SUMMARY:

The 2021 World Health Organization Classification of Tumors of the Central Nervous System (CNS5), introduced significant changes, impacting tumors ranging from glial to ependymal neoplasms. Ependymal tumors were previously classified and graded based on histopathology, which had limited clinical and prognostic utility. The updated CNS5 classification now divides ependymomas into 10 subgroups based on anatomic location (supratentorial, posterior fossa, and spinal compartment) and genomic markers. Supratentorial tumors are defined by zinc finger translocation associated (ZFTA) (formerly v-rel avian reticuloendotheliosis viral oncogene [RELA]), or yes-associated protein 1 (YAP1) fusion; posterior fossa tumors are classified into groups A (PFA) and B (PFB), spinal ependymomas are defined by MYCN amplification. Subependymomas are present across all these anatomic compartments. The new classification kept an open category of "not elsewhere classified" or "not otherwise specified" if no pathogenic gene fusion is identified or if the molecular diagnosis is not feasible. Although there is significant overlap in the imaging findings of these tumors, a neuroradiologist needs to be familiar with updated CNS5 classification to understand tumor behavior, for example, the higher tendency for tumor recurrence along the dural flap for ZFTA fusion-positive ependymomas. On imaging, supratentorial ZFTA-fused ependymomas are preferentially located in the cerebral cortex, carrying predominant cystic components. YAP1-MAMLD1-fused ependymomas are intra- or periventricular with prominent multinodular solid components and have significantly better prognosis than ZFTA-fused counterparts. PFA ependymomas are aggressive paramedian masses with frequent calcification, seen in young children, originating from the lateral part of the fourth ventricular roof. PFB ependymomas are usually midline, noncalcified solid-cystic masses seen in adolescents and young adults arising from the fourth ventricular floor. PFA has a poorer prognosis, higher recurrence, and higher metastatic rate than PFB. Myxopapillary spinal ependymomas are now considered grade II due to high recurrence rates. Spinal-MYCN ependymomas are aggressive tumors with frequent leptomeningeal spread, relapse, and poor prognosis. Subependymomas are noninvasive, intraventricular, slow-growing benign tumors with an excellent prognosis. Currently, the molecular classification does not enhance the clinicopathologic understanding of subependymoma and myxopapillary categories. However, given the molecular advancements, this will likely change in the future. This review provides an updated molecular classification of ependymoma, discusses the individual imaging characteristics, and briefly outlines the latest targeted molecular therapies.

Family business Graham’s Family Dairy has secured a multinational listing

It’s a tiny cast with just Chris, Anna Marie, and Kelley. PS5 blood money is being thrown around, while Kelley curses the asthma tax. Chris is simulating his real life job in a game that simulates his job. Anna Marie re-discovers she doesn’t like SMT. And everyone agrees cutscenes need both pause and skip options.

The post RPG Cast – Episode 592: “First World Donut Problems” appeared first on RPGamer.

Capcom has updated its list of Platinum Titles, games that have sold over one million units as of September 30, 2024. The list includes 122 games with sales over one million units, 64 over two million units, 14 over five million units, and six over 10 million units sold.

Resident Evil 4 remake sold 400,000 units to bring lifetime sales to eight million units, Resident Evil 2 remake sold 300,000 units to bring sales to 14.5 million units, and Resident Evil 3 remake sold 200,000 units to bring lifetime sales to 9.2 million units. 

Resident Evil 7: biohazard sold 300,000 units to bring lifetime sales to 14 million units and Resident Evil Village sold 400,000 units to bring sales to 10.5 million units.

Monster Hunter Rise sold 600,000 units in the quarter to bring lifetime sales to 16 million units. Monster Hunter Rise: Sunbreak sold 400,000 units to bring lifetime sales to 8.8 million units.

Monster Hunter: World sold 400,000 units in the quarter to bring lifetime sales to 20.9 million units, while the Iceborne expansion sold 600,000 units for a total of 14 million units.

Dragon's Dogma 2 sold 300,000 units in the quarter to bring lifetime sales to 3.3 million units. Street Fighter 6 sold 400,000 units in the quarter to bring lifetime sales to 4.1 million units. Devil May Cry 5 sold 300,000 units to bring sales to 8.7 million units. 

