Angola's Business Promise: Evaluating the Progress of Privatization and Other Economic Reforms 21 January 2020 — 2:30PM TO 3:30PM Anonymous (not verified) 16 January 2020 Chatham House | 10 St James's Square | London | SW1Y 4LE

Minister Nunes Júnior will discuss the progress of the Angolan government’s economic stabilization plans and business reform agenda including the privatization of some state-owned enterprises. These reforms could expand Angola’s exports beyond oil and stimulate new industries and more inclusive economic growth.

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Understanding which patients with human epidermal growth factor receptor 2 (HER2)–negative or –low metastatic breast cancer (MBC) benefit from HER2-targeted strategies is urgently needed. We assessed the whole-body heterogeneity of HER2 expression on ⁸⁹Zr-trastuzumab PET (HER2 PET) and the diagnostic performance of HER2 PET in a large series of patients, including HER2-negative and -low MBC. Methods: In the IMPACT-MBC study, patients with newly diagnosed and nonrapidly progressive MBC of all subtypes were included. Metastasis HER2 status was determined by immunohistochemistry and in situ hybridization.⁸⁹Zr-trastuzumab uptake was quantified as SUV_max and SUV_mean. HER2 immunohistochemistry was related to the quantitative ⁸⁹Zr-trastuzumab uptake of all metastases and corresponding biopsied metastasis, uptake heterogeneity, and qualitative scan evaluation. A prediction algorithm for HER2 immunohistochemistry positivity based on uptake was developed. Results: In 200 patients, ⁸⁹Zr-trastuzumab uptake was quantified in 5,163 metastases, including 186 biopsied metastases. With increasing HER2 immunohistochemistry status, uptake was higher (geometric mean SUV_max of 7.0, 7.6, 7.3, and 17.4 for a HER2 immunohistochemistry score of 0, 1, 2, or 3+, respectively; P < 0.001). High uptake exceeding 14.6 (90th percentile) was observed in one third of patients with a HER2-negative or -low metastasis biopsy. The algorithm performed best when lesion site and size were incorporated (area under the curve, 0.86; 95% CI, 0.79–0.93). Conclusion: HER2 PET had good diagnostic performance in MBC, showing considerable whole-body HER2 heterogeneity and uptake above background in HER2-negative and -low MBC. This provides novel insights into HER2-negative and -low MBC compared with standard HER2 immunohistochemistry on a single biopsy.

Genetic-testing lab 23andMe plans to cut its workforce by 40% and end its therapeutics program in an effort to cut costs, the company announced Monday.

Lunchables are being pulled from school menus throughout the United States, after food manufacturer Kraft Heinz announced Tuesday that demand for the meal kits has dropped.

Raghunandan Mathur, Senior Systems Engineer, NEC, discusses now with modern day programming frameworks designed around the paradigms of scalar architectures and vector-like extensions, many present-day programmers expect a major learning […]

The post Ease of programming on NEC’s Vector Engine or SX-Aurora TSUBASA appeared first on HPCwire.

An arms contractor is making "good progress" on the production of five B-21 Raider stealth bombers, U.S. Air Force Secretary Frank Kendall disclosed during a speech on Monday.

Genetic-testing lab 23andMe plans to cut its workforce by 40% and end its therapeutics program in an effort to cut costs, the company announced Monday.

Lunchables are being pulled from school menus throughout the United States, after food manufacturer Kraft Heinz announced Tuesday that demand for the meal kits has dropped.

NASA said on Tuesday that it will restart its Mentor-Protégé Program for contractors on Friday to expand commercial markets with eligible small businesses.

Roger Dooley, international keynote speaker and author, just launched a new, three-minute speaker reel video featuring highlights of his Neuro-Loyalty speech based on the ideas in his award-winning book, FRICTION.

The post Neuro-Loyalty: New Speaker Reel For Roger Dooley appeared first on Neuromarketing.

One Montana nonprofit tries to build connections between rural and urban students with exchange program.

Montana's highest court has struck down a tuition tax-credit program which, as enacted by that state's legislature, allowed tuition scholarships to benefit students at private religious schools as well as secular schools.

Small groups of Portland youngsters gathered in gardens, played with plant-based dyes, and cooked up vegan meals as part of Camp ELSO's mission to foster STEM learning for students of color.

An Ohio appellate court struck down a district's policy allowing staff members to carry concealed weapons in school with 24 hours of "active shooter/killer training."

The state's "Influence 100" project includes a leadership development program that will give aspiring district leaders a hands-on opportunity to work through an equity issue in their home districts.

The decision was based on how the voucher-like program is financed, not on the program itself, which is unprecedented in its scope.

The Trump administration backs three families seeking to require the state of Maine to pay tuition for their children to attend religious high schools.

A court said legislators violated the state's constitution when they passed a law that targeted specific areas to be included in the program without local consent.

A budget amendment will provide funds to develop a teacher incentive program in rural areas.

State lawmakers must create a plan to improve rural schools in response to a 2014 state Supreme Court ruling.

A handful of districts and other groups are reshaping the after-school space to provide a wide range of social and linguistic supports for newcomer students.

Academic and health offerings have increased in McDowell County, W.Va., due to a private-public partnership.

