uma UN chief says funding of WHO, humanitarians should not be cut amid COVID-19 By www.newkerala.com Published On :: Sat, 09 May 2020 21:39:01 +0530 Full Article
uma Will go for quarantine in Australia only if fate of T20 WC is unclear: BCCI treasurer Arun Dhumal By www.newkerala.com Published On :: Sat, 09 May 2020 23:15:01 +0530 Full Article
uma To celebrate win, Kejriwal visits Hanuman mandir By www.rediff.com Published On :: Tue, 11 Feb 2020 19:09:23 +0530 Kejriwal was accompanied by his family and Deputy Chief Minister Manish Sisodia. Full Article
uma Man who returned from Padarayanapura tests positive in Tumakuru district By www.thehindu.com Published On :: Sat, 09 May 2020 22:48:49 +0530 A 45-year-old man (P-764), who worked at a hotel in Padarayanapura in Bengaluru and returned to his hometown in Sira of Tumakuru district on May 4, te Full Article Karnataka
uma Mother’s Day 2020: ‘One Day isn’t enough to thank our mothers’, says Divya Khosla Kumar who feels we should express our gratitude towards them whenever we feel it By Published On :: Mother’s Day 2020: ‘One Day isn’t enough to thank our mothers’, says Divya Khosla Kumar who feels we should express our gratitude towards them whenever we feel it Full Article
uma Be more humane, Punjab CM tells police By www.newkerala.com Published On :: Fri, 27 Mar 2020 09:22:01 +0530 Full Article
uma Thirumazhisai market ready By www.thehindu.com Published On :: Sun, 10 May 2020 03:20:26 +0530 About 200 shops set to begin operations tomorrow; all vehicles to be sanitised Full Article Chennai
uma Banned Umar Akmal refuses to divulge details of two meetings with suspected bookies: PCB sources By indianexpress.com Published On :: Sun, 10 May 2020 06:25:20 +0000 Full Article Cricket Sports
uma Binding site asymmetry in human transthyretin: insights from a joint neutron and X-ray crystallographic analysis using perdeuterated protein By journals.iucr.org Published On :: A neutron crystallographic study of perdeuterated transthyretin reveals important aspects of the structure relating to its stability and its propensity to form fibrils, as well as evidence of a single water molecule that affects the symmetry of the two binding pockets. Full Article text
uma UK sees notable reduction in seismic noise caused by human activity – experts - Aberdeen Evening Express By www.eveningexpress.co.uk Published On :: Fri, 24 Apr 2020 07:00:00 GMT UK sees notable reduction in seismic noise caused by human activity – experts Aberdeen Evening Express Full Article
uma Structure of the 4-hydroxy-tetrahydrodipicolinate synthase from the thermoacidophilic methanotroph Methylacidiphilum fumariolicum SolV and the phylogeny of the aminotransferase pathway By scripts.iucr.org Published On :: 2020-04-28 The enzyme 4-hydroxy-tetrahydrodipicolinate synthase (DapA) is involved in the production of lysine and precursor molecules for peptidoglycan synthesis. In a multistep reaction, DapA converts pyruvate and l-aspartate-4-semialdehyde to 4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid. In many organisms, lysine binds allosterically to DapA, causing negative feedback, thus making the enzyme an important regulatory component of the pathway. Here, the 2.1 Å resolution crystal structure of DapA from the thermoacidophilic methanotroph Methylacidiphilum fumariolicum SolV is reported. The enzyme crystallized as a contaminant of a protein preparation from native biomass. Genome analysis reveals that M. fumariolicum SolV utilizes the recently discovered aminotransferase pathway for lysine biosynthesis. Phylogenetic analyses of the genes involved in this pathway shed new light on the distribution of this pathway across the three domains of life. Full Article text
uma Crystal and solution structures of fragments of the human leucocyte common antigen-related protein By journals.iucr.org Published On :: The crystal and solution SAXS structures of a fragment of human leucocyte common antigen-related protein show that it is less flexible than the homologous proteins tyrosine phosphatase receptors δ and σ. Full Article text
uma Bis(4-hydroxy-N,N-di-n-propyltryptammonium) fumarate tetrahydrate By scripts.iucr.org Published On :: 2019-11-12 The title compound (systematic name: bis{[2-(4-hydroxy-1H-indol-3-yl)ethyl]bis(propan-2-yl)azanium} but-2-enedioate tetrahydrate), 2C16H25N2O+·C4H2O42−·4H2O, has a singly protonated DPT cation, one half of a fumarate dianion (completed by a crystallographic centre of symmetry) and two water molecules of crystallization in the asymmetric unit. A series of N—H⋯O and O—H⋯O hydrogen bonds form a three-dimensional network in the solid state. Full Article text
