O-GlcNAcylation, the addition of a single N-acetylglucosamine residue to serine and threonine residues of cytoplasmic, nuclear, or mitochondrial proteins, is a widespread regulatory post-translational modification. It is involved in response to nutritional status and stress and its dysregulation is associated with diseases ranging from Alzheimer’s to diabetes.  While the modification was first detected over thirty-five years ago, research into the function of O-GlcNAcylation has accelerated dramatically in the last ten years due to the development of new enrichment and mass spectrometry techniques that facilitate its analysis.  This article summarizes methods for O-GlcNAc enrichment, key mass spectrometry instrumentation advancements, particularly those that allow modification site localization, and software tools that allow analysis of data from O-GlcNAc modified peptides.

Glycosylation is a prevalent, yet heterogeneous modification with a broad range of implications in molecular biology. This heterogeneity precludes enrichment strategies that can be universally beneficial for all glycan classes. Thus, choice of enrichment strategy has profound implications on experimental outcomes. Here we review common enrichment strategies used in modern mass spectrometry (MS)-based glycoproteomic experiments, including lectins and other affinity chromatographies, hydrophilic interaction chromatography (HILIC) and its derivatives, porous graphitic carbon (PGC), reversible and irreversible chemical coupling strategies, and chemical biology tools that often leverage bioorthogonal handles. Interest in glycoproteomics continues to surge as MS instrumentation and software improve, so this review aims to help equip researchers with necessary information to choose appropriate enrichment strategies that best complement these efforts.

MLCommons this week issued the results of its latest MLPerf Inference (v3.1) benchmark exercise. Nvidia was again the top performing accelerator, but Intel (Xeon CPU) and Habana (Gaudi1 and 2) […]

The post MLPerf Releases Latest Inference Results and New Storage Benchmark appeared first on HPCwire.

Benchmarking is an important topic in quantum computing. There’s consensus it’s needed but opinions vary widely on how to go about it. Last week, IBM introduced a new tool — […]

The post IBM Develops New Quantum Benchmarking Tool — Benchpress appeared first on HPCwire.

Waiting is the hardest part. In the fall of 2023, HPCwire wrote about the new diverging Xeon processor strategy from Intel. Instead of a on-size-fits all approach; Intel has opted […]

The post Granite Rapids HPC Benchmarks: I’m Thinking Intel Is Back (Updated) appeared first on HPCwire.

In this GPU age, CPUs are often considered second citizens because most of the performance comes from the GPU. In most systems, GPUs are separate PCIe devices used by the […]

The post Xeon 6 vs. Zen-5 HPC Benchmark Showdown appeared first on HPCwire.

To boost the iconic queen conch's population, researchers are relocating the heat-stressed creatures to cooler, deeper waters to help them find mates

Former Dawson City Mayor Bill Kendrick has filed his defence against the town's encroachment violation lawsuit.

CAD And Simulation Help Company Reduce Design Cycle By 40 Percent And Cut Design Costs 60 Percent

Read about the strengths of Cushing as a crude oil trading and storage hub and, in turn, for hedging crude price risk as storage utilization levels rise.

Read about the strengths of Cushing as a crude oil trading and storage hub and, in turn, for hedging crude price risk as storage utilization levels rise.

In a very special Steinhoff edition of SA Money Report, we examine the SA Reserve Bank’s recent surprise moves against former CEO Markus Jooste.

Epoch AI, a California-based research institute launched a new artificial intelligence (AI) benchmark last week. Dubbed FrontierMath, the new AI benchmark tests large language models (LLMs) on their capability of reseasoning and mathematical problem-solving. The AI firm claims that existing math benchmarks are not very useful due to factors like data contamination and AI models scoring very high scores on them.

NEW CASTLE (May 5, 2022) – Department of Health and Social Services (DHSS) Secretary Molly Magarik presented the State’s second annual Benchmark Trend Report at today’s Delaware Health Care Commission (DHCC) meeting. This report displays trends in Delaware’s health care spending and quality, comparing new 2020 data against a set benchmark, as well as baseline […]

NEW CASTLE (April 6, 2023) – Department of Health and Social Services (DHSS) Secretary Molly Magarik presented the State’s third annual Benchmark Trend Report at today’s Delaware Health Care Commission (DHCC) meeting. This report displays trends in Delaware’s health care spending and quality, comparing new 2021 data against a set benchmark, as well as baseline […]

