From 10 to 14 October 2016, ConnectinGEO and ENEON will host a joint 'Earth Observation Gap Analysis and Prioritization"  workshop followed by an ENEON Workshop and Plenary. Both events will be held at IIASA in Laxenburg, Austria. The web announcement is available at http://www.gstss.org/2016_Laxenburg and there you can also access 1-page registration for both events. An overview of the schedule during the week is available at http://www.gstss.org/2016_Laxenburg/schedule.php. Extended deadline: 21st September.

The "Gap Analysis and Prioritization" workshop will take place on October 10-11, 2016.

Earth Observation gaps and prioritization actions' Workshop. Preliminary agenda

 *   Session 1: Introduction to the ConnectinGEO Approach to Gap Analysis and Prioritization
 *   Session 2: "Top-Down" approach to Gap Analysis: Thread 1: Identification of a collection of observation requirements; Thread 2: Research programs aims and targets
 *   Session 3: "Bottom-Up" approach to Gap Analysis: Thread 1: Consultation process
 *   Session 4: "Bottom-Up" approach to Gap Analysis: Thread 2: GEOSS DAB analysis
 *   Session 5: "Bottom-Up" approach to Gap Analysis: Thread 3: Industry-Driven Challenges
 *   Session 6: Assessment of the Gaps Identified so far and Steps Towards Prioritization

The ENEON Plenary will take place on October 12-13, 2016.

ENEON Workshop and Plenary. Preliminary agenda

 *   Session 1: ENEON Developments: Networks, Committees, Working Groups, Ambassadors, Achievements
 *   Session 2: ENEON in Support of European Policy Making and Implementation
 *   Session 3: ENEON in Support of Sustainable Development Goals Monitoring and Implementation
 *   Session 4: Addressing Gaps in European Earth Observation Infrastructure, Services, and Knowledge
 *   Session 5: ENEON: European Contribution to the GEO Work Programme
 *   Session 6: ENEON Business

Dr. Indira Narayanan, MBBS, MD, FNNF, FIAP, FNAMS, is lauded for her work in newborn care and global maternal and newborn health and nutrition

Follow along with this photo compositing Photoshop tutorial to create a surreal space scene with a vibrant neon light effect. We’ll use assets from a free sample pack of the Ultimate Universe Creator product that’s exclusively available for Spoon Graphics viewers to download. I’ll show you how to compose the various space-themed graphics to make […]

The post Duotone Neon Light Space Poster Photoshop Tutorial appeared first on Spoon Graphics.

The elegance of classic Renaissance sculptures and the vibrant neon colours of the Vaporwave aesthetic are two contrasting styles you wouldn’t expect to see together, but this combination of imagery has become a popular abstract art style. In this tutorial I’ll show you how to apply a vibrant neon glow to a shape with the […]

The post Vaporwave Neon Effect Photoshop Tutorial appeared first on Spoon Graphics.

Center for Biological Diversity Press Release WASHINGTON – Four commonly used neonicotinoid pesticides can harm bees and other pollinators, according to a new analysis by California’s Department of Pesticide Regulation. The study found that current approved uses of the “neonics” … Continue reading →

Chris Bovey's new shop on Garland Avenue isn't technically open on Tuesday, but it's too enjoyably warm and sunny on a late September afternoon to keep the roll-up door along the sidewalk closed…

Hospital colleagues take to the saddle in memory of highly-regarded consultant.