uma Bis(4-acetoxy-N,N-dimethyltryptammonium) fumarate: a new crystalline form of psilacetin, an alternative to psilocybin as a psilocin prodrug By scripts.iucr.org Published On :: 2019-05-31 The title compound (systematic name: bis{2-[4-(acetyloxy)-1H-indol-3-yl]ethan-1-aminium} but-2-enedioate), 2C14H19N2O2+·C4H2O42−, has a single protonated psilacetin cation and one half of a fumarate dianion in the asymmetric unit. There are N—H⋯O hydrogen bonds between the ammonium H atoms and the fumarate O atoms, as well as N—H⋯O hydrogen bonds between the indole H atoms and the fumarate O atoms. The hydrogen bonds hold the ions together in infinite one-dimensional chains along [111]. Full Article text
uma Crystal structures of two new isocoumarin derivatives: 8-amino-6-methyl-3,4-diphenyl-1H-isochromen-1-one and 8-amino-3,4-diethyl-6-methyl-1H-isochromen-1-one By scripts.iucr.org Published On :: 2019-07-09 The title compounds, 8-amino-6-methyl-3,4-diphenyl-1H-isochromen-1-one, C22H17NO2, (I), and 8-amino-3,4-diethyl-6-methyl-1H-isochromen-1-one, C14H17NO2, (II), are new isocoumarin derivatives in which the isochromene ring systems are planar. Compound II crystallizes with two independent molecules (A and B) in the asymmetric unit. In I, the two phenyl rings are inclined to each other by 56.41 (7)° and to the mean plane of the 1H-isochromene ring system by 67.64 (6) and 44.92 (6)°. In both compounds, there is an intramolecular N—H⋯O hydrogen bond present forming an S(6) ring motif. In the crystal of I, molecules are linked by N—H⋯π interactions, forming chains along the b-axis direction. A C—H⋯π interaction links the chains to form layers parallel to (100). The layers are then linked by a second C—H⋯π interaction, forming a three-dimensional structure. In the crystal of II, the two independent molecules (A and B) are linked by N—H⋯O hydrogen bonds, forming –A–B–A–B– chains along the [101] direction. The chains are linked into ribbons by C—H⋯π interactions involving inversion-related A molecules. The latter are linked by offset π–π interactions [intercentroid distances vary from 3.506 (1) to 3.870 (2) Å], forming a three-dimensional structure. Full Article text
uma The fumarate salts of the N-isopropyl-N-methyl derivatives of DMT and psilocin By scripts.iucr.org Published On :: 2019-08-16 The solid-state structures of the salts of two substituted tryptamines, namely N-isopropyl-N-methyltryptaminium (MiPT) fumarate {systematic name: [2-(1H-indol-3-yl)ethyl](methyl)propan-2-ylazanium 3-carboxyprop-2-enoate}, C14H21N2+·C4H3O4−, and 4-hydroxy-N-isopropyl-N-methyltryptaminium (4-HO-MiPT) fumarate monohydrate {systematic name: [2-(4-hydroxy-1H-indol-3-yl)ethyl](methyl)propan-2-ylazanium 3-carboxyprop-2-enoate monohydrate}, C14H21N2O+·C4H3O4−·H2O, are reported. Both salts possess a protonated tryptammonium cation and a 3-carboxyacrylate (hydrogen fumarate) anion in the asymmetric unit; the 4-HO-MiPT structure also contains a water molecule of crystallization. Both cations feature disorder of the side chain over two orientations, in a 0.630 (3):0.370 (3) ratio for MiPT and a 0.775 (5):0.225 (5) ratio for 4-HO-MiPT. In both extended structures, N—H⋯O and O—H⋯O hydrogen bonds generate infinite two-dimensional networks. Full Article text
uma Bis(4-hydroxy-N-isopropyl-N-methyltryptammonium) fumarate: a new crystalline form of miprocin By scripts.iucr.org Published On :: 2020-03-10 The title compound, bis(4-hydroxy-N-isopropyl-N-methyltryptammonium) (4-HO-MiPT) fumarate (systematic name: bis{[2-(4-hydroxy-1H-indol-3-yl)ethyl](methyl)propan-2-ylazanium} but-2-enedioate), 2C14H21N2O+·C4H2O42−, has a singly protonated tryptammonium cation and one half of a fumarate dianion in the asymmetric unit. The tryptammonium and fumarate ions are held together in one-dimensional chains by N—H⋯O and O—H⋯O hydrogen bonds. These chains are a combination of R42(20) rings, and C22(15) and C44(30) parallel chains along (110). They are further consolidated by N—H⋯π interactions. There are two two-component types of disorder impacting the tryptammonium fragment with a 0.753 (7):0.247 (7) occupancy ratio and one of the fumarate oxygen atoms with a 0.73 (8):0.27 (8) ratio. Full Article text
uma Norpsilocin: freebase and fumarate salt By scripts.iucr.org Published On :: 2020-03-27 The solid-state structures of the naturally occurring psychoactive tryptamine norpsilocin {4-hydroxy-N-methyltryptamine (4-HO-NMT); systematic name: 3-[2-(methylamino)ethyl]-1H-indol-4-ol}, C11H14N2O, and its fumarate salt (4-hydroxy-N-methyltryptammonium fumarate; systematic name: bis{[2-(4-hydroxy-1H-indol-3-yl)ethyl]methylazanium} but-2-enedioate), C11H15N2O+·0.5C4H2O42−, are reported. The freebase of 4-HO-NMT has a single molecule in the asymmetric unit joined together by N—H⋯O and O—H⋯O hydrogen bonds in a two-dimensional network parallel to the (100) plane. The ethylamine arm of the tryptamine is modeled as a two-component disorder with a 0.895 (3) to 0.105 (3) occupancy ratio. The fumarate salt of 4-HO-NMT crystallizes with a tryptammonium cation and one half of a fumarate dianion in the asymmetric unit. The ions are joined together by N—H⋯O and O—H⋯O hydrogen bonds to form a three-dimensional framework, as well as π–π stacking between the six-membered rings of inversion-related indoles (symmetry operation: 2 − x, 1 − y, 2 – z). Full Article text
