While many people believe that poor sleep during pregnancy is inevitable, new research has determined that cognitive behavioral therapy for insomnia (CBTi) while pregnant can not only improve sleep patterns but also address postpartum depression.

The post Sleeping for 2: Insomnia therapy reduces postpartum depression, study shows was curated by information for practice.

In 2017, the Fyre Music Festival was billed as an exclusive event in the Bahamas. The reality was very different. Director Chris Smith tells the behind-the-scenes story in a new Netflix documentary.

The latest entry in the fantasy role-playing franchise 'Dragon Age' allows players to make their character trans-identifying and features a scene where one character is forced to atone for “misgendering” someone by performing a series of push-ups. 

For NHPR's series, The Show Goes On , we've been talking with artists across New Hampshire about what inspiration they've found and how they've been making it through the pandemic. Jim Tyrrell is a musician based here in New Hampshire. NHPR first reached out to him about a year ago to ask how he was doing when everything was first shutting down. Morning Edition host Rick Ganley checked in with him recently to find out what he's been up to since then.

In Zheleznogorsk, the Kursk region of Russia, fragments of an unmanned aerial vehicle crashed and exploded on a busy ringway. The incident was captured on video. The footage that was posted on Gaza Telegram channel shows the drone debris falling just several meters from passing cars and exploding, sending smaller debris flying around. It appears that the drivers of the cars that were traveling on the road during the moment of the incident did not panic and continued driving.

A woman trapped in her flooded home in Utiel, Valencia, was rescued with her dog. The video of her salvation shows the professionalism of Spanish rescuers. At least 51 people were killed in Spain's autonomous community of Valencia due to heavy rains and floodwaters, the Single Operations Coordination Centre (Cecopi) said. Rescuers found the lifeless bodies of five people in the town of Torrent: a couple, two children and a baby. Four bodies were found in Paiport: two men, a woman and a child. Victims were also reported in Chiva, Cheste, Alfafar and Alcudia.

Iran's unprecedented ballistic missile attack on Israel on October 1 shocked the world. Benjamin Netanyahu's hands were shaking shook as he read out the counter threats. This is an important signal for Russia. Iran shows everyone what's what Iranian Foreign Minister Abbas Araghchi said that Tehran, by striking Israel on the evening of October 1, exercised its right to self-defense in accordance with Article 51 of the UN Charter. He stressed that the attack was carried out only to strike military and security facilities "responsible for the genocide in the Gaza Strip and Lebanon." "Our action is concluded unless Israeli regime decides to invite further retaliation. In that scenario, our response will be stronger and more powerful. Israel's enablers now have a heightened responsibility to rein in the warmongers in Tel Aviv instead of getting involved in their folly," the minister wrote on X platform.

While retailers understand the need to move towards increased first-party data collection and personalised shopper engagement, many remain concerned about building privacy-centric experiences that meet consumers’ growing demands for the responsible use of their data, the latest research from Wunderkind, the AI-driven performance marketing solution, warns.

Ukraine showed a video of the explosion of the Kurakhove water reservoir dam in the Donetsk People's Republic (DPR). The video that was published by Ukraine's TSN TV military correspondent Yulia Kiriyenko shows the moment and aftermath of the explosion on the reservoir near the village of Starye Terny. The dam itself, the road passing through it, and a technical structure located nearby were partially damaged in the explosion. At the same time, the video does not show a possible artillery or air strike on the dam. This confirms that the Russian army was not involved in the destruction of the dam.

UCLA investigators have shown that that combining pembrolizumab, an immunotherapy drug, with standard chemotherapy can improve treatment outcomes for patients with small cell bladder cancer and small cell/neuroendocrine prostate cancer.

The title compound, [Ni(NCS)2(C6H7N)2]n, was prepared by the reaction of Ni(NCS)2 with 4-methyl­pyridine in water. Its asymmetric unit consists of two crystallographically independent NiII cations, of which one is located on a twofold rotational axis whereas the second occupies a center of inversion, two independent thio­cyanate anions and two independent 4-methyl­pyridine co­ligands in general positions. Each NiII cation is octa­hedrally coordinated by two 4-methyl­pyridine coligands as well as two N- and two S-bonded thio­cyanate anions. One of the cations shows an all-trans, the other a cis–cis–trans configuration. The metal centers are linked by pairs of μ-1,3-bridging thio­cyanate anions into [101] chains. X-ray powder diffraction shows that a pure crystalline phase has been obtained and thermogravimetry coupled to differential thermoanalysis reveals that the title compound loses half of the 4-methyl­pyridine coligands and transforms into Ni(NCS)2(C6H7N). Nearly pure samples of this compound can be obtained by thermal annealing and a Rietveld refinement demonstrated that it is isotypic to its recently reported Cd analog [Neumann et al., (2020). CrystEngComm. 22, 184–194] In its crystal structure, the metal cations are linked by one μ-1,3(N,S)- and one μ-1,3,3(N,S,S)-bridging thio­cyanate anion into single chains that condense via the μ-1,3,3(N,S,S)-bridging anionic ligands into double chains.