A handful of districts and other groups are reshaping the after-school space to provide a wide range of social and linguistic supports for newcomer students.

Chance Gray scored 14 of her career-high 31 points in the third quarter and she tied a program-best with nine 3-pointers to help No. 12 Ohio State beat Charlotte 94-53 on Tuesday night. Gray finished 9 of 14 from 3-point range to top her previous best of six makes. Gray scored 11 points in the first half after making all three of her 3-pointers to help Ohio State build a 43-17 lead.

Donna M. Wilcock
May 1, 2003; 23:3745-3751
Development Plasticity Repair

Prithviraj Rajebhosale
Oct 23, 2024; 44:e0063242024-e0063242024
Cellular

Jennifer L. Zamanian
May 2, 2012; 32:6391-6410
Neurobiology of Disease

Neuregulin1 (Nrg1) signaling is critical for neuronal development and function from fate specification to synaptic plasticity. Type III Nrg1 is a synaptic protein which engages in bidirectional signaling with its receptor ErbB4. Forward signaling engages ErbB4 phosphorylation, whereas back signaling engages two known mechanisms: (1) local axonal PI3K-AKT signaling and (2) cleavage by -secretase resulting in cytosolic release of the intracellular domain (ICD), which can traffic to the nucleus (Bao et al., 2003; Hancock et al., 2008). To dissect the contribution of these alternate signaling strategies to neuronal development, we generated a transgenic mouse with a missense mutation (V₃₂₁L) in the Nrg1 transmembrane domain that disrupts nuclear back signaling with minimal effects on forward signaling or local back signaling and was previously found to be associated with psychosis (Walss-Bass et al., 2006). We combined RNA sequencing, retroviral fate mapping of neural stem cells, behavioral analyses, and various network analyses of transcriptomic data to investigate the effect of disrupting Nrg1 nuclear back signaling in the dentate gyrus (DG) of male and female mice. The V₃₂₁L mutation impairs nuclear translocation of the Nrg1 ICD and alters gene expression in the DG. V₃₂₁L mice show reduced stem cell proliferation, altered cell cycle dynamics, fate specification defects, and dendritic dysmorphogenesis. Orthologs of known schizophrenia (SCZ)-susceptibility genes were dysregulated in the V₃₂₁L DG. These genes coordinated a larger network with other dysregulated genes. Weighted gene correlation network analysis and protein interaction network analyses revealed striking similarity between DG transcriptomes of V₃₂₁L mouse and humans with SCZ.

The 2016-17 Programme of Work and Budget will consolidate the existing actions within the Medium Term Plan and the Strategic Framework, emphasizing areas to reflect recent trends and developments, with [...]

FAO Director-General José Graziano da Silva today expressed confidence that “significant progress against hunger, food insecurity and malnutrition,” will be achieved in the next four years. He made the [...]

Washington, 15 September 2016 - The recent entry into force of a ground-breaking international accord on illegal fishing is a welcome development but it now requires "strong and effective implementation", FAO [...]

Q: Ambassador, how did the Programme Committee in its recent session judge FAO's contribution to the eradication of hunger, food insecurity and malnutrition?

Ambassador Hoogeveen: [...]

Rome - The FAO - Globally Important Agricultural Heritage Systems Programme opens the process of establishing a new Scientific Advisory Groupfor the 2021-2022 term.  The Programme is seeking for [...]

In an exceptionally challenging biennium, see how FAO rose to the challenge, implementing a global, holistic and multipronged strategy to support Members.

Rome - The Food and Agriculture Organization (FAO) is currently seeking applications from experts to join the Scientific Advisory Group (SAG) of its Globally Important Agricultural Heritage Systems [...]

The PSS Technical Cooperation Programme (TCP) team is excited to announce the launch of its newly designed webpages. The webpage has a fresh look [...]

To save a species from extinction, scientists scour the Panamanian jungle for the few remaining frogs. But will they be too late?

A pirogue's eye view of the inlet at the edge of Harper. Some of the first groups of freed American slaves landed on the shores of West Africa near here. (Credit: Clair MacDougall)

Ashley Hickey, a parent of a kid with celiac disease, is concerned that Nova Scotia's new school program does not offer any 100 per cent guaranteed gluten-free options.

FIFA Football for Schools (F4S) has come to Canada, with a pilot program in the N.W.T. already underway and offering coach training. 

A new program to help fund the post-secondary education of Indigenous students in Manitoba will award 150 scholarships to train new health-care professionals. The Southern Chiefs Organization hopes this can go a long way in addressing health-care delivery and shorter life expectancy among First Nation communities.

The agenda for Enhancement Grant Program Committee dated Thursday, 14 November 2019 has been archived. Access it here:
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The agenda for Enhancement Grant Program Committee on 2020-06-25 5:30 PM - REVISED dated Thursday, 25 June 2020 has been archived. Access it here:
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The agenda for Enhancement Grant Program Committee on 2020-06-25 5:30 PM - REVISED dated Thursday, 25 June 2020 has been archived. Access it here:
https://oregon-city.granicus.com/MediaPlayer.php?view_id=4&clip_id=2436 Download File