High-resolution single-crystal X-ray measurements of the monoclinic polymorph of bicalutamide and the aspherical atom databank approach have served as a basis for a reconstruction of the charge density distribution of the drug and its androgen receptor (AR) and albumin complexes. The contributions of various types of intermolecular interactions to the total crystal energy or ligand:AR energy were estimated. The cyan and amide groups secured the ligand placement in the albumin (Lys-137) and the AR binding pocket (Leu-704, Asn-705, Arg-752), and also determined the packing of the small-molecule crystals. The total electrostatic interaction energy on average was −230 kJ mol−1, comparable with the electrostatic lattice energy of the monoclinic bicalutamide polymorph. This is the result of similar distributions of electropositive and electronegative regions on the experimental and theoretical molecular electrostatic potential maps despite differences in molecular conformations. In general, bicalutamide interacted with the studied proteins with similar electrostatic interaction energies and adjusted its conformation and electrostatic potential to fit the binding pocket in such a way as to enhance the interactions, e.g. hydrogen bonds and π⋯π stacking.

The room-temperature experiment has been revisited for macromolecular crystallography. Despite being limited by radiation damage, such experiments reveal structural differences depending on temperature, and it is expected that they will be able to probe structures that are physiologically alive. For such experiments, the humid-air and glue-coating (HAG) method for humidity-controlled experiments is proposed. The HAG method improves the stability of most crystals in capillary-free experiments and is applicable at both cryogenic and ambient temperatures. To expand the thermal versatility of the HAG method, a new humidifier and a protein-crystal-handling workbench have been developed. The devices provide temperatures down to 4°C and successfully maintain growth at that temperature of bovine cytochrome c oxidase crystals, which are highly sensitive to temperature variation. Hence, the humidifier and protein-crystal-handling workbench have proved useful for temperature-sensitive samples and will help reveal temperature-dependent variations in protein structures.

A new temperature-controllable humidifier for X-ray diffraction has been developed. It is shown that the humidifier can successfully maintain protein crystal growth at a temperature lower than room temperature.

The effects of relative humidity on a tetragonal crystal form of hen egg white lysozyme are studied via in situ laboratory X-ray powder diffraction.

A new ZnII metallocryptand is presented, with an unprecedented diflexure helix.

The title compound, C11H11NO5, has a nearly planar geometry. In the crystal, the molecules are assembled into chains parallel to the [overline{1}11] direction by O—H...O and C—H...O hydrogen bonds.

The crystallization of amidase, the ultimate enzyme in the Trp-dependent auxin-biosynthesis pathway, from Arabidopsis thaliana was attempted using protein samples with at least 95% purity. Cube-shaped crystals that were assumed to be amidase crystals that belonged to space group I4 (unit-cell parameters a = b = 128.6, c = 249.7 Å) were obtained and diffracted to 3.0 Å resolution. Molecular replacement using structures from the PDB containing the amidase signature fold as search models was unsuccessful in yielding a convincing solution. Using the Sequence-Independent Molecular replacement Based on Available Databases (SIMBAD) program, it was discovered that the structure corresponded to dihydrolipoamide succinyltransferase from Escherichia coli (PDB entry 1c4t), which is considered to be a common crystallization contaminant protein. The structure was refined to an Rwork of 23.0% and an Rfree of 27.2% at 3.0 Å resolution. The structure was compared with others of the same protein deposited in the PDB. This is the first report of the structure of dihydrolipo­amide succinyltransferase isolated without an expression tag and in this novel crystal form.

The structure of a 22-base-pair RNA helix with mismatched pyrimidine base pairs is reported. The helix contains two symmetry-related CUG sequences: a triplet-repeat motif implicated in myotonic dystrophy type 1. The CUG repeat contains a U–U mismatch sandwiched between Watson–Crick pairs. Additionally, the center of the helix contains a dimerized UUCG motif with tandem pyrimidine (U–C/C–U) mismatches flanked by U–G wobble pairs. This region of the structure is significantly different from previously observed structures that share the same sequence and neighboring base pairs. The tandem pyrimidine mismatches are unusual and display sheared, cross-strand stacking geometries that locally constrict the helical width, a type of stacking previously associated with purines in internal loops. Thus, pyrimidine-rich regions of RNA have a high degree of structural diversity.

