of DCM mice mediating CB2R-dependent mechanisms. SIGNIFICANCE STATEMENT BCP, a CB2R agonist, shows protection against DCM. BCP attenuates oxidative stress, inflammation, and fibrosis in DCM via activating CB2Rs. BCP mediating CB2R activation favorably modulates AGE/RAGE, PI3K/AKT/Nrf2β and TGF-β/Smad and (NLRP3) inflammasome in diabetic cardiomyopathy. Full Article
cts Sex Differences in the Neural and Behavioral Effects of Acute High-Dose Edible Cannabis Consumption in Rats [Special Section: Cannabinoid Signaling in Human Health and Disease] By jpet.aspetjournals.org Published On :: 2024-10-18T07:04:15-07:00 The consumption of 9-tetrahydrocannabinol (THC)- or cannabis-containing edibles has increased in recent years; however, the behavioral and neural circuit effects of such consumption remain unknown, especially in the context of ingestion of higher doses resulting in cannabis intoxication. We examined the neural and behavioral effects of acute high-dose edible cannabis consumption (AHDECC). Sprague-Dawley rats (six males, seven females) were implanted with electrodes in the prefrontal cortex (PFC), dorsal hippocampus (dHipp), cingulate cortex (Cg), and nucleus accumbens (NAc). Rats were provided access to a mixture of Nutella (6 g/kg) and THC-containing cannabis oil (20 mg/kg) for 10 minutes, during which they voluntarily consumed all of the provided Nutella and THC mixture. Cannabis tetrad and neural oscillations were examined 2, 4, 8, and 24 hours after exposure. In another cohort (16 males, 15 females), we examined the effects of AHDECC on learning and prepulse inhibition and serum and brain THC and 11-hydroxy-THC concentrations. AHDECC resulted in higher brain and serum THC and 11-hydroxy-THC levels in female rats over 24 hours. AHDECC also produced: 1) Cg, dHipp, and NAc gamma power suppression, with the suppression being greater in female rats, in a time-dependent manner; 2) hypolocomotion, hypothermia, and antinociception in a time-dependent manner; and 3) learning and prepulse inhibition impairments. Additionally, most neural activity and behavior changes appear 2 hours after ingestion, suggesting that interventions around this time might be effective in reversing/reducing the effects of AHDECC. SIGNIFICANCE STATEMENT The effects of high-dose edible cannabis on behavior and neural circuitry are poorly understood. We found that the effects of acute high-dose edible cannabis consumption (AHDECC), which include decreased gamma power, hypothermia, hypolocomotion, analgesia, and learning and information processing impairments, are time and sex dependent. Moreover, these effects begin 2 hours after AHDECC and last for at least 24 hours, suggesting that treatments should target this time window in order to be effective.: Full Article
cts Low-Efficacy Mu Opioid Agonists as Candidate Analgesics: Effects of Novel C-9 Substituted Phenylmorphans on Pain-Depressed Behavior in Mice [Behavioral Pharmacology] By jpet.aspetjournals.org Published On :: 2024-10-18T07:04:15-07:00 Low-efficacy mu opioid receptor (MOR) agonists may serve as novel candidate analgesics with improved safety relative to high-efficacy opioids. This study used a recently validated assay of pain-depressed behavior in mice to evaluate a novel series of MOR-selective C9-substituted phenylmorphan opioids with graded MOR efficacies. Intraperitoneal injection of dilute lactic acid (IP acid) served as a noxious stimulus to depress locomotor activity by mice in an activity chamber composed of two compartments connected by an obstructed door. Behavioral measures included (1) crosses between compartments (vertical activity over the obstruction) and (2) movement counts quantified as photobeam breaks summed across compartments (horizontal activity). Each drug was tested alone and as a pretreatment to IP acid. A charcoal-meal test and whole-body-plethysmography assessment of breathing in 5% CO2 were also used to assess gastrointestinal (GI) inhibition and respiratory depression, respectively. IP acid produced a concentration-dependent depression in crosses and movement that was optimally alleviated by intermediate- to low-efficacy phenylmorphans with sufficient efficacy to produce analgesia with minimal locomotor disruption. Follow-up studies