uma Engineering a surrogate human heteromeric α/β glycine receptor orthosteric site exploiting the structural homology and stability of acetylcholine-binding protein By scripts.iucr.org Published On :: 2019-09-04 Protein-engineering methods have been exploited to produce a surrogate system for the extracellular neurotransmitter-binding site of a heteromeric human ligand-gated ion channel, the glycine receptor. This approach circumvents two major issues: the inherent experimental difficulties in working with a membrane-bound ion channel and the complication that a heteromeric assembly is necessary to create a key, physiologically relevant binding site. Residues that form the orthosteric site in a highly stable ortholog, acetylcholine-binding protein, were selected for substitution. Recombinant proteins were prepared and characterized in stepwise fashion exploiting a range of biophysical techniques, including X-ray crystallography, married to the use of selected chemical probes. The decision making and development of the surrogate, which is termed a glycine-binding protein, are described, and comparisons are provided with wild-type and homomeric systems that establish features of molecular recognition in the binding site and the confidence that the system is suited for use in early-stage drug discovery targeting a heteromeric α/β glycine receptor. Full Article text
uma Structural and kinetic insights into flavin-containing monooxygenase and calponin-homology domains in human MICAL3 By scripts.iucr.org Published On :: 2020-01-01 MICAL is an oxidoreductase that participates in cytoskeleton reorganization via actin disassembly in the presence of NADPH. Although three MICALs (MICAL1, MICAL2 and MICAL3) have been identified in mammals, only the structure of mouse MICAL1 has been reported. Here, the first crystal structure of human MICAL3, which contains the flavin-containing monooxygenase (FMO) and calponin-homology (CH) domains, is reported. MICAL3 has an FAD/NADP-binding Rossmann-fold domain for monooxygenase activity like MICAL1. The FMO and CH domains of both MICAL3 and MICAL1 are highly similar in structure, but superimposition of the two structures shows a different relative position of the CH domain in the asymmetric unit. Based on kinetic analyses, the catalytic efficiency of MICAL3 dramatically increased on adding F-actin only when the CH domain was available. However, this did not occur when two residues, Glu213 and Arg530, were mutated in the FMO and CH domains, respectively. Overall, MICAL3 is structurally highly similar to MICAL1, which suggests that they may adopt the same catalytic mechanism, but the difference in the relative position of the CH domain produces a difference in F-actin substrate specificity. Full Article text
uma The structural study of mutation-induced inactivation of human muscarinic receptor M4 By scripts.iucr.org Published On :: 2020-02-22 Human muscarinic receptor M4 belongs to the class A subfamily of the G-protein-coupled receptors (GPCRs). M4 has emerged as an attractive drug target for the treatment of Alzheimer's disease and schizophrenia. Recent results showed that M4-mediated cholinergic transmission is related to motor symptoms in Parkinson's disease. Selective ligand design for the five muscarinic acetylcholine receptor (mAchR) subtypes currently remains challenging owing to the high sequence and structural similarity of their orthosteric binding pockets. In order to obtain M4-selective antagonists, a new approach was tried to lock M4 into an inactive form by rationally designing an N4497.49R mutation, which mimics the allosteric sodium binding in the conserved sodium site usually found in class A GPCRs. In addition, the crystal structure of the mutation-induced inactive M4 was determined. By comparative analysis with other mAchR structures, followed by functional assays, the N4497.49R mutation was shown to stabilize M4 into an inactive state. Virtual screening of a focused ligand library using the crystal structure showed that the inactive M4 prefers antagonists much more than agonists. This study provides a powerful mutation strategy to stabilize GPCRs in inactive states and facilitate their structure determination. Full Article text