On April 4 the Smithsonian and the Massachusetts Institute of Technology will launch VANISHED, an 8-week online/offline environmental disaster mystery game for middle-school children, meant […]

The post Smithsonian and MIT to launch online mystery game for middle-shool children appeared first on Smithsonian Insider.

A recent decline in Ovenbirds (Seiurus aurocapilla), a ground-nesting migratory songbird, in forests in the northern Midwest United States is being linked by scientists to a seemingly unlikely culprit: earthworms.

The post Earthworms to blame for decline of Ovenbirds in northern Midwest forests, study reveals appeared first on Smithsonian Insider.

How did the earliest birds take wing? Did they fall from trees and learn to flap their forelimbs to avoid crashing? Or did they run […]

The post Baby bird study proves innate ability for midair maneuvers appeared first on Smithsonian Insider.

Named for Charles Darwin, the only known specimen of a newly discovered beetle, Darwinylus marcosi, died in a sticky battle in a gob of tree […]

The post Beetle and pollen trapped in 105 million-year-old amber reveal fourth major pollination mode in mid-Mesozoic appeared first on Smithsonian Insider.

In the first reported crystal structure involving the potential ligand N,N',N''-tris­(2-pyridin­yl)-1,3,5-benzene­tricarboxamide, inter­molecular N—H⋯O hydrogen bonds link the mol­ecules via their amide groups into slanted ladder-like chains. Only two of the three amide groups in the mol­ecule are involved in hydrogen bonding, which influences the degree of out-of-plane twisting at each amide group.

The asymmetric unit of the title compound contains two independent mol­ecules, consisting of perimidine and phenol units, which are linked through an N—H⋯O hydrogen bond. Intra­molecular O—H⋯N hydrogen bonds are observed in both independent mol­ecules.

The asymmetric unit of the title compound, C17H14N2O, contains two independent molecules each consisting of perimidine and phenol units. The tricyclic perimidine units contain naphthalene ring systems and non-planar C4N2 rings adopting envelope conformations with the C atoms of the NCN groups hinged by 44.11 (7) and 48.50 (6)° with respect to the best planes of the other five atoms. Intramolecular O—H...N hydrogen bonds may help to consolidate the molecular conformations. The two independent molecules are linked through an N—H...O hydrogen bond. The Hirshfeld surface analysis of the crystal structure indicates that the most important contributions for the crystal packing are from H...H (52.9%) and H...C/C...H (39.5%) interactions. Hydrogen bonding and van der Waals interactions are the dominant interactions in the crystal packing. Density functional theory (DFT) optimized structures at the B3LYP/ 6–311 G(d,p) level are compared with the experimentally determined molecular structure in the solid state. The HOMO–LUMO behaviour was elucidated to determine the energy gap.

In the first reported crystal structure involving the potential ligand N,N',N''-tris(pyridin-2-yl)benzene-1,3,5-tricarboxamide, C24H18N6O3, intermolecular N—H...O hydrogen bonds link the molecules via their amide groups into slanted ladder-like chains, in which the uprights of the ladder are formed by the hydrogen-bonding interactions and the benzene ring cores of the molecules act as the rungs of the ladder. Only two of the three amide groups in the molecule are involved in hydrogen bonding and this influences the degree of out-of-plane twisting at each amide group, with the twist being more significant for those amide groups participating in hydrogen bonds.

As the Covid-19 pandemic spreads, commercial payments volumes have declined across the globe due to...

While scientists have made remarkable advancements in astronomy and astrophysics since the beginning of this decade – notably the first detection of gravitational waves and the discovery of distant Earth-like planets – unforeseen constraints have slowed progress toward reaching some of the priorities and goals outlined in the Academies’ 2010 decadal survey of these disciplines, says a new report from the National Academies of Sciences, Engineering, and Medicine.

Recent gains against the burden of illness, injury, and disability and commitment to universal health coverage (UHC) are insufficient to close the enormous gaps that remain between what is achievable in human health and where global health stands today, says a new report from the National Academies of Sciences, Engineering, and Medicine.

