I'm counting down to the publication of my 20th book, RACE THE SANDS, out 4/21, by sharing pics of each #booknecklace my husband gave me to celebrate each of my prior books...

Book 10 (middle grade): THE GIRL WHO COULD NOT DREAM is about a girl whose family owns a dream shop where they buy, bottle, and sell dreams, and the adventure she goes on with her best friend, a monster named Monster who loves cupcakes. My #booknecklace is an adorable monster.

Usually my characters develop over the course of many revisions. But with Monster... It felt like he plopped down on my desk fully-formed and said, "Write my story! And feed me cupcakes!"

I'm counting down to the publication of my 20th book, RACE THE SANDS, out 4/21, by sharing pics of each #booknecklace my husband gave me to celebrate each of my prior books...

Book 11 (adult SFF): THE QUEEN OF BLOOD, Book 1 of The Queens of Renthia, is an epic fantasy set in a world filled with bloodthirsty nature spirits. Only queens have the power to control them. So my #booknecklace is a crown with a tiny blood-red stone.

Writing The Queens of Renthia was such a wonderfully immersive experience. Every day I sat down at my computer, it felt like walking through the wardrobe into Narnia... except it's a Narnia where the trees want to kill you.

I'm counting down to the publication of my 20th book, RACE THE SANDS, out 4/21, by sharing pics of each #booknecklace my husband gave me to celebrate each of my prior books...

Book 12 (middle grade): JOURNEY ACROSS THE HIDDEN ISLANDS is a fantasy adventure for kids about two sisters, one winged lion, and a LOT of monsters. My #booknecklace is a winged lion!

This book was born one day when I wandered into the kitchen and announced, "I want to write a book about a winged lion." My husband said, "Great! How about plot, characters...?" "Winged lion!" I shouted. And then I wrote it.

I'm counting down to the publication of my 20th book, RACE THE SANDS, out 4/21, by sharing pics of each #booknecklace my husband gave me to celebrate each of my prior books...

Book 13 (picture book): ROAR AND SPARKLES GO TO SCHOOL is my first picture book, art by the amazing Ben Whitehouse. Roar the dragon is worried about his first day of school, but luckily he has his big sister Sparkles to help him through it. My #booknecklace is a little dragon!

My favorite part of writing this book was inventing the dragon school -- imagining a day in the life of a draconian kindergartner. I knew from the start he'd char his lunch with his breath, play hide-and-seek-the-princess in gym, and ride a dragon bus to school!

I'm counting down to the publication of my 20th book, RACE THE SANDS, out 4/21, by sharing pics of each #booknecklace my husband gave me to celebrate each of my prior books...

Book 14 (adult SFF): THE RELUCTANT QUEEN, Book 2 of The Queens of Renthia. Bloodthirsty nature spirits, a dying queen, and a middle-aged woman who wants nothing to do with the power she could wield. This book shares a #booknecklace with THE QUEEN OF BLOOD but we added blood-red earrings!

I actually wrote 90 pages of THE RELUCTANT QUEEN (book 2) before I wrote THE QUEEN OF BLOOD (book 1). My editor at Harper Voyager, the awesome David Pomerico, read the pages and said, "Can this be book two?" And now I can't imagine it being any different.

In THE RELUCTANT QUEEN, I wrote my first middle-aged heroine. She's definitely not the last! The protagonist of my upcoming RACE THE SANDS is a badass middle-aged single mom!

I'm counting down to the publication of my 20th book, RACE THE SANDS, out 4/21, by sharing pics of each #booknecklace my husband gave me to celebrate each of my prior books...

Book 15 (MG): THE STONE GIRL'S STORY is about a twelve-year-old girl made of stone who, when the carvings that brought her and her stone friends to life begin to fade, must go on a quest to save them all. So my husband gave me a #booknecklace made of stones!

THE STONE GIRL'S STORY is, at its heart, a story about stories. I believe that stories are as essential to life as food, water, and shelter. They're how we understand who we are. I wrote this book for everyone who wants to shape the story of their life and choose their own destiny.