uma Plasmodium vivax and human hexokinases share similar active sites but display distinct quaternary architectures By scripts.iucr.org Published On :: 2020-03-26 Malaria is a devastating disease caused by a protozoan parasite. It affects over 300 million individuals and results in over 400 000 deaths annually, most of whom are young children under the age of five. Hexokinase, the first enzyme in glucose metabolism, plays an important role in the infection process and represents a promising target for therapeutic intervention. Here, cryo-EM structures of two conformational states of Plasmodium vivax hexokinase (PvHK) are reported at resolutions of ∼3 Å. It is shown that unlike other known hexokinase structures, PvHK displays a unique tetrameric organization (∼220 kDa) that can exist in either open or closed quaternary conformational states. Despite the resemblance of the active site of PvHK to its mammalian counterparts, this tetrameric organization is distinct from that of human hexokinases, providing a foundation for the structure-guided design of parasite-selective antimalarial drugs. Full Article text
uma A complete compendium of crystal structures for the human SEPT3 subgroup reveals functional plasticity at a specific septin interface By scripts.iucr.org Published On :: 2020-03-28 Human septins 3, 9 and 12 are the only members of a specific subgroup of septins that display several unusual features, including the absence of a C-terminal coiled coil. This particular subgroup (the SEPT3 septins) are present in rod-like octameric protofilaments but are lacking in similar hexameric assemblies, which only contain representatives of the three remaining subgroups. Both hexamers and octamers can self-assemble into mixed filaments by end-to-end association, implying that the SEPT3 septins may facilitate polymerization but not necessarily function. These filaments frequently associate into higher order complexes which associate with biological membranes, triggering a wide range of cellular events. In the present work, a complete compendium of crystal structures for the GTP-binding domains of all of the SEPT3 subgroup members when bound to either GDP or to a GTP analogue is provided. The structures reveal a unique degree of plasticity at one of the filamentous interfaces (dubbed NC). Specifically, structures of the GDP and GTPγS complexes of SEPT9 reveal a squeezing mechanism at the NC interface which would expel a polybasic region from its binding site and render it free to interact with negatively charged membranes. On the other hand, a polyacidic region associated with helix α5', the orientation of which is particular to this subgroup, provides a safe haven for the polybasic region when retracted within the interface. Together, these results suggest a mechanism which couples GTP binding and hydrolysis to membrane association and implies a unique role for the SEPT3 subgroup in this process. These observations can be accounted for by constellations of specific amino-acid residues that are found only in this subgroup and by the absence of the C-terminal coiled coil. Such conclusions can only be reached owing to the completeness of the structural studies presented here. Full Article text
uma Structural comparison of protiated, H/D-exchanged and deuterated human carbonic anhydrase IX By scripts.iucr.org Published On :: 2019-08-22 Human carbonic anhydrase IX (CA IX) expression is upregulated in hypoxic solid tumours, promoting cell survival and metastasis. This observation has made CA IX a target for the development of CA isoform-selective inhibitors. To enable structural studies of CA IX–inhibitor complexes using X-ray and neutron crystallography, a CA IX surface variant (CA IXSV; the catalytic domain with six surface amino-acid substitutions) has been developed that can be routinely crystallized. Here, the preparation of protiated (H/H), H/D-exchanged (H/D) and deuterated (D/D) CA IXSV for crystallographic studies and their structural comparison are described. Four CA IXSV X-ray crystal structures are compared: two H/H crystal forms, an H/D crystal form and a D/D crystal form. The overall active-site organization in each version is essentially the same, with only minor positional changes in active-site solvent, which may be owing to deuteration and/or resolution differences. Analysis of the crystal unit-cell packing reveals different crystallographic and noncrystallographic dimers of CA IXSV compared with previous reports. To our knowledge, this is the first report comparing three different deuterium-labelled crystal structures of the same protein, marking an important step in validating the active-site structure of CA IXSV for neutron protein crystallography. Full Article text
