How to maneuver Sun King's food hall maze of bars, dining areas and distillery operations.

Sunderland complete the signing of defender Sotirios Kyrgiakos on loan from VfL Wolfsburg until the end of the season.

Scientists map ancient underwater landslides in the region chosen for Jakarta's replacement.

1. Netizens swoon over Sunil Lahri's son's handsomeness; a look at rare and unseen pics of the cast of Ramayan's family members  Times of India
2. Ramayan actor Dipika Chikhlia would love to play Kaikeyi, Sunil Lahri wishes to play Raavan’s role if...  Hindustan Times
3. Throwback: Ramanand Sagar had THIS condition for roping in Arun Govil for Ram’s role in Ramayan  PINKVILLA
4. Buoyed by Ramayans record-breaking run, Kapil Sharmas episode with stars to air again - Republic World  Republic World
5. Ramayan's Sita Dipika Chikhlia and Lakshman Sunil Lahri on making of the show  Hindustan Times
6. View Full coverage on Google News

I’m not entirely sure who the Samsung Galaxy Note is aimed at, but as somebody who gets to observe from the sidelines, this is one fun, functional and loveable device — although it comes at an out of contract price of around £450-500 upwards, give or take. The biggest talking point of the Galaxy Note is its [...]

The Amateur Traveler  talks to Scott E. Jordan of Scottevest about his home in Sun Valley Idaho. 

Hear about Queensland's Sunshine Coast north of Brisbane Australia from Annabel Candy. Long white sand beachs, hiking trails, a tropical zoo in the tropics.

Google’s (and now Alphabet’s) CEO opines in the FT (sub required) on why AI needs to be regulated, joining the chorus of tech leaders who have taken the apparent high road when it comes to regulation, even as governments around the world have shown next to no ability to actually regulate anything (well, I guess … Continue reading "Sundar Pichai in the FT: Please Regulate Us (And Good Luck with All That)"

TL;DR: Have a hot meal wherever you go with the Go portable solar oven for $119, a 14% savings as of May 9.

As we look toward upcoming summer festivities, our calendars are looking pretty bleak. Nearly every event has been postponed. Festival season was straight-up canceled. And gatherings in public places are basically extinct. With fewer options on the table, you're probably going to be spending a lot of time enjoying the great outdoors in small groups or on your own as the weather warms up. By then, you'll be sick of staying home, so it's a good thing nature isn't canceled.

As you head outside for your camping, hiking, biking, and beach excursions, you'll probably need a way to cook your own food, especially if restaurants are still closed or operating on abbreviated hours. We've got just thing, and it's on sale: the Go Portable Solar Oven. All you need is a little bit of sun and this lightweight grill can cook just about anything. Read more...

The Dr Sun Yat-sen Museum will hold a fun day on November 10 to commemorate Dr Sun's revolutionary journey and enhance public knowledge of the museum.

A variety of activities including a concert, birthday cake motif cardholder workshop and cosplay will be provided.

There will also be virtual reality games and a display of early textbooks for visitors to learn more about Dr Sun's school life in Hong Kong.

In addition, a cultural tour will be held on the Dr Sun Yat-sen Historical Trail. Prior registration is required.

Visitors can also tour the museum's permanent exhibits which comprise precious historical artefacts and a wide range of audiovisual programmes.

Admission is free.

Click here for details.

General Stations: 1 to 2 (Health Risk: Low)

Roadside Stations: 2 (Health Risk: Low)

(Northumbria University ) Researchers from Northumbria University have been awarded £1.2m to help advance our understanding of the Sun and its impact on the planets within our solar system.

(Kobe University) Hydrogen is a possible next generation energy solution, and it can be produced from sunlight and water using photocatalysts. A research group from Kobe University has developed a strategy that greatly increases the amount of hydrogen produced using hematite photocatalysts. In addition to boosting the high efficiency of what is thought to be the world's highest performing photoanode, this strategy will be applied to artificial photosynthesis and solar water-splitting technologies via university-industry collaborations.

Sperm head shaping is a key event in spermiogenesis and is tightly controlled via the acrosome–manchette network. Linker of nucleoskeleton and cytoskeleton (LINC) complexes consist of Sad1 and UNC84 domain–containing (SUN) and Klarsicht/ANC-1/Syne-1 homology (KASH) domain proteins and form conserved nuclear envelope bridges implicated in transducing mechanical forces from the manchette to sculpt sperm nuclei into a hook-like shape. However, the role of LINC complexes in sperm head shaping is still poorly understood. Here we assessed the role of SUN3, a testis-specific LINC component harboring a conserved SUN domain, in spermiogenesis. We show that CRISPR/Cas9-generated Sun3 knockout male mice are infertile, displaying drastically reduced sperm counts and a globozoospermia-like phenotype, including a missing, mislocalized, or fragmented acrosome, as well as multiple defects in sperm flagella. Further examination revealed that the sperm head abnormalities are apparent at step 9 and that the sperm nuclei fail to elongate because of the absence of manchette microtubules and perinuclear rings. These observations indicate that Sun3 deletion likely impairs the ability of the LINC complex to transduce the cytoskeletal force to the nuclear envelope, required for sperm head elongation. We also found that SUN3 interacts with SUN4 in mouse testes and that the level of SUN4 proteins is drastically reduced in Sun3-null mice. Altogether, our results indicate that SUN3 is essential for sperm head shaping and male fertility, providing molecular clues regarding the underlying pathology of the globozoospermia-like phenotype.