It was surprisingly tricky to write about a character made of stone. She can't smell, taste, or sleep. Her stomach never drops, clenches, or feels butterflies. I couldn't use any of the common physical reactions to convey emotions, because stone. Made for a fun writing challenge!

I'm counting down to the publication of my 20th book, RACE THE SANDS, out 4/21, by sharing pics of each #booknecklace my husband gave me to celebrate each of my prior books...

Book 16 (adult SFF): THE QUEEN OF SORROW, Bk 3 of The Queens of Renthia, is the final battle between vicious spirits and three strong-willed queens. I loved writing these books so much that I cried when I finished. This book shares its #booknecklace with the first two in the series.

I loved writing an epic fantasy trilogy! It's something I've wanted to do ever since my mom introduced my eleven-year-old self to the SFF shelves in the Northboro Public Library and placed THE SWORD OF SHANNARA by Terry Brooks in my hands.

I'm counting down to the publication of my 20th book, RACE THE SANDS, out 4/21, by sharing pics of each #booknecklace my husband gave me to celebrate each of my prior books...

Book 17 (YA): FIRE AND HEIST is about a sixteen-year-old socialite from a family of master thieves... who can also breathe fire. Think Ocean's Eleven with were-dragons! My #booknecklace for this one is, quite appropriately, a flame!

While I was writing FIRE AND HEIST, I watched so many YouTube videos on how to pick locks, read so many articles on real-life heists, and researched the specs of so many secure vaults that I wanted to add a disclaimer to all my Google searches: "This is for a book! Really!"

I'm counting down to the publication of my 20th book, RACE THE SANDS, out 4/21, by sharing pics of each #booknecklace my husband gave me to celebrate each of my prior books...

Book 18 (adult SFF): THE DEEPEST BLUE is a standalone epic fantasy set in the same world as The Queens of Renthia (but you don't have to have read the trilogy first -- it's a true standalone). It features a LOT of sea monsters so my #booknecklace is a sea monster!

When I saw the cover for THE DEEPEST BLUE, I was thrilled to see that the artist (Larry Rostant) had depicted the sea monsters precisely as I'd imagined them. The sea dragon, the kraken, and the multi-headed snake -- those are my murder-babies!

I'm counting down to the publication of my 20th book, RACE THE SANDS, out 4/21, by sharing pics of each #booknecklace my husband gave me to celebrate each of my prior books...

Book 19 (MG): SPARK is my newest book for kids. It's about a girl and her lightning dragon (a storm beast), and how even the quietest voice can change the world. My #booknecklace is a lightning bolt, and I wore it so much that I broke the chain.

I wrote SPARK for all the quiet kids out there. But it's not about a quiet kid who learns to be loud. It's about a quiet kid who discovers that she's strong exactly as she is. She doesn't have to change herself to change the world.

I also wrote it because I not-so-secretly want my own lightning dragon.....

I'm counting down to the publication of my 20th book, RACE THE SANDS, out 4/21, by sharing pics of each #booknecklace my husband gave me to celebrate each of my prior books...

Book 20 (adult SFF): RACE THE SANDS. And this brings us to my newest book and newest #booknecklace! Tomorrow my 20th book comes out! It's a standalone epic fantasy about monster racing. The primary monster is a metal lion, and my husband found the most perfect necklace on Etsy!

Near Paris, there is no need to see if there is another car behind you...

Where's the beef? In California, it is still available, but meat eaters might need to settle for cuts other than prime steaks. The industry is dealing with production backups caused by coronavirus pandemic.

Former Denver Broncos quarterback Joe Flacco, who remains a free agent, could miss the start of the 2020 season after he underwent neck surgery.

Attribution methods provide insights into the decision-making of machine learning models like artificial neural networks. For a given input sample, they assign a relevance score to each individual input variable, such as the pixels of an image. In this work we adapt the information bottleneck concept for attribution. By adding noise to intermediate feature maps we restrict the flow of information and can quantify (in bits) how much information image regions provide. We compare our method against ten baselines using three different metrics on VGG-16 and ResNet-50, and find that our methods outperform all baselines in five out of six settings. The method's information-theoretic foundation provides an absolute frame of reference for attribution values (bits) and a guarantee that regions scored close to zero are not necessary for the network's decision. For reviews: https://openreview.net/forum?id=S1xWh1rYwB For code: https://github.com/BioroboticsLab/IBA

This brief examines the global shortage of the personal protective equipment (PPE) needed to tackle COVID-19 and suggests policy implications.