As new evidence about climate change and sea-level rise in South Florida continues to emerge, agencies responsible for the restoration of the Everglades should conduct a mid course assessment that rigorously analyzes scenarios of future change to the region’s ecosystem in its planning, says a new congressionally mandated report by the National Academies of Sciences, Engineering, and Medicine.

Rick Bright filed a complaint this week with the Office of Special Counsel, a government agency responsible for whistleblower complaints.; Credit: /Public Health Emergency via AP

Attorneys for Rick Bright, the government scientist who said he had been reassigned and subsequently filed a whistleblower complaint, say a government watchdog agrees that he should be reinstated to his post.

Bright was serving as director of the Biomedical Advanced Research and Development Authority, which is working on a vaccine to combat the coronavirus.

He said he was ousted from the position last month because he wanted to spend money on safe and vetted treatments for COVID-19 — not on ones without "scientific merit," such as hydroxychloroquine, the anti-malarial drug that President Trump and others had been touting.

Trump on Wednesday called Bright "a disgruntled employee who's trying to help the Democrats win an election."

Bright's attorneys say that the Office of Special Counsel, which hears whistleblower cases, determined there were "reasonable grounds" to believe that his removal was retaliatory and therefore prohibited.

Bright's attorneys say OSC plans to contact the Department of Health and Human Services to request that it put Bright's removal on hold for 45 days so the office can complete its investigation into the allegations.

The OSC said it "cannot comment on or confirm the status of open investigations."

In a statement to NPR, Caitlin Oakley, a spokesperson for HHS, said: "This is a personnel matter that is currently under review. However, HHS strongly disagrees with the allegations and characterizations in the complaint from Dr. Bright."

This content is from Southern California Public Radio. View the original story at SCPR.org.

Texas Gov. Greg Abbott signed an executive order banning all elective medical procedures, including abortions, during the coronavirus outbreak. The ban extends to medication abortions.; Credit: Eric Gay/AP

Governors across the country are banning elective surgery as a means of halting the spread of the coronavirus. But in a handful of states that ban is being extended to include a ban on all abortions.

So far the courts have intervened to keep most clinics open. The outlier is Texas, where the U.S. Court of Appeals for the Fifth Circuit this week upheld the governor's abortion ban.

Four years ago, Texas was also the focus of a fierce legal fight that ultimately led to a U.S. Supreme Court ruling in which the justices struck down a Texas law purportedly aimed at protecting women's health. The court ruled the law was medically unnecessary and unconstitutional.

Now Texas is once again the epicenter of the legal fight around abortion. In other states--Ohio, Iowa, Alabama, and Oklahoma--the courts so far have sided with abortion providers and their patients.

Not so in Texas where Gov. Greg Abbott signed an executive order barring all "non-essential" medical procedures in the state, including abortion. The executive order was temporarily blocked in the district court, but the Fifth Circuit subsequently upheld the governor's order by a 2-to-1 vote, declaring that "all public constitutional rights may be reasonably restricted to combat a public health emergency."

"No more elective medical procedures can be done in the state because of the potential of needing both people ... beds and supplies, and obviously doctors and nurses," said Texas Attorney General Ken Paxton in an interview with NPR.

'Exploiting This Crisis'

Nancy Northrup, CEO of the Center for Reproductive Rights, sees things very differently. "It is very clear that anti-abortion rights politicians are shamelessly exploiting this crisis to achieve what has been their longstanding ideological goal to ban abortion in the U.S.," she said.

Paxton denies that, saying Texas "is not targeting any particular group."
The state's the "only goal is to protect people from dying," he said.

Yet the American Medical Association just last week filed a brief in this case in support of abortion providers, as did 18 states, led by New York, which is the state that has been the hardest hit by the coronavirus.

They maintain that banning abortion is far more dangerous,because it will force women to travel long distances to get one. A study from the Guttmacher Institute found that people seeking abortions during the COVID-19 outbreak would have to travel up to 20 times farther than normal if states successfully ban abortion care during the pandemic. The AMA also notes that pregnant women do not stop needing medical care if they don't get an abortion.

Northrup, of the Center for Reproductive Rights, sees this as more evidence that the ban is a calculated move by the state: what "puts the lie to this is the fact that they're trying to ban medication, abortion as well; that's the use of pills for abortion.