Neuronal cytotoxic edema is implicated in neuronal injury and death, yet mitigating brain edema with osmotic and surgical interventions yields poor clinical outcomes. Importantly, neuronal swelling and its downstream consequences during early brain development remain poorly investigated, and new treatment approaches are needed. We explored Ca²⁺-dependent downstream effects after neuronal cytotoxic edema caused by diverse injuries in mice of both sexes using multiphoton Ca²⁺ imaging in vivo [Postnatal Day (P)12–17] and in acute brain slices (P8–12). After different excitotoxic insults, cytosolic GCaMP6s translocated into the nucleus after a few minutes in a subpopulation of neurons, persisting for hours. We used an automated morphology-detection algorithm to detect neuronal soma and quantified the nuclear translocation of GCaMP6s as the nuclear to cytosolic intensity (N/C ratio). Elevated neuronal N/C ratios occurred concurrently with persistent elevation in Ca²⁺ loads and could also occur independently from neuronal swelling. Electron microscopy revealed that the nuclear translocation was associated with the increased nuclear pore size. The nuclear accumulation of GCaMP6s in neurons led to neocortical circuit dysfunction, mitochondrial pathology, and increased cell death. Inhibiting calpains, a family of Ca²⁺-activated proteases, prevented elevated N/C ratios and neuronal swelling. In summary, in the developing brain, we identified a calpain-dependent alteration of nuclear transport in a subpopulation of neurons after disease-relevant insults leading to long-term circuit dysfunction and cell death. The nuclear translocation of GCaMP6 and other cytosolic proteins after acute excitotoxicity can be an early biomarker of brain injury in the developing brain.

Hyperbilirubinemia (HB) is a key risk factor for hearing loss in neonates, particularly premature infants. Here, we report that bilirubin (BIL)-dependent cell death in the auditory brainstem of neonatal mice of both sexes is significantly attenuated by ZD7288, a blocker for hyperpolarization-activated cyclic nucleotide-gated (HCN) channel-mediated current (I_h), or by genetic deletion of HCN1. GABAergic inhibitory interneurons predominantly express HCN1, on which BIL selectively acts to increase their intrinsic excitability and mortality by enhancing HCN1 activity and Ca²⁺-dependent membrane targeting. Chronic BIL elevation in neonatal mice in vivo increases the fraction of spontaneously active interneurons and their firing frequency, I_h, and death, compromising audition at the young adult stage in HCN1^+/+, but not in HCN1^–/– genotype. We conclude that HB preferentially targets HCN1 to injure inhibitory interneurons, fueling a feedforward loop in which lessening inhibition cascades hyperexcitability, Ca²⁺ overload, neuronal death, and auditory impairments. These findings rationalize HCN1 as a potential target for managing HB encephalopathy.

The vertical sign stretched across three stories of the Manhattan hotel, which once welcomed the likes of Bob Dylan, Patti Smith, Andy Warhol and Janis Joplin

Research suggests that neonatal kidney transplantation could be a game-changing solution to the organ shortage crisis, highlighting the emotional challenges faced by families.

[Erscheinungsort nicht ermittelbar] Orell Füssli Verlag 2019

CSS truly is a remarkable tool in a web designer’s toolkit, capable of bringing even the most vibrant creative visions to life. Today, we’re immersing ourselves in the radiant world of neon style buttons, showcasing the impressive spectrum of CSS …

Boca Raton : CRC Press, Taylor & Francis Group, 2024

Move follows report by food safety agency on health risks to bees

A 125cc higher-strung motor in a familiar big bike styling is a genius by Bajaj and one that will ensure that they have a significant market share.

Here is some good news for pregnant and lactating mothers: Coronavirus infection is less frequent and less severe in children (Child Sparing Pattern)D

The National Ecological Observatory (NEON) is a large-facility project managed by NEON, Inc., and funded by the National Science Foundation (NSF). NEON is a continental-scale […]

The post NEON begins to monitor changing ecology of U.S. appeared first on Smithsonian Insider.

Neonicotinoid and fipronil insecticides have a range of impacts on birds, mammals and fish, a new review of scientific literature has found. A house sparrow would need to eat just one and a half beet seeds treated with a common neonicotinoid to receive a lethal dose, for instance. The insecticides may also have equally important effects on vertebrate wildlife, such as reducing insect prey and hence food supply.

Beetles that are helpful to farmers can be poisoned if they feed on slugs that have eaten crops treated with neonicotinoids, a new study reports. The slugs themselves are not harmed by neonicotinoids. In American field trials, researchers found that plots planted with neonicotinoid-treated soybeans contained more slugs, fewer beetle predators and had 5% lower yields. The insecticide may be reducing the beetles’ effectiveness as a natural control of slug pests.

