Artificial intelligence (AI) is everywhere. Machine learning (ML) and its associated inference abilities promise to revolutionize everything from driving your car to making your breakfast. Verification is never truly complete; it is over when you run...(read more)

Each November, we are reminded of the bravery and dedication of those who have served our country. At Cadence, we thank our Veteran employees for their patriotism by reaffirming our commitment to honoring their sacrifices and recognizing their contributions to our business success. Our diverse and inclusive culture is strengthened by the unique perspective of our Veteran employees, and we are proud to support the Veterans Inclusion Group as a space for community members and their allies to connect. In celebration of Veterans Day, we were excited to catch up with Johnathan Edmonds, Veterans Inclusion Group Lead and Design Engineering Director, for a heartfelt chat on his journey through military service to leadership within Cadence. Throughout the conversation, he shared the importance of creating space for Veterans, the skills they offer, and his aspirations for what the Veterans Inclusion Group will achieve in the years ahead. Oh yeah, and he flies planes, too! Join us as we dive into what makes this holiday special for so many across the nation and how we can respectfully commemorate it together. Johnathan, you’re a retired Air Force Reservist, pilot, and now a Design Engineering Director. Can you tell us about your journey from the military to your current role at Cadence? I started my military and electronics journey in the Navy. I enlisted at 18 and served for six years as an aviation electronics technician. During this time, I was able to learn about and repair electronics on planes. This set me up for success, and when I was honorably discharged, I attended Virginia Tech to study computer engineering. Once I graduated, I continued my career as an engineer, but I still wanted to be a military pilot. From my past experience, I knew the reserves were an option where I could learn to fly and still have a civilian career. Not only was I lucky enough to get selected to go to pilot training, but after I returned from flight school, my luck grew, and I was hired at Cadence. Cadence has supported me throughout my military career, which has been a great benefit, as many companies don’t support reservists. The best thing about serving and being employed at Cadence is how I could blend my skill sets to further the Air Force’s mission and achieve great things in engineering. As the first lead of Cadence’s Veterans Inclusion Group, you played an integral part in growing our culture and building community at the company since launching the group four years ago. What inspired you to take on the role of Inclusion Group Lead? I was inspired by three things: camaraderie, service, and outreach. I wanted to see if we could achieve a similar sense of community through the Veterans Inclusion Group as we had during our service life. I also wanted to see how we could better serve our Veterans here at Cadence. I wanted to explore any benefits that could be expanded, roles that could be developed by Vets, and, lastly, I wanted to serve a broader community. COVID-19 put a damper on some of the community support, but we are getting back on track with Veteran employment programs and volunteer efforts like Carry the Load and Gold Star Families. Why is it important to have this space dedicated to Veteran employees? There are many reasons! Networking, for one, creates a stronger, more unified Cadence culture. Two, Vets face a variety of issues not generally understood by those who have not served, such as PTSD, where to get help for disabilities, how to get an old medical record, etc. As I mentioned, I’m also passionate about connecting Veterans with employment and job opportunities. It is so nice to work for a company that actively recruits Vets. We have our own “language,” if you will, so it’s nice to have a space to talk in the language that we are familiar with. What have been some of your favorite moments leading this group over the past few years? Are there any “wins” that you would like to recognize? We have a lot of wins. Events held during COVID-19 and getting past COVID-19, donating to worthwhile causes, and hosting guest speakers are all fantastic milestones and accomplishments. That said, the biggest win is the hiring of new Veteran employees. Mark Murphy, Corporate VP of Sales Operations, and I have both welcomed Vets to our team during this time, and it is such a joy to watch what someone can do when given the opportunity to succeed in the right environment. As you are set to transition out of the lead role next year, what do you hope to see the Veterans Inclusion Group accomplish next? My hope is that the Veterans Inclusion Group partners with other companies, expanding our reach externally and exploring new opportunities to engage Veterans outside of Cadence. Johnathan (left) speaks on an inclusion group panel, along with David Sallard (center), lead of Cadence's Black Inclusion Group and Sr. Principal Application Engineer; Christina Jamerson (on screen), lead of Cadence's Abilities Inclusion Group and Demand Generation Director; and Dianne Rambke (right), lead of Cadence's Latinx Inclusion Group and Marketing Communications Director. What are the important ways that people can signal inclusion and respectfully honor Veterans at work? What are the most meaningful or impactful actions employees everywhere can take to support Veteran coworkers? I think there is one answer to both questions. I recommend that people engage with their companies’ employee resource groups (ERGs) and have conversations with them. Opening up the lines of communication will lead to new paths in their journeys. What are you looking forward to in 2025, both personally and professionally? In 2025, professionally, I am looking forward to taking mixed-signal systems and verification to another level by including emulation, automatic model generation, and seeing which boundaries we can push in our SerDes and Chiplets products. Personally, I am looking forward to making my SXS street legal so I can drive places without getting a ticket, seeing my children participate in sports, church, and school, and taking my wife on vacation to Europe or somewhere else we can unplug. Learn more about Cadence’s Inclusion Groups, diverse culture, and commitment to belonging.