uma Controlled dehydration, structural flexibility and gadolinium MRI contrast compound binding in the human plasma glycoprotein afamin By scripts.iucr.org Published On :: 2019-11-19 Afamin, which is a human blood plasma glycoprotein, a putative multifunctional transporter of hydrophobic molecules and a marker for metabolic syndrome, poses multiple challenges for crystallographic structure determination, both practically and in analysis of the models. Several hundred crystals were analysed, and an unusual variability in cell volume and difficulty in solving the structure despite an ∼34% sequence identity with nonglycosylated human serum albumin indicated that the molecule exhibits variable and context-sensitive packing, despite the simplified glycosylation in insect cell-expressed recombinant afamin. Controlled dehydration of the crystals was able to stabilize the orthorhombic crystal form, reducing the number of molecules in the asymmetric unit from the monoclinic form and changing the conformational state of the protein. An iterative strategy using fully automatic experiments available on MASSIF-1 was used to quickly determine the optimal protocol to achieve the phase transition, which should be readily applicable to many types of sample. The study also highlights the drawback of using a single crystallographic structure model for computational modelling purposes given that the conformational state of the binding sites and the electron density in the binding site, which is likely to result from PEGs, greatly varies between models. This also holds for the analysis of nonspecific low-affinity ligands, where often a variety of fragments with similar uncertainty can be modelled, inviting interpretative bias. As a promiscuous transporter, afamin also seems to bind gadoteridol, a magnetic resonance imaging contrast compound, in at least two sites. One pair of gadoteridol molecules is located near the human albumin Sudlow site, and a second gadoteridol molecule is located at an intermolecular site in proximity to domain IA. The data from the co-crystals support modern metrics of data quality in the context of the information that can be gleaned from data sets that would be abandoned on classical measures. Full Article text
uma Identification of Ca-rich dense granules in human platelets using scanning transmission X-ray microscopy By scripts.iucr.org Published On :: 2020-03-16 Whole-mount (WM) platelet preparation followed by transmission electron microscopy (TEM) observation is the standard method currently used to assess dense granule (DG) deficiency (DGD). However, due to the electron-density-based contrast mechanism in TEM, other granules such as α-granules might cause false DG detection. Here, scanning transmission X-ray microscopy (STXM) was used to identify DGs and minimize false DG detection of human platelets. STXM image stacks of human platelets were collected at the calcium (Ca) L2,3 absorption edge and then converted to optical density maps. Ca distribution maps, obtained by subtracting the optical density maps at the pre-edge region from those at the post-edge region, were used to identify DGs based on the Ca richness. DGs were successfully detected using this STXM method without false detection, based on Ca maps for four human platelets. Spectral analysis of granules in human platelets confirmed that DGs contain a richer Ca content than other granules. The Ca distribution maps facilitated more effective DG identification than TEM which might falsely detect DGs. Correct identification of DGs would be important to assess the status of platelets and DG-related diseases. Therefore, this STXM method is proposed as a promising approach for better DG identification and diagnosis, as a complementary tool to the current WM TEM approach. Full Article text
uma Hard X-ray phase-contrast-enhanced micro-CT for quantifying interfaces within brittle dense root-filling-restored human teeth By journals.iucr.org Published On :: Phase-contrast enhanced micro-computed tomography reveals huge discontinuities at the interfaces between dental fillings and the tooth substrate. Despite the complex micromorphology, gaps in bonding could be visualized and quantified in 3D. Full Article text
uma Structure of the 4-hydroxy-tetrahydrodipicolinate synthase from the thermoacidophilic methanotroph Methylacidiphilum fumariolicum SolV and the phylogeny of the aminotransferase pathway By journals.iucr.org Published On :: Insights were obtained into the structure of the 4-hydroxy-tetrahydrodipicolinate synthase from the thermoacidophilic methanotroph Methylacidiphilum fumariolicum SolV and the phylogeny of the aminotransferase pathway for the biosynthesis of lysine. Full Article text