with two low-efficacy phenylmorphans (JL-2-39 and DC-1-76.1) indicated that both drugs produced naltrexone-reversible antinociception with a rapid onset and a duration of ~1 h. Potency of both drugs increased when behavior was depressed by a lower IP-acid concentration, and neither drug alleviated behavioral depression by a non-pain stimulus (IP lithium chloride). Both drugs produced weaker GI inhibition and respiratory depression than fentanyl and attenuated fentanyl-induced GI inhibition and respiratory depression. Results support further consideration of selective, low-efficacy MOR agonists as candidate analgesics. SIGNIFICANCE STATEMENT This study used a novel set of mu opioid receptor (MOR)-selective opioids with graded MOR efficacies to examine the lower boundary of MOR efficacy sufficient to relieve pain-related behavioral depression in mice. Two novel low-efficacy opioids (JL-2-39, DC-1-76.1) produced effective antinociception with improved safety relative to higher- or lower-efficacy opioids, and results support further consideration of these and other low-efficacy opioids as candidate analgesics. Full Article
cts Unpicking influence and conflicts of interest in prescribing By bjgp.org Published On :: 2024-10-31T16:05:26-07:00 Full Article
cts Housebuilder completes 'one of the largest' new Highland homes projects since 1970s By www.heraldscotland.com Published On :: Tue, 12 Nov 2024 04:35:00 +0000 A rural housing project branded as ‘truly transformative’ has been completed Full Article
cts Kamala’s GOP Posse Predicts ‘Hidden Harris’ Victory By www.thedailybeast.com Published On :: Wed, 16 Oct 2024 21:48:43 GMT Evelyn Hockstein /ReutersWASHINGTON CROSSING, Pennsylvania—At a campaign rally in the most important swing state in the country, anti-Trump activist George Conway told the Daily Beast why he thinks Kamala Harris can win over Republicans.“She’s kind of done it already,” he said. “Look at all those people who voted for [Nikki] Haley when she was already done. I actually think there’s kind of a hidden Harris vote for Republicans who are just exhausted by Donald Trump.”Turnout is another factor that plays to Democrat’s advantage, Conway predicted. “I also think that even the people who are still for Trump and won’t vote for Harris, I don’t think the turnout’s going to be great for him.”Read more at The Daily Beast. Full Article Politics
cts The Raid homage Acts Of Blood is Sifu’s jankier, snackier cousin By www.rockpapershotgun.com Published On :: Thu, 07 Nov 2024 09:35:13 +0000 Calling a game ‘no frills’ or ‘no nonsense’ is always a back-handed compliment, because it sounds like you're saying it's a bit straightforward and simple. And yes, that’s exactly what I’m saying here. Acts Of Blood feels like a spiffy PS2 action brawler; a slightly tighter old Yakuza game, or a stripped-back Sifu. It’s snacky and a bit janky, but it’s also great coffee break fodder, assuming you want to spend your break breaking a selection of heavy objects over the crumbly skulls of ne’er-do-wells. I mean, they might have done some things well, I don’t know them. But they aren’t doing any well to my character in the game, so violence it is. Read more Full Article Fighting PC Indiescovery Arcade Acts Of Blood
cts News Wrap: Sessions insists he didn’t lie about Russian contacts to Senate By www.pbs.org Published On :: Wed, 18 Oct 2017 22:45:56 +0000 Watch Video | Listen to the AudioHARI SREENIVASAN: In the day’s other news: Attorney General Jeff Sessions insisted he never lied to the Senate Judiciary Committee about his conversations with the Russian ambassador during the presidential campaign. At a hearing today, he bridled at Democratic Senator Al Franken’s accusation that he’d — quote — “moved the goalposts” on the nature of his discussions. SEN. AL FRANKEN, D-Minn.: First it was, I didn’t have communications with Russians, which wasn’t true. Then it was, I never met with any Russians to discuss any political campaign, which may or may not be true. Now it’s, I didn’t discuss interference in the campaign. JEFF SESSIONS, Attorney General: Well, let me just say without hesitation, that I conducted no improper discussions with the Russians at any time regarding the campaign or any other item facing this