Honeybees and bumblebees prefer feeding on nectar laced with certain neonicotinoid pesticides to uncontaminated food, new research has shown. Far from the predictions of some, that bees would avoid food contaminated with neonicotinoid pesticides if given the choice, a new study has shown that bees did not avoid any of the three most common neonicotinoids: imidacloprid, thiamethoxam or clothianidin. Furthermore, they showed a preference for imidacloprid and thiamethoxam over uncontaminated sugar solutions.

Neonicotinoids are pesticides applied to plants to protect them from insects. The use of neonicotinoids may lead to contamination of aquatic environments through, among other routes, the input of contaminated plant material into waterways. While it is well established that direct exposure to contaminated water endangers aquatic invertebrates, scientists have now published findings indicating that dietary exposure through the consumption of contaminated plant material puts leaf-shredding species at increased risk. The researchers recommend that policymakers registering systemic insecticides (those whose active ingredients are transported throughout the plant tissues) consider dietary exposure, and its potential implications for ecosystem integrity, in addition to other exposure pathways.

The new auroral form called a sky dune has been discovered by amateur stargazers.

The pesticides are effective against a wide range of insects — including the good guys.

AI-Based Personalization Solution Provider and a Microsoft Partner to Demonstrate Latest Capabilities at NRF

It's beautiful Nima! Love the neon colors .

Margaret Parker, MD, MCCM, speaks with James L. Wynn, MD.

Margaret Parker, MD, MCCM, speaks with Jason W. Custer, MD

The glitz of Las Vegas lures every explorer. However, a trip to Nevada can offer much more than its famed glamor. The state of Nevada, which houses Las Vegas...

Center for Biological Diversity Press Release WASHINGTON – Four commonly used neonicotinoid pesticides can harm bees and other pollinators, according to a new analysis by California’s Department of Pesticide Regulation. The study found that current approved uses of the “neonics” … Continue reading →

The trauma of premature birth has additional complications for parents who live hundreds of kilometres from their baby's neonatal hospital.

Rock On Neon Radio Is A Live365 Radio Station. The Station's Motto Is “some That You Recognize, Some That You've Hardly Even Heard Of” Which Is A Quote From The Song Celluloid Heroes By The Kinks.

IL-17–producing RORγt+ γδ T cells (γδT17 cells) are innate lymphocytes that participate in type 3 immune responses during infection and inflammation. Herein, we show that γδT17 cells rapidly proliferate within neonatal lymph nodes and gut, where, upon entry, they upregulate T-bet and coexpress IL-17, IL-22, and IFN-γ in a STAT3- and retinoic acid–dependent manner. Neonatal expansion was halted in mice conditionally deficient in STAT5, and its loss resulted in γδT17 cell depletion from all adult organs. Hyperactive STAT5 mutant mice showed that the STAT5A homolog had a dominant role over STAT5B in promoting γδT17 cell expansion and downregulating gut-associated T-bet. In contrast, STAT5B preferentially expanded IFN-γ–producing γδ populations, implying a previously unknown differential role of STAT5 gene products in lymphocyte lineage regulation. Importantly, mice lacking γδT17 cells as a result of STAT5 deficiency displayed a profound resistance to experimental autoimmune encephalomyelitis. Our data identify that the neonatal microenvironment in combination with STAT5 is critical for post-thymic γδT17 development and tissue-specific imprinting, which is essential for infection and autoimmunity.

The rainbow eucalyptus may look like a digital rendering of a kid’s drawing, but it’s 100% real. These trees (also known as rainbow gum, Mindanao gum, and Eucalyptus deglupta) have brown bark that peels away, revealing layers of color across the ROYGBIV spectrum.Rainbow eucalyptus are native to Indonesia, Papua New Guinea, and the Philippines, but you can also find them in the United States, in places including Hawaii, Florida, and San Diego. READ MORE...

