Cullin RING E3 Ligases (CRLs) ubiquitylate hundreds of important cellular substrates. Here we have assembled and purified the Ankyrin repeat and SOCS Box protein 9 CUL5 RBX2 Ligase (ASB9-CRL) in vitro and show how it ubiquitylates one of its substrates, CKB. CRLs occasionally collaborate with RING between RING E3 ligases (RBRLs) and indeed, mass spectrometry analysis showed that CKB is specifically ubiquitylated by the ASB9-CRL-ARIH2-UBE2L3 complex. Addition of other E2s such as UBE2R1 or UBE2D2 contribute to polyubiquitylation but do not alter the sites of CKB ubiquitylation. Hydrogen-deuterium exchange mass spectrometry (HDX-MS) analysis revealed that CUL5 neddylation allosterically exposes its ARIH2 binding site, promoting high affinity binding, and it also sequesters the NEDD8 E2 (UBE2F) binding site on RBX2. Once bound, ARIH2 helices near the Ariadne domain active site are exposed, presumably relieving its autoinhibition. These results allow us to propose a model of how neddylation activates ASB-CRLs to ubiquitylate their substrates.

CAMBRIDGE, England, Oct. 15, 2024 — Nu Quantum has announced a proof-of-principle prototype that advances the development of modular, distributed quantum computers by enabling connections across different qubit modalities and […]

The post Nu Quantum Unveils Qubit-Photon Interface to Enable Distributed Quantum Computing Networks appeared first on HPCwire.

COLLEGE PARK, Md. and VISTA, Calif., Nov. 8, 2024 — IonQ has announced that it has reached a definitive agreement to acquire substantially all of the operating assets of Qubitekk, […]

The post IonQ to Expand Quantum Networking Portfolio with Qubitekk Acquisition appeared first on HPCwire.

Last week the University of Colorado (Boulder), the CUbit Quantum Initiative, and the Elevate Quantum consortium released workforce roadmap for educating and building a quantum workforce. “This roadmap provides a […]

The post Go (Mountain) West, Quantum Workers! CU, CUbit, and Elevate Quantum Issue Workforce Roadmap appeared first on HPCwire.

Nov. 11, 2024 — University of Sydney quantum researchers Dominic Williamson and Nouédyn Baspin have revealed a new architecture for managing errors that emerge in the operation of quantum computers. Their […]

The post University of Sydney Scientists Unveil Quantum Code to Enhance Error Correction with Fewer Qubits appeared first on HPCwire.

Quantum computing pioneer D-Wave today announced it had completed calibration and benchmarking the latest latest version of its Advantage2 quantum processor, a 4,400-plus-qubit device. D-Wave said that compared with the […]

The post D-Wave Readies 4,400-plus-qubit Advantage2 System for Use appeared first on HPCwire.

President Joe Biden will hold a White House meeting with President Prabowo Subianto of Indonesia on Tuesday to celebrate 75 years of U.S.-Indonesian relations and discuss ways to strengthen their countries' cooperation.

Hyperbilirubinemia (HB) is a key risk factor for hearing loss in neonates, particularly premature infants. Here, we report that bilirubin (BIL)-dependent cell death in the auditory brainstem of neonatal mice of both sexes is significantly attenuated by ZD7288, a blocker for hyperpolarization-activated cyclic nucleotide-gated (HCN) channel-mediated current (I_h), or by genetic deletion of HCN1. GABAergic inhibitory interneurons predominantly express HCN1, on which BIL selectively acts to increase their intrinsic excitability and mortality by enhancing HCN1 activity and Ca²⁺-dependent membrane targeting. Chronic BIL elevation in neonatal mice in vivo increases the fraction of spontaneously active interneurons and their firing frequency, I_h, and death, compromising audition at the young adult stage in HCN1^+/+, but not in HCN1^–/– genotype. We conclude that HB preferentially targets HCN1 to injure inhibitory interneurons, fueling a feedforward loop in which lessening inhibition cascades hyperexcitability, Ca²⁺ overload, neuronal death, and auditory impairments. These findings rationalize HCN1 as a potential target for managing HB encephalopathy.

Ethnomusicologists visited a North African country to help local singers and a Sudanese Nubian believer write a worship song in his language and style.

Tencent Holdings and Ubisoft Entertainment SA's founding Guillemot family are considering options, including a potential buyout of the French video game developer, after it lost more than half its market value this year, according to people familiar with the matter.

Trump’s expected choice of Sen. Marco Rubio and Rep. Mike Waltz indicates China is going to be at the center of U.S. foreign policy, deepening U.S.-China tensions.

As the Super Eagles prepare to take on Benin Republic and Rwanda in the final phase of the 2025 Africa Cup of Nations qualification series, interim coach Austin Eguavoen will be relying on the searing form of his frontmen Victor Osimhen, Victor Boniface, and Ademola Lookman, who have been consistently among the goals for their

Rubio, 53, has said in recent interviews that Ukraine needs to seek a negotiated settlement with Russia rather than focus on regaining all territory that Russia has taken in the last decade.