Designing 3D-ICs with integrity involves a commitment to ethical practices, reliability, and sustainability throughout the design and manufacturing process. This includes using environmentally friendly materials, ensuring robust and efficient performance, and incorporating thorough testing and verification. By prioritizing transparency, responsibility, and long-term sustainability, designers can create advanced integrated circuits that meet high standards of quality and social responsibility.

Start Learning Now!

Start with our Designing with Integrity 3D-IC online course, which introduces Integrity 3D-IC, the industry's first comprehensive, high-capacity 3D-IC platform that integrates 3D design planning, implementation, and system analysis in a single, unified environment. You will be guided through the following activities involved in designing a silicon interposer with a digital ASIC and HBM2 interface in a 2.5D configuration.

• You will design the interposer from scratch in the new Integrity System Planner and the Integrity 3D-IC implementation environment.
• You will examine the ASIC and interposer designs using some of the new 3D-IC multi-die design features.
• You will route the interposer using some of the new advanced routing capabilities with NanoRoute

—and this in only two days!

WATCH VIDEO

Interested? Get an overview in less than two minutes.

Are you primarily interested in selected snippets instead? Then, take our Training Bytes, which—like the online training course—are available to Cadence customers for free 24/7 in the Cadence Learning and Support portal.

Cadence Training Services now offers free Digital Badges for all popular online training courses. These badges indicate proficiency in a certain technology or skill and give you a way to validate your expertise to managers and potential employers. You can add the digital badge to your email signature or any social media channels, such as Facebook or LinkedIn, to highlight your expertise.

To find out more, see the blog post. It’s the Digital Era; Why Not Showcase Your Brand Through a Digital Badge!

Related Resources

• 3D-IC Introduction (Video)
• 3D-IC Development Process With Challenges. (Video)
• Demo: How to Create the Interposer Contact Pads and Die Connectivity Using the Integrity 3D-IC? (Video)
• Demo: How To Pull The Interposer Design From System Planner Into Integrity 3D-IC Layout? (Video)
• Demo: Routing The Interposer Design Using The Integrity 3D-IC Layout_Part 1 (Video)
• Demo: Routing The Interposer Design Using The Integrity 3D-IC Layout_Part 2 (Video)
• Demo: How To Create C4 Bumps For NC Connections And Generating C4 Dummy Cover Bumps In Integrity 3D-IC? (Video)

Related Blogs

• How Cadence Is Expanding Innovation for 3D-IC Design
• Training Bytes: They May Be Shorter, But the Impact Is Stronger!
• Training Insights — 3D-IC: What Is Silicon Interposer?
• System Analysis Knowledge Bytes: What’s New in the Clarity 3D Solver Course
• System Analysis Knowledge Bytes - Early System-Level Thermal Analysis
• 3D-IC: The Future of Integrated Electronics Is the Future of Electronics Itself

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• OrbitIO System Planner
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The Cadence Cerebrus Intelligent Chip Explorer is a revolutionary, machine learning-driven, automated approach to chip design flow optimization. Block engineers specify the design goals, and Cadence Cerebrus will intelligently optimize the Cadence digital full flow to meet the power, performance, and area (PPA) goals in a completely automated way. Use Cerebrus Apps to optimize some aspects of the design as well.

Running a full RTL to GDSII flow, Cadence Cerebrus has a lot of possibilities and combinations of different tool settings to explore.

Using the knowledge from previous runs, combined with on-the-fly analysis within the flow, Cadence Cerebrus can assess many settings combinations and fine-tune the flow accordingly in a very efficient manner.

As technology advances, projects become bigger and way more complex than before. The ability of a single engineer to run simultaneously a large number of blocks in a traditional way is limited. Cadence Cerebrus allows a single engineer to work more efficiently and implement more blocks, while maintaining the same or even better PPA, using compute power.

