Tony Mulvihill has only one secret for training a good working dog, a lesson he learned 30 years ago from an Oregon buckaroo.

Newly retired NRL star Sam Burgess will appear in court in December over an alleged incident at a residence near Bowral earlier this month.

Divisions in the AFLW over a proposed collective bargaining agreement put the future of the league's 2020 season in limbo, as the head of the players' association criticises a "damaging" campaign against the deal.

A South Australian business says it's been forced to lay off workers because of almost $200,000 in unpaid bills, amid the collapse of several building companies based in South Australia in the past 12 months.

A police investigation is underway in a quiet corner of WA's south-west, after more than 150 people brawled with baseball bats and poles near a local football club's post-grand final celebration.

A Flinders Ranges woman who killed a man after ramming him with her ute as part of a family dispute over a trailer is found guilty of manslaughter, not murder, with an Adelaide judge saying she "cannot be sure" the woman intended to kill.

A South Australian woman, who killed a man by hitting him with her ute amid a dispute over the use of a trailer, is sentenced to nine years in jail.

One phone call closed a popular waterfront camp that has hosted thousands of children over 75 years but documents obtained by the ABC show that a NSW Government office went against the advice of experts.

Inmates at four South Australian prisons will be confronted with the faces of cold case murder victims in what authorities hope will be a "conscious jogger" for people to come forward with information.

It was spruiked as Victoria's own Gold Coast, but people who bought land along Ninety Mile Beach in the 1950s could never build on their blocks.

Australian soldiers in WWII were mystified by the strange footwear of their Japanese enemies, but they also gave them a competitive advantage.

Three objects carefully preserved at Parliament House tell the story of its construction and will form part of a new display.

A "silk" map used by WWII Australian commandos in Borneo is on display at the Australian War Memorial.

Indigenous objects presented to Hazel Hawke at the the 1988 Barunga Festival are on display for the first time at Parliament House.

Fragments of moon rock and an Australian flag sent into space will go on public display next year to celebrate the 50th anniversary of the lunar landing.

Townsville resident Bronwyn Creedy says she feels like a "first-world refugee" after six months of living away from her flood-ravaged home, and hundreds of people are in a similar position.

A jury finds a former Canberra police officer who improperly used police data to impersonate his neighbour, in order to call authorities about a suburban dispute, acted reasonably and did not commit a crime.

The ACT Government has told grocers to display signs supporting 'genuinely free-range' egg farmers, based on a much stricter definition than the national standard.

No agreement is reached to avert the planned train strike at the end of this month, despite four hours of negotiations between Sydney Trains and unions.

AMC Theatres has hit hard at Universal Pictures, announcing it will no longer play any of the studio's films in the wake of NBCUniversal CEO Jeff Shell's promise to open titles on premium and in theaters at the same time. Universal used the PVOD format to release "Trolls World Tour" on April 10 amid the […]

AFB TECH Director Mark Uslan talks about how how an existing mathematical model for large digital displays might apply to measuring small-display quality, making them accessible to the nearly 21 million Americans who suffer from vision loss.

The ability to read small visual displays (SVDs) affects successful functioning at home and in the workplace. SVDs can be found in products as diverse as cell phones, personal digital assistants, photocopiers, fax machines, kitchen and laundry appliances, home entertainment devices, exercise equipment, and diabetes self-management technology. Individuals with vision loss face severe limitations in using such products safely and effectively because the visual displays lack accessibility features.

RT @IsaacScher__: NEW: Half of all Brooklynites are white, but 97.5% of the borough's social distancing arrests were of people of color.

Living in Montreal, I often have to create multi-lingual websites for clients. That means finding the right plugin for the job. I don’t always use WPML, but it’s one of…

The post Displaying Different Logos with WPML appeared first on bavotasan.com.

On Monday, Denver dispensaries saw their biggest sales day of the year so far, according to data firm Flowhub. Sales were up 140% compared to an average Monday, the company reported.

As the coronavirus pandemic disrupts daily life and commerce in Colorado, many in the state’s marijuana industry believe it makes the case for allowing dispensaries to begin delivering to customers' homes now.

Dispensaries and cultivations reported 10 burglaries in the first two weeks of April, Denver police said. That's up from eight burglaries reported during the whole month of April 2019.

Boulder will soon be home to two dispensaries legally delivering medical marijuana.

A large lobbying effort mobilized almost immediately. Conducted outside the public’s view, its goal was to keep hundreds of stores open, thousands of Denverites employed, and entire industries functioning across the city.

This is the second part of a three-part series on use of litigation interest and risk assessment (LIRA), growing out of a program at CPR’s annual meeting in February 2020. The first part of this series describes how to do LIRAs and includes results from a survey of participants in our program.  This part describes … Continue reading Early Dispute Resolution Processes →

This is the final part of a three-part series on litigation interest and risk assessment (LIRA) and early dispute resolution procedures.  The first part explains how lawyers can use LIRA procedures to help clients make better decisions about litigation and negotiation.  The second part describes some early dispute resolution procedures, which can benefit from good … Continue reading Dispute Prevention and Early Dispute Resolution Framework →

A recent post anticipates that as we go through the current crisis, we will develop a “crisis new normal” and, after we recover from the crisis, a “normal new normal” (NNN).  At this point, governments, institutions, and individuals are still developing new routines as we wait out the crisis by doing things like sheltering in … Continue reading The Next New Normal in Law, Dispute Resolution, and Legal Education →

A Weld County man is being investigated on suspicion of attempted first-degree murder for allegedly shooting at a neighbor over a property dispute.

The “Funds for Morehouse” campaign gave more than $260,000.

The verbal altercation turned deadly.