Check out the complete list below:

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463020/capcom-updates-its-best-sellers-list-monster-hunter-world-at-209m-re4-remake-at-8m-more/

Nintendo announced it will host a Super Nintendo World Direct livestream on Monday, November 11 at 2:00 pm PT / 5:00 pm ET. You will be able to watch it on YouTube.

The Direct will be roughly 10 minutes and feature the Donkey Kong Country area of Super Nintendo World at Universal Studios Japan.

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463031/super-nintendo-world-direct-set-for-november-11/

Nintendo today hosted a Super Nintendo World Direct livestream that featured Shigeru Miyamoto giving a deep dive look into the Donkey Kong Country-themed land.

The new land will feature a family roller coaster, called Mine-Cart Madness, congas you can hit to a rhythm, letters that can found throughout the land that can be scanned on the new Donkey Kong Power-Up Band, character meet and greets, and new food options.

Donkey Kong Country will open at Universal Studios Japan on December 11, 2024, and will also be a part of Super Nintendo World at Epic Universe in Florida when the theme park opens in May 2025.

View the Direct below:

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463038/super-nintendo-world-direct-dives-into-the-donkey-kong-country-themed-land/

I never completed the original Red Dead Redemption, but not for the usual reasons of being terrible at the game, or thinking that open worlds are too big and boring these days and I just want to lie down forever and watch anime. I never finished it because my Xbox 360 version was not, in practice, an open world game, but a lonely farm at the bottom of a vortex of butchered spacetime. In the prologue, reformed outlaw John Marston confronts an old bandit acquaintance and gets himself roundly shot to bits. He’s rescued by local rancher Bonnie MacFarlane, who nurses him back to health and gives him a few odd jobs to warm him up for the next plot point.

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Palworld developers Pocketpair have finally revealed which patents Nintendo and the Pokémon Company are suing them about. It looks like they're focusing on the act of throwing capsular items to catch or release monsters, together with the usage of monsters as mounts.

If you've somehow yet to encounter Palworld, it's a bestselling survival game that takes hefty - some would say, scandalous - inspiration from Pokémon, with players poaching Pokésque critters using magic spheres, and deploying them as soldiers and minions.

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The James Webb Space Telescope has spotted six strange worlds the size of planets that formed like stars – and the smallest may be building its own miniature solar system

Greg Eghigian's After the Flying Saucers Came and Luis Elizondo's Imminent both show how our fascination with UFOs goes beyond simple curiosity

See the world's best space images from the Astronomy Photographer of the Year 2024 award

Supremacy, a new book from tech journalist Parmy Olson, takes us inside the rise of machine learning and AI, and examines the people behind it

Four-legged robot dogs learned to perform new tricks by practising in a virtual platform that mimics real-world obstacles – a possible shortcut for training robots faster and more accurately

Meta had huge success last year with its flagship Quest 3 VR headset and it is back with a significantly cheaper 3S device that compromises on visuals but still delivers a great experience

The Pokemon Company is teaming up with content creators to stage a 24-hour unboxing live stream for its new Scarlet & Violet - Surging Sparks card set as you Gotta Catch 'Em All

Kurt “CyberGuy" Knutsson discusses how Axiom Space and luxury designer Prada are collaborating on NASA's Artemis III spacesuit design.

HARRY KANE is now the clear favourite to win the World Cup Golden Boot after his hat-trick against Panama..

In Canada, your IP address has the right to remain silent. Elon Musk is suing OpenAI for not being Open. Apple faces a class action not allowing competitive access to backup services and the World Server Throwing Competition in March 2024 is accused of being too violent towards servers.   All this and more on the […]

Facing an unprecedented crisis, IT World Canada, a beacon of technology journalism, is on the brink of closure. This poses a critical question: Without IT World Canada, who will narrate Canada’s tech story? After decades of serving the Canadian tech industry, IT World Canada needs help to survive. As of midnight tonight, the company is […]

The spy writing star, whose series has become a huge television hit starring Gary Oldman, is to chair the Theakston Old Peculier Crime Writing Festival 2025

However, the comparative Win 11 AMD tests were on an unpatched (L3 cache, CPPC2) PC.