"Those do not need to take place in a clinic and they can be done, taken effectively by tele-medicine. So it shows that the real goal here, tragically, is shutting down one's right to make the decision to end the pregnancy, not a legitimate public health response."

'I Was Desperate'

Affidavits filed in the Texas case tell of harrowing experiences already happening as the result of the Texas ban. One declaration was filed by a 24-year-old college student. The week she lost her part-time job as a waitress, she found out she was pregnant. She and her partner agreed they wanted to terminate the pregnancy, and on March 20 she went to a clinic in Forth Worth alone; because of social distancing rules, her partner was not allowed to go with her.

Since she was 10 weeks pregnant, still in her first trimester, she was eligible for a medication abortion. Under state law, she had to wait 24 hours before getting the pills at the clinic, but the night before her scheduled appointment, the clinic called to cancel because of Abbott's executive order.

He partner was with her and we "cried together," she wrote in her declaration. "I couldn't risk the possibility that I would run out of time to have an abortion while the outbreak continued," and it "seemed to be getting more and more difficult to travel."

She made many calls to clinics in New Mexico and Oklahoma. The quickest option was Denver--a 12-hour drive, 780-mile drive from where she lives. Her partner was still working, so her best friend agreed to go with her. They packed sanitizing supplies and food in the car for the long drive and arrived at the Denver Clinic on March 26, where she noticed other cars with Texas plates in the parking lot, according to the affidavit.

At the clinic, she was examined, given a sonogram again, and because Colorado does not have a 24-hour waiting requirement, she was given her first abortion pill without delay and told she should try to get home within 30 hours to take the second pill.

She and her friend then turned around to go home. They were terrified she would have the abortion in the car, and tried to drive through without taking breaks. But after six hours, when it turned dark they were so exhausted they had to stop at a motel to catch some sleep. The woman finally got home and took the second pill just within the 30-hour window.

She said that despite the ordeal she was grateful she had the money, the car, the friend, and the supportive partner with a job, to make the abortion possible. Others will not be so lucky, she wrote. But "I was desperate and desperate people take desperate steps to protect themselves."

A 'Narrative' Of Choice

Paxton, the Texas attorney general, does not seem moved by the time limitations that pregnancy imposes, or the hardships of traveling out of state to get an abortion. He told NPR "the narrative has always been 'It's a choice' ... that's the whole narrative. I'm a little surprised by the question, given that's always been the thing."

On Thursday abortion providers and their patients returned to the district court in Texas instead of appealing directly to the U.S. Supreme Court to overturn the Fifth Circuit's ruling from earlier this week. The district court judge, who originally blocked the governor's ban, instead narrowed the governor's order so that medical abortions--with pills--would be exempt from the ban, as well as abortions for women who are up against the state-imposed deadline. Abortions in Texas are banned after 22 weeks.

In the end, though, this case may well be headed to the U.S. Supreme Court. And because of the addition of two Trump appointees since 2016--the composition of the court is a lot more hostile to abortion rights.

This content is from Southern California Public Radio. View the original story at SCPR.org.

; Credit: /Jackie Ferrentino for NPR

A lot is at stake for students taking Advanced Placement exams, even in normal times. If you score high enough, you can earn college credit. It's also a big factor in college applications. But for some students, the idea of studying right now feels impossible.

"I'm constantly thinking about making sure my family doesn't get sick and I don't get sick," says Elise, a high school junior outside Boston. (We're not using her full name because she's worried about hurting her college applications.)

Concerns about the coronavirus have put most standardized tests, such as the SAT and ACT, on hold this spring. But AP exams are going forward with a new online format — and that's raising questions about fairness.

Elise, 17, says she spent months preparing for what is typically a three-hour, multiple-choice and essay-based exam; she was blindsided when she learned it will now be an online, 45-minute, open-response test.

"I have no idea what I'm going to get when I open that test," she says.

Elise was hoping the College Board, which administers AP exams, would cancel this year's exams, as it did the spring SATs. But since the tests are being offered, she says she feels she has to take them. She worries it would look bad on her college applications if she opted out.

