SUMMARY:

The 2021 World Health Organization Classification of Tumors of the Central Nervous System (CNS5), introduced significant changes, impacting tumors ranging from glial to ependymal neoplasms. Ependymal tumors were previously classified and graded based on histopathology, which had limited clinical and prognostic utility. The updated CNS5 classification now divides ependymomas into 10 subgroups based on anatomic location (supratentorial, posterior fossa, and spinal compartment) and genomic markers. Supratentorial tumors are defined by zinc finger translocation associated (ZFTA) (formerly v-rel avian reticuloendotheliosis viral oncogene [RELA]), or yes-associated protein 1 (YAP1) fusion; posterior fossa tumors are classified into groups A (PFA) and B (PFB), spinal ependymomas are defined by MYCN amplification. Subependymomas are present across all these anatomic compartments. The new classification kept an open category of "not elsewhere classified" or "not otherwise specified" if no pathogenic gene fusion is identified or if the molecular diagnosis is not feasible. Although there is significant overlap in the imaging findings of these tumors, a neuroradiologist needs to be familiar with updated CNS5 classification to understand tumor behavior, for example, the higher tendency for tumor recurrence along the dural flap for ZFTA fusion-positive ependymomas. On imaging, supratentorial ZFTA-fused ependymomas are preferentially located in the cerebral cortex, carrying predominant cystic components. YAP1-MAMLD1-fused ependymomas are intra- or periventricular with prominent multinodular solid components and have significantly better prognosis than ZFTA-fused counterparts. PFA ependymomas are aggressive paramedian masses with frequent calcification, seen in young children, originating from the lateral part of the fourth ventricular roof. PFB ependymomas are usually midline, noncalcified solid-cystic masses seen in adolescents and young adults arising from the fourth ventricular floor. PFA has a poorer prognosis, higher recurrence, and higher metastatic rate than PFB. Myxopapillary spinal ependymomas are now considered grade II due to high recurrence rates. Spinal-MYCN ependymomas are aggressive tumors with frequent leptomeningeal spread, relapse, and poor prognosis. Subependymomas are noninvasive, intraventricular, slow-growing benign tumors with an excellent prognosis. Currently, the molecular classification does not enhance the clinicopathologic understanding of subependymoma and myxopapillary categories. However, given the molecular advancements, this will likely change in the future. This review provides an updated molecular classification of ependymoma, discusses the individual imaging characteristics, and briefly outlines the latest targeted molecular therapies.

PURPOSE

HIV pre-exposure prophylaxis (PrEP) may increase rates of bacterial sexually transmitted infections (STIs) among gay, bisexual, and other men who have sex with men (GBM) through risk compensation (eg, an increase in condomless sex or number of partners); however, longitudinal studies exploring the time-dependent nature of PrEP uptake and bacterial STIs are limited. We used marginal structural models to estimate the effect of PrEP uptake on STI incidence.

Tam plays the waifu games for the "plot." Chris teaches his cats to play DDR. Kelley blames everyone else for her Vampire Survivors addiction.

The post RPG Cast – Episode 661: “I Got Addicted to the Pentagram” appeared first on RPGamer.

A grand jury has formally charged a 22-year-old man with capital murder and rape in the death of Nabra Hassanen, who was killed on her walk back to a Virginia mosque.

The Fairfax County Circuit Court indicted Darwin Martinez-Torres of Sterling, Virginia, on Monday on four counts of capital murder for killing Nabra, who was with friends while they had a meal before Ramadan services. Dozens of people had gathered outside the courthouse today, chanting “Justice for Nabra.”

Virginia law has specific conditions for pursuing the death penalty, but the Associated Press reported that the grand jury’s indictment described in graphic detail how Nabra’s killing was grounds for a death penalty against Martinez-Torres. The indictment appears to acknowledge for the first time that the 17-year-old Muslim teen was raped. Under state law, the combination of a rape charge with a premeditated murder charge means the death penalty can be pursued.

Police have said that Martinez-Torres, who is an undocumented immigrant, got into a confrontation on June 18 with a group of teens walking back to the All Dulles Area Muslim Society after grabbing a late meal. He is accused of returning later and beating Nabra with a baseball bat. Police said Nabra’s body was later discovered in a pond. A search warrant affidavit revealed that Martinez-Torres admitted to killing Nabra and had led authorities to where he dumped her body, AP reported.

Nabra’s parents and Muslim advocates have said that Nabra’s death was motivated by hate, but police has said that they will not treat the killing as a hate crime. Instead, police have said it was a road rage incident.

“The reason this guy he hit my daughter is because she’s Muslim,” Nabra’s father Mahmoud Hassanen told WAMU. “Why [didn’t he] hit the boy who bothered him?”

Nabra’s father added that he hoped for the death penalty, while her mother said she wanted Martinez-Torres to serve life in prison.

“I just want people to remember her, and don’t forget her,” Mahmoud told WAMU. “I think nobody can forget her too, for what she did in her life.”