country. HARI SREENIVASAN: Sessions has recused himself from the Justice Department’s investigation into Russia’s election meddling. President Trump had new criticism today for former FBI Director James Comey over the Hillary Clinton e-mail probe. He complained again that Comey decided to clear Clinton before she was even interviewed. That’s based on newly released draft statements by Comey from May of 2016. FBI officials say it was already clear that no charges were warranted. On another issue, the president faced fallout over the death of Army Sergeant La David Johnson in Niger this month. Congresswoman Frederica Wilson says she was with Mrs. Johnson when the president called. The Florida Democrat told The Washington Post that Mr. Trump said — quote — “He knew what he was signing up for, but I guess it hurts anyway.” The sergeant’s mother confirmed it, but the president denied it, and White House Press Secretary Sarah Huckabee Sanders went after Wilson. SARAH SANDERS, White House Press Secretary: This is a president who loves our country very much, who has the greatest level of respect for men and women in uniform and wanted to call and offer condolences to the family, and I think to try to create something from that, that the congresswoman is doing, is, frankly, appalling and disgusting. HARI SREENIVASAN: The Post also reported on another incident today. It quoted the father of a soldier killed in Afghanistan as saying the president offered $25,000 from his personal account, but never followed through. We will get more detail on all of this after the news summary. The death toll in Northern California’s wildfires rose to 42 today. Officials in Sonoma County found the remains of the latest victim, as they searched hundreds of burned homes. Meanwhile, fire crews made new gains overnight with the help of cooler weather and low winds. A two-time Olympic medalist says the former team doctor for U.S. women’s gymnastics sexually abused her for years. McKayla Maroney is the highest profile athlete to come forward in the scandal. In a statement today, she said Dr. Larry Nassar began molesting her when she was just 13. He’s awaiting sentencing on a child pornography charge, but has denied any sexual abuse. More questions tonight about drug pricing. A new study finds the costs of injectable cancer drugs, approved since 1996, rose an average of 25 percent over eight years. That’s far higher than the rate of inflation. The study was based at Emory University and published in “The Journal of Clinical Oncology.” And on Wall Street, health insurers and IBM fueled a surge in stocks today. The Dow Jones industrial average gained 160 points, more than half-a-percent, to close above 23000 for the first time. The Nasdaq rose just a fraction, and the S&P 500 was up two points. The post News Wrap: Sessions insists he didn’t lie about Russian contacts to Senate appeared first on PBS NewsHour. Full Article james comey jeff sessions senate judiciary committee
cts Falling satellite will give clues to how objects burn up on re-entry By www.newscientist.com Published On :: Fri, 30 Aug 2024 13:00:35 +0100 A chance to observe the high-speed re-entry of a falling satellite will give researchers important insights on how debris burns up in our atmosphere Full Article
cts Complex chemicals found on Enceladus improve prospects for life By www.newscientist.com Published On :: Fri, 13 Sep 2024 15:00:12 +0100 The Cassini mission’s samples from Saturn’s moon Enceladus have signs of various organic molecules that could be among the ingredients needed for life to get started Full Article
cts A new life on Mars? Expect toxic dust, bad vibes and insects for lunch By www.newscientist.com Published On :: Tue, 12 Nov 2024 16:00:00 +0000 You might have heard about plans to establish a self‑sustaining city on Mars. Here’s what life would really be like on the Red Planet Full Article
cts Cold war spy satellites and AI detect ancient underground aqueducts By www.newscientist.com Published On :: Mon, 16 Sep 2024 22:27:42 +0100 Archaeologists are using AI and US spy satellite imagery from the cold war to find ancient underground aqueducts that helped humans survive in the desert Full Article