Being such a revolutionary tool, integrating Cerebrus into your existing flow is surprisingly simple as it can wrap around any existing flow scripts.

Please join me in this course, to learn about the features and basics of Cadence Cerebrus Intelligent Chip Explorer.

We’ll walk through the tool setting stage, explain what is a primitive and how it effects our run, talk about the cost function and the run goals.

We’ll understand the concept of scenarios, learn how to analyze the results of the different runs, and compare them.

In addition, we’ll talk about basic debug rules and methods to analyze failures.

Sounds Interesting?

Please join our “live” one-day Cadence Cerebrus Intelligent Chip Explorer Training @Cadence Feldkirchen planned for October 9th, 2024!

For more details and registration, please contact Training Germany.

If you would like to have an instructor-led training session in another region please contact your local training department.

Become Cadence Certified

Cadence Training Services offers a digital badge for this training course. This badge indicates proficiency in a certain technology or skill and gives you a way to validate your expertise to managers and potential employers. You can highlight your expertise by adding this digital badge to your email signature or any social media platform, such as Facebook or LinkedIn.

Related Training

Innovus Block Implementation with Stylus Common UI

Related Training Bytes

Cerebrus Primitives (Video) 

How to Reuse Cerebrus (Video) 

Cerebrus - Verifying Distribution Script (Video)

How to distribute Cerebrus Scenarios (Video) 

Cerebrus Web Interface Monitor and Control (Video) 

How to Setup Cerebrus for a Successful Run (Video) 

Flow Wrapping: The Cadence Cerebrus Intelligent Chip Explorer Must Have (Webinar) (Video) 

Cerebrus Cost Functions (Video) 

Related Blogs

Training Insights: Cadence Cerebrus Webinar Recording Now Available!

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New to Equivalence Checking? Restart from the Basic Concepts

Training Insights - Free Online Courses on Cadence Learning and Support Portal

Training Insights – Important Facts You Should know About Our Cadence Learning and Support Portal

Robotics developers can greatly accelerate their work on AI-enabled robots, including humanoids, using new AI and simulation tools and workflows that NVIDIA revealed this week at the Conference for Robot Learning (CoRL) in Munich, Germany. The lineup includes the general availability of the NVIDIA Isaac Lab robot learning framework; six new humanoid robot learning workflows Read Article

Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.

BAKU, Azerbaijan — The head of the United Nations' nuclear watchdog said Tuesday he's hopeful that meetings this week with Iranian officials, including the country's new president, can lead to a breakthrough in monitoring the country's nuclear program, a longstanding issue that has gained new urgency as Israel has twice struck Iran amid rising tensions in the Middle East. Rafael Mariano Grossi, director general of the International Atomic Energy Agency, will travel to Iran on Wednesday to meet for the first time with President Masoud Pezeshkian, who was elected in July. Grossi said he hopes to build on positive discussions he had with Iranian Foreign Minister Abbas Araghchi during the U.N. General Assembly in September. "We have a problem that we need to solve," Grossi said in an interview at the U.N. climate conference in Azerbaijan. "That is this gap, this lack of confidence, which we should not allow to grow into a self-fulfilling prophecy of using nuclear facilities as targets." He added: "There has been a bit of a dire straits dynamic with Iran that we want to go beyond." Iran is rapidly advancing its atomic program while increasing stockpiles of uranium enriched to near weapons-grade levels, all in defiance of international demands, according to the IAEA. Iran says its program is for energy purposes, not to build weapons. Grossi's visit comes as Israel and Iran have traded missile attacks in recent months after more than a year of war in Gaza, which is governed by Hamas, a group supported by Iran. Grossi noted that international law prohibits the attack of nuclear facilities and "it's obvious that is something that can have radiological consequences." The Biden administration said last month that it had won assurances from Israel that it would not attack nuclear or oil sites. A 2015 nuclear agreement between Iran and world powers put limits on Iran's nuclear program, which the West fears could be used to make nuclear weapons. The deal included the lifting of economic sanctions on Iran. But that deal collapsed after Donald Trump's administration in 2018 pulled the United States from it. That led Iran to abandon all limits put on its program and enrich uranium to up to 60% purity. When asked if the IAEA feared Iran may be developing a bomb, Grossi said he didn't "have any information that would sustain that." He added that inspectors' job was not to "judge intentions," but rather verify that what Iran says about its nuclear program was true. Trump's reelection last week raises questions about whether and how the incoming administration and Iran may engage. Grossi said he had worked with the first Trump administration, which he said engaged in "seamless, professional work," and looked forward to looking with Trump's second administration. "Circumstances have changed in that the problem has grown bigger than it was," said Grossi. "The problem of not finding a solution."