For other students, just the idea of taking the exam at home is causing anxiety. Kayleen Guzman, 17, from Boston says it's hard to find peace and quiet in her house right now.

"Currently, it's me, my mom, my dog, my sister and my stepdad," she explains. "Sometimes I feel like it's too much chaos."

But Guzman is glad she still has the opportunity to take the AP exams at all this year. She says she worked hard in her two AP classes and she wants the chance to earn college credit.

However, it's still unclear how much credit colleges will give students for this year's exams.

"None of us would say that we are confident that a 3 or 4 or 5 on the AP exam this year means the exact same thing as a 3, 4 and 5 on the exam last year," says Harvard University's Andrew Ho, who studies the reliability of educational tests.

Ho says that because of the new format, this year's AP exams won't be measuring the same thing as previous years' exams. For one, the new tests will cover less material. And changing where kids take it — from a proctored classroom to their laptops at home — is a big deal. But Ho adds, "Just because it's not completely comparable doesn't mean the College Board and colleges, through their own policies, couldn't adjust."

Some colleges are already adjusting. The University of California system has come out explicitly to say it won't change the way it credits AP scores. Other colleges that didn't want to go on the record say they are planning to change their policies, but the details weren't ready to share just yet.

In a statement, College Board spokesperson Jerome White said the organization decided to move forward with AP testing to give motivated students the opportunity to earn college credit. He added that the organization is making "a significant financial investment" to make the exams available online, from cheating prevention software to helping students who may not have an Internet connection or access to a computer.

Still, some educators worry that those efforts won't be enough.

"This situation has created a lot of distraction," says Savannah Lodge-Scharff, an AP Physics teacher for Boston Public Schools. She argues that without in-person classes, many students won't be able to engage with the material in the same way. On top of that, financial stress means many of her students are juggling additional responsibilities, like taking care of siblings.

"I have some of my students who are working 40, 50, 60 hours a week at the grocery store right now in the fear their parents are going to be laid off," she explains.

And then there's the question of geographic equity. This year's exams will be administered at the same time worldwide, meaning students in Hong Kong will be up at midnight to take it.

This content is from Southern California Public Radio. View the original story at SCPR.org.

; Credit: Fanatic Studio/Gary Waters/Science Photo Library/Getty Images

There has been a rise in the number of minors contacting the National Sexual Assault Hotline to report abuse. That's according to RAINN, the Rape, Abuse and Incest National Network, which runs the hotline.

By the end of March, with much of the country under lockdown, there was a 22% increase in monthly calls from people younger than 18, and half of all incoming contacts were from minors. That's a first in RAINN's history, Camille Cooper, the organization's vice president of public policy, tells NPR.

Of those young people who contacted the hotline in March, 67% identified their perpetrator as a family member and 79% said they were currently living with that perpetrator. In 1 out of 5 cases where the minor was living with their abuser, RAINN assisted the minor in immediately contacting police.

"As a result of looking at the information that we had from those sessions, it was clear that the abuse was escalating in both frequency and severity," Cooper says. "So a lot of the kids that were coming to the hotline were feeling pretty vulnerable and traumatized. And it was a direct result of COVID-19, because they were quarantined with their abuser. The abuser was now abusing them on a daily basis."

Lockdown orders are first and foremost public health and safety measures. But statistically speaking, home is not the safest place for every young person. RAINN reports that about 34% of child sexual abusers are family members. Closing schools and canceling youth activities like sports removes children from the watchful eyes of "mandatory reporters" — those trusted adults, like teachers, nurses and child care providers, who are required by law in most states to report suspicions of child abuse or neglect.

However, Cooper says her organization has confirmed with authorities around the country that the child welfare system is still operating during the pandemic. That is, an official report of current and ongoing abuse will still trigger an investigation, and, if necessary, a child will be removed from the home.

"[Child welfare workers] will be coming to the home in person and proceeding with a formal investigation and a child forensic interview and things like that," she says. If the abuse is farther in the past and the child is not quarantined with the accused, Cooper says, the interview may take place over video chat.

In the meantime, RAINN and other child welfare organizations are lobbying to make it easier for children to report abuse. Cooper says, "One of the solutions we came up with that we are now currently working directly with the leadership in Congress on is to get all of the online learning platforms that children are interacting with to have a reporting function on that platform in plain sight for children."