While operating in the area, soldiers from the Shaldag Unit identified several tunnel shafts leading to the compound, which led to the exposure of the full tunnel. 

Trump to appoint hardliners Rubio and Waltz as foreign policy chiefs, reports claim

Allowing for moves that create quantum superpositions makes a quantum version of a Rubik’s cube incredibly complex, but not impossible to solve

Once seen as miraculous, these days ice is no longer extraordinary. But in a winter season when Antarctic sea ice hit a historic low, it is clear we should cherish it more, says Max Leonard

Allowing for moves that create quantum superpositions makes a quantum version of a Rubik’s cube incredibly complex, but not impossible to solve

"Imagine you buy a pinball machine, and years later, you enter your den to go play it, only to discover that all the paddles are missing, the pinball and bumpers are gone, and the monitor that proudly displayed your unassailable high score is removed". As reported by Polygon, that's an argument put forth by a new lawsuit against Ubisoft, filed by two Californian players of The Crew. They're suing the company in a proposed class action lawsuit over shutting down the racing game's servers, rendering it unplayable.

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In What's Next? Bill Gates digs into AI, climate, inequality, malaria and more. But the man looms too large for alternative solutions to emerge, says Bethan Ackerley

Speculation has already run rampant on who Florida Gov. Ron DeSantis will appoint to replace Sen. Marco Rubio if Rubio becomes President-elect Trump's secretary of state.

Quantum computing is a devilishly complex technology, with many technical hurdles impacting its development. Of these challenges two critical issues stand out: miniaturization and qubit quality.

IBM has adopted the superconducting qubit road map of reaching a 1,121-qubit processor by 2023, leading to the expectation that 1,000 qubits with today’s qubit form factor is feasible. However, current approaches will require very large chips (50 millimeters on a side, or larger) at the scale of small wafers, or the use of chiplets on multichip modules. While this approach will work, the aim is to attain a better path toward scalability.

Now researchers at MIT have been able to both reduce the size of the qubits and done so in a way that reduces the interference that occurs between neighboring qubits. The MIT researchers have increased the number of superconducting qubits that can be added onto a device by a factor of 100.

“We are addressing both qubit miniaturization and quality,” said William Oliver, the director for the Center for Quantum Engineering at MIT. “Unlike conventional transistor scaling, where only the number really matters, for qubits, large numbers are not sufficient, they must also be high-performance. Sacrificing performance for qubit number is not a useful trade in quantum computing. They must go hand in hand.”

The key to this big increase in qubit density and reduction of interference comes down to the use of two-dimensional materials, in particular the 2D insulator hexagonal boron nitride (hBN). The MIT researchers demonstrated that a few atomic monolayers of hBN can be stacked to form the insulator in the capacitors of a superconducting qubit.

Just like other capacitors, the capacitors in these superconducting circuits take the form of a sandwich in which an insulator material is sandwiched between two metal plates. The big difference for these capacitors is that the superconducting circuits can operate only at extremely low temperatures—less than 0.02 degrees above absolute zero (-273.15 °C).

Superconducting qubits are measured at temperatures as low as 20 millikelvin in a dilution refrigerator.Nathan Fiske/MIT

In that environment, insulating materials that are available for the job, such as PE-CVD silicon oxide or silicon nitride, have quite a few defects that are too lossy for quantum computing applications. To get around these material shortcomings, most superconducting circuits use what are called coplanar capacitors. In these capacitors, the plates are positioned laterally to one another, rather than on top of one another.

As a result, the intrinsic silicon substrate below the plates and to a smaller degree the vacuum above the plates serve as the capacitor dielectric. Intrinsic silicon is chemically pure and therefore has few defects, and the large size dilutes the electric field at the plate interfaces, all of which leads to a low-loss capacitor. The lateral size of each plate in this open-face design ends up being quite large (typically 100 by 100 micrometers) in order to achieve the required capacitance.

In an effort to move away from the large lateral configuration, the MIT researchers embarked on a search for an insulator that has very few defects and is compatible with superconducting capacitor plates.

“We chose to study hBN because it is the most widely used insulator in 2D material research due to its cleanliness and chemical inertness,” said colead author Joel Wang, a research scientist in the Engineering Quantum Systems group of the MIT Research Laboratory for Electronics.

On either side of the hBN, the MIT researchers used the 2D superconducting material, niobium diselenide. One of the trickiest aspects of fabricating the capacitors was working with the niobium diselenide, which oxidizes in seconds when exposed to air, according to Wang. This necessitates that the assembly of the capacitor occur in a glove box filled with argon gas.

While this would seemingly complicate the scaling up of the production of these capacitors, Wang doesn’t regard this as a limiting factor.

“What determines the quality factor of the capacitor are the two interfaces between the two materials,” said Wang. “Once the sandwich is made, the two interfaces are “sealed” and we don’t see any noticeable degradation over time when exposed to the atmosphere.”