Cat’s fast language acquisition process differs from how dogs learn words, often requiring training and rewards. However, cats form associations through subtle behaviors, such as gaze.

Co founder of Electronic Music Malta Edwin Balzan tells all in our Q&A

Solar power is now priced competitively with traditional forms of energy, which makes new nuclear power plants financially unviable.

North Korea conducted its fourth hydrogen bomb test last week, and reactions from around the world have ranged from outrage and alarm to dismissiveness.

The warnings from the United Nations and from anti-nuclear activists are increasingly ominous: the world is closer to a nuclear war—by design or by accident—more than ever before. The current conflicts—and the intense war of words—between nuclear and non-nuclear states—Russia vs. Ukraine, Israel vs. Palestine and North Korea vs. South Korea—are adding fuel to a […]

In recent years, the rhetoric, strategy and practice of nuclear deterrence has grown riskier, more urgent, more dangerous, less stable, and increasingly in the hands of deficient leaders and policymakers. Playing Nuclear Games The ten States that have manufactured and test detonated nuclear weapons since 1945, each have received and/or provided assistance to other States […]

The United Nations Secretary General António Guterres congratulated grassroots Japanese organization Nihon Hidankyo on being awarded the 2024 Nobel Peace Prize. “The atomic bomb survivors from Hiroshima and Nagasaki, also known as the hibakusha, are selfless, soul-bearing witnesses of the horrific human cost of nuclear weapons,” he said in a statement. “While their numbers grow smaller each […]

Satellite images show China working on nuclear reactor for new warship

Global education is facing a critical moment amid severe setbacks. Millions of children are out of school, learning levels are falling, and millions are leaving school without the skills they need. New out-of-school figures reveal that global progress in reducing the number of out-of-school children has been just 1 percent since 2015, leaving 251 million […]

Research on ICT and capacity building for poverty reduction, focusing on lessons learned from a distant learning course in microfinance.

India’s federal power minister on Tuesday asked the states that are away from coal resources to consider setting up nuclear-based power plants, besides identifying and listing the power utilities to meet investments to support growing power demand.

The Indian government in its federal budget this year had proposed to partner with private players to develop small nuclear reactors to increase the amount of electricity from sources that do not produce carbon dioxide emissions.

States should consider setting up nuclear power plants at the sites where coal-based thermal power plants have completed their life, Manohar Lal, the country’s power minister, told states as per a government statement.

India’s stringent nuclear compensation laws have hampered talks with foreign power plant builders such as General Electric GE.N and Westinghouse.

The country, which currently has about 8 gigawatts of nuclear capacity, aims to increase it to 20 GW by 2032.

The minister also asked the states to identify and list their power utilities in the country’s stock exchange to meet increasing investment demand in the power sector as well as improve the transmission system to add more renewable capacity.

India has pledged to achieve a net zero carbon emission target by 2070 and has a target of 500 GW of renewable energy by 2030.

This brief shows how India sparked a digital payments boom and boosted financial inclusion through the introduction of its Unified Payments Interface (UPI) and outlines ways countries in the region can ramp up their own digital transformation.

After the release of a shocking video showing Olympic rider Charlotte Dujardin whipping a horse, it is time for equestrians to educate themselves on the science of horse training, says Christa Lesté-Lasserre

Two important barriers to a stable, powerful fusion reaction have been leapt by an experiment in a small tokamak reactor, but we don’t yet know if the technique will work in larger devices

Concern over the risks of enabling nuclear weapons development is usually focused on nuclear fission reactors, but the potential harm from more advanced fusion reactors has been underappreciated

Two types of fusion reactor called tokamaks and stellarators both have drawbacks – but a new design combining parts from both could offer the best of both worlds

A recent atomic physics workshop was outside my dark matter comfort zone, but learning about science beyond my usual boundaries was invigorating, says Chanda Prescod-Weinstein

These stunning photographs are all shortlisted for the Sony World Photography Awards 2024