Reaction of copper(I)chloride with 2,3-di­methyl­pyrazine in ethanol leads to the formation of the title compound, poly[[μ-chlorido-μ-(2,3-di­methyl­pyrazine)-copper(I)] ethanol hemisolvate], {[CuCl(C6H8N2)]·0.5C2H5OH}n or CuCl(2,3-di­methyl­pyrazine) ethanol hemisolvate. Its asymmetric unit consists of two crystallographically independent copper cations, two chloride anions and two 2,3-di­methyl­pyrazine ligands as well as one ethanol solvate mol­ecule in general positions. The ethanol mol­ecule is disordered and was refined using a split model. The methyl H atoms of the 2,3-di­methyl­pyrazine ligands are also disordered and were refined in two orientations rotated by 60° relative to each other. In the crystal structure, each copper cation is tetra­hedrally coordinated by two N atoms of two bridging 2,3-di­methyl­pyrazine ligands and two μ-1,1-bridg­ing chloride anions. Each of the two copper cations are linked by pairs of bridging chloride anions into dinuclear units that are further linked into layers via bridging 2,3-di­methyl­pyrazine coligands. These layers are stacked in such a way that channels are formed in which the disordered solvent mol­ecules are located. The topology of this network is completely different from that observed in the two polymorphic modifications of CuCl(2,3-di­methyl­pyrazine) reported in the literature [Jess & Näther (2006). Inorg. Chem. 45, 7446–7454]. Powder X-ray diffraction measurements reveal that the title compound is unstable and transforms immediately into an unknown crystalline phase.

PayComplete has unveiled a report that...

Actor Dwayne Johnson (L) and Simone Alexandra Johnson attend the People's Choice Awards 2017 at Microsoft Theater on January 18, 2017 in Los Angeles, California. ; Credit: Christopher Polk

When Dwayne "The Rock" Johnson debuted his Hollywood persona in World Wrestling Entertainment in 2003, he was two years removed from his first successful protagonist role in "The Scorpion King" and on the heels of more film success with roles in "The Rundown" and "Walking Tall." 

Little did anyone foresee that "Hollywood" Rock would buoy the overall representation for Asian and Pacific Islanders in popular film for the next 20 years.

Last week, the USC Annenberg Inclusion Initiative released a report documenting the prevalence of Asian and Pacific Islanders both on-and off-screen across the top-grossing films each year from 2007 to 2019.  Of the 1,300 films examined, only 44 featured API actors playing lead roles, nearly a third of which were played by Johnson. 

The report offers more staggering statistics:

• In 2019, over a quarter of API characters in the top-grossing films died. Most died by drowning, explosions, stabbing or suicides

• Of the over 51,000 speaking characters in the 1,300 films examined, only 6% were Asian, Asian American or Native Hawaiian/Pacific Islanders

• Only 50 of the 1,447 directors in the 1,300 films examined were of API heritage.

• In 2019, 67% of API characters played stereotyped roles

The release of this report comes at a time of rising anti-Asian hate crimes nationally, and the authors of the report believe the portrayal of Asian and Pacific Islanders in mass media contributes to that. Today on FilmWeek, we delve into the study's findings and discuss the history of API filmmakers and actors in Hollywood.

Guests: 

Nancy Wang Yuen, professor of sociology at Biola University in La Mirada; she is co-author of “The Prevalence and Portrayal of Asian and Pacific Islanders Across 1,300 Popular Films”; she tweets @nancywyeun

Justin Chang, film critic for the Los Angeles Times and NPR’s Fresh Air; he tweets @JustinCChang

This content is from Southern California Public Radio. View the original story at SCPR.org.

Source: Dr. David Nierengarten 11/07/2024

TScan Therapeutics Inc. (TCRX:NASDAQ) Phase 1 ALLOHA study, evaluating its lead therapeutic candidates TSC-100 and TSC-101 in hematologic malignancies, showed patients continuing to have a positive response after one year, reported Wedbush analyst Dr. David Nierengarten in a Nov. 5 research note. TSC-100 and TSC-101 are T-cell receptor-engineered T-cell therapies (TCR-Ts).