cts Trump selects Fox host Pete Hegseth for defense secretary By www.washingtontimes.com Published On :: Tue, 12 Nov 2024 19:42:12 -0500 President-elect Donald Trump said he will nominate Fox News host Pete Hegseth to be secretary of defense. Full Article
cts NASA reconnects with interstellar Voyager 1 spacecraft using technology not used in decades By www.foxnews.com Published On :: Thu, 31 Oct 2024 17:00:54 -0400 NASA reconnected with Voyager 1, which is located nearly 15 billion miles away from Earth, after a brief pause that triggered the spacecraft's fault protection system. Full Article b33b13b1-2e91-5fe7-a2d7-cb2367883390 fnc Fox News fox-news/science/air-and-space/nasa fox-news/us/us-regions/west/california fox-news/science/air-and-space/spaceflight fox-news/science/air-and-space/astronomy fox-news/science article
cts Planetary Researchers Examine Tidal Effects on Interiors of Planets and Their Moons By www.sci.news Published On :: Thu, 07 Nov 2024 23:02:22 +0000 A team of scientists from the Lunar and Planetary Laboratory at the University of Arizona, TU Delft, and Caltech has developed a new method to compute how tides affect the interiors of planets and moons in the Solar System. The post Planetary Researchers Examine Tidal Effects on Interiors of Planets and Their Moons appeared first on Sci.News: Breaking Science News. Full Article Planetary Science Space Exploration Enceladus Europa Exoplanet Io Jupiter Mercury Moon NASA Planet Saturn Solar System Tidal deformation Tidal force Tidal heating
cts How much should we worry about the health effects of microplastics? By www.newscientist.com Published On :: Wed, 25 Sep 2024 23:06:49 +0100 A flurry of studies has found microplastics in nearly every organ in the human body, from the brain to the testicles. But very few have revealed whether these tiny bits of plastic impact our health Full Article
cts The surprisingly simple supernutrient with far-reaching health impacts By www.newscientist.com Published On :: Wed, 30 Oct 2024 17:00:00 +0000 Most ingredients touted as the key to better health fail to live up to the hype but fibre bucks this trend, with benefits for the whole body, not just the gut Full Article
cts Cowboys' Dak Prescott elects to have season-ending surgery to address injured hamstring, Jerry Jones says By www.foxnews.com Published On :: Tue, 12 Nov 2024 20:24:25 -0500 The Dallas Cowboys quarterback got another opinion on his hamstring and decided that surgery would be the best way to address the injury. Full Article f8d4b7f0-229c-5132-b195-d53df731c643 fnc Fox News fox-news/sports/nfl/dallas-cowboys fox-news/sports/nfl fox-news/person/dak-prescott fox-news/sports fox-news/health/medical-research/surgery fox-news/sports article
cts Trump selects South Dakota Gov Kristi Noem to run Department of Homeland Security By www.foxnews.com Published On :: Tue, 12 Nov 2024 21:57:35 -0500 President-elect Trump announced on Tuesday that Kristi Noem is his pick for secretary of the Department of Homeland Security. Full Article 9e2a0339-2cb6-5255-919a-162a332ea710 fnc Fox News fox-news/politics fox-news/person/donald-trump fox-news/person/kristi-noem fox-news/politics article
cts The Odd Arctic Military Projects Spawned by the Cold War By www.smithsonianmag.com Published On :: Thu, 19 Sep 2024 12:00:00 +0000 Many offbeat research efforts were doomed to fail, from atomic subways to a city under the ice. Full Article
cts This Parasitic Fungus Turns Flies Into Zombie Insects By www.smithsonianmag.com Published On :: Fri, 08 Nov 2024 13:00:00 +0000 The pathogen takes over the brains of its hosts and controls them for its own sinister ends Full Article
cts The Best Natural Hair Products -- Celebrity Hairstylists Weigh In By feedproxy.google.com Published On :: Tue, 11 Aug 2020 17:42:50 PDT The experts behind Beyoncé, Kerry Washington and Serena Williams' tresses reveal their all-time favorite products for natural hair. [[ This is a content summary only. Visit my website for full links, other content, and more! ]] Full Article Shopping
cts Barack Obama Reacts to Kamala Harris' Historic VP Nomination By feedproxy.google.com Published On :: Tue, 11 Aug 2020 17:48:44 PDT The former president thinks Joe Biden 'nailed this decision.' [[ This is a content summary only. Visit my website for full links, other content, and more! ]] Full Article News