This content is from Southern California Public Radio. View the original story at SCPR.org.

Education Secretary Betsy DeVos says there is 'no reason' to waive main parts of the federal special education law.; Credit: Alex Brandon/AP

U.S. Education Secretary Betsy DeVos will not recommend that Congress waive the main requirements of three federal education laws, including the Individuals with Disabilities Education Act, known as IDEA. The federal law ensures that children with disabilities have a right to a free, appropriate public education whenever and wherever schools are operating.

When Congress passed the coronavirus relief package, known as the CARES act, they included a provision that allowed the Secretary to request waivers to parts of the special education law during the pandemic. The concern was that holding strictly to IDEA and other laws could hinder schools in the urgency to move schooling from the classroom setting to online and home-based approaches.

Th waiver provision, however, made disability advocates nervous. "We're talking about waiving a civil right for our most vulnerable people in our society, children who don't vote, who have no voice, who are relying on their parents to advocate for them," Stephanie Langer, a Florida civil rights attorney who focuses on education and disability, told NPR in March.

But the Education Department came to the conclusions that in general, big changes weren't needed. "While the Department has provided extensive flexibility to help schools transition," Devos said in a statement, "there is no reason for Congress to waive any provision designed to keep students learning."

While the bulk of the IDEA remains unchanged, Devos did issue limited waivers to a few sections of the law, including one that will extend the timeline schools have to offer services. The provision that bans discrimination based on disability status, will go untouched.

"This is truly a celebration," says Kelly Grillo, a special education coordinator in Indiana. "My teams are elated to keep IDEA intact. Waivers would seriously threaten equitable education."

As schools and learning have moved online, one of the biggest challenges has been providing special education. School districts were concerned they might get sued if their digital offerings couldn't meet the needs of their students with disabilities, though the Education Department issued guidance in March telling schools to be flexible, writing in a fact sheet that disability law, "should not prevent any school from offering educational programs through distance instruction."

Educators say that flexibility helped them improve their offerings for students. "This situation made us get creative and actually allowed us to have an all-hands-on-deck approach," says Grillo.

But advocates warn there are still areas to watch, including in New Jersey, where parents have been asked to waive their right to sue before districts are able to provide their children with special education services.

This content is from Southern California Public Radio. View the original story at SCPR.org.

Pedestrians walk by the Castro Theatre that has a marquee announcing that they are closed due to a statewide ordinance banning gatherings of more than 250 people in San Francisco, California. ; Credit: Justin Sullivan/Getty Images

Hollywood has come to a stand still. The film and entertainment industry has been hit hard by the coronavirus outbreak as theaters close, film releases and events are being postponed, and studios are putting a pause on film production.

The gravity of the coronavirus is being felt all throughout the country and Hollywood is not coming out of the outbreak unscathed. Social distancing measures being enforced to help control the outbreak has studios and theatres taking a huge hit. It’s predicted that about 170,000 people in the film industry will lose their jobs. Many of the lowest-paid positions and freelance jobs have been the first to go. From events to films, the industry is trying to strategize around the outbreak with no clear picture on how long these conditions could last. Hollywood unions, activist groups and nonprofits are coming together to help provide some kind of emergency relief for workers who are getting hit the hardest. It’s been a period of economic shock for the entertainment industry and it’s still too early to see what Hollywood could look like after the outbreak is over.

Today on AirTalk, we check-in with people in the entertainment industry who have been impacted by the outbreak and where might Hollywood go from here. If you work in entertainment, we'd like to hear from you! How are you coping as most productions are shut down? Join the live conversation by calling 866-893-5722.

Guest:

Andrew Wallenstein, co-editor-in-chief at Variety; he tweets @awallenstein

This content is from Southern California Public Radio. View the original story at SCPR.org.

Rick Bright filed a complaint this week with the Office of Special Counsel, a government agency responsible for whistleblower complaints.; Credit: /Public Health Emergency via AP

Attorneys for Rick Bright, the government scientist who said he had been reassigned and subsequently filed a whistleblower complaint, say a government watchdog agrees that he should be reinstated to his post.