Title: Necklace Spots A-Fib in Just Over 30 Seconds
Category: Health News
Created: 5/6/2020 12:00:00 AM
Last Editorial Review: 5/7/2020 12:00:00 AM

A necklace outfitted with a high-tech pendant may be able to screen for signs of an abnormal heart rhythm condition known as atrial fibrillation.

Early recognition of longus colli calcific tendinitis can prevent unnecessary interventions including antibiotics and surgical procedures.

RNA viruses form a dynamic distribution of mutant swarms (termed "quasispecies") due to the accumulation of mutations in the viral genome. The genetic diversity of a viral population is affected by several factors, including a bottleneck effect. Human-to-human transmission exemplifies a bottleneck effect, in that only part of a viral population can reach the next susceptible hosts. In the present study, two lineages of the rhesus rotavirus (RRV) strain of rotavirus A were serially passaged five times at a multiplicity of infection (MOI) of 0.1 or 0.001, and three phenotypes (infectious titer, cell binding ability, and specific growth rate) were used to evaluate the impact of a bottleneck effect on the RRV population. The specific growth rate values of lineages passaged under the stronger bottleneck (MOI of 0.001) were higher after five passages. The nucleotide diversity also increased, which indicated that the mutant swarms of the lineages under the stronger bottleneck effect were expanded through the serial passages. The random distribution of synonymous and nonsynonymous substitutions on rotavirus genome segments indicated that almost all mutations were selectively neutral. Simple simulations revealed that the presence of minor mutants could influence the specific growth rate of a population in a mutant frequency-dependent manner. These results indicate a stronger bottleneck effect can create more sequence spaces for minor sequences.

IMPORTANCE In this study, we investigated a bottleneck effect on an RRV population that may drastically affect the viral population structure. RRV populations were serially passaged under two levels of a bottleneck effect, which exemplified human-to-human transmission. As a result, the genetic diversity and specific growth rate of RRV populations increased under the stronger bottleneck effect, which implied that a bottleneck created a new space in a population for minor mutants originally existing in a hidden layer, which includes minor mutations that cannot be distinguished from a sequencing error. The results of this study suggest that the genetic drift caused by a bottleneck in human-to-human transmission explains the random appearance of new genetic lineages causing viral outbreaks, which can be expected according to molecular epidemiology using next-generation sequencing in which the viral genetic diversity within a viral population is investigated.

Background:

Limited treatment options are available for oral mucositis, a common, debilitating complication of cancer therapy. We examined the association between daily delivery time of radiotherapy and the severity of oral mucositis in patients with head and neck cancer.

While smoking is inextricably linked to oral/head and neck cancer (HNSCC), only a small fraction of smokers develop HNSCC. Thus, we have sought to identify other factors, which may influence the development of HNSCC in smokers including microbiology. To determine microbial associations with HNSCC among tobacco users, we characterized oral microbiome composition in smokers with and without HNSCC. 16S rRNA MiSeq sequencing was used to examine the oral mucosa microbiome of 27 smokers with (cases) and 24 without HNSCC (controls). In addition, we correlated previously reported levels of DNA damage with the microbiome data. Smokers with HNSCC showed lower microbiome richness compared with controls (q = 0.012). Beta-diversity analyses, assessed as UniFrac (weighted and unweighted) and Bray–Curtis distances, showed significant differences in oral mucosal microbiome signatures between cases and controls (r² = 0.03; P = 0.03) and higher interindividual microbiome heterogeneity in the former (q ≤ 0.01). Higher relative abundance of Stenotrophomonas and Comamonadaceae and predicted bacterial pathways mainly involved in xenobiotic and amine degradation were found in cases compared with controls. The latter, in contrast, exhibited higher abundance of common oral commensals and predicted sugar degradation pathways. Finally, levels of DNA damage in the oral cavity were correlated with the microbiome profiles above. Oral microbiome traits differ in smokers with and without HNSCC, potentially informing the risk of eventual HNSCC and shedding light into possible microbially mediated mechanisms of disease. These findings present data that may be useful in screening efforts for HNSCC among smokers who are unable to quit.