cts Donald Trump Selects Elon Musk, Vivek Ramaswamy to 'Lead the Department of Government Efficiency' By www.breitbart.com Published On :: Wed, 13 Nov 2024 01:44:00 +0000 President-elect Donald Trump announced he has picked Tesla CEO and X owner Elon Musk and entrepreneur and former Republican presidential candidate Vivek Ramaswamy to "lead the Department of Government Efficiency." The post Donald Trump Selects Elon Musk, Vivek Ramaswamy to ‘Lead the Department of Government Efficiency’ appeared first on Breitbart. Full Article 2024 Election Politics Donald Trump Elon Musk Vivek Ramaswamy
cts Bulldozer justice: SC lays down pan-India guidelines for demolition of properties, says Executive can’t become judge and accused, convicts have certain rights - The Hindu By news.google.com Published On :: Wed, 13 Nov 2024 05:31:00 GMT Bulldozer justice: SC lays down pan-India guidelines for demolition of properties, says Executive can’t become judge and accused, convicts have certain rights The Hindu"House Embodies Hope": Supreme Court Demolishes 'Bulldozer Justice' Idea NDTVUnconstitutional to demolish house without following due process merely because they are involved in a crime: SC The Indian ExpressSupreme Court on bulldozer action: ‘No demolition without following guidelines, 15-day notice’ Hindustan TimesBulldozer justice: Executive can't become judge, demolish house of accused, SC says The Times of India Full Article
cts Mesopotamia Artifacts Help Explain How Language Evolved from Pictures to Words By www.discovermagazine.com Published On :: Wed, 06 Nov 2024 20:00:00 GMT By comparing early markings used for business purposes to 'proto' cuneiform, we can say language transitioned from symbols to writing. Full Article The Sciences
cts DoP rejects Aristo Pharma's review application for its multivitamin tablets By www.pharmabiz.com Published On :: Friday, November 8, 2024 08:00 IST The Department of Pharmaceuticals (DoP) has upheld the retail price fixation of National Pharmaceutical Pricing Authority (NPPA) for Mumbai─based Aristo Pharmaceuticals for its multivitamin tablets with Full Article
cts Ayush and herbal products exports grow over 10 per cent in H1 FY25 By www.pharmabiz.com Published On :: Monday, November 11, 2024 08:00 IST Exports of Ayush and herbal products for the first six months of the current fiscal has reported a 10.34 per cent growth, as compared to an almost stagnant exports reported in the same period of previous fiscal Full Article
cts Bonus Episode: Fast Facts on the ACRO D&I Grants Program By mailchi.mp Published On :: Tue, 21 May 2024 10:13:00 +0000 ACRO’s Good Clinical Podcast is back with bonus episode! Host Sophia McLeod sat down with Tafoya Hubbard and Kristen Surdam to discuss ACRO’s new D&I Site Resource Grants Program. The post Bonus Episode: Fast Facts on the ACRO D&I Grants Program first appeared on ACRO. Full Article DEI News
cts Regulatory update for post-registration of biological products in Brazil By www.gabionline.net Published On :: Tue, 29 Oct 2024 09:23:29 +0000 <p>On 3<sup> </sup>June 2024, Resolution RDC No. 876 was published in Brazil in the Official Journal of the Union (DOU)[1], modifying the current regulations regarding the post-registration of biological products (RDC 413/2020).</p> Full Article
cts Food companies sell products that are less healthy in poorer countries, says report By www.asiaone.com Published On :: Thu, 07 Nov 2024 17:31:59 +0800 LONDON — The world's biggest food and beverage companies on average sell products in low-income countries that are less healthy than what they sell in high-income countries, according to a new report. Products sold by companies including Nestle, Pepsico and Unilever were assessed as part of a global index published by the Access to Nutrition Initiative (ATNI), its first since 2021. The non-profit group found that across 30 companies, the products sold in low-income countries scored lower on a star rating system developed in Australia and New Zealand than those sold in high-income countries. In the Health Star Rating system, products are ranked out of five on their healthiness, with five the best, and a score above 3.5 considered to be a healthier choice. Full Article