"We see a catalyst-rich next few months ahead with data building in prominence on stock impact," Nierengarten wrote.

87% Return Potential

Wedbush has a US$10 per share target price on the Massachusetts-based biotech, trading at the time of the report at about US$5.36 per share, noted the analyst. The difference between these figures implies an 87% return potential for investors.

TScan Therapeutics remains rated Outperform.

Durability of Response Data

Nierengarten presented the clinical trial's latest results. As of the July 8, 2024 data cutoff date, in Phase 1 of ALLOHA, 16 patients with hematologic tumors had been administered TSC-100 or TSC-101, and 11 patients had been given a placebo. Median follow-ups had occurred at 5.8 months and 5.3 months, respectively.

At the time, none of the patients in the treatment arm had had a relapse. In the control arm, however, three, or 27% of, the 11 patients had, and the median time to relapse was 159 days. The analyst explained that this is typical for patients receiving a hematopoietic stem cell transplant after reduced-intensity conditioning.

One year out from treatment, five patients were evaluable, and all remained relapse free and minimal residual disease negative at the time. These data underscore the durability of response to this TCR-T treatment, Nierengarten commented. Its safety profile was shown to be favorable still, with no patients experiencing dose-limiting toxicities or adverse events associated with allogeneic hematopoietic cell transplantation.

"Enrollment continues in dose expansion cohorts, and results could support a registrational trial as early as 2025, pending regulatory feedback," Nierengarten wrote.

On the Horizon

TScan Therapeutics has several catalysts related to its clinical programs on the horizon, which Nierengarten listed.

On Nov. 8 and 9, the company will present preclinical data in the poster sessions at the annual Society for Immunotherapy of Cancer meeting. One poster will show in vitro combinatorial data for T-Plex, TScan's cellular therapy for treating solid tumors. It is comprised of two to three different TCR-Ts that target different tumor antigens on different human leukocyte antigen (HLA) types.

A second poster will detail the expansion of ImmunoBank, the biotech's diverse bank of therapeutic T-cell receptors (TCRs) that recognize diverse targets and are associated with multiple HLA types. The third will depict development of a target agnostic platform to evaluate how TCR-Ts affect primary human tissues.

On Dec. 9, TScan Therapeutics will present updated one-year data from ALLOHA, at the American Society for Hematology Annual Meeting in December.

By year-end, the biotech will announce initial data from administering singleplex therapy, cell therapy engineered using a single TCR, to patients with solid tumors. This treatment is being given to establish safety before administering multiplex therapy, cell therapy engineered from multiple TCRs.

In 2025, TScan Therapeutics will provide long-term duration of response data for multiplex therapy in solid tumors and will potentially commence a registrational trial for TSC-100 and TSC-101.

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Disclosures for Wedbush, TScan Therapeutics Inc., November 5, 2024

Analyst Certification We, David Nierengarten, Martin Fan and Dennis Pak, certify that the views expressed in this report accurately reflect our personal opinions and that we have not and will not, directly or indirectly, receive compensation or other payments in connection with our specific recommendations or views contained in this report.

Company Specific Disclosures This information is subject to change at any time. 1. WS makes a market in the securities of TScan Therapeutics, Inc.. 6. WS is acting as a financial advisor for TScan Therapeutics, Inc..

Wedbush disclosure price charts are updated within the first fifteen days of each new calendar quarter per FINRA regulations. Price charts for companies initiated upon in the current quarter, and rating and target price changes occurring in the current quarter, will not be displayed until the following quarter. Additional information on recommended securities is available on request. Disclosure information regarding historical ratings and price targets is available: Research Disclosures *WS changed its rating system from (Strong Buy/ Buy/ Hold/ Sell) to (Outperform/ Neutral/ Underperform) on July 14, 2009. Applicable disclosure information is also available upon request by contacting the Research Department at (212) 833-1375, by email to leslie.lippai@wedbush.com. You may also submit a written request to the following: Wedbush Securities, Attn: Research Department, 142 W 57th Street, New York, NY 10019.