uma Crystal structure of an oxidized mutant of human mitochondrial branched-chain aminotransferase By scripts.iucr.org Published On :: 2020-01-01 This study presents the crystal structure of a thiol variant of the human mitochondrial branched-chain aminotransferase protein. Human branched-chain aminotransferase (hBCAT) catalyzes the transamination of the branched-chain amino acids leucine, valine and isoleucine and α-ketoglutarate to their respective α-keto acids and glutamate. hBCAT activity is regulated by a CXXC center located approximately 10 Å from the active site. This redox-active center facilitates recycling between the reduced and oxidized states, representing hBCAT in its active and inactive forms, respectively. Site-directed mutagenesis of the redox sensor (Cys315) results in a significant loss of activity, with no loss of activity reported on the mutation of the resolving cysteine (Cys318), which allows the reversible formation of a disulfide bond between Cys315 and Cys318. The crystal structure of the oxidized form of the C318A variant was used to better understand the contributions of the individual cysteines and their oxidation states. The structure reveals the modified CXXC center in a conformation similar to that in the oxidized wild type, supporting the notion that its regulatory mechanism depends on switching the Cys315 side chain between active and inactive conformations. Moreover, the structure reveals conformational differences in the N-terminal and inter-domain region that may correlate with the inactivated state of the CXXC center. Full Article text
uma Engineering the Fab fragment of the anti-IgE omalizumab to prevent Fab crystallization and permit IgE-Fc complex crystallization By scripts.iucr.org Published On :: 2020-03-02 Immunoglobulin E (IgE) plays a central role in the allergic response, in which cross-linking of allergen by Fc∊RI-bound IgE triggers mast cell and basophil degranulation and the release of inflammatory mediators. The high-affinity interaction between IgE and Fc∊RI is a long-standing target for therapeutic intervention in allergic disease. Omalizumab is a clinically approved anti-IgE monoclonal antibody that binds to free IgE, also with high affinity, preventing its interaction with Fc∊RI. All attempts to crystallize the pre-formed complex between the omalizumab Fab and the Fc region of IgE (IgE-Fc), to understand the structural basis for its mechanism of action, surprisingly failed. Instead, the Fab alone selectively crystallized in different crystal forms, but their structures revealed intermolecular Fab/Fab interactions that were clearly strong enough to disrupt the Fab/IgE-Fc complexes. Some of these interactions were common to other Fab crystal structures. Mutations were therefore designed to disrupt two recurring packing interactions observed in the omalizumab Fab crystal structures without interfering with the ability of the omalizumab Fab to recognize IgE-Fc; this led to the successful crystallization and subsequent structure determination of the Fab/IgE-Fc complex. The mutagenesis strategy adopted to achieve this result is applicable to other intractable Fab/antigen complexes or systems in which Fabs are used as crystallization chaperones. Full Article text
uma Hall of Human Origins to open at Smithsonian’s Natural History Museum, March 17, 2010 By insider.si.edu Published On :: Mon, 19 Oct 2009 15:42:06 +0000 A major new exhibition hall dedicated to the discovery and understanding of human origins will open next year at the Smithsonian's National Museum of Natural History: The David H. Koch Hall of Human Origins The post Hall of Human Origins to open at Smithsonian’s Natural History Museum, March 17, 2010 appeared first on Smithsonian Insider. Full Article Anthropology Research News Science & Nature exhibitions extinction National Museum of Natural History
uma New Hall of Human Origins points to environmental change as major force in evolution of hominins By insider.si.edu Published On :: Mon, 29 Mar 2010 14:31:29 +0000 Based on decades of cutting-edge research, the 15,000-square-foot Hall of Human Origins offers visitors an immersive, interactive journey through 6 million years of human evolution spelling out how defining characteristics of the human species have evolved during millions of years in response to a changing world. The post New Hall of Human Origins points to environmental change as major force in evolution of hominins appeared first on Smithsonian Insider. Full Article Anthropology Research News Science & Nature evolution exhibitions extinction National Museum of Natural History
uma Ancient bond between humans and dogs revealed in isotopic signatures of their bones By insider.si.edu Published On :: Thu, 10 Mar 2011 19:48:03 +0000 In recent research on Santa Rosa Island off the coast of Southern California, isotope readings of carbon and nitrogen found in the bones of Chumash Indians and domestic dogs excavated from archaeological sites show that both humans and dogs have nearly identical signatures of stable isotopes. The post Ancient bond between humans and dogs revealed in isotopic signatures of their bones appeared first on Smithsonian Insider. Full Article Anthropology Dinosaurs & Fossils Research News Science & Nature mammals National Museum of Natural History prehistoric
uma Artist’s recreation of 7- to 6-million-year-old early human unveiled in Hall of Human Origins By insider.si.edu Published On :: Wed, 23 Mar 2011 11:49:34 +0000 Meet Sahelanthropus tchadensis. This newly unveiled bust by artist John Gurche is now on view in the the Hall of Human Origins at the Smithsonian's National Museum of Natural History. The post Artist’s recreation of 7- to 6-million-year-old early human unveiled in Hall of Human Origins appeared first on Smithsonian Insider. Full Article Anthropology Science & Nature fossils mammals National Museum of Natural History new acquisitions
