1. Sensex, Nifty50 decline for 5th straight session; now down over 9% from peak | Stock Market News  Mint
2. Stock Market LIVE Updates: Nifty at 23,700, Sensex tanks 520 pts; auto, metal, realty major drag  Moneycontrol
3. Markets fall, Nifty, Sensex slip nearly 1 per cent: What’s worrying investors at the moment?  The Financial Express
4. Sensex Today | Stock Market LIVE Updates: Sensex off day's low, trades 500 pts lower; Nifty below 23,750;...  The Economic Times
5. Stock market today: Trade setup for Nifty 50 to Q2 results today; five stocks to buy or sell on Wednesday — Nov 13  Mint

Network Power in the Asia-Pacific: Making Sense of the New Regionalism and Opportunities for Cooperation 7 February 2020 — 9:45AM TO 5:30PM Anonymous (not verified) 17 January 2020 Chatham House | 10 St James's Square | London | SW1Y 4LE

The Asia-Pacific region continues to increase in geopolitical and geoeconomic importance. The rise of China and tensions with the US are affecting bilateral relationships and traditional alliances in the region. Whether seen from the perspective of the Quad – Australia, India, Japan and the US – or the Indo-Pacific concept embraced by a wide range of countries but with no shared consensus on scope and objectives or with ASEAN who insists on the importance of its own centrality, the region is redefining and reconceptualising itself.

With a diverse range of initiatives – including the Regional Comprehensive Economic Partnership (RCEP) and Comprehensive and Progressive Agreement for Trans-Pacific Partnership (CPTPP) – there are a plethora of regional agreements and institutional groupings that add further complexity.

As the Bretton Woods architecture continues to be dominated by Western powers, China is also spearheading parallel governance initiatives such as the Asian Infrastructure Investment Bank (AIIB), the Belt and Road Initiative and the Shanghai Cooperation Organization (SCO) as a means of enhancing its geopolitical and geoeconomic influence.

This one-day conference will focus on how such networks and alliances have been built, and sustained, in the Asia-Pacific region. In order to understand how new regional initiatives might open up opportunities for new forms of international cooperation, the conference will focus on the themes of cyber-technology and innovation, sustainable development and mitigating the impacts of climate change and new infrastructure initiatives. It will assess whether there is a zero-sum conflict between competing networks and agendas or whether a common approach can be developed.

Expert

Large-scale genome-wide association studies (GWASs) have associated intronic variants in PDE4B, encoding cAMP-specific phosphodiesterase-4B (PDE4B), with increased risk for post-traumatic stress disorder (PTSD), as well as schizophrenia and substance use disorders that are often comorbid with it. However, the pathophysiological mechanisms of genetic risk involving PDE4B are poorly understood. To examine the effects of PDE4B variation on phenotypes with translational relevance to psychiatric disorders, we focused on PDE4B missense variant M220T, which is present in the human genome as rare coding variant rs775201287. When expressed in HEK-293 cells, PDE4B1-M220T exhibited an attenuated response to a forskolin-elicited increase in the intracellular cAMP concentration. In behavioral tests, homozygous Pde4b^M220T male mice with a C57BL/6JJcl background exhibited increased reactivity to novel environments, startle hyperreactivity, prepulse inhibition deficits, altered cued fear conditioning, and enhanced spatial memory, accompanied by an increase in cAMP signaling pathway-regulated expression of BDNF in the hippocampus. In response to a traumatic event (10 tone–shock pairings), neuronal activity was decreased in the cortex but enhanced in the amygdala and hippocampus of Pde4b^M220T mice. At 24 h post-trauma, Pde4b^M220T mice exhibited increased startle hyperreactivity and decreased plasma corticosterone levels, similar to phenotypes exhibited by PTSD patients. Trauma-exposed Pde4b^M220T mice also exhibited a slower decay in freezing at 15 and 30 d post-trauma, demonstrating enhanced persistence of traumatic memories, similar to that exhibited by PTSD patients. These findings provide substantive mouse model evidence linking PDE4B variation to PTSD-relevant phenotypes and thus highlight how genetic variation of PDE4B may contribute to PTSD risk.

Female worker bees, which forage for the whole colony, struggle more to detect scents in the heat than males do, per the recent research

Study participants with lifelong anosmia sniffed less than those with a normal sense of smell. Future research could shed light on whether this has negative implications for their health

For Irish teens Nicole and Saoirse, interacting with their church’s Immersion student, Bree, led to an understanding of the gospel.

A 5th grade teacher uses fractions to promote both language and math skills in her dual-language classroom.

Equity benchmark indices rallied in early trade on Wednesday amid continuous foreign fund inflows along with buying in heavyweight IT stocks, Reliance Industries and HDFC Bank.

Nifty hit a fresh record high on Friday, as faster-than-expected economic growth in the September-quarter added to optimism over the global interest rate outlook.

India's benchmark indexes opened at fresh all-time highs on Monday, aided by strong domestic macroeconomic data and elevated bets of a US rate cut in March

PHILADEPHIA — The Attorneys General of Delaware, New Jersey, and Pennsylvania reiterated their support for common sense gun safety laws today as attorneys for the States of Delaware and New Jersey delivered oral arguments defending landmark gun safety legislation. In Delaware State Sportsmen’s Association v. Delaware Department of Safety & Homeland Security, currently before the […]

Read the in depth Review of Hisense 55 inches Ultra HD 4K Smart LED TV(55A71F) TV. Know detailed info about Hisense 55 inches Ultra HD 4K Smart LED TV(55A71F) configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

Hello,

A mybe silly question came to my mind: When routing sense lines, is it better to hav them as close as possible to DUT or afer the decoupling capacitors ?

Force in red, sense in purple.

Best way is 1 or 2 ?