Permanent neonatal diabetes mellitus (PNDM) is caused by reduced β-cell number or impaired β-cell function. Understanding of the genetic basis of this disorder highlights fundamental β-cell mechanisms. We performed trio genome sequencing for 44 patients with PNDM and their unaffected parents to identify causative de novo variants. Replication studies were performed in 188 patients diagnosed with diabetes before 2 years of age without a genetic diagnosis. EIF2B1 (encoding the eIF2B complex α subunit) was the only gene with novel de novo variants (all missense) in at least three patients. Replication studies identified two further patients with de novo EIF2B1 variants. In addition to having diabetes, four of five patients had hepatitis-like episodes in childhood. The EIF2B1 de novo mutations were found to map to the same protein surface. We propose that these variants render the eIF2B complex insensitive to eIF2 phosphorylation, which occurs under stress conditions and triggers expression of stress response genes. Failure of eIF2B to sense eIF2 phosphorylation likely leads to unregulated unfolded protein response and cell death. Our results establish de novo EIF2B1 mutations as a novel cause of permanent diabetes and liver dysfunction. These findings confirm the importance of cell stress regulation for β-cells and highlight EIF2B1’s fundamental role within this pathway.

OBJECTIVE

Neonatal diabetes has been shown to be associated with high neuropsychiatric morbidity in a genotype-phenotype–dependent manner. However, the specific impact of different mutations on intellectual functioning is still insufficiently characterized. Specifically, only a small number of subjects with developmental delay have been comprehensively assessed, creating a knowledge gap about patients carrying the heaviest burden.

Jennifer M. Yamamoto
Jul 1, 2018; 41:1346-1361
Reconsidering Pregnancy With Diabetes

OBJECTIVE

Transient neonatal diabetes mellitus (TNDM) occurs during the 1st year of life and remits during childhood. We investigated glucose metabolism and socioeducational outcomes in adults.

Berlin : Heuser, 1889.

Berlin : C. Nohring, 1868.

Hydrocephalus is a pathologic condition associated with various brain diseases, including Alzheimer's disease (AD). Dysfunctional ependymal cells (EpCs) are believed to contribute to the development of hydrocephalus. It is thus of interest to investigate EpCs' development and function. Here, we report that vacuolar protein sorting-associated protein 35 (VPS35) is critical for EpC differentiation, ciliogenesis, and survival, and thus preventing neonatal hydrocephalus. VPS35 is abundantly expressed in EpCs. Mice with conditional knock-out (cKO) of Vps35 in embryonic (Vps35^GFAP-Cre and Vps35^Emx1-Cre) or postnatal (Vps35^Foxj1-CreER) EpC progenitors exhibit enlarged lateral ventricles (LVs) and hydrocephalus-like pathology. Further studies reveal marked reductions in EpCs and their cilia in both Vps35^GFAP-Cre and Vps35^Foxj1-CreER mutant mice. The reduced EpCs appear to be due to impairments in EpC differentiation and survival. Additionally, both Vps35^GFAP-Cre and Vps35^Foxj1-CreER neonatal pups exhibit increased cell proliferation and death largely in a region close to LV-EpCs. Many microglia close to the mutant LV-EpC region become activated. Depletion of the microglia by PLX3397, an antagonist of colony-stimulating factor 1 receptor (CSF1R), restores LV-EpCs and diminishes the pathology of neonatal hydrocephalus in Vps35^Foxj1-CreER mice. Taken together, these observations suggest unrecognized functions of Vps35 in EpC differentiation, ciliogenesis, and survival in neonatal LV, and reveal pathologic roles of locally activated microglia in EpC homeostasis and hydrocephalus development.

SIGNIFICANCE STATEMENT This study reports critical functions of vacuolar protein sorting-associated protein 35 (VPS35) not only in promoting ependymal cell (EpC) differentiation, ciliogenesis, and survival, but also in preventing local microglial activation. The dysfunctional EpCs and activated microglia are likely to induce hydrocephalus.