uma Damai, a two-and-a-half-year-old female Sumatran tiger, makes her debut at the National Zoo By insider.si.edu Published On :: Thu, 02 Jun 2011 12:09:05 +0000 The National Zoo’s great cat program recently expanded with the arrival of two-and-a-half-year-old female Sumatran tiger, Damai, who is now out of quarantine and spending time outside in her exhibit where visitors can see her. The post Damai, a two-and-a-half-year-old female Sumatran tiger, makes her debut at the National Zoo appeared first on Smithsonian Insider. Full Article Animals Science & Nature captive breeding conservation conservation biology endangered species mammals new acquisitions Smithsonian's National Zoo veterinary medicine
uma Scientists show that modern humans never co-existed with Homo erectus By insider.si.edu Published On :: Wed, 06 Jul 2011 16:28:34 +0000 New excavations in Indonesia and dating analyses by scientists at the Smithsonian and their colleagues show that modern humans never co-existed with Homo erectus. The post Scientists show that modern humans never co-existed with <em>Homo erectus</em> appeared first on Smithsonian Insider. Full Article Anthropology Dinosaurs & Fossils Research News Science & Nature National Museum of Natural History
uma Research on tungara frogs may be applicable to hearing loss/attention deficits in humans By insider.si.edu Published On :: Mon, 01 Aug 2011 15:01:16 +0000 A new study has revealed information about the way tungara frogs in the tropical rain forest hear, sort, and process sounds which is very similar to the way humans do. The knowledge could be applicable to communication disorders associated with hearing loss and attention deficits or difficulties. The post Research on tungara frogs may be applicable to hearing loss/attention deficits in humans appeared first on Smithsonian Insider. Full Article Research News Science & Nature amphibian Center for Tropical Forest Science frogs Tropical Research Institute
uma Dodo bird a resilient island survivor before the arrival of humans, study reveals By insider.si.edu Published On :: Mon, 26 Sep 2011 15:17:36 +0000 A new study on the dodo’s island home of Mauritius in the Indian Ocean, paints a picture of this unusual bird as an intrepid survivor on par with the giant tortoise for its resiliency. The post Dodo bird a resilient island survivor before the arrival of humans, study reveals appeared first on Smithsonian Insider. Full Article Dinosaurs & Fossils Science & Nature biodiversity birds carbon dioxide climate change conservation biology endangered species extinction National Museum of Natural History
uma 2013 exhibition to celebrate first complete human genome sequence By insider.si.edu Published On :: Wed, 23 May 2012 15:02:43 +0000 To celebrate the 10th anniversary of researchers producing the first complete human genome sequence — the genetic blueprint of the human body — the Smithsonian’s National Museum of Natural History, will open a new high-tech, high-intensity exhibition in 2013. The post 2013 exhibition to celebrate first complete human genome sequence appeared first on Smithsonian Insider. Full Article Research News Science & Nature exhibitions National Museum of Natural History
uma Report paints a new picture of early human impact on the Amazon River Basin By insider.si.edu Published On :: Fri, 15 Jun 2012 12:28:21 +0000 The newly reported reconstruction of Amazonian prehistory by a Smithsonian scientist, Dolores R. Piperno, and her colleagues suggests that large areas of western Amazonia were sparsely inhabited. The post Report paints a new picture of early human impact on the Amazon River Basin appeared first on Smithsonian Insider. Full Article Anthropology Dinosaurs & Fossils Research News Science & Nature biodiversity National Museum of Natural History Peru South America Tropical Research Institute
uma As robins disperse, West Nile mosquitoes switch diet to humans: Q&A with Smithsonian ornithologist Peter Marra By insider.si.edu Published On :: Fri, 14 Sep 2012 16:31:18 +0000 A rising spike in West Nile virus is taking health officials across the country by surprise as this year more than 2,600 people in 45 states and the District of Columbia, have been stricken with severe symptoms of this mosquito-transmitted disease. The post As robins disperse, West Nile mosquitoes switch diet to humans: Q&A with Smithsonian ornithologist Peter Marra appeared first on Smithsonian Insider. Full Article Animals Q & A Research News Science & Nature birds Caribbean conservation conservation biology mammals Migratory Bird Center migratory birds veterinary medicine