Archaeologists say they have discovered the oldest known evidence for intensive ochre mining worldwide, at least 48,000 years ago, in Lion Cavern at Ngwenya in Eswatini, a landlocked country in southern Africa.

The post Lion Cavern in Eswatini is World’s Oldest Ochre Mine, Archaeologists Say appeared first on Sci.News: Breaking Science News.

Climate change is extending mosquito season and helping to drive outbreaks of dengue fever, Oropouche virus and eastern equine encephalitis

Experts predict that the number of cancer cases around the world will skyrocket, resulting in millions more fatalities by 2050

More blazes break out where wild land and urban areas overlap.

The storm decimated a region rich with dozens of species already struggling with habitat loss and disease

Operation Synergia II took aim at phishing, ransomware, and information stealing.

The conflict in Syria rages on, the United States' relationship with Iran remains strained, and China is taking hold as an emerging superpower. As part of TOTN's "Looking Ahead" series, NPR commentator Ted Koppel looks to the future of international relations.

Tickets for the event will go on sale on November 10, 2024, via BookMyShow

Directed by Julius Onah, the upcoming film sees Ford as President Thaddeus “Thunderbolt” Ross, who offers Wilson an official role within the military, hoping to make Captain America a government ally

Hello gentle readers, and welcome to the SwitchArcade Round-Up for August 19th, 2024. It’s the beginning of a new week, …

Continue reading "SwitchArcade Round-Up: Reviews Featuring ‘SteamWorld Heist II’, Plus the Latest Releases and Sales"

Another mobile reveal from Gamescom Opening Night Live 2024 was the latest trailer for the open world dress up game …

Continue reading "Open World Dress Up Game ‘Infinity Nikki’ Gets New Trailer With Closed Beta Sign Ups Now Live, Pre-Registrations Also Available"

Following pre-installation going live earlier in the week, HoYoverse has just released the major Genshin Impact (Free) version 5.0 “Flowers …

Continue reading "‘Genshin Impact’ Version 5.0 Update Is Now Available Worldwide on iOS, Android, PC, PS5, and More"

Fans of Jujutsu Kaisen and beautiful, anime-inspired JRPGs received a special reason to rejoice this week following the announcement that …

Continue reading "BILIBILI GAME Will Launch ‘Jujutsu Kaisen Mobile’ Worldwide Before the End of 2024"

The former striker will depart the programme at the end of the 2024/25 season

Screaming girls. Sudden riches. Your face on the cover of Smash Hits magazine. Life in a Nineties boyband sounds like a dream, but one survivor of the maelstrom likens it more to being in the military. Jessie Thompson goes behind the scenes of revealing new BBC documentary ‘Boybands Forever’

Given all the contradictory expectations we have for clothes, it’s easy to get your kickers in a twist, but finding the right clothes as a non-binary person challenges those expectations. ...

The post Navigating Non-Binary Fashion In A Binary World appeared first on Star Observer.

If you're looking for a place to live and you don't mind some seriously frosty winters, you have plenty of options to choose from. But some places endure more than a few blustery months, and no parka or insulated mittens will feel like enough. Those are contenders for the title of coldest city in the world.

Any avid traveler knows there are far too many gorgeous landscapes and jaw-dropping views to make one all-encompassing list of the most beautiful countries in the world. We're lucky to have such a diverse world, and beauty is subjective.

His early personnel choices indicate his incoming administration would be willing to use sticks as well as carrots to deal with Russia.

Canada’s privacy commissioner has launched an investigation into the World Anti-Doping Agency (WADA) and “its handling of biological samples collected from athletes.”

Dec 15, 2023

Calder Walton writes that if proved, Victor Manuel Rocha's espionage would place him among the longest-serving spies in modern times. Allowing him to operate as a spy in the senior echelons of the U.S. government for so long would represent a staggering U.S. security failure.

The columnist puts the spotlight on India’s star female wrestlers who have accused Wrestling Federation of India chief Brij Bhushan Sharan Singh of serial sexual harassment

Dec 8, 2022

A conversation hosted by the Woodrow Wilson Center featuring Ambassador Paula J. Dobriansky and Dr. Melvyn Leffler for a discussion on the role that U.S. President Ronald Reagan played in the peaceful end of the Cold War.