A preliminary hearing for Martinez-Torres reportedly turned emotional on Friday, with Nabra’s parents both shouting at the suspect in court. Nabra’s mother Sawsan Gazzar apparently threw a shoe at Martinez-Torres during the proceedings.

READ MORE: D.C. memorial for slain Muslim teen was set on fire, officials say

The post Man accused of killing Muslim teen indicted on capital murder charges appeared first on PBS NewsHour.

Genetic analysis shows that microbes growing inside the International Space Station have adaptations for radiation and low gravity, and may pose a threat to astronauts

The UK government's decision to return the Chagos Islands to Mauritius surprisingly threatens the extinction of millions of website addresses ending in ".io", and no one is quite sure what will happen next

Or, for the other half of you: Here Is Our Ivy Wolk Explainer.

President-elect Donald Trump has announced that he will nominate former Arkansas Gov. Mike Huckabee to be the U.S. ambassador to Israel.

President-elect Donald Trump announced a flurry of appointments Tuesday for key posts in his new administration, including former Director of National Intelligence John Ratcliffe to lead the CIA and the expected nomination of South Dakota Gov. Kristi Noem to head the Department of Homeland Security.

LIVERPOOL midfielder Georginio Wijnaldum will be pivotal for Jurgen Klopp at Manchester City..

A stadium-sized asteroid is passing relatively close to Earth on Tuesday, NASA announced. Its distance from Earth and its massive size makes it a "potentially hazardous object."

A coronal mass ejection could strike the Earth's magnetosphere this week and cause a geomagnetic storm due to conditions caused by the autumnal equinox.

Wastewater is a major reservoir for antibiotic resistance genes, but modified bacteria can chop up this DNA before the dangerous microbes reach people

Genetic analysis of a bird flu virus detected in a person in Missouri who didn’t previously have contact with animals offers more details on the case, but experts say there isn’t substantial evidence to suggest human-to-human transmission is happening

Experts predict that the number of cancer cases around the world will skyrocket, resulting in millions more fatalities by 2050

Health officials in Saskatchewan Canada are urging customers of Domino’s Pizza in Martensville to watch for symptoms of typhoid fever. The restaurant’s customers may have been exposed to Salmonella typhi, also known as typhoid fever. Anyone who consumed food or drink from the Domino’s store at 717 Centennial Drive South... Continue Reading

Woman claims to have a degree from "Havard" and be licensed by the "Estate Board."

President-elect Donald Trump has made many selections to lead his administration as his transition gets underway, ranging from chief of staff to head of the Environmental Protection Agency (EPA). At the same time, a number of crucial positions have yet to be filled just one week removed from the landslide election.

The post Donald Trump’s Administration Takes Shape After 15 Official or Expected Picks appeared first on Breitbart.

The two men found guilty of mischief and firearms offences for their roles in the 2022 Coutts border blockade want the Alberta Court of Appeal to overturn their convictions, while prosecutors are seeking new trials on the more serious charge of conspiring to murder RCMP officers, for which they were acquitted.

Team at Kolkata institute engineers bacteria to solve maths problems  The Hindu

1. Study reveals how 3D environments affect bacterial growth and survival  The Hindu
2. 3D environments influence bacterial growth & survival  The Times of India
3. Shape Matters: New Research Reveals Impact of 3D Environments on Bacterial Growth  Research Matters
4. Study reveals role of 3D environments in influencing bacterial survival and growth  Bangalore Mirror

1. Eight-month-old among six abducted in Manipur; two burnt to death  The Hindu
2. Manipur on boil: 2 more bodies found, 6 missing  The Times of India
3. Centre rushes 20 more CAPF companies to Manipur after fresh violence  The Indian Express
4. Three women, three children missing after Jiribam gunfight; Meiteis and Kukis hold bandhs in Manipur  The New Indian Express
5. Letters to The Editor — November 13, 2024  The Hindu

‘Singham Again’ had an ensemble cast which includes Ajay Devgn, Akshay Kumar, Ranveer Singh, Tiger Shroff, Kareena Kapoor Khan, Deepika Padukone, Arjun Kapoor and Jackie Shroff

Earlier this month, Bandai Namco Entertainment and developer Ganbarion revealed Dragon Ball Project:Multi, the franchise’s first 4v4 team based battle …

Continue reading "‘Dragon Ball Project:Multi’ Gets New Character Trailers Showcasing Super Saiyan Goku, Krillin, and Piccolo"

NPR's Juana Summers talks with Cindy Nava, a Democrat, who will be joining the New Mexico state senate in Albuquerque. She is one of the millions of "Dreamers" who are protected by DACA.

Company expects to be cash flow positive in the next two quarters.

Netflix is crowing that its ad-supported tier now boasts 70 million users throughout the globe, as reported by Variety. The company announced 40 million users back in May, so this is some real growth. The streamer has been slowly ramping up its ad tier, going all the way back to 2022.

Amy Reinhard, president of advertising at Netflix, says that the company continues “to see steady progress across all countries’ member bases.” She also noted that over 50 percent of new Netflix sign-ups are for these ad-supported plans. The transformation of streaming into regular TV is nearly complete.