uma Relocating elephants fails to decrease human–wildlife conflict By insider.si.edu Published On :: Mon, 10 Dec 2012 15:38:47 +0000 Smithsonian scientists and partners find that technique meant to keep animals and humans safe has opposite effects. The post Relocating elephants fails to decrease human–wildlife conflict appeared first on Smithsonian Insider. Full Article Animals Science & Nature conservation conservation biology endangered species Smithsonian's National Zoo
uma Human shadow cast over the Caribbean slows coral growth By insider.si.edu Published On :: Tue, 09 Apr 2013 11:14:19 +0000 Striking Caribbean sunsets occur when particles in the air scatter incoming sunlight. But a particulate shadow over the sea may have effects underwater. A research […] The post Human shadow cast over the Caribbean slows coral growth appeared first on Smithsonian Insider. Full Article Marine Science Research News Science & Nature biodiversity carbon dioxide Caribbean climate change conservation biology coral reefs ocean acidification pollution Tropical Research Institute
uma Forensic analysis of 17th-century human remains at Jamestown, Va., reveals evidence of survival cannibalism By insider.si.edu Published On :: Wed, 01 May 2013 15:04:04 +0000 Douglas Owsley, the division head for physical anthropology at the Smithsonian’s National Museum of Natural History, presented today a forensic analysis of 17th-century human remains […] The post Forensic analysis of 17th-century human remains at Jamestown, Va., reveals evidence of survival cannibalism appeared first on Smithsonian Insider. Full Article Anthropology Research News Science & Nature National Museum of Natural History
uma Effects of human impact are long lasting for forests in Northeast U.S. By insider.si.edu Published On :: Wed, 18 Sep 2013 14:48:31 +0000 Grow fast, die young is not a lifestyle normally associated with trees. But in the forests of the Northeastern United States the red maple follows […] The post Effects of human impact are long lasting for forests in Northeast U.S. appeared first on Smithsonian Insider. Full Article Research News Science & Nature biodiversity birds carbon dioxide climate change conservation conservation biology insects Smithsonian Conservation Biology Institute
uma Losing large mammals increases human risk from rodent-borne diseases By insider.si.edu Published On :: Mon, 28 Apr 2014 19:14:41 +0000 Save the Rhinos! Save the Elephants! Save the humans?! It seems strange to be connecting our own fate to that of wildlife but new research […] The post Losing large mammals increases human risk from rodent-borne diseases appeared first on Smithsonian Insider. Full Article Animals Q & A Research News Science & Nature biodiversity conservation biology endangered species mammals National Museum of Natural History veterinary medicine
uma Interstellar exploration – five planets where humans may (or may not) be able to live someday By insider.si.edu Published On :: Mon, 10 Nov 2014 17:54:43 +0000 Unless you live under a lunar rock, you’ve probably heard about or seen director Christopher Nolan’s latest blockbuster “Interstellar.” Starring Anne Hathaway and Matthew McConaughey, […] The post Interstellar exploration – five planets where humans may (or may not) be able to live someday appeared first on Smithsonian Insider. Full Article Research News Science & Nature Space planets
uma Smithsonian Scientists Trace Anthropocene Roots to Early Human Activity By insider.si.edu Published On :: Wed, 16 Dec 2015 18:15:05 +0000 A new analysis of the fossil record by scientists at the Smithsonian’s National Museum of Natural History has revealed that the structure of plant and […] The post Smithsonian Scientists Trace Anthropocene Roots to Early Human Activity appeared first on Smithsonian Insider. Full Article Anthropology Dinosaurs & Fossils Research News Science & Nature climate change conservation biology technology
uma Human health risks of eating sea turtle eggs could benefit species By insider.si.edu Published On :: Fri, 02 Sep 2016 16:33:17 +0000 According to a new study, eating sea turtle eggs increases the health risk of heavy metal exposure in local communities in Panama and may provide […] The post Human health risks of eating sea turtle eggs could benefit species appeared first on Smithsonian Insider. Full Article Animals Marine Science Research News Science & Nature conservation biology endangered species extinction Tropical Research Institute
uma Sumatran tiger cub born National Zoo By insider.si.edu Published On :: Thu, 13 Jul 2017 15:52:35 +0000 Great Cats keepers at the Smithsonian’s National Zoo are celebrating the birth of a Sumatran tiger, a critically endangered species. The cub’s mother, 8-year-old Damai, […] The post Sumatran tiger cub born National Zoo appeared first on Smithsonian Insider. Full Article Science & Nature Spotlight