Title: Children Learn to Share by Age 7 or 8
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The pursuit of harnessing data for knowledge creation has been an enduring quest, with the advent of machine learning (ML) and artificial intelligence (AI) marking significant milestones in this journey. ML, a subset of AI, emerged as the practice of employing mathematical models to enable computers to learn and improve autonomously based on their experiences. In the pharmaceutical and biopharmaceutical sectors, a significant portion of manufacturing data remains untapped or insufficient for practical use. Recognizing the potential advantages of leveraging the available data for process design and optimization, manufacturers face the daunting challenge of data utilization. Diverse proprietary data formats and parallel data generation systems compound the complexity. The transition to Pharma 4.0 necessitates a paradigm shift in data capture, storage, and accessibility for manufacturing and process operations. This paper highlights the pivotal role of AI in converting process data into actionable knowledge to support critical functions throughout the whole product life cycle. Furthermore, it underscores the importance of maintaining compliance with data integrity guidelines, as mandated by regulatory bodies globally. Embracing AI-driven transformations is a crucial step toward shaping the future of the pharmaceutical industry, ensuring its competitiveness and resilience in an evolving landscape.

Massively parallel reporter assays (MPRAs) are powerful tools for quantifying the impacts of sequence variation on gene expression. Reading out molecular phenotypes with sequencing enables interrogating the impact of sequence variation beyond genome scale. Machine learning models integrate and codify information learned from MPRAs and enable generalization by predicting sequences outside the training data set. Models can provide a quantitative understanding of cis-regulatory codes controlling gene expression, enable variant stratification, and guide the design of synthetic regulatory elements for applications from synthetic biology to mRNA and gene therapy. This review focuses on cis-regulatory MPRAs, particularly those that interrogate cotranscriptional and post-transcriptional processes: alternative splicing, cleavage and polyadenylation, translation, and mRNA decay.

Memory formation is contingent on molecular and structural changes in neurons in response to learning stimuli—a process known as neuronal plasticity. The initiation step of mRNA translation is a gatekeeper of long-term memory by controlling the production of plasticity-related proteins in the brain. The mechanistic target of rapamycin complex 1 (mTORC1) controls mRNA translation, mainly through phosphorylation of the eukaryotic initiation factor 4E (eIF4E)-binding proteins (4E-BPs) and ribosomal protein S6 kinases (S6Ks). mTORC1 signaling decreases throughout brain development, starting from the early postnatal period. Here, we discovered that in mice, the age-dependent decrease in mTORC1 signaling occurs selectively in excitatory but not inhibitory neurons. Using a gene conditional knockout (cKO) strategy, we demonstrate that either up- or downregulating the mTORC1-4E-BP2 axis in GAD65 inhibitory interneurons, but not excitatory neurons, results in long-term object recognition and object location memory deficits. Our data indicate that the mTORC1 pathway in inhibitory but not excitatory neurons plays a key role in memory formation.

ABSTRACTWe document the effort over the last 30 years to respond to the call by women advocates at the International Conference on Population and Development for more woman-initiated single or dual-purpose contraceptive methods by developing the Caya contoured diaphragm, an innovative diaphragm designed to meet the needs of women and their partners and expand options for nonhormonal barrier contraception. We describe the complex and interrelated set of activities undertaken to develop the product using a human-centered design process and how we are working to create a corollary sustainable market. This review includes the evidence generated around improved acceptability among couples in low- and middle-income countries and depicts challenges and practical actions on how to dispel misconceptions about diaphragm use. Importantly, we share programmatic lessons learned on increasing universal access to this new sexual and reproductive health technology. Following our new model for increasing access to new and underutilized methods, Caya is now registered and being marketed in nearly 40 countries worldwide.

ABSTRACTTraining health workers is one of the biggest challenges and cost drivers when introducing a new contraceptive method or service delivery innovation. PATH developed a digital training curriculum for family planning providers who are learning to offer subcutaneous DMPA (DMPA-SC), including through self-injection, as an option among a range of contraceptive methods. The DMPA-SC eLearning course for health workers includes 10 lessons with an emphasis on informed choice counseling and training clients to self-inject. In partnership with Ministries of Health in Senegal and Uganda, the course was rolled out in select areas in 2019–2020, including during the COVID-19 pandemic when physical distancing requirements restricted in-person training. We conducted evaluations in both countries to assess the practical application of this digital training approach for contraceptive introduction. The evaluation consisted of a post-training survey, an observational assessment conducted during post-training supportive supervision, and an estimation of training costs.In both countries, a majority (88.6% in Uganda and 64.3% in Senegal) scored above 80% on a DMPA-SC knowledge test following the training. In Senegal, where there was a comparison group of providers trained in person, those providers scored similar on the post-test to eLearners. Providers in both groups and in both countries felt more prepared to administer DMPA-SC or offer self-injection to clients after receiving a supervision visit (93%–98% of eLearners felt very prepared after supervision as compared to 45%–72% prior). The evaluation results suggest that digital approaches offer a number of benefits, can be cost-effective, and are most optimal when blended with in-person training and/or supportive supervision.