Bright was serving as director of the Biomedical Advanced Research and Development Authority, which is working on a vaccine to combat the coronavirus.

He said he was ousted from the position last month because he wanted to spend money on safe and vetted treatments for COVID-19 — not on ones without "scientific merit," such as hydroxychloroquine, the anti-malarial drug that President Trump and others had been touting.

Trump on Wednesday called Bright "a disgruntled employee who's trying to help the Democrats win an election."

Bright's attorneys say that the Office of Special Counsel, which hears whistleblower cases, determined there were "reasonable grounds" to believe that his removal was retaliatory and therefore prohibited.

Bright's attorneys say OSC plans to contact the Department of Health and Human Services to request that it put Bright's removal on hold for 45 days so the office can complete its investigation into the allegations.

The OSC said it "cannot comment on or confirm the status of open investigations."

In a statement to NPR, Caitlin Oakley, a spokesperson for HHS, said: "This is a personnel matter that is currently under review. However, HHS strongly disagrees with the allegations and characterizations in the complaint from Dr. Bright."

This content is from Southern California Public Radio. View the original story at SCPR.org.

American Express has

Outputs of conservation planning research are likely to be translated into action more quickly and successfully if a transdisciplinary approach is adopted, according to a recent study. The researchers have applied a transdisciplinary framework 'pyramid of knowledge' to aid in understanding the process of converting research into action, which may also be applicable to other academic disciplines.

Online retailers such as Myntra and Tjori have their consumer engagement teams working on to engage their customers till the time the lockdown eases.

DDoS attacks during the first three months of this year have seen a significant spike in attacks on educational websites.

Companies like Sony, Samsung, Panasonic, Haier and Godrej Appliance are leveraging Livechat, WhatsApp, DIY video as well as on-call assistance, and helping remotely on real time basis as their service centres are closed in compliance with the government directives.

There are more than 30,000 microwave ovens, AC and washing machines which needs repair at a time when Indians are locked indoors and doing household chores themselves due to the lockdown.

As revenues dry up from traditional streams of mobility services amidst slowdown, intense competition and price wars, telcos are now focusing on emerging technologies and core emerging services, especially in the areas of IoT

DDoS attacks during the first three months of this year have seen a significant spike in attacks on educational websites.

Wastewater sludge is widely used to remove toxic polycyclic aromatic hydrocarbons (PAHs) from soil, and yet the mechanisms underlying this process remain unclear. A new study reveals the extent of PAH removal following different treatments, and could provide a useful resource for those looking to diminish the effects that these pollutants have both on people and on the environment.

Up to 90% of consumed drugs enter the environment. This may have negative effects on wildlife, especially when the drugs take long periods to break down. This study assessed the breakdown of sulphonamides — a class of antibacterials — in samples from two rivers in Poland. The results showed that sulphamethoxazole, a common veterinary antibiotic, was the most persistent and that various factors inhibit degradation, including low temperatures, heavy metal pollution and low pH.

THE Premier has moved quickly to placate angry landlords by offering to help struggling Tasmanians pay their rent.

THE small pool of houses for sale in Greater Hobart is getting smaller.

FREDERICKSBURG, Va. ⸺  Long-term repair work is underway to rebuild state-maintained roads that sustained severe damage during Tropical Storm...

It’s the same story whether you’re a celeb or a pleb - we’re all getting on each other’s nerves in lockdown. And it’s the same story for Kim and Kanye.

Josh Shaw returned his best figures of the season as Gloucestershire gained the upper hand by bowling Middlesex out on the opening day of their County Championship clash in Northwood.

Tim Murtagh grabbed his fourth five-wicket haul in the County Championship this season as Middlesex rolled Gloucestershire over for 137 to clinch victory inside three days at Merchant Taylors’ School.

Steven Finn feels Middlesex’s Vitality Blast side possess similar qualities to the team that clinched the county’s first and only T20 triumph 11 years ago.

Middlesbrough stand between Watford Ladies and a place in the FAWNL Plate final after the Golden Girls swept aside Chichester City 4-0 to march into the last four.

The bad weather has caused yet more frustration for Watford Ladies after their FAWNL Plate semi-final at Middlesbrough tomorrow was postponed.