There’s one major potential caveat. The company released the aforementioned data regarding new sign-ups, which is impressive, but there isn’t any information regarding pre-existing customers. It’s highly possible a whole lot of people downgraded from a premium tier to an ad-supported tier.

I’m one of them. I don’t mind watching an ad or two as I mindlessly stuff food down my gullet while pseudo-watching an episode of The Diplomat or The Circle. In other words, there’s an argument to be made that the ad-supported tier could be eating into the more expensive offerings.

There’s also an argument to be made that this year’s growth spurt for the ad-supported tier could attract companies with deeper ad-spending budgets, thus making up the difference. Netflix is airing live NFL broadcasts on Christmas Day, and it says it has already sold out all available commercial inventory. The streamer is actually betting big on live streams, with wrestling events, cooking shows and talk shows all airing in the near future. The company’s recent forays into audience measurement and the ad-tech space should help entice sponsors for these events.

Netflix even has plans for “themed” advertisements with certain shows. The next season of Squid Game will include a three-part linked commercial by Kia. Nothing makes me want to buy a car more than a deadly dystopian bloodsport that seems closer and closer to the real world by the day.

Mumbai (AFP) Nov 2, 2024
Indian security forces killed three suspected militants in two separate firefights in disputed Kashmir, the army and a senior police official said Saturday. Muslim-majority Kashmir has been divided between rivals India and Pakistan since their independence from British rule in 1947 and is home to a long-running insurgency. The first firefight broke out after Indian troops moved to check

Une découverte biochimique intrigante pourrait permettre d’identifier rapidement les patients à haut risque.

Humans and pigs could both serve as mixing vessels for a bird flu–seasonal flu hybrid, posing a risk of wider spread

A team at Columbia University School of Engineering and Applied Science has developed a technique to enhance chimeric antigen receptor (CAR) T cell therapy in solid tumors. The technique involves engineering E. coli bacteria, that naturally tend to accumulate in the immune privileged core of solid tumors. The bacteria have been engineered to interact with […]

Two former board chairs of the Coalition for Healthcare Communication (CHC) were named as the Medical Advertising Hall of Fame (MAHF) 2025 inductees – Sharon Callahan, former Chief Client Officer at Omnicom Health Group (OHG), and Nick Colucci, former Chairman and CEO of Publicis Health/COO of Publicis Groupe North America. The inductees will be honored […]

AbbVie schizophrenia drug candidate emraclidine failed to beat a placebo in two Phase 2 clinical trials. The drug, once projected to compete with Bristol Myers Squibb’s Cobenfy, is from AbbVie’s $8.7 billion acquisition of Cerevel Therapeutics.

The post AbbVie Drug Expected to Rival Bristol Myers’s New Schizophrenia Med Flunks Phase 2 Test appeared first on MedCity News.

Chicken products cause an estimated 1 in 7 of the nation’s human Salmonella illnesses each year, partly because the pathogen can easily contaminate the environments where birds are raised. To reduce the risk that contaminated meat will reach consumers, poultry companies need measures that control the bacterium on farms where chickens are bred and raised.

Pakistan is one of a handful of countries (including India, Brazil, and South Africa) that routinely oppose the United States in multilateral debates despite strong bilateral ties to the U.S.

As leaders mull over who will head the party next, the Congress Working Committee announced that elections will be held on October 17.

Polling was held on December 4 and the results were announced on Wednesday.

Jul 17, 2023

Apekshya Prasai, a political science doctoral candidate at the Massachusetts Institute of Technology, was recently named a 2023 Harry Frank Guggenheim Foundation Emerging Scholar.   The Emerging Scholars (nine in all) are doctoral candidates who are in the final year of writing dissertations on the nature of and responses to violence around the world.

The Key to Inspiring Innovation: Brought to You by the National Inventors Hall of Fame Inductees

When Christen Press puts her game face on, she makes sure she helps protect it with Coppertone� Sport. Use and reapply as directed.

Government of IndiaMinistry of FinanceDepartment of Revenue(Central Board of Indirect Taxes & Customs)North Block, New Delhi. Dated:30th October, 2024To All Principal Chief Commissioners/Chi

What steps should be taken if bank deducted TDS at a higher rate and a PAN was obtained afterward?

You’re the one who called in this pizza? Slow down there, chief, we’ll get to the pizza. You won’t mind if I step in. Nice place you got here; looks expensive.

The Hon'ble Delhi High Court in the case of M/s Sanjay Sales India v. Principal Commissioner of Department of Trade and Taxes, Government of NCT, Delhi [Writ Petition (Civil) No. 10234 of 2024 dated July 26, 2024] held that the application for the cancellation of the GST registration cannot be denie

The merger between Reliance Jio's Viacom18 and Star India Private Limited is set to transform India's streaming landscape. This collaboration will introduce a new OTT platform, likely named Jio Star, combining JioCinema and Disney+ Hotstar. The domain jiostar.com is live, hinting

Outside experts found that two studies cited in a federal case on medication abortion had serious design problems and that their authors had undisclosed conflicts of interest