This lack of degradation is because around 90 percent of the electric field is contained within the sandwich structure, so the oxidation of the outer surface of the niobium diselenide does not play a significant role anymore. This ultimately makes the capacitor footprint much smaller, and it accounts for the reduction in cross talk between the neighboring qubits.

“The main challenge for scaling up the fabrication will be the wafer-scale growth of hBN and 2D superconductors like [niobium diselenide], and how one can do wafer-scale stacking of these films,” added Wang.

Wang believes that this research has shown 2D hBN to be a good insulator candidate for superconducting qubits. He says that the groundwork the MIT team has done will serve as a road map for using other hybrid 2D materials to build superconducting circuits.

Sen. John Fetterman (D-PA) weighed in on reports regarding President-elect Donald Trump's choice for secretary of state.

The post Fetterman Calls Rubio ‘Strong Choice’ as Trump Reportedly Considers Him for Secretary of State appeared first on Breitbart.

The numbers don't lie: Games as "live" services bring in more money over time.

Explore Marco Rubio's personal life: Meet his wife and their children. Get the full story now!

The post Who Is Marco Rubio’s Wife? Jeanette Dousdebes’ Kids & Relationship History appeared first on ComingSoon.net - Movie Trailers, TV & Streaming News, and More.

Allowing for moves that create quantum superpositions makes a quantum version of a Rubik’s cube incredibly complex, but not impossible to solve

Probability of operating an alarm clock

Trubion Pharmaceuticals, Inc. Reports First-Quarter 2010 Financial Results

Nvidia fired a salvo at the Computex conference, showcasing its commitment to maintaining leadership in the AI chip market. The company unveiled a multi-pronged strategy that includes faster chip release cycles, a next-generation AI platform codenamed Rubin, and a collaboration with

Following his win over Democratic candidate and US Vice President Kamala Harris, Trump is moving to fill out his foreign policy and national security team ahead of his formal inauguration in January 2025.

Rubin, Tamar, 1986- author

[United States] : Kindle Direct Publishing, 2020.

Lublin : Wydawnictwo Werset, 2023.

México : Editorial Innovación, 1980.

Stina Ehrensvärd has one mission: to keep people safe online. Her Silicon Valley-based company, Yubico, produces the Yubikey, which is designed to stop people being terrible with their passwords. ABOUT WIRED SECURITY Hundreds of cybersecurity professionals, business decision makers and technology influencers met at the second WIRED Security event, at Kings Place, London on September 28 2017. Discover some of the fascinating insights from the speakers here: http://wired.uk/ZOgF8z ABOUT WIRED EVENTS WIRED events shine a spotlight on the innovators, inventors and entrepreneurs who are changing our world for the better. Explore this channel for videos showing on-stage talks, behind-the-scenes action, exclusive interviews and performances from our roster of events. Join us as we uncover the most relevant, up-and-coming trends and meet the people building the future. ABOUT WIRED WIRED brings you the future as it happens - the people, the trends, the big ideas that will change our lives. An award-winning printed monthly and online publication. WIRED is an agenda-setting magazine offering brain food on a wide range of topics, from science, technology and business to pop-culture and politics. CONNECT WITH WIRED Web: http://po.st/WiredVideo Twitter: http://po.st/TwitterWired Facebook: http://po.st/FacebookWired Google+: http://po.st/GoogleWired Instagram: http://po.st/InstagramWired Magazine: http://po.st/MagazineWired Newsletter: http://po.st/NewslettersWired

Incite Presents a conversation between Laura Boykin, Computational Biologist at Cassava Virus Action Project, and Malkia Devich-Cyril, Founding Director of MediaJustice, speak with WIRED's Peter Rubin as part of WIRED25, WIRED's second annual conference in San Francisco (Sponsored Content)

What is Universal Basic Income (UBI) and how could it help us deal with the coronavirus outbreak? What if... we gave people free money? The idea of a basic income is that everybody would receive a modest amount paid each week or each month without conditions, paid equally to every man and every woman with a smaller amount to pay for every child. Advocates for Universal Basic such as Guy Standing, co-founder of the Basic Income Earth Network, argue that it would be the ideal response to the crisis, but that it would also bring huge long term benefits, which he explains in this video. This video was produced as part of Digital Society, a publishing partnership between WIRED and Vontobel where all content is editorially independent. Visit Vontobel Impact for more stories on how technology is shaping the future of society: https://www.vontobel.com/en-int/about-vontobel/impact/

When a restaurant owner from Chennai made space in her suitcase for Khasi delicacies, smoked meats, and some local liquor

Weinheim, Germany : Wiley-VCH, [2024]

[New York] : Criterion Collection, [2014]

Senator Marco Rubio, long-time admirer of US-India relations and foreign policy hawk, will be named by Donald Trump as Secretary of State.

As a core issue is financial feasibility, what may work best in India is using a modified policy as a base to which other transfer policies can be added as and when appropriate