ABSTRACTIntroduction: Nigeria has the highest number of children who have not received any vaccines in Africa. The training-of-trainers (TOT) model used to train program managers (PMs) and health care workers (HCWs) is ineffective for adult learning and limits immunization programs’ success. We incorporated adult learning principles (ALPs) in designing and delivering TOT for immunization PMs and HCWs to use data to engage communities for tailored immunization strategies.Methods: Our study was implemented in 3 local government areas (LGAs) of the Federal Capital Territory, Nigeria. A training curriculum was developed, integrating ALPs and technical and operational content based on best practices in delivering immunization training and the training needs assessment findings. State PMs (n=10), LGA PMs (n=30), and HCWs (n=42) were trained on the human-centered design for tailoring immunization programs (HCD-TIP) approaches using ALPs. We used interviews and surveys with purposively and conveniently sampled PMs and HCWs, respectively, and observations to assess participants’ satisfaction, knowledge and competence, behavior changes, and results. The interviews were analyzed thematically, and surveys were statistically.Results: There was a high level of satisfaction with the training among LGA PMs (100%), state PMs (91%), and HCWs (85%), with significant knowledge and competence improvements post-training (P<.001). The trained participants conducted 2 HCD sessions with 24 undervaccinated communities and co-designed 24 prototype solutions for testing. Results showed increased coverage of the pentavalent vaccine first dose (54%) and third dose (188%) across 12 participating communities. Improved community colaboration, communication skills, and data-driven approaches were the most cited behavior changes in practice.Conclusion: The application of ALPs in training, use of HCD-TIP approaches and tools, and supportive supervision enhanced PMs’ and HCWs’ capacity for tailored interventions. Countries should consider adopting a holistic approach that focuses on using these approaches in immunization programs to strengthen the health system for equitable vaccine coverage.

ABSTRACTWe describe the development, implementation, and evaluation of a novel twinning approach: the Twinning Partnership Network (TPN). Twinning is a well-known approach to peer learning that has been used in a variety of settings to build organizational capacity. Although twinning takes many forms, the heart of the approach is that institutions with shared characteristics collaborate via sharing information and experiences to achieve a specific goal. We adapted a twinning partnership strategy developed by the World Health Organization to create a network of like-minded health institutions. The key innovation of the TPN is the network, which ensures that an institution always has a high-performing peer with whom to partner on a specific topic area of interest. We identified 10 hospitals and 30 districts in Rwanda to participate in the TPN. These districts and hospitals participated in a kickoff workshop in which they identified capacity gaps, clarified goals, and selected twinning partners. After the workshop, districts and hospitals participated in exchange visits, coaching visits, and virtual and in-person learning events. We found that districts and hospitals that selected specific areas and worked on them throughout the duration of the TPN with their peers improved their performance significantly when compared with those that selected and worked on other areas. Accreditation scores improved by 5.6% more in hospitals selecting accreditation than those that did not. Districts that selected improving community-based health insurance coverage improved by 4.8% more than districts that did not select this topic area. We hypothesize that these results are due to senior management’s interest and motivation to improve in these specific areas, the motivation gained by learning from high-performing peers with similar resources, and context-specific knowledge sharing from peer hospitals and districts.