The city is seeing disproportionate cases among minorities.

The verbal altercation turned deadly.

iGiant not only screwed up the wiring, it knew it was shipping dodgy gear, it is claimed

Apple is potentially facing a class-action lawsuit over the failure of displays on its MacBook Pro line.…

Tumor-associated peptide–human leukocyte antigen complexes (pHLAs) represent the largest pool of cell surface–expressed cancer-specific epitopes, making them attractive targets for cancer therapies. Soluble bispecific molecules that incorporate an anti-CD3 effector function are being developed to redirect T cells against these targets using 2 different approaches. The first achieves pHLA recognition via affinity-enhanced versions of natural TCRs (e.g., immune-mobilizing monoclonal T cell receptors against cancer [ImmTAC] molecules), whereas the second harnesses an antibody-based format (TCR-mimic antibodies). For both classes of reagent, target specificity is vital, considering the vast universe of potential pHLA molecules that can be presented on healthy cells. Here, we made use of structural, biochemical, and computational approaches to investigate the molecular rules underpinning the reactivity patterns of pHLA-targeting bispecifics. We demonstrate that affinity-enhanced TCRs engage pHLA using a comparatively broad and balanced energetic footprint, with interactions distributed over several HLA and peptide side chains. As ImmTAC molecules, these TCRs also retained a greater degree of pHLA selectivity, with less off-target activity in cellular assays. Conversely, TCR-mimic antibodies tended to exhibit binding modes focused more toward hot spots on the HLA surface and exhibited a greater degree of crossreactivity. Our findings extend our understanding of the basic principles that underpin pHLA selectivity and exemplify a number of molecular approaches that can be used to probe the specificity of pHLA-targeting molecules, aiding the development of future reagents.

Seizures often herald the clinical appearance of gliomas or appear at later stages. Dissecting their precise evolution and cellular pathogenesis in brain malignancies could inform the development of staged therapies for these highly pharmaco-resistant epilepsies. Studies in immunodeficient xenograft models have identified local interneuron loss and excess glial glutamate release as chief contributors to network disinhibition, but how hyperexcitability in the peritumoral microenvironment evolves in an immunocompetent brain is unclear. We generated gliomas in WT mice via in utero deletion of key tumor suppressor genes and serially monitored cortical epileptogenesis during tumor infiltration with in vivo electrophysiology and GCAMP7 calcium imaging, revealing a reproducible progression from hyperexcitability to convulsive seizures. Long before seizures, coincident with loss of inhibitory cells and their protective scaffolding, gain of glial glutamate antiporter xCT expression, and reactive astrocytosis, we detected local Iba1+ microglial inflammation that intensified and later extended far beyond tumor boundaries. Hitherto unrecognized episodes of cortical spreading depolarization that arose frequently from the peritumoral region may provide a mechanism for transient neurological deficits. Early blockade of glial xCT activity inhibited later seizures, and genomic reduction of host brain excitability by deleting MapT suppressed molecular markers of epileptogenesis and seizures. Our studies confirmed xenograft tumor–driven pathobiology and revealed early and late components of tumor-related epileptogenesis in a genetically tractable, immunocompetent mouse model of glioma, allowing the complex dissection of tumor versus host pathogenic seizure mechanisms.

Prenatal alcohol exposure (PAE) affects at least 10% of newborns globally and leads to the development of fetal alcohol spectrum disorders (FASDs). Despite its high incidence, there is no consensus on the implications of PAE on metabolic disease risk in adults. Here, we describe a cohort of adults with FASDs that had an increased incidence of metabolic abnormalities, including type 2 diabetes, low HDL, high triglycerides, and female-specific overweight and obesity. Using a zebrafish model for PAE, we performed population studies to elucidate the metabolic disease seen in the clinical cohort. Embryonic alcohol exposure (EAE) in male zebrafish increased the propensity for diet-induced obesity and fasting hyperglycemia in adulthood. We identified several consequences of EAE that may contribute to these phenotypes, including a reduction in adult locomotor activity, alterations in visceral adipose tissue and hepatic development, and persistent diet-responsive transcriptional changes. Taken together, our findings define metabolic vulnerabilities due to EAE and provide evidence that behavioral changes and primary organ dysfunction contribute to resultant metabolic abnormalities.

A nationwide class action lawsuit filed against Apple in Northern California court this week accuses the company of knowingly concealing a defect with a display-related flex cable on recent 13-inch and 15-inch MacBook Pro models.


As discovered by repair website iFixit last year, some MacBook Pro models released in 2016 and 2017 have experienced issues with uneven backlighting caused by a delicate flex cable that can wear out and break after repeated opening and closing of the display. Impacted notebooks can exhibit uneven lighting at the bottom of the screen, which has been described as a "stage light" effect, and the backlighting system can eventually fail entirely.

Since the issue often takes time to manifest, the affected ‌MacBook Pro‌ units can be outside of Apple's one-year warranty period when they start exhibiting symptoms, resulting in an out-of-warranty repair fee of up to $850.

"Imagine spending more than $2,500 on a laptop only for it to fail shortly after the manufacturer's warranty expires," said PARRIS Law Firm attorney R. Rex Parris. "What's even more appalling is Apple requiring customers to spend an additional $600 to $850 to replace the screen."

Apple seemingly fixed the issue by extending the length of the flex cable by 2mm in the 2018 MacBook Pro. It also launched a free repair program in May 2019, but the program only applies to 13-inch MacBook Pro models released in 2016.

Chuck Todd tells Andrea Mitchell that Hillary Clinton will win the African-American and Hispanic vote in spite of the intellectual appeal of Bernie Sanders to liberal white voters Continue reading →