OTHER DISCLOSURES The information herein is based on sources that we consider reliable, but its accuracy is not guaranteed. The information contained herein is not a representation by this corporation, nor is any recommendation made herein based on any privileged information. This information is not intended to be nor should it be relied upon as a complete record or analysis: neither is it an offer nor a solicitation of an offer to sell or buy any security mentioned herein. This firm, Wedbush Securities, its officers, employees, and members of their families, or any one or more of them, and its discretionary and advisory accounts, may have a position in any security discussed herein or in related securities and may make, from time to time, purchases or sales thereof in the open market or otherwise. The information and expressions of opinion contained herein are subject to change without further notice. The herein mentioned securities may be sold to or bought from customers on a principal basis by this firm. Additional information with respect to the information contained herein may be obtained upon request. Wedbush Securities does and seeks to do business with companies covered in its research reports. Thus, investors should be aware that the firm may have a conflict of interest that could affect the objectivity of this report. Investors should consider this report as only a single factor in making their investment decision. Please see pages 3–7 of this report for analyst certification and important disclosure information. Retail Investors The information provided is for general informational purposes only and should not be considered an individual recommendation or personalized investment advice. The companies/investments mentioned may not be suitable for everyone. Each investor needs to review their own respective situation(s) before making any investment decisions. All expressions of opinion are subject to change without notice due to shifting market(s), economic or political conditions. Investment involves risks including the risk of principal. Past performance is no guarantee of future results and the opinions presented cannot be viewed as an indicator of future performance.

( Companies Mentioned: TCRX:NASDAQ, )

Global Analyst Adrian Day reviews results from two high-quality companies, a gold miner and a global blue chip. He also looks at changes in gold trends.

Annual Financial Report for Fiscal Year 2012-2013 shows Catawba County improved its financial position with conservative approach.

For the past several years, the baking industry has faced a long list of serious, ongoing challenges.

With more consumers attending gatherings, the dessert category is having a renaissance. 

The study found that carbohydrates and polyphenols in prunes act as prebiotics and help restore bone health.

Planning ahead helps ensure you get the most out of the events you attend.

The analysis of nearly 10 million drug tests reveals a surge in cheating, particularly related to marijuana.

More consumers are engaging in the active nutrition community, offering more opportunities for protein fortification. Suppliers are developing animal- and plant-based protein solutions to meet this growing demand. 

With many people following different diets such as gluten-free or dairy-free, NCSolutions conducted a survey to know how consumers are embracing new lifestyle-friendly dishes this holiday season.

With the price of Oktoberfest brews higher than other beers, Oktoberfest beers, festivities bring big sales opportunities that many operators can capitalize on.

Colangelo & Partners and Wine Opinions conducted its second annual wine survey, this year honing in on U.S. wine drinker attitudes and behaviors, as well as trends related to beverage alcohol consumption and health.

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ProMach’s brand Texwrap demonstrated its updated DX-130 Dual Roll Bundler and the Kayat SRX-CUF Single Roll Bundler at PACK EXPO.

BZBGEAR exhibiting at NAB Show and HIMSS 2023—two of the largest tech-oriented trade shows in their respective industries in the same week.

This accessible and fun story about the causes of harmful algae in water teaches kids about environmental pollutants and how they can help stop them.

Bryter's Female Gamers Report reveals highest levels of toxicity towards females in gaming ever recorded, in the next few weeks we will see whether this translates into greater reluctance to give 'gaming' gifts to female friends and family this year

The PHS Patient No-Show Predictor solution can help enhance the healthcare experience for both patients and caregivers alike by maximizing health outcomes, minimizing revenue loss and improving operational efficiencies.

The new video from Miss Walker is out now. It's called "Navigating Office Tensions: Conflict Resolution Hacks." This video gives workers useful advice that they can use to handle and solve workplace conflicts with confidence and ease.

Tickets are on sale now and this event is open to the public. Dick Albert, Jim Boyd, Jack Williams, Matt Siegel, George Capalbo, Jane Christo, Joseph Ryan and others to be honored as well

The tax attorneys at Blue Tax save the day!

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As Halloween approaches, it's the perfect time to dive into some spine-chilling content.

Remember the days of 3% mortgage rates? As a relieved nation emerged from the Covid-19 pandemic in 2021, along with it came those historically low average mortgage rates below 5.00%, 4.00% or even sub-3.00%. But as inflation began to increase so too did mortgage rates, rising to nearly 8.00% in 2023 and 2024, their highest…

The post Lender Data Shows Refinance Offers Have Increased 42% Nationwide Over the Last Year appeared first on RISMedia.

Canada Goose has reported a 5 per cent YoY revenue drop to CAD $267.8 million (~$192.43 million) in Q2 FY25. Direct-to-consumer revenue declined 5 per cent, and wholesale revenue decreased 15 per cent due to planned inventory adjustments. Gross margin fell to 61.3 per cent. Revised FY25 guidance forecasts a slight revenue change, with adjusted EBIT margin at -60 to +60 basis points.

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The NFIB reports a rise in small business optimism in October, though challenges like inflation, hiring difficulties, and low sales persist.