SUMMARY:

The olfactory bulbs and tracts are central nervous system white matter tracts maintained by central neuroglia. Although rare, gliomas can originate from and progress to involve the olfactory apparatus. Through a Health Insurance Portability and Accountability Act–compliant retrospective review of the institutional teaching files and brain MR imaging reports spanning 10 years, we identified 12 cases of gliomas involving the olfactory bulbs and tracts, including 6 cases of glioblastoma, 2 cases of anaplastic oligodendroglioma, and 1 case each of pilocytic astrocytoma, diffuse (grade II) astrocytoma, anaplastic astrocytoma (grade III), and diffuse midline glioma. All except the pilocytic astrocytoma occurred in patients with known primary glial tumors elsewhere. Imaging findings of olfactory tumor involvement ranged from well-demarcated enhancing masses to ill-defined enhancing infiltrative lesions to nonenhancing masslike FLAIR signal abnormality within the olfactory tracts. Familiarity with the imaging findings of glioma involvement of the olfactory nerves is important for timely diagnosis and treatment of recurrent gliomas and to distinguish them from other disease processes.

BACKGROUND AND PURPOSE:

Endolymphatic hydrops in patients with Menière disease relies on delayed postcontrast 3D-FLAIR sequences. The purpose of this study was to compare the degree of perilymphatic enhancement and the detection rate of endolymphatic hydrops using constant and variable flip angles sequences.

Arrokoth, a strange two-lobed space rock, was hit by another rock at some point – the collision may have snapped Arrokoth’s narrow neck before it reformed again

Super Bowl champion quarterback Joe Flacco underwent neck surgery last month and is expected to be out until September, according to multiple reports.

Baltimore Ravens safety Earl Thomas appears to have reconciled with his wife after reports emerged earlier this week that she held him at gunpoint last month after discovering an alleged affair. 

Canada Emergency Response Benefit (CERB), for people who lost income due to COVID-19, provides $2,000 a month for up to four months.

A round of applause for our carers

Megha-bling

The Federal Opposition Leader accuses Scott Morrison of misleading Federal Parliament over the sports rorts saga, saying Bridget McKenzie was made a "scapegoat" over the affair.

Reports of interference with aircraft radio communications at one of regional Victoria's busiest airports, where a flying school training pilots for Chinese airlines has been operating for about a year, are being investigated.

What is this recommendation about? Obviously this recommendation is an attempt of the Commission to manage administative barriers to placing PPE (personal protective equipment) and medical devices on the market that would be needed in the struggle to get the current Covid-19 pandemic under control. In my view you can also see this as a […]

is looking down at your phone really like putting an aardvark on your head?

This kind of trailer means you can eliminate the head-banging sleeping loft.

Uniting Voices Across Europe to Show Support for Head and Neck Cancer Patients

With football on hold during the coronavirus pandemic, one of the world’s leading freestylers is helping fans remain active under lockdown. Every day, Liv Cooke a four-time world record holder, posts footage of herself performing a freestyle trick with instructions on how to follow suit at home

• A trick a day: how freestyler Liv Cooke is bringing light to the lockdown

This necklace was inspired by one my friend Rebecca made. She’s a big bakelite fan and didn’t want to pay a bunch of a bakelite cherry necklace, so she took matters into her own hands and made her own version using red bakelite beads. So when I was at Michael’s … Continue reading →

To kick of the fabulous month of October here is a DIY that you can make super easy & simply, or fancy it up by adding beads and loads of images. Here’s what you need: –Inkjet Shrink Plastic -chain -jump rings (in a color that matches your chain..I went with … Continue reading →

March is national Craft Month, and the folks at Jo­‐Ann Fabric And Craft Stores asked me to help celebrate by creating a DIY based on one of the latest Spring Trends. I decided to go with a mix of trends, flowers and geometric. I created a English paper pieced hexagon … Continue reading →