NEW CASTLE (February 12, 2024) – The Delaware Department of Health and Social Services and the Delaware Health Care Commission have launched the Benchmark Trend Report Dashboard to further support the State’s efforts to improve health care quality for all residents, while simultaneously working to monitor and reduce the economic burden of health care spending. […]

NEW CASTLE (May 7, 2024) – Per capita health care spending in Delaware increased 6.3% in 2022 to $9,657, outpacing a 3% growth rate benchmark, according to the State of Delaware’s fourth annual Benchmark Trend Report presented Thursday May 2 to the Delaware Health Care Commission (DHCC) by Department of Health and Social Services (DHSS) […]

Students across Delaware benefitted from multiple enrichment programs this summer designed to enhance literacy skills and overall well-being. Backed by the Delaware Department of Education (DDOE), Governor John Carney, and key community partners, the programs were offered in school districts and charter schools statewide.

Reichman University launches a new medical school to address Israel's doctor shortage, with hands-on training from day one.

  Matthias Schmale is the Assistant Secretary-General, UN Resident and Humanitarian Coordinator in Ukraine. Schmale brings more than 30 years of experience in humanitarian and development work. He previously served as Senior Adviser to the UN Development Coordination Office’s regional team for Africa, as Resident and Humanitarian Coordinator (a.i) in Nigeria, and in several high-level […]

There has been another shock at the Grand Slam of Darts.

FrontierMath's difficult questions remain unpublished so that AI companies can't train against it.

Sam Trabucco, the former Alameda Research co-CEO, will forfeit a 53-foot yacht and forgo $70 million worth of claims in a proposed settlement with the FTX bankruptcy estate.

The post Sam Bankman-Fried Henchman to Forfeit $70 Million, Yacht in Proposed Settlement appeared first on Breitbart.

A research team at the University of California San Diego have developed a smartphone attachment that can provide information on changes in pupil size, which can be used to assess neurological phenomena, such as traumatic brain injury and Alzheimer’s disease. Such changes in pupil size have been difficult to characterize in the past in those […]

Benchmarking the Accounting & Finance Function: 2014

INRIX: 10 Cities with Worst Traffic

Turtle Beach Reveals the All-New Elite Pro

The Hon'ble Delhi High Court in the case of JV Creatives (P.) Ltd. v. Principal Additional Director General, DGGI, Gurugram Zonal Unit [W.P. (C) No. 10042 of 2024 dated July 23, 2024] dismissed the writ petition filed against the order of provisional attachment passed under Section 83 of the Central

STAAR Surgical to Present at The Benchmark Company Investor Conference

Data isn’t meaningful unless you do something with it. Let’s say your average RevPAR for June is $150. Alone, that doesn’t mean very much. But what if you compare that number to the average RevPAR, globally and within your region? If you measure whether you’re improving year-on-year, month-on-month? If you look beyond RevPAR to accompanying key metrics?

Haldwani Land Encroachment: आज सुबह मुझे वाशिंगटन से एक ईमेल आया| ईमेल इंडियन अमेरिकन मुस्लिम काउन्सिल का है। वाशिंगटन में मुख्यालय वाली यह संस्था भारत में होने वाली घटनाओं को मुस्लिम एंगल से उठाकर दुनिया भर में भारत को बदनाम

Manchester : Manchester University Press, [2018]

London : Verso, 2022.

Manchester : Manchester University Press, [2021]

Articles Eritrean Ladies → Tips for meeting women from Eritrea Why carry out Columbia -mail order brides make most suitable wives? Mucutuy, who have arrived at the hospital at start with other family, said the youngsters had been provided mental overall health services. “I thank the president to get his help and the Local people […]

Spanning seven acres, the resort features landscaped gardens, a swimming pool, and a multi-cuisine restaurant, making it ideal for families seeking relaxation and exploration.

The drive at 25 locations will go on till November 29; a team comprising police, revenue, PWD and local administration officials launched the work on Jawaharlal Nehru Street and East Car Street

Following public complaints and newspaper reports highlighting illegal encroachments causing hindrance to free movement of vehicles and pedestrians on thoroughfares and arterial roads, the District Administration launched a month-long drive a few days ago

‘The marginalised who have taken small loans and repaid as much they could are being made easy targets by banks, while big defaulters are left free,’ says Anti-SARFAESI official

National Bureau of Economic Research

National Bureau of Economic Research

National Bureau of Economic Research