Neonatal stroke is as frequent as stroke in the elderly, but many pathophysiological injury aspects are distinct in neonates, including immune signaling. While myeloid cells can traffic into the brain via multiple routes, the choroid plexus (CP) has been identified as a uniquely educated gate for immune cell traffic during health and disease. To understand the mechanisms of myeloid cell trafficking via the CP and their influence on neonatal stroke, we characterized the phenotypes of CP-infiltrating myeloid cells after transient middle cerebral artery occlusion (tMCAO) in neonatal mice of both sexes in relation to blood-brain barrier permeability, injury, microglial activation, and CX3CR1-CCR2 signaling, focusing on the dynamics early after reperfusion. We demonstrate rapid recruitment of multiple myeloid phenotypes in the CP ipsilateral to the injury, including inflammatory CD45⁺CD11b⁺Ly6c^highCD86⁺, beneficial CD45⁺CD11b⁺Ly6c^lowCD206⁺, and CD45⁺CD11b⁺Ly6c^lowLy6g^high cells, but only minor leukocyte infiltration into acutely ischemic-reperfused cortex and negligible vascular albumin leakage. We report that CX3CR1-CCR2-mediated myeloid cell recruitment contributes to stroke injury. Considering the complexity of inflammatory cascades triggered by stroke and a role for TLR2 in injury, we also used direct TLR2 stimulation as an independent injury model. TLR2 agonist rapidly recruited myeloid cells to the CP, increased leukocytosis in the CSF and blood, but infiltration into the cortex remained low over time. While the magnitude and the phenotypes of myeloid cells diverged between tMCAO and TLR2 stimulation, in both models, disruption of CX3CR1-CCR2 signaling attenuated both monocyte and neutrophil trafficking to the CP and cortex.

SIGNIFICANCE STATEMENT Stroke during the neonatal period leads to long-term disabilities. The mechanisms of ischemic injury and inflammatory response differ greatly between the immature and adult brain. We examined leukocyte trafficking via the choroid plexus (CP) following neonatal stroke in relation to blood-brain barrier integrity, injury, microglial activation, and signaling via CX3CR1 and CCR2 receptors, or following direct TLR2 stimulation. Ischemia-reperfusion triggered marked unilateral CX3CR1-CCR2 dependent accumulation of diverse leukocyte subpopulations in the CP without inducing extravascular albumin leakage or major leukocyte infiltration into the brain. Disrupted CX3CR1-CCR2 signaling was neuroprotective in part by attenuating monocyte and neutrophil trafficking. Understanding the migratory patterns of CP-infiltrating myeloid cells with intact and disrupted CX3CR1-CCR2 signaling could identify novel therapeutic targets to protect the neonatal brain.

Little is known about the pharmacokinetics and required dosage of metronidazole in preterm neonates.

In this study the pharmacokinetics of metronidazole in preterm neonates was investigated by measurement of the drug in dried blood-spot samples. A dosage regimen is proposed that should result in more appropriate, less frequent dosing in the most preterm neonates. (Read the full article)

Two UK models predict the risk of mortality in very preterm Western infants (1) alive at onset of labor and (2) admitted for neonatal intensive care. Prognostic models need temporal and geographic validation to evaluate their performance.

The 2 models showed very good performance in a recent large cohort of very preterm infants born in another Western country. The accurate performance of both models suggests application in clinical practice (Read the full article)

Several studies have focused on birth weight heritability, reporting results that range between 40% and 80%. Few studies have focused on the process of weight gain and were mainly based on heterogeneous samples of infants.

The present work looks at a uniform set of healthy preterm newborn twins. The resulting high heritability estimate could suggest using the inclusion criteria to identify genes that regulate postnatal weight gain or failure. (Read the full article)

Recent studies have called into question the benefit of perioperative corticosteroids in children undergoing heart surgery, but have been limited by small sample size, the lack of placebo control, and the grouping of various steroid regimens together in analysis.

We evaluated outcomes across methylprednisolone regimens versus no steroids in a large cohort of neonates and found no mortality or length-of-stay benefit associated with any regimen, and a higher risk of infection in certain subgroups. (Read the full article)