Thanks in advance and Merry Christmas to everybody !

The Hisense 50" Class R6 Series 4K UHD Roku Smart TV is currently on sale for $138 at Walmart's early Black Friday sale — get it now and save 43% or $100-off.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

Grace is not merely poured out in the moment of salvation; it is evident throughout His eternal plan of redemption. After all, He chose those whom He would save before the foundation of the world (Ephesians 1:4). Theologians refer to this precious truth as the doctrine of election, and it has been a major point of debate and division in the church.

Artificial intelligence has more in common with ants than humans, says Neil Lawrence. Only by taking a more nuanced view of intelligence can we see how machines will truly transform society

New research is revealing that common sense is a lot more idiosyncratic than we thought, with important implications for tackling political polarisation and the future of AI

New research is revealing that common sense is a lot more idiosyncratic than we thought, with important implications for tackling political polarisation and the future of AI

Title: Being Social May Be Key to 'Sense of Purpose' as You Age
Category: Health News
Created: 7/12/2022 12:00:00 AM
Last Editorial Review: 7/12/2022 12:00:00 AM

We identified a de novo heterozygous transient receptor potential cation channel subfamily M (melastatin) member 3 (TRPM3) missense variant, p.(Asn1126Asp), in a patient with developmental delay and manifestations of cerebral palsy (CP) using phenotype-driven prioritization analysis of whole-genome sequencing data with Exomiser. The variant is localized in the functionally important ion transport domain of the TRPM3 protein and predicted to impact the protein structure. Our report adds TRPM3 to the list of Mendelian disease–associated genes that can be associated with CP and provides further evidence for the pathogenicity of the variant p.(Asn1126Asp).

UPDATES: Senator Nick Xenophon said it doesn’t make sense for the agreement between the Liberal and National parties to be kept as a private secret.

Anil Ananthaswamy's Why Machines Learn: The elegant maths behind modern AI explores the mechanics of the AI revolution, but doesn't examine its ethics

Artificial intelligence has more in common with ants than humans, says Neil Lawrence. Only by taking a more nuanced view of intelligence can we see how machines will truly transform society

New research led by scientists from the University of Pennsylvania, Karolinska Institute and Linköping University provides a landscape view of the human sense of touch.

The post Neuroscientists Identify 16 Neuronal Types Involved in Human Sense of Touch appeared first on Sci.News: Breaking Science News.

Legendary film director, Rahul Rawail, who was in Bengaluru to conduct a masterclass, talks about his cinematic journey

As winter arrives and daylight hours decrease, it gets easier to hit the snooze button and stay in bed. It turns out that there’s a scientific reason behind this phenomenon that helps to explain why people struggle to adjust their internal clocks—also known as circadian rhythm or sleep-wake cycle—when the weather turns colder.

Jun 26, 2024

Global demand for renewable energy is surging so why make solar panels, wind turbines and EVs dearer for western consumers?

The new HomeKit-enabled Onelink by First Alert� Wi-Fi Smoke + Carbon Monoxide (CO) Alarm pairs First Alert�s legacy of safety and innovation with Apple�s revolutionary HomeKit technology.

Video of legally-blind photographer living his Whole Day, as he captures a celebration of senses and movement

A new technique to make electronic fibers could help solve wearable technology’s flexibility problem

Kelly Lee Owens “Dreamstate” There’s not a lot of lyrics to “Dreamstate” beyond variations on the phrases “feel the dreamstate” and “dream to live,” but Kelly Lee Owens gets a lot out of those words. It’s in the repetition, the re-arranging of the words, and how she seems to surf the waves of her synth […]

Walking is a basic human activity that affects physical mobility, as well as cognitive and sensory perceptions. The use of Virtual Reality (VR) and Augmented

BSE Sensex crashed nearly 413 points and NSE Niftycracked below the 8,400-mark in early trade today on profit-booking at higher levels and foreign capital outflows ahead of IIP data to be released later in the day.

Actresses put out their best fashion foot forward at the screening of the much anticipated OTT series Citadel: Honey Bunny

Sensex was trading at 79,584.29 after rising 88.14 points or 0.11 per cent, while Nifty was trading at 24,172.95 after rising 31.65 points or 0.13 per cent.

The Indian stock market closed in red on Tuesday as heavy selling was seen in all sectors except IT and realty.

While Amazon Go helped popularize the concept of completely contactless stores, the arena is growing with others like 7-Eleven and Walmart entering the category, as well as several startups such as Standard Cognition, Zippin, AiFi, Grabango, and Trigo.  In Europe, Portuguese startup Sensei has been capitalizing on this momentum to grow its contactless store platform, and […]

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1. SENSEX down 50 pts, NIFTY50 hovers around 23,850; KNR Constructions up 13%, Bosch rises 3% after Q2 results  Upstox
2. Stock Market LIVE Updates: Nifty below 23,750, Sensex down 400 pts; all sectors in the green  Moneycontrol
3. Stock market: Why Sensex, Nifty are down today; what's spooking share investors?  Business Today
4. Sensex Today | Stock Market LIVE Updates: Sensex tumbles over 400 pts, Nifty below 23,800; auto stocks bleed  The Economic Times
5. Stock market today: Trade setup for Nifty 50 to Q2 results today; five stocks to buy or sell on Wednesday — Nov 13  Mint

Sony has introduced the Chroma Collection accessories and a Fortnite Limited Edition DualSense wireless controller for PlayStation 5 users in India. These new offerings provide stylish customisation options with unique colours and designs, enhancing the gaming experience. The Chroma Collection features

Manchester : Manchester University Press, [2020]

Princeton : Princeton University Press, [2005]

A companionable book filled with personal advice shared with honesty

Fundamental queries on the Smart Cities Mission answered.

Lopetz, Christian, author