Editor Matt Egan sits down with staff writer at PC Advisor Lewis Painter to chat about Samsung's S8 rumours. Editor of Techworld.com Charlotte Jee discusses all the goings on from London Tech Week and if London is as much of a tech city as it says it is (12:00). Finally, regular guest David Price, editor at Macworld UK, comes on to discuss Mark Zuckerberg's webcam paranoia and cyber security (22:00).  

See acast.com/privacy for privacy and opt-out information.

Matt Egan hosts as we delve into the tech headlines of the week. Senior Staff Writer at PC Advisor Henry Burrell talks the gang through the latest on Samsung's upcoming smartphone and why it's been delayed, plus another brand comes back from the brink. Online Editor at Techworld Tamlin Magee then explores the strange but true story of Silicon Valley billionaires buying private islands with underground bunkers in case everything really does go Pete Tong. Finally Staff Writer at Macworld UK and PC Advisor Dominic Preston talks us through the frights of the latest Resident Evil game while everyone agrees they can be more terrifying than most horror films.  

See acast.com/privacy for privacy and opt-out information.

Sperm head shaping is a key event in spermiogenesis and is tightly controlled via the acrosome–manchette network. Linker of nucleoskeleton and cytoskeleton (LINC) complexes consist of Sad1 and UNC84 domain–containing (SUN) and Klarsicht/ANC-1/Syne-1 homology (KASH) domain proteins and form conserved nuclear envelope bridges implicated in transducing mechanical forces from the manchette to sculpt sperm nuclei into a hook-like shape. However, the role of LINC complexes in sperm head shaping is still poorly understood. Here we assessed the role of SUN3, a testis-specific LINC component harboring a conserved SUN domain, in spermiogenesis. We show that CRISPR/Cas9-generated Sun3 knockout male mice are infertile, displaying drastically reduced sperm counts and a globozoospermia-like phenotype, including a missing, mislocalized, or fragmented acrosome, as well as multiple defects in sperm flagella. Further examination revealed that the sperm head abnormalities are apparent at step 9 and that the sperm nuclei fail to elongate because of the absence of manchette microtubules and perinuclear rings. These observations indicate that Sun3 deletion likely impairs the ability of the LINC complex to transduce the cytoskeletal force to the nuclear envelope, required for sperm head elongation. We also found that SUN3 interacts with SUN4 in mouse testes and that the level of SUN4 proteins is drastically reduced in Sun3-null mice. Altogether, our results indicate that SUN3 is essential for sperm head shaping and male fertility, providing molecular clues regarding the underlying pathology of the globozoospermia-like phenotype.

They say that Africans, Will have to fight for a place on the bus, So I am pulling out all the stops. I am burning incense and, Turning out closets, -exorcising demons- I am fumigating my life, Throwing out old clothes and, Trying to curry favour, -surely children were not meant for the streets, Nor […]

Europe's common agricultural policy (CAP) on sugar is due to change, and Emilie Aguirre, from the UKCRC Centre for Diet and Activity Research at the University of Cambridge, argues that an influx of cheap high fructose corn syrup (HFCS, isoglucose) into the European market will have a negative effect on on the health of the continent. Read the...

“Juliet”, a woman living in London, was diagnosed with a mysterious illness in November 2015, Ian Cropley, a consultant in infectious disease from The Royal Free London NHS Foundation Trust, was there to investigate. In this podcast, we find out how Zika, once a little known virus causing a rash and fever, has subsequently become a global health...

The number of people estimated to be latently infected with TB - that is infected with TB, which has not yet manifested symptoms - is around 2 billion. That is 1 in 3 people on the planet are infected by the bacteria. The World Health Organization’s website notes that on average 5-10% of those infected with TB will develop active TB. That number...

Diabetes is synonymous with sugar, but diabetes insipidus, "water diabetes", can't be forgotten. Between 2009 and 2016, 4 people died in hospital in England, when lifesaving treatment for the condition was not given. In this podcast, we hear some practical tips for non-specialists to aid diagnosis, and how patients should be managed during...

In 2012, Eleni Linos, professor of dermatology at Stanford university, published a systematic review and meta-analysis of the link between non-melanoma cancer and sun-beds. That bit of pretty standard research, and a particular rapid response to it, has kicked of years of work - and in this podcast I talk to Eleni and her colleagues Stanton...

The ADA announced April 6 the recipients of its third annual 10 Under 10 Awards, which recognizes 10 new dentists who demonstrate excellence early in their careers.

A face-aging app could encourage young people to protect their skin from harmful UV rays and lessen their risk for skin cancer, a study published Wednesday by JAMA Dermatology has found.

This recipe features on Foodie Tuesday, a weekly segment on 774 Drive with Raf Epstein, 3.30PM, shared by Hetty McKinnon, founder of Surry Hills community kitchen Arthur Street Kitchen and author of 'Neighbourhood'.

U.S. Secretary of Education Betsy DeVos is not famous for pressuring states into desired outcomes, but did put at least two states' Title I funding on "high-risk" status last year.

Tohoku Earthquake and Tsunami, Japan, 2011.

London ; New York : Ward, Lock and Co., 1891.

1938.

1938.

Leipzig : G. Thieme, 1890-1891.

Berlin : Hirschwald, 1902.

Berlin : A. Hirschwald, 1845.

Berlin : G. Reimer, 1893.

Berlin : G. Reimer, 1863.

Berlin : G. Reimer, 1876.

Jena : G. Fischer, 1887.

Leipzig : Alfred Langkammer, 1894.

Stuttgart : F. Enke, 1883.

Wien : Urban & Schwarzenberg, 1891.

Leipzig : Roszberg, 1884.

Berlin : Hirschwald, 1905.

Leipzig : Veit, 1896.