The diagnostic work-up of patients with fever of unknown origin (FUO) begins with a thorough history and physical examination, complete blood count with differential, chest x-ray, urinalysis and culture, electrolyte panel, liver enzymes, erythrocyte sedimentation rate, and C-reactive protein level. Additional imaging procedures, including nuclear medicine tests, are generally used as second-line procedures, with ¹⁸F-FDG PET and PET/CT assuming increasingly important roles in the diagnostic work-up. The Society of Nuclear Medicine and Molecular Imaging, the Infectious Diseases Society of America, and the American College of Nuclear Medicine convened an autonomous expert work group to comprehensively review the published literature for nuclear imaging in adults and children with FUO and establish appropriate use criteria (AUC). This process was performed in accordance with the Protecting Access to Medicare Act of 2014, which requires that all referring physicians consult AUC by using a clinical decision support mechanism before ordering advanced diagnostic imaging services. The complete findings and discussions of the work group were published on January 8, 2023, and are available at https://www.snmmi.org/ClinicalPractice/content.aspx?ItemNumber=15666. The AUC in the final document are intended to assist referring health care providers in appropriate use of nuclear medicine imaging procedures in patients with FUO. The work group noted limitations in the current literature on nuclear medicine imaging for FUO, with the need for well-designed prospective multicenter investigations. Consensus findings from published data and expert opinions were used to create recommendations in common clinical scenarios for adults and children. Included in the complete document is a discussion of inflammation of unknown origin (IUO), a recently described entity. In view of the fact that the criteria for FUO and IUO are similar (except for fever > 38.3°C [100.9°F]) and that the most common etiologies of these 2 entities are similar, it is the expert opinion of the work group that the recommendations for nuclear medicine imaging of FUO are also applicable to IUO. These recommendations are included in the full guidance document. This summary reviews rationale, methodology, and main findings and refers the reader to the complete AUC document.

BACKGROUND AND PURPOSE:

Intracranial vessel wall imaging is technically challenging to implement, given the simultaneous requirements of high spatial resolution, excellent blood and CSF signal suppression, and clinically acceptable gradient times. Herein, we present our preliminary findings on the evaluation of a deep learning–optimized sequence using T1-weighted imaging.

Chris embraces our cyberpunk subscription overlords. Josh kills the innkeeper (accidentally). Meanwhile Robert plunges down the .Hack hole.

The post RPG Cast – Episode 610: “No One Should Learn Japanese from Super Robot Wars” appeared first on RPGamer.

Sony president Hiroki Totoki in a Q&A session with investors was asked about the failure of Concord, which was shut down less than two weeks after it released.

"Currently, we are still in the process of learning," said Totoki (via VideoGamesChronicle). "And basically, with regards to new IP, of course, you don’t know the result until you actually try it.

"So for us, for our reflection, we probably need to have a lot of gates, including user testing or internal evaluation, and the timing of such gates. And then we need to bring them forward, and we should have done those gates much earlier than we did.

"Also, we have a siloed organisation, so going beyond the boundaries of those organisations in terms of development, and also sales, I think that could have been much smoother.

"And then going forward, in our own titles and in third-party titles, we do have many different windows. And we want to be able to select the right and optimal window so that we can deploy them on our own platform without cannibalization, so that we can maximize our performance in terms of title launches. That’s all I have."

Sony senior vice president for finance and IR Sadahiko Hayakawa discussed the success of Helldivers 2 and the failure of Concord.

"We launched two live-service games this year," he said. "Helldivers 2 was a huge hit, while Concord ended up being shut down. We gained a lot of experience and learned a lot from both.

"We intend to share the lessons learned from our successes and failures across our studios, including in the areas of title development management as well as the process of continually adding expanded content and scaling the service after its release so as to strengthen our development management system.

"We intend to build on an optimum title portfolio during the current mid-range plan period that combines single-player games – which are our strengths and which have a higher predictability of becoming hits due to our proven IP – with live-service games that pursue upside while taking on a certain amount of risk upon release."

Concord released for the PlayStation 5 and PC on August 23, and it was shut down on September 6.

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463026/sony-discusses-what-lessons-can-be-learned-from-the-failure-of-concord/

The mystery surrounding Deadlock, Valve’s work-in-progress MOBA shooter, has largely evaporated. Its freely extendable invite system is about as effective at controlling player headcount as a disinterested football steward, meaning pretty much anyone with a clued-in Steam friend can get in and start poking around its secrets. And yet, being a lane-pushing wizard fighter in the Dota 2 vein, it’s already a vast tangle of interplaying abilities, items, strats, and often unspoken rules, of the kind that even experienced gankists will take hundreds of hours to learn. It’s been too much for poor Brendy, at any rate.

Still, Brendy is but one man. What if we had but four men, working in tandem to crush lanes and flatten Patrons just as Gabe intended? To find out if Deadlock is indeed more comprehensible as a team sport, Graham, Ed, Ollie, and James joined forces, promptly getting fucked up yet emerging from the warlock hospital with a deeper understanding of its workings. Or, at least, if anyone would keep playing.

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