Victoria finally has a permanent kangaroo pet food program, but farmers are concerned red tape will result in carcasses left to rot in paddocks.

The NSW Nationals leader John Barilaro says "green tape" is standing in the way of long-term solutions to the drought crisis, and suggests the state could borrow money to reshape water infrastructure.

Revisit what it’s like to run a PDP-10 and be eaten by a grue

Source code for seminal adventure game Zork, dating back to 1977 and recovered from MIT tapes, was published this week on GitHub.…

IBM Research scientists have achieved a new world record in tape storage – their fifth since 2006. The new record of 201 Gb/in2 (gigabits per square inch) in areal density was achieved on a prototype sputtered magnetic tape developed by Sony Storage Media Solutions. The scientists presented the achievement today at the 28th Magnetic Recording Conference (TMRC 2017) here.

Reader Marvyn Lindsey found it "bizarre" that a long piece of black tape was blocking part of the book review he wanted to read.

For some UCLA players hoping to be selected in the NFL draft this month, their fates may largely be determined from tapes during the regular season.

It's our visual prompt to stay away, but stay-at-home orders have given new purpose to caution tape.

Center Theatre Group lands Jeremy O. Harris' provocative hit 'Slave Play' for a 2020-21 season still full of coronavirus-driven questions.

There is very little guidance on withdrawing or tapering opioids in chronic pain (not caused by cancer). People can fear pain, withdrawal symptoms, a lack of social and healthcare support, and they may also distrust non-opioid methods of pain management. This can mean that patients receive repeat opioid prescriptions for extended periods of...

Cabbage at its best.

First loves -- Fiction.

DRAKE - DARK LANE DEMO TAPES

The business of buying things for schools is a key part of making sure that hard-fought K-12 funding actually turns into a quality education at the school and classroom level.

Tapentadol is used in the treatment of chronic pain, specifically diabetic neuropathy. It has known action on the μ-opioid receptor leading to drowsiness and apneas. There is no published information on the effects of tapentadol in small children.

After an accidental overdose in a child, tapentadol may be expected to cause μ-opioid clinical effects similar to other opioids. While the opioid effects predominate sympathomimetic effects are also seen. The risk of respiratory depression and dyspnea should be acknowledged. (Read the full article)

Background

Optimal concentrations of unbound antimicrobials are essential for maximum microbiological effect. Although hypoalbuminemia and albumin fluid resuscitation are common in critical care, the effects of different albumin concentrations on the unbound concentrations of highly protein-bound antimicrobials are not known. The aim of this study was to compare effects of different albumin states on total and unbound concentrations of ertapenem and ceftriaxone using an ovine model.

Methods

Design

Prospective, three phase intervention observational study.

Subjects

Healthy Merino sheep.

Interventions

Eight sheep were subject to three experimental phases; normoalbuminemia, hypoalbuminemia using plasmapheresis and albumin replacement using a 25% albumin solution. In each phase, ceftriaxone 40 mg/kg and ertapenem 15 mg/kg were given intravenously. Blood samples were collected at pre-defined intervals and analyzed using an ultra-high-performance liquid chromatography tandem mass spectrometry method. Pharmacokinetic parameters such as area under the curve (AUC_0-24), plasma clearance (CL) and apparent volume of distribution in the terminal phase (V_d) were estimated and compared between the phases.

Results

The protein and albumin concentrations were significantly different between phases. Hypoalbuminemia resulted in a significantly lower AUC_0-24 and higher CL of total and unbound concentrations of ceftriaxone compared to the other phases. Whereas albumin replacement led to higher AUC_0-24 and lower CL compared to other phases for both drugs. The V_d for total drug concentrations for both drugs were significantly lower with albumin replacement.

Conclusions

For highly protein-bound drugs such as ceftriaxone and ertapenem, both hypoalbuminemia and albumin replacement may affect unbound drug exposure.

T. Michael O'Shea
Jul 1, 1999; 104:15-21
ARTICLES

The Chancellor has announced some important changes to the capital gains tax (CGT) regime. These changes may have a significant impact on the tax payable by your employees holding shares in your company traded on the full list. Abolition of taper r...

Fancy bidding on a Christmas present steeped in science history? Find out what they'll set you back, and which present-day artefacts might be worth investing in

Title: Red Tape Means Many Cancer Patients Get Radiation Treatments Late
Category: Health News
Created: 5/2/2019 12:00:00 AM
Last Editorial Review: 5/3/2019 12:00:00 AM

Congratulations to Drake, who scores the Official Chart double this week as his Dark Lane Demo Tapes mixtape and song Toosie Slide claim Number 1 on the Official Albums and Singles Charts.

EXCLUSIVE

Drake dropped a surprise 14-track mixtape and announced his next studio album will be released this summer.

Show has been praised for its representation of consensual sex

'Of course you want to delete it, but you can't'

OVO
There are flashes of skill and rawness in this odds-and-ends mixtape but it feels like a clumsy lunge at commercial success

In a world where the boundary between mixtapes and albums is becoming ever more blurred, the title of Drake’s latest album highlights its interstitial nature. That said, it’s still slightly misleading. There are tracks here that sound like demos – the mopey James Blake-isms of Chicago Freestyle are audibly unpolished – but for the most part, it ’s a way of collecting up leftovers and leaks, spare tracks he apparently has lying around the studio.

Those inclined to view Drake’s career with a cool eye might be surprised he has any spare tracks lying around the studio, given the state of his last album. Listening to Scorpion, 25 songs long, required a certain degree of mental stamina: you needed to steel yourself against the panicky sensation that you might die of old age before it ended. But it wasn’t the sheer quantity that was the problem so much as the quality of what was there. Scorpion had its moments but was so hopelessly uneven that it was easy to buy into the theory that its length was not due to its author’s teeming multiplicity of fantastic ideas, but an attempt to game the streaming services: more songs means more streams, more streams means a higher chart placing.

Fancy your home as an "hermetically sealed space ship" this winter, and keeping warm to boot? Here's how you can do both and not pump out more electricity, gas or wood smoke.

“In January 2008, Attorney General Michael Mukasey appointed Assistant United States Attorney John Durham to investigate the destruction by CIA personnel of videotapes of detainee interrogations," said Matthew Miller, Director, Office of Public Affairs.

Come one, come all, witness The Twittertape Machine that prints a feed of your tweets and mentions on Twitter.

The device made from household objects could replace AA batteries for powering small electronics.

British born artist Nick Gentry transforms obsolete technology, such as VHS tapes, cassettes and floppy disks into amazing and haunting pieces.

Official music video for Crazy. Song by illWIN and Theory

Official music video for Crazy. Song by illWIN and Theory

The stocks making the biggest moves in premarket trading include Twitter, Comcast, McDonald's Tapestry, and more.